To construct a compiler for a modern higher-level programming languagel one needs to structure the translation to a machine-like intermediate language in a way that reflects the semantics of the language. little is said about such struc turing in compiler texts that are intended to cover a wide variety of program ming languages. More is said in the Iiterature on semantics-directed compiler construction [1] but here too the viewpoint is very general (though limited to 1 languages with a finite number of syntactic types). On the other handl there is a considerable body of work using the continuation-passing transformation to structure compilers for the specific case of call-by-value languages such as SCHEME and ML [21 3]. ln this paperl we will describe a method of structuring the translation of ALGOL-like languages that is based on the functor-category semantics devel oped by Reynolds [4] and Oles [51 6]. An alternative approach using category theory to structure compilers is the early work of F. L. Morris [7]1 which anticipates our treatment of boolean expressionsl but does not deal with procedures. 2 Types and Syntax An ALGOL-like language is a typed lambda calculus with an unusual repertoire of primitive types. Throughout most of this paper we assume that the primi tive types are comm(and) int(eger)exp(ression) int(eger)acc(eptor) int(eger)var(iable) I and that the set 8 of types is the least set containing these primitive types and closed under the binary operation -.
Challenging many of the premises of conventional anthropological theory, 'On the evolution of human behavior' draws on recent evidence from psychobiology, linguistics, and ethology to trace the evolution of human social behavior from that of other primates. Rejecting the assumption that significant behavioral discrepancies between man and other primate species stem from equally significant psychological differences, Reynolds argues instead that small evolutionary changes may result in greatly increased complexity of behavior. His frankly ethological theory of human origins assumes that reason and instinct evolve together and that instinctual mechanisms are necessary for the emergence of human culture." -- book cover.
Randomised Clinical Trials: Design, Practice and Reporting provides a detailed overview of the methodology for conducting clinical trials, including developing protocols, data capture, randomisation, analysis and reporting. Assuming no prior background, this user-friendly resource describes the statistical, regulatory, and practical components required for conducting randomised clinical trials. Numerous examples and case studies from industry, academia, and the research literature help readers understand each stage of the clinical trial process. This second edition contains extensively revised material throughout, including new chapters covering designs for repeated measures, non-inferiority, cluster and stepped wedge trials. Other new chapters describe data and safety monitoring, biomarker studies, and feasibility studies. Updated and expanded sections discuss situations where multiple organs, different body locations or competing risks are involved, subgroup analysis, and multiple outcomes. Written by an author team with extensive experience in conducting clinical trials, this book: Provides comprehensive coverage of randomised clinical trials, ranging from basic to advanced Features several new chapters, updated case studies and examples, and references to changes in regulations Explains basic randomised trials, including the parallel two-group controlled trial with a single outcome measure Covers paired trial designs and trials with more than two interventions Includes a chapter on miscellaneous topics such as adaptive designs, large simple trials, Bayesian methods for very small trials, alpha-spending functions and the predictive probability test Randomised Clinical Trials is essential reading for clinicians, nurses, data managers, and medical statisticians involved in clinical trials, and for health practitioners responsible for direct patient care in a clinical trial setting.
Ecotoxicology offers a comprehensive overview of the science underpinning the recognition and management of environmental contamination. It describes the toxicology of environmental contaminants, the methods used for assessing their toxicity and ecological impacts, and approaches employed to mitigate pollution and ecological health risks globally. Chapters cover the latest advances in research, including genomics, natural toxins, endocrine disruption and the toxicology of radioactive substances. The second half of the book focuses on applications, such as cradle-to-grave effects of selected industries, legal and economic approaches to environmental regulation, ecological risk assessment, and contaminated site remediation. With short capsules written by invited experts, numerous case studies from around the world and further reading lists, this textbook is designed for advanced undergraduate and graduate one-semester courses. It is also a valuable reference for graduate students and professionals. Online resources for instructors and students are also available.
From Angkor Wat to Agent Orange, Southeast Asia An Environmental History tells the story of some of the most dramatic effects humans have had on the natural and developed environment anywhere in the world and examines the ways in which environmental factors have helped shape the culture, politics, and societies of the region. Ever since the first humanlike creatures arrived some 80,000 years ago, Southeast Asia's varied and challenging environment has helped shape the course of human destiny. From the importance of its spices to 17th-century Europeans to the jungle canopies that sheltered Communist insurgents throughout much of the 20th century, the region's environment has often proven decisive in human affairs. Packed with key facts and analysis, Southeast Asia provides an expert guide to the complex interplay between human societies and the environment from Burma to the Philippines and from Vietnam to Indonesia. How has the environment helped shape politics, trade, and religion? What are the likely consequences of ongoing deforestation for Southeast Asia's people and animals? Part of ABC-CLIO's Nature and Human Societies series, this work charts the region's environmental history from prehistory to modern times and is essential reading for students and experts alike.
Dr. Peter Hotez discusses how an antivaccine movement became a dangerous political campaign promoted by elected officials and amplified by news media, causing thousands of American deaths. During the height of the COVID-19 pandemic, one renowned scientist, in his famous bowtie, appeared daily on major news networks such as MSNBC, NPR, the BBC, and others. Dr. Peter J. Hotez often went without sleep, working around the clock to develop a nonprofit COVID-19 vaccine and to keep the public informed. During that time, he was one of the most trusted voices on the pandemic and was even nominated for a Nobel Peace Prize for his selfless work. He also became one of the main targets of anti-science rhetoric that gained traction through conservative news media. In this eyewitness story of how the anti-vaccine movement grew into a dangerous and prominent anti-science element in American politics, Hotez describes the devastating impacts it has had on Americans' health and lives. As a scientist who has endured antagonism from anti-vaxxers and been at the forefront of both essential scientific discovery and advocacy, Hotez is uniquely qualified to tell this story. By weaving his personal experiences together with information on how the anti-vaccine movement became a tool of far-right political figures around the world, Hotez opens readers' eyes to the dangers of anti-science. He explains how anti-science became a major societal and lethal force: in the first years of the pandemic, more than 200,000 unvaccinated Americans needlessly died despite the widespread availability of COVID-19 vaccines. Even as he paints a picture of the world under a shadow of aggressive ignorance, Hotez demonstrates his innate optimism, offering solutions for how to combat science denial and save lives in the process.
Accurately identify the full range of clinical and pathological entities with Rosen’s Diagnosis of Breast Pathology by Needle Core Biopsy, Fourth Edition! With guidance from the same trusted authorities responsible for the esteemed clinical reference, Rosen’s Breast Pathology, you’ll gain masterful insights on how to confidently meet diagnostic challenges on needle core biopsy material. These challenges are summarized in the three maxims stated by Dr Paul Peter Rosen in the Preface to the First Edition of this book, and which continue to relevant today: 1. Anything can turn up. 2. What you see is what you have. It may not be all there is. 3. What you see may be all there is. The pathologist must always keep these precepts in mind when offering a diagnosis based on limited material in needle core biopsy samples. This book will serve as a complete guide to interpreting this material.
Understanding organogenesis is central to current efforts to direct stem cell differentiation and function in the context of a complex organ. Defects in organogenesis are often the major manifestations of human genetic disease syndromes. This volume describes the development of 10 major organ systems, reviewed by experts in each, to provide an up-to-date overview for researchers within and outside the field, students, teachers and clinicians. - Summarizes the key morphological and cellular events - Emphasizes up-to-date research relating to molecular control mechanisms - Draws on a range of model vertebrates and contemporary experimental approaches, including lessons learnt from human developmental disease - Distils common themes and differences for comparative studies - Highlights key remaining questions and sets the agenda for future research
Many patients referred for an epilepsy evaluation actually suffer from one of many conditions that can imitate it. Imitators of epilepsy are a diverse group that involve consideration of many areas of internal medicine, neurology, and psychiatry. The most important imitators of epileptic seizures are dizziness, vertigo, syncope, complicated migraine; and somewhat less frequently sleep disorders, transient cerebral ischemia, paroxysmal movement disorders, endocrine or metabolic dysfunction, delirium, psychiatric conditions or transient global amnesia. Clearly under-recognized are hyperventilation episodes, panic attacks, and other psychogenic and psychiatric paroxysmal disorders that may simulate epileptic seizures. This volume provides a comprehensive review of the differential diagnosis of seizures: how do the imitators of epilepsy present clinically, what are their particular distinguishing historical features, and what tests are helpful with diagnosis? Expanding beyond the first edition, this second edition is divided into four sections. The first deals with an introduction and approach diagnosing spells, the electroencephalography of epilepsy and its imitators, and specialized tests of diagnosis such as measurement of serum prolactin. There are chapters on epileptic seizures that do not look like typical epileptic seizures, and conversely, apparent epileptic seizures that are not. A second section approaches imitators of epileptic seizures along age-based lines; i.e., what sorts of spells are likely to beset infants, children, or the elderly? A third section addresses individual imitators of epilepsy, ranging from the common to the rare, from dizziness and faintness to startle disease, arranged according to whether they might simulate partial, generalized, or both types of epileptic seizures. The volume finishes off with hyperventilation syndrome, psychogenic seizures (with or without epilepsy), and panic disorders. Most chapters review the basic definitions and physiology of the respective imitator, followed by the clinical characteristics. Emphasis is given to those features that may differentiate it from an epileptic event, but also mark it for what it is, and give possible criteria for an alternate diagnosis. Case vignettes are used to illustrate particular aspects, along with tables that compare and contrast phenotypically similar conditions. Based on their extensive clinical experience, the authors provide a personal perspective on diagnosis and treatment.
Activist and Socially Critical School and Community Renewal comes about at an incredibly important point in history, and it offers a genuinely new paradigm. This book attempts what few others have tried—to bring together knowledge and literature around school reform and community renewal through authentic ethnographic stories of real schools and communities.
ICE Core Concepts: Hydraulics for Civil Engineers is an accessible introduction to the principles of hydraulics. Combining core theories with the need for sustainable solutions, the book covers all the fundamental areas in hydraulics, it is ideal reading for both student and graduate engineers seeking a concise overview of the subject.
More than one hundred and fifty years after Confederates fired on Fort Sumter, the Civil War still occupies a prominent place in the national collective memory. Paintings and photographs, plays and movies, novels, poetry, and songs portray the war as a battle over the future of slavery, often focusing on Lincoln’s determination to save the Union, or highlighting the brutality of brother fighting brother. Battles and battlefields occupy us, too: Bull Run, Antietam, and Gettysburg all conjure up images of desolate landscapes strewn with war dead. Yet the frontlines were not the only landscapes of the war. Countless civilians saw their daily lives upended while the entire nation suffered. Home Front: Daily Life in the Civil War North reveals this side of the war as it happened, comprehensively examining the visual culture of the Northern home front. Through contributions from leading scholars from across the humanities, we discover how the war influenced household economies and the cotton economy; how the absence of young men from the home changed daily life; how war relief work linked home fronts and battle fronts; why Indians on the frontier were pushed out of the riven nation’s consciousness during the war years; and how wartime landscape paintings illuminated the nation’s past, present, and future. A companion volume to a collaborative exhibition organized by the Newberry Library and the Terra Foundation for American Art, Home Front is the first book to expose the visual culture of a world far removed from the horror of war yet intimately bound to it.
Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.
This book explores the role of singularities in general relativity (GR): The theory predicts that when a sufficient large mass collapses, no known force is able to stop it until all mass is concentrated at a point. The question arises, whether an acceptable physical theory should have a singularity, not even a coordinate singularity. The appearance of a singularity shows the limitations of the theory. In GR this limitation is the strong gravitational force acting near and at a super-massive concentration of a central mass. First, a historical overview is given, on former attempts to extend GR (which includes Einstein himself), all with distinct motivations. It will be shown that the only possible algebraic extension is to introduce pseudo-complex (pc) coordinates, otherwise for weak gravitational fields non-physical ghost solutions appear. Thus, the need to use pc-variables. We will see, that the theory contains a minimal length, with important consequences. After that, the pc-GR is formulated and compared to the former attempts. A new variational principle is introduced, which requires in the Einstein equations an additional contribution. Alternatively, the standard variational principle can be applied, but one has to introduce a constraint with the same former results. The additional contribution will be associated to vacuum fluctuation, whose dependence on the radial distance can be approximately obtained, using semi-classical Quantum Mechanics. The main point is that pc-GR predicts that mass not only curves the space but also changes the vacuum structure of the space itself. In the following chapters, the minimal length will be set to zero, due to its smallness. Nevertheless, the pc-GR will keep a remnant of the pc-description, namely that the appearance of a term, which we may call "dark energy", is inevitable. The first application will be discussed in chapter 3, namely solutions of central mass distributions. For a non-rotating massive object it is the pc-Schwarzschild solution, for a rotating massive object the pc-Kerr solution and for a charged massive object it will be the Reissner-Nordström solution. This chapter serves to become familiar on how to resolve problems in pc-GR and on how to interpret the results. One of the main consequences is, that we can eliminate the event horizon and thus there will be no black holes. The huge massive objects in the center of nearly any galaxy and the so-called galactic black holes are within pc-GR still there, but with the absence of an event horizon! Chapter 4 gives another application of the theory, namely the Robertson-Walker solution, which we use to model different outcomes of the evolution of the universe. Finally the capability of this theory to predict new phenomena is illustrated.
The New York Mets Encyclopedia provides the full and exciting story of modern-era baseball’s most popular expansion-age franchise. From those lovable losers of 1962 and 1963, to the Miracle Mets of 1969 and 1973, and on to year-in and year-out contenders of the 1980s and 1990s, New York’s National League Mets have written some of the most exciting and colorful pages in Major League history. This is the team that captured the hearts of fans everywhere with its often-laughable antics under colorful and celebrated manager Casey Stengel. Only half a dozen years later, the Mets reached baseball’s pinnacle under gifted manager Gil Hodges. This colorful volume combines detailed narrative history with archival photographs, rich statistical data, and intimate portraits of the team’s most memorable personalities. This is also a franchise that has been home to many of the game’s biggest on-field stars. Among them are such unforgettable diamond characters as reckless slugger Darryl Strawberry; glue-fingered first sacker Keith Hernandez; baseball’s all-world catcher, Mike Piazza; pitching ace Johan Santana; and record-breaking third baseman David Wright. The full scope of the Mets’ fifty-plus-year history is discussed in an expansive chapter that gives the reader a historical detailed overview and features a year-by-year Mets chronology and season-by-season opening-day lineups. This newly revised edition offers insight on everything a Mets fan would want or need to know.
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