Soils form a unique and irreplaceable essential resource for all terrestrial organisms, including man. Soils form not only the very thin outer skin of the earth's crust that is exploited by plant roots for anchorage and supply of water and nutrients. Soils are complex natural bodies formed under the influence of plants, microorganisms and soil animals, water and air from their parent material, i.e. solid rock or unconsolidated sediments. Physically, chemically and mineralogically they usually differ strongly from the parent material, and normally are far more suitable as a rooting medium for plants. In addition to serving as a substrate for plant growth, including crops and pasture, soils play a dominant role in the biogeochemical cycling of water, carbon, nitrogen and other elements, influencing the chemical composition and turnover rates of substances in the atmosphere and the hydrosphere. Soils take decades to millennia to form. We tread on them and do not usually see their interior, so we tend to take them for granted. But improper and abusive agricultural management, careless land- clearing and reclamation, man-induced erosion, salinisation and acidification, desertification, air- and water pollution, and withdrawal of land for housing, industry and transportation now destroy soils more rapidly than they can be formed.
The gastrointestinal mucosal defense system serves to minimize mucosal injury by either ingested or endogenously produced noxious substances. The mucosal defense system is stratified into pre-epithelial (alkaline mucus), epithelial (dynamic epithelial lining), and post-epithelial (microcirculation) components. The mucus lining the epithelial surface presents a diffusional barrier to ingested material (e.g., lipids) and also serves as an unstirred layer in which a pH gradient can be established to prevent acid-induced injury. The epithelial lining prevents entrance of any toxic material to the interstitium and, should it be damaged, it is rapidly resealed by migration of adjacent viable epithelial cells to cover the defect. Any acid or other material that has entered the interstitium is washed out by an intense neurogenic hyperemia. In general, the mucosal defense system is quite effective and any adverse gastrointestinal effects associated with the normal course of nutrient assimilation are minimal. However, there are two situations in which the mucosal defense system is known to be ineffective and result in gastric mucosal injury: inadvertent ingestion of H. pylori. or intentional ingestion of NSAIDs. H. pylori can penetrate the mucus layers and cause epithelial injury and inflammation, while at the same time preventing its clearance by the host immune system. NSAIDs weaken the mucus layer and cause epithelial cell injury. Table of Contents: Acknowledgments / Introduction / The Mucus Layer / Epithelial Lining / Gastrointestinal Circulation / Integration of Mucosal Defense / Mucosal Defense System: Physiologic / Mucosal Defense System: H. pylori / Mucosal Defense System: Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) / Overall Summary and Conclusions / References / Author Biographies
Diversity and density in housing today Accomodation of diversity and the creation of urban density are a focus of world-wide building and planning activities today. This book combines the architectural and urban scales to demonstrate that it is a specific quality, urban intensity, which determines the success of housing. The authors provide a typology of housing according to the ways in which diversity and density are created. Comparisons with historical models and critical appraisals based on the authors’ unique standing give ample information on the pros and cons of major types of housing, their pitfalls and successful examples. Newly created sets of drawings, from floor plans to spectacular 3D aerial views of the buildings in their urban contexts, accompany each of the more than twenty case studies that are described and analyzed in detail. The approach taken here relates to many pressing issues in contemporary housing, including the avoidance of urban sprawl, the revival of city centers and the ongoing search for innovative housing types. A qualitative approach to diversity and density in housing A concept that unites architectural and urban design A wide range of original drawings of benchmark case studies
The explanation and implementation of statistical methods for the medical researcher or statistician remains an integral part of modern medical research. This book explains the use of experimental and analytical biostatistics systems. Its accessible style allows it to be used by the non-mathematician as a fundamental component of successful research. Since the third edition, there have been many developments in statistical techniques. The fourth edition provides the medical statistician with an accessible guide to these techniques and to reflect the extent of their usage in medical research. The new edition takes a much more comprehensive approach to its subject. There has been a radical reorganization of the text to improve the continuity and cohesion of the presentation and to extend the scope by covering many new ideas now being introduced into the analysis of medical research data. The authors have tried to maintain the modest level of mathematical exposition that characterized the earlier editions, essentially confining the mathematics to the statement of algebraic formulae rather than pursuing mathematical proofs. Received the Highly Commended Certificate in the Public Health Category of the 2002 BMA Books Competition.
The microcirculation of the gastrointestinal tract is under the control of both myogenic and metabolic regulatory systems. The myogenic mechanism contributes to basal vascular tone and the regulation of transmural pressure, while the metabolic mechanism is responsible for maintaining an appropriate balance between O2 demand and O2 delivery. In the postprandial state, hydrolytic products of food digestion elicit a hyperemia, which serves to meet the increased O2 demand of nutrient assimilation. Metabolically linked factors (e.g., tissue pO2, adenosine) are primarily responsible for this functional hyperemia. The fenestrated capillaries of the gastrointestinal mucosa are relatively permeable to small hydrolytic products of food digestion (e.g., glucose), yet restrict the transcapillary movement of larger molecules (e.g., albumin). This allows for the absorption of hydrolytic products of food digestion without compromising the oncotic pressure gradient governing transcapillary fluid movement and edema formation. The gastrointestinal microcirculation is also an important component of the mucosal defense system whose function is to prevent (and rapidly repair) inadvertent epithelial injury by potentially noxious constituents of chyme. Two pathological conditions in which the gastrointestinal circulation plays an important role are ischemia/reperfusion and chronic portal hypertension. Ischemia/reperfusion results in mucosal edema and disruption of the epithelium due, in part, to an inflammatory response (e.g., increase in capillary permeability to macromolecules and neutrophil infiltration). Chronic portal hypertension results in an increase in gastrointestinal blood flow due to an imbalance in vasodilator and vasoconstrictor influences on the microcirculation. Table of Contents: Introduction / Anatomy / Regulation of Vascular Tone and Oxygenation / Extrinsic Vasoregulation: Neural and Humoral / Postprandial Hyperemia / Transcapillary Solute Exchange / Transcapillary Fluid Exchange / Interaction of Capillary and Interstitial Forces / Gastrointestinal Circulation and Mucosal Defense / Gastrointestinal Circulation and Mucosal Pathology I: Ischemia/Reperfusion / Gastrointestinal Circulation and Mucosal Pathology II: Chronic Portal Hypertension / Summary and Conclusions / References / Author Biography
A unique approach to a core topic in organic chemistry presented by an experienced teacher to students and professionals Heterocyclic rings are present in the majority of known natural products, contributing to enormous structural diversity. In addition, they often possess significant biological activity. Medicinal chemists have embraced this last property in designing most of the small molecule drugs in use today. This book offers readers a fundamental understanding of the basics of heterocyclic chemistry and their occurrence in natural products such as amino acids, DNA, vitamins, and antibiotics. Based on class lectures that the author has developed over more than 40 years of teaching, it focuses on the chemistry of such heterocyclic substances and how they differ from carbocyclic systems. Introductory Heterocyclic Chemistry offers in-depth chapters covering naturally occurring heterocycles; properties of aromatic heterocycles; π-deficient heterocycles; π-excessive heterocycles; and ring transformations of heterocycles. It then offers an overview of 1,3-dipolar cycloadditions before finishing up with a back-to-basics section on nitriles and amidines. Presents a conversational approach to a fundamental topic in organic chemistry teaching Offers a unique look at this core organic chemistry topic via important naturally occurring and/or biologically active heterocycles Based on the author's many years of class lectures for teaching at the undergraduate and graduate level as well as pharmaceutical-industry courses Clear, concise, and accessible for advanced students of chemistry to gain a fundamental understanding of the basics of heterocyclic chemistry Introductory Heterocyclic Chemistry is an excellent text for undergraduate and graduate students as well as chemists in industrial environments in chemistry, pharmacy, medicinal chemistry, and biology.
The authors provide a compelling argument for a radically modular view of the human language faculty. The authors argue that complex words are generated by a dedicated rule system which interacts with the syntax on the one hand and the phonology on the other.
5 Stars! from Doody's Book Reviews! (of the 13th Edition) "This edition continues to raise the bar for books on drug use and abuse. The presentation of the material is straightforward and comprehensive, but not off putting or complicated." As a long-standing, reliable resource Drugs & Society, Fourteenth Edition continues to captivate and inform students by taking a multidisciplinary approach to the impact of drug use and abuse on the lives of average individuals. The authors have integrated their expertise in the fields of drug abuse, pharmacology, and sociology with their extensive experiences in research, treatment, drug policy making, and drug policy implementation to create an edition that speaks directly to students on the medical, emotional, and social damage drug use can cause.
Reciprocal Translation Between Pathophysiology and Practice in Health and Disease brings a novel perspective, closing the knowledge gap between normal/abnormal physiology. Chapters describe the basic mechanisms underlying a disease or trauma-related response, describe consequences in practice, and provide insights on how to use information to better understand disease outcomes. Other sections explore how these responses are beneficial and driven by similar hormones and inflammatory immune cell derived modulators. This is a must-have resource for those seeking an authoritative and comprehensive understanding on how to treat the basic mechanisms underlying disease or trauma-related responses.With contributions from Petronella L.M. Reijven. - Provides an overview of fundamental/foundational content and then goes on to translate the information to more clinically-oriented perspectives - Highlights the benefit of normal pathophysiological response to stress and the misunderstandings surrounding the treatment of this response - Explains how treatment should be adapted to support the inflammatory response and how to treat its inflammatory cause - Includes case studies and slides
First Published in 1991. This work is a follow-up on the European Science Foundation Project (ESF) entitled the Ecology of Adult Language Acquisition. The subject of this study is the process of untutored language acquisition in adults and the focus is on Turkish and Moroccan immigrants during the first three years of their stay in the Netherlands.
The Parisi were a tribe located somewhere within the present day East Riding of Yorkshire, UK, known from a brief reference by Ptolemy They were originally immigrants from Gaul and share their name with the tribe that occupied modern day France. Fairly obvious from their name, they gave the French capital its name.The investigation of the Parisi began in the sixteenth and seventeenth centuries, following the trend for antiquarian exploration elsewhere in Britain. Before that the remains of Roman buildings encountered in medieval East Yorkshire were treated with little respect and used as a resource. The Parisi tells this captivating story of the history of the archaeology of The Parisi, from the initial investigations in the sixteenth century right through to modern day investigations.
Intended for cell biologists, biophysicists, biochemists, molecular biologists, physiologists, researchers in hemostatsis and thrombosis and pathologists, this book provides an insight into cell adhesion from three interdisciplinary perspectives: fundamental facts of adhesion; molecular biochemistry of adhesion and physiological aspects. It summarizes the basic aspects of surfaces in general and describes the theoretical and experimental tools necessary to investigate cell adhesion, including the basic biochemistry and molecular biology of adhesion. The book offers concise treatment of individual topics, features current material, and provides key references as a guide to further study.
Imports pour into the United States, up by 79 percent in six years. The trade deficit more than doubles. The House of Representatives solidly rejects a bill that would liberalize global and regional trade and endorses import quotas for a major manufactured product by a two-to-one margin. Although at first glance these events of the 1990s might sound like past chapters of US trade politics, in fact the political dynamics have changed in significant ways. As the impact of globalization comes into focus, politically important constituencies have begun to resist trade liberalization. Labor and environmental groups in particular, demanding that their concerns be addressed, have succeeded in fracturing the long-standing, bipartisan, protrade coalition in Congress, and in the process have undercut US leadership in liberalizing global trade. This new study reexamines the landscape of trade politics. It shows how trade advocates and labor and environmental skeptics differ significantly in both their substantive views and their political and organizational cultures. The authors demonstrate how this new challenge differs from that of traditional trade protectionism, likening it instead to the debate a century ago over whether and how to regulate American capitalism for social purposes. The analysis leads to a set of recommendations aimed at constructive compromise and a new political foundation for US trade policy leadership.
Feigin and Cherry's Textbook of Pediatric Infectious Diseases helps you put the very latest knowledge to work for your young patients with unparalleled coverage of everything from epidemiology, public health, and preventive medicine through clinical manifestations, diagnosis, treatment, and much more. Ideal for all physicians, whether in an office or hospital setting, Feigin and Cherry’s equips you with trusted answers to your most challenging clinical infectious disease questions. Meet your most difficult clinical challenges in pediatric infectious disease, including today’s more aggressive infectious and resistant strains as well as emerging and re-emerging diseases, with unmatched, comprehensive coverage of immunology, epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. Find the answers you need quickly thanks to an organization both by organ system and by etiologic microorganism, allowing you to easily approach any topic from either direction.
Chronic obstructive pulmonary disease (COPD), which encompasses both chronic bronchitis and emphysema, is one of the most common respiratory conditions of adults in the developed world. Asthma and COPD: Basic Mechanisms and Clinical Management provides a unique, authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it is a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.* Highlights distinguishing features between asthma and COPD* Reviews benefits and limitations of current therapies* Summarises key information in two-colour artwork * Extensively referenced to primary literature
Kenen (economics and international finance, Princeton University) reviews the reform efforts that followed the 1994-95 Mexican crisis, and evaluates their results in the time since then. He compares the existing efforts with the more radical recommendations of the Meltzer Report, and considers the implications of his analysis for the role of the IMF. He then offers his own recommendations for further reform. c. Book News Inc.
Long-term landscape evolution of the Netherlands during the Holocene, described and visualized in national, regional and local palaeogeographical map series
Long-term landscape evolution of the Netherlands during the Holocene, described and visualized in national, regional and local palaeogeographical map series
The topic of this book is the Origin of the Dutch coastal landscape during the Holocene. The landscape evolution is vizualized in series of palaeogeographical maps and the driving mechanisms behind the environmental changes are discussed. The practice to make palaeogeographical map reconstructions in the Netherlands developed after the Second World War when a lot of regional geological and soil scientific mapping programs were carried out by government institutions and universities. These maps show when and how the surveyed sediments were formed. The palaeogeographical map reconstructions are subsequently used for the understanding and modelling of the long-term coastal evolution, coastal-management issues, landscape-archaeological purposes and for education and public information reasons. Geoarchaeological investigations play an important role in this study. Geological and palaeo-environmental data from archaeological excavations (‘key sites') provided essential information for the palaeolandscape reconstructions. In the presented regional- and local-case studies of this book, examples of these sites are shown.
Only rarely in Europe do the surface remains of Neolithic flint mines remain so dramatically for all to see as those located along the South Downs and in the Breckland of England. Even within England they represent a diminishing resource and only ten sites have been recorded with any certainty. As examples of our earliest industrial heritage they represent archaeological sites of the first importance and have a special part to play in the history of technology. However, despite a lengthy history of archaeological investigation, they have rarely been considered nationally as a class of monument. Although some sites such as Grime's Graves are well known through excavation campaigns, others are known only through obscure articles and unpublished archival material. Many of those that survive as earthworks or cropmarks have never been surveyed previously or accurately planned. Consequently, English Heritage has compiled detailed plans of the surface areas of all of the known flint mines and investigated the sites of other potential examples. Using a combination of field survey, aerial photography and archival research, this volume looks at each site in its own right as a major and important complex and - for the first time - offers a synthesis of the evidence to date.
Offering practical guidance for all members of the transplant team, Kidney Transplantation, Principles and Practice, 8th Edition, provides the balanced, up-to-date information you need to achieve optimal outcomes for your patients. A global team of internationally renowned surgeons and nephrologists, many new to this edition, offers fresh perspectives on everything from applied science and surgical techniques to immunosuppressive methods, outcomes, risks, and medical considerations related to kidney transplantation, in both adults and children. - Offers state-of-the-art coverage of all areas of kidney transplantation such as preservation of kidneys; mechanisms of rejection and the induction of tolerance; techniques of laparoscopic live donor nephrectomy; and immunosuppression. - Contains up-to-date outcomes data and analysis of the evidence supporting current practice in the field. - Includes new information on desensitization and considerable new data on the clinical use of costimulation blockade. - Keeps you current with new chapters on kidney allocation policy that reflects the ethical and societal values of different countries and populations; and biomarkers of kidney injury and rejection, including the need for better monitoring tools to guide therapy and patient management. - Covers hot topics such as management of chronic allograft failure, the sensitized patient and antibody-mediated rejection, and paired exchange principles. - Features hundreds of superb illustrations to help you visualize key concepts and nuances of renal transplantation. - Provides dynamic visual guidance with new real-time video coverage of ultrasound-guided pancreas allograft biopsy; a new animation of calcineurin inhibitor mechanism of action animation; and videos that demonstrate the formation of an immune synapse, 3-D rotational images of immune synapses, an NK cell killing its target, peritoneal dialysis-catheter insertion techniques, laparoendoscopic single site (LESS) donor nephrectomy, and more. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices
With 200 detailed maps and a 32-page full-color arts and crafts section, this practical guide is an essential tool for all travelers to Bali, Irian Jaya, Java, Sumatra, and other Indonesian islands. The guide includes an eight-page guide on the best surfing, the lowdown on where to stay and eat for all budgets, and transportation details, from canoes to jet-powered ferries. color. 200 maps.
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