RNA is a chemical found in the nucleus and cytoplasm of cells. RNA plays an important role in protein synthesis and other chemical activities of the cell. The structure of RNA is similar to that of DNA, although RNA is single stranded whereas DNA has a characteristic "double helix". Genetic information is stored by DNA in the nucleus of cells, and RNA carries that information to other parts of the cell where it is converted into protein. Three types of RNA are; mRNA (messenger RNA, which contains the specific sequence of nucleotides necessary to dictate amino acid sequence in proteins), tRNA (transfer RNA, which serves as the "adapter" to position the appropriate amino acid next to a growing polypeptide chain during protein synthesis), and rRNA (ribosomal RNA, which is the RNA component of ribosomes). This book presents state-of-the-research from throughout the world.
Zakim and Boyer's Hepatology-the defining work in hepatology-presents comprehensive coverage of both basic science and clinically relevant developments so you can provide the best possible patient care. Drs. Thomas Boyer, Michael Manns, and Arun Sanyal have reorganized and updated the contents of this trusted global reference to reflect today's more clinical approach to hepatology. They bring you up to date on hot topics including HIV Co-Infection Drug Toxicity, Hepatocellular Carcinoma (HCC), and much more. This new streamlined edition is now a single volume with access to the fully searchable contents and an image bank online at www.expertconsult.com making it easier to find the treatment information you need. Effectively treat all liver diseases currently seen in clinical practice with authoritative guidance from leading international authorities. Reinforce your foundation in basic science with the concise Pathophysiology of Therapeutic Targets section. See clear presentations of liver disease through hundreds of detailed, color illustrations. Explore topics further with up-to-date references that direct you to the significant literature. Access the complete, fully searchable contents of the book online at www.expertconsult.com, along with a downloadable image bank and complete list of references. Stay current on new developments in the field through five new chapters on Pathogenesis Liver Injury in HBV, HCV; HCC; Imaging and Non-Invasive DX Liver Disease CT, US, Fibroscan, MRI; HIV Co-Infection Drug Toxicity; and HBC, HCV in Non-Liver Transplant Patients, plus comprehensive updates throughout. Apply best practices with reorganized and updated content that reflects today's need for a more clinical approach to hepatology. Reference key information more easily thanks to streamlined content that now fits into one volume.
Contemporary Architecture and the Digital Design Process introduces the reader to new developments in the computer modelling of design form in contemporary architectural practice through a series of detailed case studies. The book illustrates how evolving design practices use and exploit the potential of new computing technologies in a wide range of areas and application. A central thesis of this book is that technology follows design demand, rather than design adjusting to available new technology. Designers are not merely passive recipients of prescribed computing tools and techniques. Instead, they are increasingly able to express their intuitive design ideas through the rational medium of computing. The book features several contemporary building projects, each of which introduces a range of CAD and computing issues based upon the work of creative architectural and engineering design practices. These include the offices of Frank O. Gehry, Peter Cook and Colin Fournier, Anthony Hunt Associates, Peter Hubner, Szyskowitz-Kowalski, and Faulkner Brown. All these examples show what architects need to know and the skills they need to acquire to use advanced CAD technology.
This new edition of the book series dedicated to “Progress in Epileptic Disorders” is the result of a recently held unique gathering of international experts that debated on the prognostic and therapeutic issues raised by the management of first unprovoked seizures and of newly diagnosed epilepsy. Current knowledge on natural evolution of a first seizure, the role of co-morbid conditions, the impact of immediate versus delayed treatment and recent guidelines are thoroughly addressed. The new ideas and suggestions that emerge from this book offer challenging perspectives for both patient care and clinical as well as fundamental research. The first section of the book includes an up to date review of epidemiological data, encompassing the natural evolution of single unprovoked seizures, risk factors for recurrent seizures, and the potential for comorbid conditions such as depression, migraine, ADHD, and dysimmune metabolic disorders to promote the development of epilepsy. The impact of febrile convulsions on long-term brain hyperexcitability is also discussed. The second section concentrates on therapeutic issues, concerning the management of single unprovoked seizures and newly diagnosed epilepsy. These include the impact of immediate versus deferred treatment and the choice of the most appropriate antiepileptic drug therapy. Several methodological issues are addressed in parallel with the chapters, providing new insights into domains, such as the representativeness of the patient population in the studies under consideration, as well as the limitations and pitfalls of most randomised controlled trials. The value of these trials in the development of treatment guidelines is also discussed.
This landmark study provides the first comprehensive assessment of the nature and associations between the three main forms of social disadvantage in Australia: poverty, deprivation and social exclusion. Drawing on the author's extensive research expertise and his links with welfare practitioners, it explains the limitations of existing approaches and presents new findings that build on the insights of disadvantaged Australians and views about the essentials of life, providing the basis for a new deprivation-based poverty measure.
Since 1984, the year of the publication of its first edition, the famous “Blue Guide” has been the international reference for paediatricians and neuropaediatricians with regard to epileptic syndromes in infants, children and adolescents. This 6th edition reviews some of the most noteworthy developments in the field, particularly in epileptic syndromes, but also focuses on the genetic aspects of the syndromes and their development. Progress brought about by advances in neuroimaging is also discussed in addition to specific etiologies such as parasitic diseases and immune and autoimmune diseases. The different backgrounds of the contributors - coordinators and authors – ensure that the book’s longstanding reputation for objectivity and seriousness, built over almost 35 years, remain well-deserved. This book written by the current leading specialists is recognized worldwide as the international reference in epilepsy.
Facing the most formidably concentrated air defences in history, pilots of the F-105D flew against North Vietnamese targets day after day during the 43 months of Operation Rolling Thunder. Despite its limited maneuverability and the lack of self-sealing fuel tanks, which made it susceptible to combat damage, the 'bombers' shot down 27 MiG fighters in 1966 – 67. This book illustrates the importance of the Thunderchief in the Rolling Thunder campaign, including the pioneering suppression of enemy air defences (SEAD) methods developed by the F-105 'Wild Weasel' crews. Discussing the aircraft's strengths and weaknesses and using first-hand narratives, Peter Davies captures the essence of flying the 'Thud' against heavy defences, and describes the development of wartime tactics and the heroic accomplishments of a selection of its aircrew.
Packed with advice, vignettes and case studies, as well as useful tips and checklists for improving teaching, the second edition of Developing Your Teaching is the ideal toolkit to support the development of teaching practice. Providing a blend of ideas, interactive review points and case study examples from university teachers, this accessible handbook for professional practice provides ideas on a range of topics including: learning from student feedback and peer review students as consumers and their expectations building effective partnerships with students and colleagues developing a teaching portfolio choosing effective teaching practices the challenges and benefits of securing an initial teacher qualification A must-read for all those new to teaching in higher education, as well as more experienced lecturers looking to refresh and advance the quality of their teaching, this fully updated new edition is the ideal toolkit to support the development of teaching practice.
The Routledge Encyclopedia of Second Language Acquisition offers a user-friendly, authoritative survey of terms and constructs that are important to understanding research in second language acquisition (SLA) and its applications. The Encyclopedia is designed for use as a reference tool by students, researchers, teachers and professionals with an interest in SLA. The Encyclopedia has the following features: * 252 alphabetized entries written in an accessible style, including cross references to other related entries in the Encyclopedia and suggestions for further reading * Among these, 9 survey entries that cover the foundational areas of SLA in detail: Development in SLA, Discourse and Pragmatics in SLA, Individual Differences in SLA, Instructed SLA, Language and the Lexicon in SLA, Measuring and Researching SLA, Psycholingustics of SLA, Social and Sociocultural Approaches to SLA, Theoretical Constructs in SLA. * The rest of the entries cover all the major subdisciplines, methodologies and concepts of SLA, from "Accommodation" to the "ZISA project." Written by an international team of specialists, the Routledge Encyclopedia of Second Language Acquisition is an invaluable resource for students and researchers with an academic interest in SLA.
• Fundamental concepts and rules of research are explained for both consumers and producers of research reports. • The philosophical basis of research is examined and set forth as the foundation of a formal method of inquiry. • Clearly presents guidelines for research and demonstrates their use in the design and improvement of programs. • Provides guidance on what one should do as well as on what one should not to do in conducting research. • Numerous practical examples amply demonstrate the principles presented in this book. • End-of-chapter exercises provide an opportunity to apply the constructs discussed in the chapters. • An Instructor’s Guide is included with your examination copy. Table of Contents Part I: The Beginning Chapter 1: Research As Inquiry Chapter 2: Consuming Research Part II The Rules Chapter 3: The Theoretical Basis of Research Chapter 4: The Purpose of the Study Chapter 5: The Design of the Study Chapter 6: Know the Evidence Chapter 7: Know the Evidence Source Chapter 8: Gather the Evidence Chapter 9: Review the Evidence Chapter 10: Display the Findings Chapter 11: Answer the Question Chapter 12: Determine Closure Part III Resources Chapter 13: Research in Action Chapter 14: Annotated Bibliography Glossary Composite Bibliography Subject Index Appendix
In this beautiful and practical book, one of the world's foremost sailors, Peter Blake, now head of the Cousteau Society, tells you all you need to know about the basics of sailing.
The Fords: An American Epic is the dramatic story of three generations of Fords and of the dramatic conflict between fathers and sons played out against the backdrop of America's greatest industrial empire. The story begins with Henry I, the mechanical wizard, tinkerer, and mad genius who drove the automobile into the heart of American life and conquered the world with it. But in the end he became an embittered crank who so possessively loved the company he built that when his son, Edsel, tried to change it to suit the times, Henry destroyed him. It was left to Edsel's son, Henry II, to avenge him and save the Ford Motor Company. From the details of Henry I's illicit affair, which produced an illegitimate son, to the life and loves of Hank the Deuce and his celebrated feud with Lee Iacocca, this is an engrossing account of a vital chapter in American history. The authors have added a new preface to this now classic work, showing how Henry II's line lost out to the line of his brother William Clay Ford in the quest to control the company in the twentieth century.
Quickly and accurately diagnose and treat the psychiatric disorders you will encounter in clinical practice CURRENT Diagnosis and Treatment: Psychiatry offers instant access to relevant etiology, phenomenology, pathophysiology, and drug information. Designed in the time-saving outline style that makes LANGE® CURRENT titles so popular, the book covers need-to-know information on interviewing techniques, emergency psychiatry, treatment strategies, psychiatry and the law, psychological testing, emergency psychiatry, and evaluating infants. This authoritative resource reviews essential psychopharmacologic and psychotherapeutic approaches, and provides evaluation, testing, and decision-making tools and criteria. Renowned authorities on the subject, the editors have a cumulative 100+ years treating patients and teaching residents. • Covers both adult and pediatric disorders • Reviews essential psychopharmacologic and psychotherapeutic approaches • Provides evaluation, testing, and decision-making tools and criteria
Practical, accessible and up-to-date, this book draws directly on the work of teachers and other professional trainers concerned with programs for continuing professional development.
Now in a fully updated 9th Edition, Kendig's Disorders of the Respiratory Tract in Children, by Drs. Robert Wilmott, Andrew Bush, Robin Deterding, and Felix Ratjen, continues to provide authoritative, evidence-based information to residents, fellows, and practitioners in this wide-ranging specialty. Bringing key knowledge from global experts together in one easy-to-understand volume, it covers everything from the latest basic science and its relevance to today's clinical issues, to improving patient outcomes for the common and rare respiratory problems found in newborns and children worldwide. - Uses succinct, straightforward text, numerous tables and figures, summaries at the end of each chapter, and more than 500 full-color images to convey key information in an easy-to-digest manner. - Contains new chapters reflecting expanding knowledge on the respiratory complications of Down syndrome and other genetic disorders, modern molecular therapies for cystic fibrosis and asthma, and pulmonary embolism and thromboembolic disease. - Includes access to a new video library with demonstrations of key procedures. - Features a new templated format with more descriptive headings and bulleted text for quick reference and navigation. - Covers today's key issues, including the genetic basis of respiratory disease, new and emerging respiratory infections, interstitial lung diseases in infants and young children, technology and diagnostic techniques for pulmonary function tests, emerging lung infections, and new therapies for cystic fibrosis and asthma. - Provides up-to-date instruction on important procedures, such as bronchoscopy and pulmonary function testing. - Highlights the knowledge and expertise of three new editors, as well as more than 100 world authorities in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, critical care, otolaryngology, allergy, and surgery. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
This book approaches macroprudential oversight from the viewpoint of three tasks. The focus concerns a tight integration of means for risk communication into analytical tools for risk identification and risk assessment. Generally, this book explores approaches for representing complex data concerning financial entities on low-dimensional displays. Data and dimension reduction methods, and their combinations, hold promise for representing multivariate data structures in easily understandable formats. Accordingly, this book creates a Self-Organizing Financial Stability Map (SOFSM), and lays out a general framework for mapping the state of financial stability. Beyond external risk communication, the aim of the visual means is to support disciplined and structured judgmental analysis based upon policymakers' experience and domain intelligence.
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