The hereditary retinopathy, retinitis pigmentosa (RP), which affects 1 in 3,500 people worldwide, is the most common cause of registered visual handicap among those of the working age in developed countries. RP is a highly variable disorder where patients may develop symptomatic visual loss in early childhood, while others may remain asymptomatic until mid-adulthood. Most cases of RP segregate in autosomal dominant, recessive or X-linked recessive modes, with approximately 41 genes being implicated in disease pathology to date (RetNet). The extensive genetic heterogeneity associated with autosomal dominant RP (adRP) is an undisputed hindrance to the development of genetically based therapeutics.
Celebrating Rock's 60th Birthday, from the formation of the Rolling Stones and the heyday of the British Invasion to the spawning of the Reading Festival, this book explores the music history of the London clubs that were the engine rooms for British rock n roll. The Rolling Stones, the Who, Rod Stewart, Pink Floyd, The Faces, David Bowie and The Yardbirds are amongst the many acts who performed on the London club circuit at venues such as The Ealing Club, The Crawdaddy Club, The Bull's Head, The Half Moon, The Ricky Tick, The Marquee, The 100 Club, and the infamous Eel Pie Island Hotel. We revisit the days when Eric Clapton was God and Rock ruled the world. Play it Loud! Why is 2022 'Rock's Diamond Year'? On March 17th 1962, Alexis Korner and Cyril Davies started the EALING BLUES CLUB. The first UK gig devoted to 'electric blues music'. Musicologists agree that this event was the catalyst that would define British Rock music. The Ealing Blues Club sparked a musical revolution that grew further at Twickenham's Eel Pie Island and Richmond's Crawdaddy Club, 3 venues that were vital in the careers of: The Rolling Stones, The Yardbirds / Eric Clapton, The Who, Cream and many more. Elsewhere in 1962 there were rumblings of a cultural shift with The Beatles, Dusty Springfield, The Animals, Marshall Amplification and many others setting the tone for what became the UK's most significant cultural export... Rock & Pop Music. 60 years on from 1962 and 'ROCK'S DIAMOND YEAR' will celebrate the UK's unique contribution to what has become a global music form. The initiative is led by The Ealing Club Community Interest Company' set up to champion West London music heritage while inspiring new music opportunity for the future. www.rocksdiamondyear.com WRITERS Introduction by Ralph Brookfield The Ealing Club by Alistair Young The Eel Pie Island Club/Eel Pie Club, Twickenham by Gina Way The Crawdaddy Club, Richmond by David Sinclair The Ricky Tick Club, Windsor by Pete Clack The Half Moon Club, Putney by Nina Jackson The Marquee Club, Soho by Charlotte Banks The 100 Club by Richard Luck
Outlines an exercise program for women that features a fifteen-minute daily regimen designed to accelerate the metabolism past the workout time, in a guide complemented by a simple eating plan, supplement prescriptions, and recipes.
This book explores the evolution of male writers marked by peculiar traits of childlike immaturity. The ‘Boy-Man’ emerged from the nexus of Rousseau’s counter-Enlightenment cultural primitivism, Sensibility’s ‘Man of Feeling’, the Chattertonian poet maudit, and the Romantic idealisation of childhood. The Romantic era saw the proliferation of boy-men, who congregated around such metropolitan institutions as The London Magazine. These included John Keats, Leigh Hunt, Charles Lamb, Hartley Coleridge, Thomas De Quincey and Thomas Hood. In the period of the French Revolution, terms of childishness were used against such writers as Wordsworth, Keats, Hunt and Lamb as a tool of political satire. Yet boy-men writers conversely used their amphibian child-adult literary personae to critique the masculinist ideologies of their era. However, the growing cultural and political conservatism of the nineteenth century, and the emergence of a canon of serious literature, inculcated the relegation of the boy-men from the republic of letters.
This short book, taken from Remembered For A While, tells the stories and circumstances that surround every known recording in Nick Drake's canon (as well as a few unrecorded songs). The result is like a detailed, extended series of liner notes, something to read while sitting in your favourite chair, in your favourite room, listening to the imperishably beautiful music they describe. A Nick Drake companion.
Species acclimatization--the organized introduction of organisms to a new region--is much maligned in the present day. However, colonization depended on moving people, plants, and animals from place to place, and in centuries past, scientists, landowners, and philanthropists formed acclimatization societies to study local species and conditions, form networks of supporters, and exchange supposedly useful local and exotic organisms across the globe. Pete Minard tells the story of this movement, arguing that the colonies, not the imperial centers, led the movement for species acclimatization. Far from attempting to re-create London or Paris, settlers sought to combine plants and animals to correct earlier environmental damage and to populate forests, farms, and streams to make them healthier and more productive. By focusing particularly on the Australian colony of Victoria, Minard reveals a global network of would-be acclimatizers, from Britain and France to Russia and the United States. Although the movement was short-lived, the long reach of nineteenth-century acclimatization societies continues to be felt today, from choked waterways to the uncontrollable expansion of European pests in former colonies.
Long an icon of American musical and political life, Pete Seeger has written eloquently in a diverse array of publications but nowhere is his life story more personally chronicled than in these, his private writings, documents and letters stored for decades in his family barn. Pete Seeger: His Life in His Own Words, collects Seeger's letters, notes, published articles, rough drafts, stories and poetry - creating the most intimate picture yet available of Seeger as a musician, an activist and a family man. The book covers the passions, personalities and experiences of a lifetime of struggle - from the pre-WWII labour movement and the Communist Party, to Woody Guthrie, the Civil Rights movement and the struggle against the war in Vietnam. The portrait that emerges is not of a saint, but a flesh-and-blood man, struggling to understand his time and his place.
Neighbourhood regeneration looks at how community capacity building is currently delivered within neighbourhood regeneration programmes, focusing on the key issue of resourcing. The authors frame this review within the context of the government's emerging national strategy for neighbourhood renewal, Bringing Britain Together, and the Local Government Association's New Commitment to Regeneration initiative. The report is essential reading for policy makers in community- and agency-led regeneration partnerships, local authorities and communities themselves, as well as anyone with an interest in neighbourhood regeneration strategies.
*** 'Lots of great stories... A fascinating insight.' -JOHN MAHER, Buzzcocks 'Perfectly executed, highly detailed, incredibly interesting.' -HENRY ROLLINS, Black Flag 'Pete and Buzzcocks were there right from the beginning.' -BERNARD SUMNER, Joy Division, New Order When Pete Shelley, lead singer of legendary punk band Buzzcocks, passed away in 2018 we lost the chance to hear one of music's brightest stars tell his story. Or so it seemed. Now, recordings have surfaced of a series of remarkable interviews in which Pete tells the story of his life, his band and his place at the beating heart of the punk explosion in fascinating detail. Recorded over a series of late-night calls with a close friend, the tapes hear Pete talk song-by-song through Buzzcocks releases to reveal the personal memories behind the music and the inspiration for masterpieces such as 'Ever Fallen in Love (With Someone You Shouldn't've)' and 'What Do I Get?'. Published for the first time and with the blessing of Pete's estate, Ever Fallen In Love: The Lost Buzzcocks Tapes is a tribute to a founding member of punk and a chance to hear one of music's true visionaries tell his own story at last. 'A true gentleman and a great artist and songwriter.' -PETER HOOK, Joy Division, New Order 'Shot through with self-doubt and mild regret, Pete Shelley's lovesick pop classics have a bittersweet charm that will forever speak to the young romantic' -JOHN COOPER CLARKE 'Buzzcocks were the blue touchpaper for my love of music. Pure pop met punk and the result was perfection.' -TIM BURGESS, The Charlatans
The Art of Business in Music: Unlocking Real-World Business Strategies In a world brimming with music business guides, 'The Art of Business in Music' stands out as the genuine article. Music industry opinions are plentiful, and theories on what should happen are readily available, but they often fall short in real-world application. This book is the real deal, forged from the fires of the author's journey in the cutthroat music industry. Starting from scratch, when the author's name was only known to a few in the business of music, he climbed to heights of success that only a small number of people ever have the opportunity to reach. This rarity occurred when well-respected superstar icons, Mariah Carey and Jermaine Dupri, chose to record a song the author penned with his partner, Rainy Davis. This milestone marked the beginning of an extraordinary chapter. Their song, 'Sweetheart,' was included in four of Mariah's albums that sold over twenty-two million records, earned multiple multi-platinum awards, and received Grammy nominations as a testament to their success. 'The Art of Business in Music' is the author's blueprint detailing every tactic and strategy and how he implemented them. You'll discover all the riveting details from the beginning of his career through the present, with no filters. The author candidly reveals his triumphs, tribulations, and missteps, so there's a takeaway for you from all sides. Peeling back the layers of the music industry's most closely guarded secrets, from the art of deal-making to the subtle strategies of the game, this book serves as your exclusive pass to 'The Art of Business in Music'. It offers a wealth of knowledge, typically reserved for a select few insiders who are often reluctant to share. This book equips you with a deep understanding of these industry secrets, drawn from the author's proven strategies that have stood the test of time. It covers a wide range of topics, including publishing, copyrights, both analog and digital production, marketing expenditures, and management. Empowering you to better navigate the treacherous waters of the business aspect that governs the music you make. Get ready for a seismic shift in your understanding, prepare to be informed, to be shocked, and above all, for the blueprint to master 'The Art of Business in Music'. Arm yourself with the knowledge to not just survive, but to rule. Grab your copy of 'The Art of Business in Music' today. This isn't just a handbook; it's your key to unlocking some of the best-kept secrets of the music industry.
In 1918, the Spanish flu killed up to 40 million people across the planet. From the remotest villages in Arctic climates to crowded U.S. cities to the battlefields of Europe, there were plague houses in which whole families lay sick or dead. In Madras, train services stopped running, as one-third of its workforce fell ill. In Calcutta, the postal service and the legal system ground to a halt. And in the United States, it killed more Americans than all the wars fought in the twentieth century put together. The disease did not discriminate. It took whom it pleased -- rich or poor, distinguished or humble, hungry or well nourished, healthy or infirm. It was a flu unlike any that the world had encountered before or that has come along since.
In this fifth edition of the best-selling core introductory textbook, Pete Alcock and Lee Gregory provide a comprehensive and engaging introduction to social policy. Continuing with the unbeaten narrative style and accessible approach of the previous editions, the authors explore the major topics of social policy in a clear and digestible way. By breaking down the complexities behind policy developments and their outcomes, the book demonstrates the relationship between core areas of policy and the society we live in. This new edition has been thoroughly revised and updated to cover the impact of Brexit and contains reflections on the implications of the Covid-19 pandemic for social policy. Each chapter contains comprehension activities to aid understanding, as well as helpful summary points and suggestions for further reading.
The path to a better world can’t be found without knowledge of history. "It’s Not Over" analyzes attempts to supplant capitalism in the past in order to draw lessons for emerging and future movements that seek to overcome the political and economic crises of today. This history is presented through the words and actions of the men and women who made these revolutions, and the everyday experiences of the millions of people who put new revolutionary ideas into practice under the pressures of enormous internal and external forces. This is history that can be applied to today’s struggles to shape our world, in which new ideas are emerging to bring about the economic democracy that is indispensable to a rational and sustainable future.
Foot-tracks in New Zealand examines the development of walking tracks over two centuries, from the early 19th century to about 2011. The paperback version comes in two volumes but is otherwise identical to the electronic version. Page size: A4 Format: Paperback, 2 vol. ISBN: 0473191911, 9780473191917 Number of pages: 1000 About: Trails, Tracks, New Zealand, History, Recreation, Land access. Availability: By print on demand from The Fine Print Company, Waipukurau, Central Hawke’s Bay, 4200, NZ.
Have so many ever cheered so much for so little? The Chicago Cubs last won the World Series in 1908 and last appeared in the Fall Classic the year World War II ended. Yet Cubs fans are among the most loyal, the most knowledgable, and the most rabid in baseball. The teams they've loved and the players they've cherished have provided some of the game's finest moments, as well as a treasure trove of baseball lore. The Cubs' home park, Wrigley Field, is as much a national landmark as the Empire State Building or the Golden Gate Bridge. A charter member of the National League, the Cubs were born in 1876 -- the same year the Seventh Cavalry fought at Little Big Horn. Cap Anson, baseball's first superstar and possibly the finest player of the 19th century, played for early Cubs squads. In the early years of this century, the fantastic double-play combination of Tinkers to Evers to Chance was immortalized in verse. Mordecai "Three Finger" Brown, Grover Cleveland Alexander, and Fergie Jenkins rank among baseball's greatest pitchers, while hitters like Kiki Cuyler, Hack Wilson, Billy Herman, Ernie Banks, Billy Williams, and Sammy Sosa have put up amazing numbers. But the Cubs transcend baseball like Paris transcends Europe. The story of the Cubs is part legend, part pathos, often heroic, and, on occasion, hilarious.
Beer is the most popular alcoholic drink on the planet, but few who enjoy it know much about how its four ingredients – hops, malted barley, water and yeast – miraculously combine. From the birth of brewing in the Middle East, through the surreal madness of drink-sodden hop-blessings in the Czech Republic and the stunning recreation of the first ever modern beer, Miracle Brew is an extraordinary journey through the nature and science of the world's greatest beverage. Along the way, we’ll meet and drink with a cast of characters who reveal the magic of beer and celebrate the joy of drinking it.
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