Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on recent data on enzyme structure, mode of action, and inhibitor design, it describes?from a biochemical point of view?the six most important neurotransmitter systems and their constituent enzymes and receptors. Misfolding and aggregation of proteins within the brain is also covered. In addition, the book surveys a wide range of proven and prospective therapeutic agents that modulate key processes in the brain, from their chemical synthesis to their mode of action in model systems as well as in the patient. Chemical Biology of Neurodegeneration: A Molecular Approach is presented in two parts. The first introduces the neurotransmitter systems and provides a general explanation of the synapse and a description of the main structures involved in neurotransmission that can be considered therapeutic targets for disorders of the central nervous system. The second part presents molecular and chemical aspects directly involved or affected in neurodegeneration, including the metabolism of neurotransmitters, enzymes processing neurotransmitters, protein misfolding, and therapeutic agents. -Uses an interdisciplinary approach to bridge the gap between the basic biochemical events in a nerve cell and their neurological effects on the brain -Places emphasis on the chemistry of small molecule modulators that are potential lead molecules for new drugs -Covers six key neurotransmitter systems and their enzymes and receptors?dopaminergic, noradrenergic, serotonergic, cholinergic, GABAergic, and glutamatergic Chemical Biology of Neurodegeneration: A Molecular Approach is a key resource for medicinal chemists, neurobiologists, neurochemists, biochemists, molecular biologists, and neurophysiologists.
The plot unfolds in a nursery room where some children are engaged to play in a small fishbowl. To do this they used toy packages in plastic and lead miniatures, as "The village of Magcaguas", and "Scientific expedition of Engineer SABA", beings made of wind and water that sniff their homeland from a distance. Absurd elements like elephants resting on the snow, butterflies fluttering in a snowstorm, crocodiles swimming in icy waters, etc., where the imagination of children goes beyond the aspirations of the characters, handcuffed and prone to disappearances in each habitat, where the stroke of effect, or the unexpected, it will to the reader a second reading in end developer about each miniature toy.
The plot takes place in Havana at the beginning of the third millennium. Gary, a young Cuban painter, suffers Syndrome Blank Canvas, who is trying to minimize it through his uncle Febles, owner of the boat Daydream, who is an experienced fisherman licensed 50s to fish on the northern coast Havana. Gary is inspired by the seabed to enrich his imagination of artist, who is far away in a migratory adventure beyond the sea horizon. He is lucky enough to find a mysterious cylindrical object trapped by the reefs in Boca Chipiona, Santa Cruz del Norte, area the wreck of the Spanish frigate "Navigator", based in real events, it occurred on February 4, 1814, and it being victim of looting from fishermen and divers, etc., where Gary discovers a cylindrical object that appears to be related to the wreck. It is a look at the visual arts, from figurative painting to abstract painting through various facets more where the ambition, the plagiarism, the fame, merge with history and make an encounter with the true artist.
De la misma manera que en el nuevo mileniolos géneros sexuales languidecen, por fortuna,lo mismo ocurre con los literarios. Esta antología incluye cuento, poesía, crónica, ensayo personal y novela. Muchos de los textos están felizmente contaminados de uno y otro estilo.Toda literatura es una experiencia. Salvo un par que publicó en los 90, este trabajo reúne autores que en casi dos décadas hicieron una obraen tierra norteamericana: algunos describen la relación con el país extranjero en el que viven;a la vez, los escenarios se extienden por el resto del mundo. Es decir: los escritores que ya están afincados no siguen necesariamente hablando de inmigración, indocumentados, etc. Ya lo hicieron y ahora tienen nuevas obsesiones.
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