Since 1975, Dr. Kenneth Swaiman's classic text has been the reference of choice for authoritative guidance in pediatric neurology, and the 6th Edition continues this tradition of excellence with thorough revisions that bring you fully up to date with all that's new in the field. Five new sections, 62 new chapters, 4 new editors, and a reconfigured format make this a comprehensive and clearly-written resource for the experienced clinician as well as the physician-in-training. - Nearly 3,000 line drawings, photographs, tables, and boxes highlight the text, clarify key concepts, and make it easy to find information quickly.
This book fills an important and unique niche in pediatric neurology, and will be a frequently referenced textbook for all clinicians caring for children with epilepsy. It is well-organized and readable, and provides essential and up-to-date clinical data on these individually rare, but collectively more common, disorders." -Elaine Wirrell, MD, Neurology "Specialists in pediatric neurology, epilepsy, and biochemical genetics will find this volume to be indispensable for their daily practice. The organized approach to an incredibly complex set of disorders will also benefit trainees trying to make sense of the complex field and developing their own clinical approach, as knowledge about metabolic epilepsies continues to grow." -Carl E. Stafstrom, MD, PhD, Journal of Pediatric Epilepsy The continued explosion of information in neurogenetics and metabolism mandates increasing awareness of current diagnostic and therapeutic strategies in disease settings where prompt identification and intervention is crucial for a positive outcome. This thoroughly revised and greatly expanded new edition of the first book to bridge clinical epilepsy with inherited metabolic diseases brings together leading authorities to present state-of-the-art clinical reviews covering the science, recognition, and treatment of the inherited metabolic epilepsies and related disorders. Inherited Metabolic Epilepsies, Second Edition contains 15 new chapters, and all existing chapters have been updated to reflect the latest science and clinical advances in this fast-moving field. New sections on basic and clinical science —covering energetics, metabolomics, pathways, the use of novel investigations like transcranial magnetic stimulation, neuropathology, and genomic technologies—supplement the disease-focused sections. Dedicated chapters focus on recently recognized disorders having novel therapeutic implications, pyridoxal-5-phosphate dependency, Menkes disease, and thiamine transporter deficiency. The book also includes new clinical applications of genomics and advanced generation gene sequencing in the diagnosis of inherited metabolic epilepsies. This readable, well-illustrated reference concludes with an updated clinical algorithm to aid physicians in screening and identifying suspected metabolic disorders and a collection of resources for families. Features Synthesizes cutting-edge diagnostic, clinical, and scientific information on epilepsy and inborn errors of metabolism Completely updated and expanded second edition contains the latest knowledge and 15 entirely new chapters Authored and edited by international experts in neurology, metabolic disorders, and genetics A readable and well-illustrated reference for clinicians Essential coverage of the new generation of genetic tests, which were not widely available or utilized when the first edition was published New chapter on inherited metabolic epilepsies in adult
How do governments govern today and how well do they do it? How do governments choose the tools or instruments they will use to get things done? In today's world, how could these decisions be improved from the standpoint of efficiency, effectiveness, legitimacy and accountability? "Designing Government" brings together leading experts to examine the "instrument choice" perspective on government and public policy over the past two decades. The authors examine such issues as accountability, effectiveness, sustainability, legitimacy, and the impact of globalization. The debate is enriched by contributors from several countries who provide a comparative context and, most importantly, help chart a course for the future. Moving beyond the traditional regulatory sphere and its preoccupations with deregulation and efficiency, the authors trace the complex relationships between instrument choices and governance. "Designing Government" encourages the reader to consider factors in the design of complex mixes, such as issues of redundancy, context, the rule of law and accountability. These latter factors are especially central in today's world to the design and implementation of effective instrument choices by governments and, ultimately, to good governance. The authors conclude, in fact, that seeing instrument choice itself as part and parcel of designing government and achieving good governance is both the promise and the challenge for instrument-based perspectives in the years ahead. Contributors include Hans Bressers (University of Twente), Neil Gunningham (Australian National University), John Hoornbeck (University of Pittsburgh), Margaret Hill (Infrastructure Canada), Michael Howlett (Simon Fraser University), Bridget Hutter (London School of Economics and Political Science), Pierre Issalys (Université Laval), Réjean Landry (Laval University), Roderick A. Macdonald (McGill University), Larry O'Toole (University of Georgia), B. Guy Peters (University of Pittsburgh), Michael J. Prince (University of Victoria), Sean Rehaag (University of Toronto), Arthur B. Ringeling (Erasmus University), Stephen J. Toope (McGill University), Michael J. Trebilcock (University of Toronto), Frédéric Varone (Université Catholique de Louvain, Belgium), and Kernaghan Webb (Carleton University).
The explosion of information in neurogenetics and metabolism mandates increasing awareness of appropriate diagnostic and therapeutic strategies in the setting of certain epilepsies, especially those of very early onset. There are over 200 inherited disorders that are associated with seizures and prompt identification and intervention is crucial for a positive outcome. This text brings together the leading authorities working in this area to present state-of-the-art clinical reviews covering the science, recognition, and treatment of the inherited metabolic epilepsies and related disorders. The book begins with general principles for diagnosis and targeted intervention including screening protocols, laboratory testing, seizure patterns and EEG findings, imaging, new technologies, and the ketogenic diet. The next two sections are devoted to the cohort of specific small molecule and large molecule disorders that are treatable yet can be so vexing to clinicians and investigators. The book concludes with a clinical algorithm designed to be a resource for the physician in search of direction while considering an inherited metabolic disorder as the explanation for a patient with epilepsy.
In the tradition of The Ice Master and Endurance, here is the incrediblestory of the first truly modern explorer, whose death-defyingadventures and uncommon modesty make this book itself anextraordinary discovery. Hubert Wilkins was the most successfulexplorer in history no one saw with his own eyes more undiscoveredland and sea. Largely self-taught, Wilkins became a celebratednewsreel cameraman in the early 1900s, as well as a reporter, pilot, spy, war hero, scientist, and adventurer, capturing in his lens warand famine, cheating death repeatedly, meeting world leaders likeLenin and Stalin, and circling the globe on a zeppelin. Apprenticing with the greats of polar exploration, including Shackletonin the Antarctic, Wilkins recognized the importance of newtechnologies such as the airplane and submarine. He helped mapthe Canadian Arctic and plumbed the ocean depths from the icecap.A pioneer in the truest sense of the word, he became the firstman to fly across the North Pole, which won him a knighthood;the first to fly to the Antarctic and discover land there by airplane;and the first to take a submarine under the Arctic ice. Grasping thelink between the poles and changing global weather, Wilkins was avisionary in weather forecasting and the study of global warming.A true hero of the earth, he changed the way we look at our world.
Provides an understanding of the intersection of race and region while addressing contemporary issues such as the future of elementary and higher education, the nature of health-care disparities, and voting and representation. The research presented here reveals that race and class-based problems remain, and geography often is a contributing factor to those differences.
<<>> In Chronicles of a Child, we follow the life of a child named Bessie. We are allowed to see life through the eyes of a child. Sometimes she seems to be wise and somewhat mature for her age. Other times, she just wants to be loved by her mother and treated like a child. She gives us insight on how children experience and process life. Bessie helps us to understand that children take in everything—they take on the problems of the adults in their life. Sometimes they even take on the blame. Will Bessie overcome her guilt?
Live to Tell the Story gives an awe-inspiring and true account of the author’s overwhelming social, emotional, spiritual, and economic challenges over a lifetime. Her book begins by recounting a bittersweet childhood growing up in rural Pineland, South Carolina, until the age of eight. Life begins on a farm with fourteen siblings, where her parents grew vegetables and raised animals to survive. Early on, she and her family begin to witness turmoil when her father’s womanizing and physical abuse causes her mother to have fits of rage that end in horrid physical fights between the two. Life takes even more of a turn for the worse in the author’s family when her mother discovers her husband has also been sexually abusing her eldest daughter, Marvet. Marvet’s rebellion against the abuse results in her being sent to live up north with an aunt who secretly introduces her to different dark side of life. Marvet returns home paralyzed after a botched abortion and eventually dies. Her mother’s death follows soon thereafter. She vividly recalls the dreadful moment she bursts into tears when her uncle informs her and her siblings that their mother is gone. Unable to cope with or forgive himself for the destruction of his family, her father becomes depressed and preoccupied with women. Following her mother’s untimely death, the remainder of the family moves to the urban low-income area of Newark, New Jersey, where life continues to spiral through more hurdles. She mourns her mother’s death until well into her late twenties, but memories of her mother’s love helps her to find forgiveness in her heart to forgive her father, and to move on with her life as she is faced with her own battles. Live to Tell the Story tells a real story of triumph over some of life’s worst situations. It is a testimony of come hell or high water, faith, and how placing God in the center of one’s life will make anyone the victor over a past doomed for a failed future.
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