In November 1973, William J. Wright, a former patient and trustee of the Farview State Hospital for the Criminally Insane, brutally murdered two teenage boys, Edmund Keen and Paul Freach, in Lackawanna County, a region that took great pride in not only its history, but its reputation as a friendly, family-oriented, safe place to live. It was a place where families could leave their doors unlocked, and be confident about allowing their children to play and explore outdoors. Yet all that would change in an instant. The brutal murders of these two boys forever altered the way people thought of this region and the safe neighborhoods they had come to take for granted. Kathleen P. Munley and Paul R. Mazzoni tell a story of unbelief, anger, and fear, but also courage and fortitude. They delve deep into the Commonwealth v. William J. Wright trial, looking inside the investigation, the trial, and how the public was impacted by this unthinkable crime. In captivating detail, the authors weave together the events of this devastating crime and remind us that, even in the pleasant light of day, evil can and does exist, and one must always be on guard.
This book represents the first complete and systematic guide to the virus-like particles (VLPs) and their applications as vaccines, therapeutic tools, nanomaterials, and nanodevices. The grouping of the VLPs follows the most recent virus taxonomy and the traditional Baltimore classification of viruses, which are based on the genome structure and mechanism of mRNA synthesis. Within each of the seven Baltimore classes, the order taxon serves as a framework of the chapter’s arrangement. The term "VLP" is used as a universal designation for the virus-, core-, or capsid-like structures, which became an important part of the modern molecular virology. The 3D structures, expression systems, and nanotechnological applications are described for VLPs in the context of the original viruses and uncover their evolving potential as novel vaccines and medical interventions. Key Features Presents the first full guide to the VLP nanotechnology, classified by current viral taxonomy Outlines specific structural properties and interconnection of the virions and VLPs Explains generation and characteristics of VLPs produced by various expression systems Offers up-to-date summary of VLPs designed as vaccines and delivery tools Unveils interconnection of VLPs with novel organic and inorganic nanomaterials
Access the latest information available in the challenging area of HIV/AIDS management with Sande's HIV/AIDS Medicine, 2nd Edition. Authored by a veritable "who's who" of current global experts in the field, this medical reference book will provide you with all the practical, indispensable guidance you'll need to offer your patients the best possible care. - Access reliable, up-to-the-minute guidance that addresses the realities of HIV/AIDS management in your geographical region, thanks to contributions from a global cast of renowned expert clinicians and researchers. - Locate the clinically actionable information you need quickly with an organization that mirrors the current state of the AIDS epidemic and the different needs of Western vs. developing-world patients and clinicians. - Diagnose AIDS manifestations confidently by comparing them to full-color clinical images. - Improve patient outcomes with the latest findings on the management of AIDS as a chronic illness. - Efficiently review essential data through numerous at-a-glance tables. - Get the most relevant information available on pediatric HIV and AIDS issues; anti-retroviral drugs, including integrase inhibitors; and the use of second- and third-line anti-retroviral drugs in resource-poor settings. - Stay current on the latest actionable information, such as using antiretroviral therapy in patients with tuberculosis and drug-resistant tuberculosis; antiretroviral therapy; immune reconstitution inflammatory syndromes (IRIS); and implementation of the HPV vaccine.
From new research and equipment to new procedures, applications, and approaches, the field of interventional cardiology is one of the fastest-changing areas in medicine. Increasing data and recent technological advances have resulted in exciting changes – and an even greater need for cutting-edge, authoritative guidance on current practice. Textbook of Interventional Cardiology, 8th Edition, covers the theories, trends, and applications of diagnostic and interventional cardiology that cardiologists, cardiac surgeons, vascular surgeons, referring physicians, and advanced practitioners need to know. - Focuses on the latest treatment protocols for managing patients at every level of complexity. - Includes all-new chapters on Coronary Stenting, Diagnosis and Treatment of Coronary Microvascular Disease, Percutaneous Transcatheter Valve in Valve Implantation, and Percutaneous Tricuspid Valve Repair. - Features hundreds of new illustrations, tables, and boxes for visual clarity and quick reference. - Offers expanded coverage of transcatheter aortic valve interventions with extensive updates on practice implications. - Discusses hot topics such new atherectomy devices, percutaneous mitral valve replacement, and percutaneous treatment of paravalvular leak. - Provides the unique insights of expert leaders in the field who have pioneered today's innovative devices and techniques and lend their own analysis of practical, evidence-based clinical applications. - Presents the most recent data on how genomics and genetics impact interventional cardiology. - Provides an in-depth understanding of cardiology, making it well suited for cardiology and interventional cardiology exam preparation. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Ideal for cardiologists, surgeons, and referring physicians who need a clinical guide to interventional procedures, Textbook of Interventional Cardiology focuses on the latest treatment protocols for managing heart disorders at every level of complexity. In this updated edition, Dr. Topol continues to bring together experts in the field who present the current state of knowledge and clinical practice in interventional cardiology, including cutting-edge theories, trends, and applications of diagnostic and interventional cardiology, as well as peripheral vascular techniques and practices. Offers an in-depth understanding of cardiology, making it well suited for cardiology and interventional cardiology exam preparation. Expert guidance from leading authorities ensures a fresh and balanced perspective on every aspect of interventional cardiology. Presents the most recent genetic information and clinical trials related to interventional cardiology. Highlights the latest treatment advances, procedures, devices, and techniques, including transcatheter aortic valve implantation (TAVI). Brand-new chapters include Radiation Safety, Renal Denervation for Resistant Hypertension, Post PCI Hospitalization, Length of Stay and Discharge Planning, and Interventional Heart Failure. Offers balanced coverage of the entire scope of technologies available, without favoring one particular device over another. Integrates the latest trial data into discussions on clinical practice and recommendations. Multiple images of devices and intra-procedural imaging enhance your visual understanding of the material. Key Points boxes at the beginning of each chapter summarize the most important facts. Features 45 videos easily accessible via Expert Consult. Expert Consult eBook version included with purchase. This enhanced eBook experience offers access to all of the text, figures, videos, and references from the book on a variety of devices.
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