Enzymes are the molecular machines that make life possible. Working as catalysts, teams of enzymes carry out the processes that power the bodies of living things, from making DNA to digesting food. This book explains what enzymes are, what they do, and how they do it, from enzymes inside our cells to those in washing powders and food production.
In this book ethnographic, historical and epidemiologic data are brought to bear on the subject of the Acquired Immune Deficiency Syndrome (AIDS) in Haiti. The forces that have helped to determine rates and pattern of spread of Human Immunodeficiency Virus (HIV) are examined, as are social responses to AIDS in rural and urban Haiti, and in parts of North America. History and its calculus of economic and symbolic power also help to explain why residents of a small village in rural Haiti came to understand AIDS in the manner that they did. Drawing on several years of fieldwork, the evolution of a cultural model of AIDS is traced. In a small village in rural Haiti, it was possible to document first the lack of such a model, and then the elaboration over time of a widely shared representation of AIDS. The experience of three villagers who died of complications of AIDS is examined in detail, and the importance of their suffering to the evolution of a cultural model is demonstrated. Epidemiologic and ethnographic studies are prefaced by a geographically broad historical analysis, which suggests the outlines of relations between a powerful center (the United States) and a peripheral client state (Haiti). These relations constitute an important part of a political-economic network termed the "West Atlantic system." The epidemiology of HIV and AIDS in Haiti and elsewhere in the Caribbean is reviewed, and the relation between the degree of involvement in the West Atlantic system and the prevalence of HIV is suggested. It is further suggested that the history of HIV in the Dominican Republic, Jamaica, Trinidad and Tobago, and the Bahamas is similar to that documented here for Haiti.
An Integrated Guide to Human Drug Metabolism: From Basic Chemical Transformations to Drug-Drug Interactions uses the chemistry of each of the metabolic transformations to underpin the discussion of drug interactions with foods, herbal medicines and other drugs. Each of the human metabolic processes will be covered, employing examples drawn from known metabolic transformations of drugs used clinically. The clinical relevance of metabolism is discussed, focusing on appropriate prescribing (age-related dosage adjustments, routes of administration, and personalized medicines). Appropriate for use in the classroom or for self-study, An Integrated Guide to Human Drug Metabolism is useful for students and researchers needing a reference for interdisciplinary research in drug interactions. Metabolism is at the center of personalized medicine, as it is a governing factor in the response of the patient to a drug. For example, does the patient express the genes, and so enzymes, which are responsible for the metabolism of a drug? Do they express the genes responsible for the bioactivation of a prodrug into its active form? Examples of clinically used agents for which metabolic phenotyping is essential will be used to highlight the increasing necessity for understanding the genetic profile of individual patients. This book includes questions and answers to gauge learning of each chapter, real-life case studies, and the basic science as a basis for the discussion of clinical aspects. - Covers each of the human metabolic processes, employing examples drawn from known metabolic transformations of drugs used clinically - Provides an integrated approach, linking together the science and practice strands of human drug metabolism - Contains questions and answers to assess learning of material and real-life case studies
The widely acclaimed response to the postmodernists attacks on science, with a new afterword. With the emergence of "cultural studies" and the blurring of once-clear academic boundaries, scholars are turning to subjects far outside their traditional disciplines and areas of expertise. In Higher Superstition scientists Paul Gross and Norman Levitt raise serious questions about the growing criticism of science by humanists and social scientists on the "academic left." This edition of Higher Superstition includes a new afterword by the authors.
Although the scientific literature on drug metabolism is extensive, it suffers from the disadvantage that the material is diffuse and consists largely of specialist monographs dealing with particular aspects of the subject. In addi tion, although there are a few excellent texts on drug metabolism in print, these tend to be earlier publications and hence do not take into account the many recent advances in this area. Our motivations for writing this book therefore arose from the clear need for a recent and cohesive introductory text on this subject, specifically designed to cater for the needs of undergraduate and postgraduate students. Much of the subject matter in this text is derived from various courses on drug metabolism given at the University of Surrey and the University of Glasgow to basic science students in pharmacology, biochemistry, nutrition and nursing studies, to pre-clinical medical students and to under graduate and post-graduate students in toxicology. Therefore, it is our inten tion that this text will serve as a primer in drug metabolism to a variety of students in the life sciences taking courses in this subject. The term 'drug metabolism' in its broadest sense may be considered as the absorption, distribution, biotransformation and excretion of drugs. To cover all these facets of drug metabolism in a single text is a voluminous task and therefore we have focused primarily on the biotransformation aspects of the subject.
Winner, Oscar G. Brockett Book Prize in Dance Research, 2014 Honorable Mention, Sally Banes Publication Prize, American Society for Theatre Research, 2014 de la Torre Bueno® Special Citation, Society of Dance History Scholars, 2013 From Christopher Columbus to “first anthropologist” Friar Bernardino de Sahagún, fifteenth- and sixteenth-century explorers, conquistadors, clerics, scientists, and travelers wrote about the “Indian” dances they encountered throughout the New World. This was especially true of Spanish missionaries who intensively studied and documented native dances in an attempt to identify and eradicate the “idolatrous” behaviors of the Aztec, the largest indigenous empire in Mesoamerica at the time of its European discovery. Dancing the New World traces the transformation of the Aztec empire into a Spanish colony through written and visual representations of dance in colonial discourse—the vast constellation of chronicles, histories, letters, and travel books by Europeans in and about the New World. Scolieri analyzes how the chroniclers used the Indian dancing body to represent their own experiences of wonder and terror in the New World, as well as to justify, lament, and/or deny their role in its political, spiritual, and physical conquest. He also reveals that Spaniards and Aztecs shared an understanding that dance played an important role in the formation, maintenance, and representation of imperial power, and describes how Spaniards compelled Indians to perform dances that dramatized their own conquest, thereby transforming them into colonial subjects. Scolieri’s pathfinding analysis of the vast colonial “dance archive” conclusively demonstrates that dance played a crucial role in one of the defining moments in modern history—the European colonization of the Americas.
This addition to the Advances in Environmental Control Technology Series contains 23 chapters designed to provide an extensive overview and reference on human physiological responses to various forms of pollution.
Major advances have been made in recent years in clarifying the molecular properties of the cytochrome P-450 system. These advances stem, in practical terms, from the generally recognized importance of cytochrome P-450 in the metabolism of drugs and in the bioactivation of xenobiotics to toxic products. The fascinating multiplicity and differential regulation of cytochrome P-450 isozymes, and their ability to catalyze extraordinarily difficult chemical transformations, have independently drawn many chemists and biochemists into the P-450 circle. Progress in the field, from a technical point of view, has been propelled by the de velopment of reliable procedures for the purification of membrane-bound enzymes, by the growing repertoire of molecular biological techniques, and by the development of chemical models that mimic the catalytic action of P-450. As a result, our understanding of the P-450 system is moving from the descriptive, pharmacological level into the tangible realm of atomic detail. The rapid progress and multidisciplinary character of the cytochrome P-450 field, which cuts across the lines that traditionally divide disciplines as diverse as inorganic chemistry and genetics, have created a need for an up-to-date evaluation of the advances that have been made. It is hoped that this book, with its molecular focus on the cytochrome P-450 system, will alleviate this need. The authors of the individual chapters have strived to emphasize recent results without sacrificing the background required to make their chapters comprehensible to informed nonspecialists.
In eighteenth-century Mexico, outbreaks of typhus and smallpox brought ordinary residents together with administrators, priests, and doctors to restore stability and improve the population's health. This book traces the monumental shifts in preventive medicine and public health measures that ensued. Reconstructing the cultural, ritual, and political background of Mexico's early experiments with childhood vaccines, Paul Ramírez steps back to consider how the design of public health programs was thoroughly enmeshed with religion and the church, the spread of Enlightenment ideas about medicine and the body, and the customs and healing practices of indigenous villages. Ramírez argues that it was not only educated urban elites—doctors and men of science—whose response to outbreaks of disease mattered. Rather, the cast of protagonists crossed ethnic, gender, and class lines: local officials who decided if and how to execute plans that came from Mexico City, rural priests who influenced local practices, peasants and artisans who reckoned with the consequences of quarantine, and parents who decided if they would allow their children to be handed over to vaccinators. By following the multiethnic and multiregional production of medical knowledge in colonial Mexico, Enlightened Immunity explores fundamental questions about trust, uncertainty, and the role of religion in a moment of discovery and innovation.
V. 1 The plant cell. v. 2. Metabolism and respiration. v. 3. Carbohydrates. v. 4. Lipids. v. 5. Amino acids and derivates. v. 6. Proteins and nucleic acids. v. 7. Secondary plant products. v. 8. Photosynthesis. v. 9. Lipids: structure a nd function. v. 10. Photosynthesis. v. 11. Biochemistry of metabolism. v. 12. P hysiology of metabolism. v. 13. Methodology. v. 14. Carbohydrates. v. 15. Molecular biology. v.16. Intermediary nitrogen metabolism.
Why do we behave the way we do? Biologist Paul Ehrlich suggests that although people share a common genetic code, these genes "do not shout commands at us...at the very most, they whisper suggestions." He argues that human nature is not so much result of genetic coding; rather, it is heavily influenced by cultural conditioning and environmental factors. With personal anecdotes, a well-written narrative, and clear examples, Human Natures is a major work of synthesis and scholarship as well as a valuable primer on genetics and evolution that makes complex scientific concepts accessible to lay readers.
Biological Diversity takes a fresh, innovative approach to the teaching of biodiversity. Rather than detailing and cataloguing the major taxa and their evolutionary relationships, the authors have selected 18 groups of organisms and used these as a framework in which to discuss the species and their interactions with man and each other. There is a strong narrative theme throughout – the exploited and the exploiters - and, in many cases, there is emphasis on the historical context. A wide range of organisms are covered, from the unicellular to birds and mammals and with an equal consideration of plants and animals. Species have been chosen for their ability to best illustrate particular biological principles, and for their strong interaction with other species. After an introduction the book is divided into two parts: 'Exploited' and 'Exploiters'. Each of the chapters, although linked to each other, forms a stand-alone essay. They are scientifically rigorous, up-to-date and do not shy away from addressing some controversial issues. Chapters have 'text boxes' highlighting important issues and concepts, lists of further reading and references. In addition to tables and figures the book has a selection of original illustrations drawn by leading artist Steven Appleby. This fresh approach will appeal to all those interested in the biological sciences, and aims to be accessible to people with a diversity of backgrounds. It will prove particularly useful to biology students, enabling them to get to grips with important biological principles and concepts that underpin the diversity of life, and the interrelationship of humans with other groups of organisms.
Ce volume rassemble les textes des communications faites lors du symposium organisé à Rouen les 23 et 24 mai 1985. Au cours de ce colloque sur l'hépatotoxicité, les sujets suivants ont été abordés : les aspects chimiques et anatomopathologiques des hépatites aiguës et chroniques d'origine médicamenteuse, les méca¬nismes d'action (qui ont occupé la plus grande partie de ces communications), les mécanismes de protection cellulaire vis-à-vis de certains métabolites toxiques, la quantification de la toxicité hépatique... Il est impossible de tout citer mais il est certain que l'ouvrage constitue un excellent document de travail pour tous ceux qui sont préoccupés par ce problème de l'hépatotoxicité tant expérimentale qu'humaine.
Preston explores the political and personal mysteries of the former Spanish monarch's life in a story of unprecedented sweep and exquisite detail which is at once a history of modern Spain and an indispensable exegesis of how democracies come to be.
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