The paucity of published material on the borders of New Guinea and the international significance of the Irian boundary led me to bring together the information I had gathered over the past few years. Ideally, a book of this kind should cover the subject in its total historical and geographical context. The aim of this work is more modest: it intends merely to throw some light on the birth and development of New Guinea's boundaries. With this purpose in mind, after an introductory chapter attention is given to the historical events leading up to the parti tion of New Guinea among three European powers. In subsequent chapters the development of the boundaries between the various parts of the island is discussed. It is realized that this approach may tend to convey the impression that each particular border is in some way unique. This, however, is not intended and it is hoped that the reader will recognize some of the common underlying themes and problems which are given attention in the introductory and concluding chapters. It was intended originally to present in a brief appendix those docu ments which define the borders. It soon appeared desirable to include also the unpublished records of more recent border conferences and relevant correspondence leading up to the actual treaties, exchange of notes, Orders in Council, or (as the case might be) lack of action.
The efficient management of trees and other woody plants can be improved given an understanding of the physiological processes that control growth, the complex environmental factors that influence those processes, and our ability to regulate and maintain environmental conditions that facilitate growth. - Emphasizes genetic and environmental interactions that influence woody plant growth - Outlines responses of individual trees and tree communities to environmental stress - Explores cultural practices useful for efficient management of shade, forest, and fruit trees, woody vines, and shrubs
The advances made in vascular biology in the last 25 years have considerably changed the perception that one could have of the endothelial cells. Once considered as a diffusion barrier preventing the access of the blood cells to the vascular matrix, the endothelium is now recognized as playing a major role in the control of blood fluidity, platelet aggregation, and vascular tone, but also in immunology, inflammation, angiogenesis, and for serving as a metabolizing and an endocrine organ. -- from the preface Cardiovascular diseases, so prevalent in the Western world during the twentieth century, could well become the scourge of the twenty-first century in emerging countries as well as the West. Endothelial dysfunction linked to an imbalance in the synthesis and/or release of contracting and relaxing factors is often evoked to explain the initiation of the cardiovascular pathology or its development and perpetuation. Two decades ago, when nitric oxide was demonstrated to mediate endothelium-dependent relaxations, the vascular world seemed convinced that nitric oxide was the ultimate and sole explanation for such relaxations. However not everyone agreed. EDHF: The Complete Story is the work of two leading researchers who did not accept that simple conclusion, but instead continued to search, along with others, for a deeper understanding of the ways in which endothelial cells communicate with the underlying smooth muscle to signal it to hyperpolarize. Now with most, if not all, of those ways, uncovered, the authors offer this summary as way of bringing closure to the quest. This monograph reports on the work of many researchers. It summarizes the significant recent discoveries concerning endothelium-dependent hyperpolarizations, which are likely to play a much more important role in cardiovascular physiology and pathology than was originally foreseen Extensively illustrated with original diagrams and schematics that summarize the different steps of endothelium-dependent hyperpolarization, the text is designed for vascular biologists, and cardiologists, as well as graduate students looking to gain an understanding of the intimate functioning of the blood vessel wall.
Art In Its Time takes a close look at the way in which art has become integral to the everyday 'ordinary' life of modern society. It explores the prevalent notion of art as transcending its historical moment, and argues that art cannot be separated from the everyday as it often provides material to represent social struggles and class, to explore sexuality, and to think about modern industry and our economic relationships.
This edited collection showcases the contribution of women to the development of political ideas during the Enlightenment, and presents an alternative to the male-authored canon of philosophy and political thought. Over the course of the eighteenth century increasing numbers of women went into print, and they exploited both new and traditional forms to convey their political ideas: from plays, poems, and novels to essays, journalism, annotated translations, and household manuals, as well as dedicated political tracts. Recently, considerable scholarly attention has been paid to women’s literary writing and their role in salon society, but their participation in political debates is less well studied. This volume offers new perspectives on some better known authors such as Mary Wollstonecraft, Catharine Macaulay, and Anna Laetitia Barbauld, as well as neglected figures from the British Isles and continental Europe. The collection advances discussion of how best to understand women’s political contributions during the period, the place of salon sociability in the political development of Europe, and the interaction between discourses on slavery and those on women’s rights. It will interest scholars and researchers working in women’s intellectual history and Enlightenment thought and serve as a useful adjunct to courses in political theory, women’s studies, the history of feminism, and European history.
THE WESTERN WORLD IS BURNING... For Richard Hawkwood and his crew, a desperate venture to carry refugees to the uncharted land across the Great Western Ocean offers the only chance of escape from the Inceptines’ pyres. In the East, Lofantyr, Abeleyn and Mark – three of the five Ramusian Kings – have defied the cruel pontiff’s purge and must fight to hold their thrones through excommunication, intrigue and civil war. In the quiet monastery city of Charibon, two humble monks make a discovery that will change the whole world. Aekir, the Holy City, has fallen and all now seems lost, but even on the eve of destruction the Faithful still war amongst themselves... Hawkwood and the Kings collects Hawkwood’s Voyage and The Heretic Kings, the first two books in Paul Kearney’s spectacular The Monarchies of God cycle.
Combining the intellectual history of the Enlightenment, Atlantic history, and the history of the French Revolution, Paul Cheney explores the political economy of globalization in eighteenth-century France. The discovery of the New World and the rise of Europe's Atlantic economy brought unprecedented wealth. It also reordered the political balance among European states and threatened age-old social hierarchies within them. In this charged context, the French developed a "science of commerce" that aimed to benefit from this new wealth while containing its revolutionary effects. Montesquieu became a towering authority among reformist economic and political thinkers by developing a politics of fusion intended to reconcile France's aristocratic society and monarchical state with the needs and risks of international commerce. The Seven Years' War proved the weakness of this model, and after this watershed reforms that could guarantee shared prosperity at home and in the colonies remained elusive. Once the Revolution broke out in 1789, the contradictions that attended the growth of France's Atlantic economy helped to bring down the constitutional monarchy. Drawing upon the writings of philosophes, diplomats, consuls of commerce, and merchants, Cheney rewrites the history of political economy in the Enlightenment era and provides a new interpretation of the relationship between capitalism and the French Revolution.
A ROYAL REBELLION... When the power-mad Himerius won himself enough support to have foreigners and magicians put to death, Lofantyr, Abeleyn and Mark – three of the five Ramusian Kings – defied the cruel pontiff’s purge. Now they must fight to hold their thrones through excommunication, intrigue and civil war. Meanwhile, in the quiet monastery city of Charibon, two humble monks make a discovery that will change the whole world...
This book gives a detailed description of all books, published in the Dutch Republic and its Generality Lands between 1567 and 1773 – the year in which the Society of Jesus was suppressed by Pope Clement XIV for political reasons –, written by Jesuits from the Low Countries and elsewhere. Locations of the books are given, as far as possible, as well as bibliographical sources. Many of these publications are pirate editions, mainly from France and Germany. Technical and historical introductions precede this bibliography, and several indexes and registers conclude this work. The titles show the areas in which Jesuits have been active, and indicate their influence in many fields. A similar work has never been attempted before.
Trends in Linguistics is a series of books that publishes state-of-the-art work on core areas of linguistics across theoretical frameworks as well as studies that provide new insights by building bridges to neighboring fields such as neuroscience and cognitive science. The series considers itself a forum for cutting-edge research based on solid empirical data on language in its various manifestations, including sign languages. It regards linguistic variation in its synchronic and diachronic dimensions as well as in its social contexts as important sources of insight for a better understanding of the design of linguistic systems and the ecology and evolution of language. Bonfiglio examines the ideological legacy of the metaphors "mother tongue" and "native speaker" by historicizing their linguistic development. The early nation states constructed the ideology of ethnolinguistic nationalism, a composite of language, identity, geography, and ethnicity that configured the national language as originating in the mother-infant relationship, as well as in local organic nature. These insular protectionist strategies generated the philologies of (early) modernity and their genetic and arboreal "families" of languages, and continue today to evoke folkloric notions that configure language ethnically. Scholarly recognition of the biological metaphors that racialize language will help to illuminate persisting gestures of ethnolinguistic discrimination.
With prevalence figures close to 0.2% at birth and rising to 0.35% during adolescence, hearing loss is the most frequent sensory impairment in childhood. This silent handicap has to be actively sought for without delay as it will seriously interfere with the development of speech, language, cognitive and socio-emotional behavior. Objective physiological techniques (evoked potentials, oto-acoustic emissions, tympanometry) combined according to the cross-check principle allow early diagnosis. Objective testing yields invaluable information about the mechanism of the loss and the contribution of disruption of the neural code to the handicap. Among the acquired causes, cytomegalovirus (CMV) infections plays a major role and may take elusive forms. Aminoglycoside ototoxicity has a genetic determinant. Meningitis can lead to rapid endocochlear ossification prompting for rapid cochlear implantation. Genetic causes account for more than 60% of congenital hearing loss, new genetic causes being discovered at an amazing rate. The high number of genetic entities and their huge heterogeneity among them requires guidelines for requesting genetic testing when desirable. Several syndromes prone to request neuropediatricians’ attention as an early diagnosis followed by specific treatment can considerably limit the ensuing handicap. Whatever the type of assistive device fitted (amplifying hearing aid or cochlear implant) and the importance of associated handicaps, a multidisciplinary rehabilitation combined with educated parental commitment is necessary for optimal results.
Endosonography—by Drs. Robert H. Hawes, Paul Fockens, and Shyam Varadarjulu—is a rich visual guide that covers everything you need to effectively perform EUS, interpret your findings, diagnose accurately, and choose the best treatment course. World-renowned endosonographers help beginners apply endosonography in the staging of cancers, evaluating chronic pancreatitis, and studying bile duct abnormalities and submucosal lesions. Practicing endosonographers can learn cutting-edge techniques for performing therapeutic interventions such as drainage of pancreatic pseudocysts and EUS-guided anti-tumor therapy. This updated 2nd edition features online access to the fully searchable text, videos detailing various methods and procedures, and more at www.expertconsult.com. You’ll have a complete overview of all aspects of EUS, from instrumentation to therapeutic procedures. Gain a detailed visual understanding on how to perform EUS using illustrations and high-quality images. Understand the role of EUS with the aid of algorithms that define its place in specific disease states. Locate information quickly and easily through a consistent chapter structure, with procedures organized by body system. Access the fully searchable text online at www.expertconsult.com, along with 60 procedural video clips, 300 downloadable PowerPoint slides, and 400 downloadable images, and regular updates reflecting the latest findings. Stay abreast of the most recent studies thanks to downloadable tables that summarize new information, updated on a quarterly basis. Master the technique of systematically performing EUS, then download the hundreds of slides and videos available online to teach and train the newer generation of endoscopists. Find coverage relevant to your needs with detailed chapters, illustrations, and videos on how to perform EUS for the beginner; a new section on international EUS and technical tips on how to handle difficult FNAs for the advanced user; a totally revised chapter on cytopathology for the pathologist; and a chapter on EBUS and EUS dedicated to the mediastinum for the pulmonologist. Get a clear overview of everything you need to know to establish an endoscopic practice, from what equipment to buy to providing effective cytopathology service. Tap into the expertise of world-renowned leaders in endosonography, Drs. Robert H. Hawes, Paul Fockens, and Shyam Varadarajulu.
Clinical Ultrasound has been thoroughly revised and updated by a brand new editorial team in order to incorporate the latest scanning technologies and their clinical applications in both adult and paediatric patients. With over 4,000 high-quality illustrations, the book covers the entire gamut of organ systems and body parts where this modality is useful. It provides the ultrasound practitioner with a comprehensive, authoritative guide to image diagnosis and interpretation. Colour is now incorporated extensively throughout this edition in order to reflect the advances in clinical Doppler, power Doppler, contrast agents. Each chapter now follows a consistent organizational structure and now contains numerous summary boxes and charts in order to make the diagnostic process practical and easy to follow. Covering all of the core knowledge, skills and experience as recommended by the Royal College of Radiologists, it provides the Fellow with a knowledge base sufficient to pass professional certification examinations and provides the practitioner with a quick reference on all currently available diagnostic and therapeutic ultrasound imaging procedures. - Individual chapters organized around common template therefore establishing a consistent diagnostic approach throughout the text and making the information easier to retrieve. - Access the full text online and download images via Expert Consult. - Three brand new editors and many new contributing authors bring a fresh perspective on the content. - Authoritative coverage of the most recent advances and latest developments in cutting edge technologies such as: colour Doppler, power Doppler, 3D and 4D applications, harmonic imaging, high intensity focused ultrasound (HIFU) microbubble contrast agents, interventional ultrasound , laparoscopic ultrasound brings this edition right up to date in terms of the changes in technology and the increasing capabilities/applications of ultrasound equipment. - New sections on musculoskeletal imaging. - Addition of coloured text, tables, and charts throughout will facilitate quick review and enhance comprehension.
From the latest vaccination evidence, recommendations, and protocols . . . to new vaccine development and the use of vaccines in reducing disease, Plotkin's Vaccines, 8th Edition, covers every aspect of vaccination. Now completely revised and updated from cover to cover, this award-winning text continues to provide reliable information from global authorities, offering a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as "an indispensable guide to the enhancement of the well-being of our world," Plotkin's Vaccines is a must-have reference for current, authoritative information in this fast-moving field. - Contains all-new chapters on COVID-19, vaccine hesitancy, and non-specific effects of vaccines, as well as significantly revised content on new vaccine technologies such as mRNA vaccines, emerging vaccines, and technologies to improve immunization. - Presents exciting new data on evolution of adjuvants across the centuries, dengue vaccines, human papillomavirus vaccines, respiratory syncytial virus vaccines, tuberculosis vaccines, and zoster vaccines. - Provides up-to-date, authoritative information on vaccine production, available preparations, efficacy and safety, and recommendations for vaccine use, with rationales and data on the impact of vaccination programs on morbidity and mortality. - Provides complete coverage of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well as epidemiology and public health and regulatory issues. - Keeps you up to date with information on each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. - Covers vaccine-preventable diseases, vaccine science, and licensed vaccine products, as well as product technologies and global regulatory and public health issues. - Analyzes the cost-benefit and cost-effectiveness of different vaccine options. - Helps you clearly visualize concepts and objective data through an abundance of tables and figures. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Completely revised and updated, this respected reference offers comprehensive and current coverage of every aspect of vaccination--from development to use in reducing disease. It also includes access to a companion Web site for more coverage.
From the development of each vaccine to its use in reducing disease, Plotkin's Vaccines, 7th Edition, provides the expert information you need to provide optimal care to your patients. This award-winning text offers a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as "an indispensable guide to the enhancement of the well-being of our world," Plotkin's Vaccines is a must-have reference for current, authoritative information in this fast-moving field. - Includes complete information for each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, epidemiology, and public health and regulatory issues – plus complete information for each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. - Analyzes the cost-benefit and cost-effectiveness of different vaccine options. - Helps you clearly visualize concepts and objective data through an abundance of tables and figures. - Covers the new oral cholera and zoster vaccines, as well as newly licensed meningococcal group B vaccines and a newly licensed dengue vaccine. - Brings you up to date on successful human trials of Ebola vaccines, an enterovirus 71 vaccine licensed in China, and new recommendations and changes to polio vaccines. - Features a new chapter on maternal immunization. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
As a palliative medicine physician, you struggle every day to make your patients as comfortable as possible in the face of physically and psychologically devastating circumstances. This new reference equips you with all of today's best international approaches for meeting these complex and multifaceted challenges. In print and online, it brings you the world's most comprehensive, state-of-the-art coverage of your field. You'll find the answers to the most difficult questions you face every day...so you can provide every patient with the relief they need. Equips you to provide today's most effective palliation for terminal malignant diseases • end-stage renal, cardiovascular, respiratory, and liver disorders • progressive neurological conditions • and HIV/AIDS. Covers your complete range of clinical challenges with in-depth discussions of patient evaluation and outcome assessment • ethical issues • communication • cultural and psychosocial issues • research in palliative medicine • principles of drug use • symptom control • nutrition • disease-modifying palliation • rehabilitation • and special interventions. Helps you implement unparalleled expertise and global best practices with advice from a matchless international author team. Provides in-depth guidance on meeting the specific needs of pediatric and geriatric patients. Assists you in skillfully navigating professional issues in palliative medicine such as education and training • administration • and the role of allied health professionals. Includes just enough pathophysiology so you can understand the "whys" of effective decision making, as well as the "how tos." Offers a user-friendly, full-color layout for ease of reference, including color-coded topic areas, mini chapter outlines, decision trees, and treatment algorithms. Comes with access to the complete contents of the book online, for convenient, rapid consultation from any computer.
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