Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications. This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.
As a palliative medicine physician, you struggle every day to make your patients as comfortable as possible in the face of physically and psychologically devastating circumstances. This new reference equips you with all of today's best international approaches for meeting these complex and multifaceted challenges. In print and online, it brings you the world's most comprehensive, state-of-the-art coverage of your field. You'll find the answers to the most difficult questions you face every day...so you can provide every patient with the relief they need. Equips you to provide today's most effective palliation for terminal malignant diseases • end-stage renal, cardiovascular, respiratory, and liver disorders • progressive neurological conditions • and HIV/AIDS. Covers your complete range of clinical challenges with in-depth discussions of patient evaluation and outcome assessment • ethical issues • communication • cultural and psychosocial issues • research in palliative medicine • principles of drug use • symptom control • nutrition • disease-modifying palliation • rehabilitation • and special interventions. Helps you implement unparalleled expertise and global best practices with advice from a matchless international author team. Provides in-depth guidance on meeting the specific needs of pediatric and geriatric patients. Assists you in skillfully navigating professional issues in palliative medicine such as education and training • administration • and the role of allied health professionals. Includes just enough pathophysiology so you can understand the "whys" of effective decision making, as well as the "how tos." Offers a user-friendly, full-color layout for ease of reference, including color-coded topic areas, mini chapter outlines, decision trees, and treatment algorithms. Comes with access to the complete contents of the book online, for convenient, rapid consultation from any computer.
Borley Rectory in Essex, built in 1862, should have been an ordinary Victorian clergyman's house. However, just a year after its construction, unexplained footsteps were heard within the house, and from 1900 until it burned down in 1939 numerous paranormal phenomena, including phantom coaches and shattering windows, were observed. In 1929 the house was investigated by the Daily Mail and paranormal researcher Harry Price, and it was he who called it 'the most haunted house in England.' Price also took out a lease of the rectory from 1937 to 1938, recruiting forty-eight 'official observers' to monitor occurences. After his death in 1948, the water was muddied by claims that Price's findings were not genuine paranormal activity, and ever since there has been a debate over what really went on at Borley Rectory. Paul Adams, Eddie Brazil and Peter Underwood here present a comprehensive guide to the history of the house and the ghostly (or not) goings-on there.
A thrilling account of the rescue of RAF crewmen after their aircraft crashes in Afghanistan in 1919. This is the story of an unknown incident during the little-known Third Afghan War. An aircraft from the No. 20 Squadron RAF was lost while investigating gathering tribesman. The crew were rescued, and most of the aircraft was recovered by the Kurram Militia and the 22nd Battery Motor Machine Gun Service. It was an all-arms action—the lives of two airmen were saved at the cost of an Indian Militiaman and an unknown number of Afghan tribesmen. It also illustrates the experience of a virtually unknown group of soldiers, the 22nd Battery of the Motor Machine Gun Service. They had volunteered to serve as Motor Machine Gunners in France, had been through an intense, competitive, and sometimes costly selection process, and had now suddenly found themselves dispatched half way round the globe to the heat, dust, snows and monsoons of India and the North-West Frontier. This book examines the conflict’s background, the Kurram Militia, the history of the squadron and the lives of the key players. While this was not the only action the 22nd Battery of the Motor Machine Gun Service fought during the Third Afghan War, this one was recorded in the account of A/Sjt Ernest “Bill” Macro, who was in charge of the section of 22nd Battery dispatched to Badama Post in late July 1919. This is his story, and the stories of the other men for whom the climax of their experience in the Third Afghan War came during the action at Badama Post
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