The integrated theory of dynamic interpretation set out here will be a surprise to advanced researchers in linguistics. It combines classical formal semantics and modern dynamic semantics without altering the fundamental paradigm. At the book’s core lies a pragmatically motivated notion of a dynamic conjunction of meanings, an idea that is worked out in full formal detail. This is applied to linguistic phenomena that involve anaphora, quantification and modality. The author demonstrates that in each area of application existing data can be neatly combined with new dynamic insights, but more importantly, there is a genuine further pay-off: the work generates treatments of phenomena that were not initially intended, with functional readings of pronouns and quantifiers, ‘Hob-Nob’ sentences, and insights into what we now call ‘Pierce’s Puzzle’. The outcome of a decade of work by the Amsterdam School of dynamic semantics, this volume condenses and reflects upon a vital body of research.
The integrated theory of dynamic interpretation set out here will be a surprise to advanced researchers in linguistics. It combines classical formal semantics and modern dynamic semantics without altering the fundamental paradigm. At the book’s core lies a pragmatically motivated notion of a dynamic conjunction of meanings, an idea that is worked out in full formal detail. This is applied to linguistic phenomena that involve anaphora, quantification and modality. The author demonstrates that in each area of application existing data can be neatly combined with new dynamic insights, but more importantly, there is a genuine further pay-off: the work generates treatments of phenomena that were not initially intended, with functional readings of pronouns and quantifiers, ‘Hob-Nob’ sentences, and insights into what we now call ‘Pierce’s Puzzle’. The outcome of a decade of work by the Amsterdam School of dynamic semantics, this volume condenses and reflects upon a vital body of research.
Environmental regulations provide protection to the public, workers and the environment. To protect themselves from long-term liabilities, however, companies have to do more than just comply with the basic responsibilities. This handbook is designed to introduce terminology, methodology, tools, procedures and practical guidance for incorporating efficient pollution prevention strategies into the overall business plan. It is a company’s responsibility to protect and control its management of waste and pollution, and a company that fails to do so will ultimately inflict a negative impact on its bottom line, especially in financial performance. Responsible Care delivers critical guidelines and rules of thumb required for industrial managers to improve their companies’ profitability through waste reduction, cleaner production technologies and sound management practices.
Changes and additions are sprinkled throughout. Among the significant new features are: • Markov-chain simulation (Sections 1. 3, 2. 6, 3. 6, 4. 3, 5. 4. 5, and 5. 5); • gradient estimation (Sections 1. 6, 2. 5, and 4. 9); • better handling of asynchronous observations (Sections 3. 3 and 3. 6); • radically updated treatment of indirect estimation (Section 3. 3); • new section on standardized time series (Section 3. 8); • better way to generate random integers (Section 6. 7. 1) and fractions (Appendix L, program UNIFL); • thirty-seven new problems plus improvements of old problems. Helpful comments by Peter Glynn, Barry Nelson, Lee Schruben, and Pierre Trudeau stimulated several changes. Our new random integer routine extends ideas of Aarni Perko. Our new random fraction routine implements Pierre L'Ecuyer's recommended composite generator and provides seeds to produce disjoint streams. We thank Springer-Verlag and its late editor, Walter Kaufmann-Bilhler, for inviting us to update the book for its second edition. Working with them has been a pleasure. Denise St-Michel again contributed invaluable text-editing assistance. Preface to the First Edition Simulation means driving a model of a system with suitable inputs and observing the corresponding outputs. It is widely applied in engineering, in business, and in the physical and social sciences.
The book provides a comprehensive treatment of statistical inference using permutation techniques. It features a variety of useful and powerful data analytic tools that rely on very few distributional assumptions. Although many of these procedures have appeared in journal articles, they are not readily available to practitioners.
A must have resource for clinicians and investigators interested in pulmonary embolism and deep venous thrombosis Highly illustrated with numerous tables and graphs alongside clear concise text Includes chapters addressing pulmonary embolism (PE) and deep venous thrombosis (DVT) in relation to diseases and disorders such as; chronic heart failure, cancer, diabetes, stroke, chronic obstructive pulmonary disease (COPD) and many more Discusses the role the different tools offered in imaging for PE, including echocardiography, multidetector computed tomography (CT), single photon emission computed tomography (SPECT), ventilation-perfusion (V-Q) imaging, dual energy CT, and magnetic resonance angiography Contains 29 new chapters and includes new content on epidemiology of deep venous thrombosis; use of the new anticoagulants (dabigatran, rivaroxaban, and apixaban) for DVT and PE; indications and results with thrombolytic therapy and with vena cava filters; and information and indications for invasive mechanical thrombectomy and thrombolysis Written by an internationally recognized and respected expert in the field
Ecological Golf Course Management is the most comprehensive work ever done on ecological turf management. It's a must-have for any golf course superintendent, sports field manager, or turf professional interested in reducing or eliminating chemical pesticide use. Ecological Golf Course Management focuses on managing the health and welfare of all soil organisms from a single-celled bacterium to fully developed turf plants and connects the reader to the important and relevant interactions between them. It points out ways to exploit natural plant defense systems that have been largely ignored and to engage many of the powerful allies that live above and below ground. Ecological Golf Course Management explores in detail the many aspects of: * Biological and botanical pest control * Plant stress management * Compost production and use * Natural disease suppressants * Biological fertility management * Soil, leaf tissue, and water analysis * The ecological impact of conventional pesticides and cultural practices
Fully engage learners in your classroom. Discover how to create high-quality assessments using a five-phase design protocol. Explore types and traits of quality assessment, and learn how to develop assessments that are innovative, effective, and engaging.
This edition of 'Introduction to Food Engineering' presents the engineering concepts and unit operations used in food processing, in a unique and challenging blend of principles with applications.
Studies of Adjuvants involve many scientific fields from basic research of the chemistry, through investigations into physiological effects and environmental impact, to mixture formulation and field use. These important areas are illustrated in these two volumes, which are contributions from the First International Symposium on Adjuvants for Agrochemicals, held in Brandon, Manitoba on August 5 to 7, 1986. A total of 200 participants from 19 countries met to discuss their common interest in adjuvant science, technology, and application. It is the editors hope that these volumes will stimulate interest in and promote a better understanding of the chemical, physiological, and agronomic aspects of adjuvants as they relate agrochemicals. In addition, the revisedAdjuvants for Agrochemicals: A Selected Bibliography of World Literature in the English Language will be a valuable resource for agricultural researchers and other users. We hope that adjuvant research will lead to even safer, more efficient, and more economical use of chemicals in agriculture and forestry.
“Highly recommended!” – CHOICE New Edition Offers Improved Framework for Understanding Polymers Written by well-established professors in the field, Polymer Chemistry, Second Edition provides a well-rounded and articulate examination of polymer properties at the molecular level. It focuses on fundamental principles based on underlying chemical structures, polymer synthesis, characterization, and properties. Consistent with the previous edition, the authors emphasize the logical progression of concepts, rather than presenting just a catalog of facts. The book covers topics that appear prominently in current polymer science journals. It also provides mathematical tools as needed, and fully derived problems for advanced calculations. This new edition integrates new theories and experiments made possible by advances in instrumentation. It adds new chapters on controlled polymerization and chain conformations while expanding and updating material on topics such as catalysis and synthesis, viscoelasticity, rubber elasticity, glass transition, crystallization, solution properties, thermodynamics, and light scattering. Polymer Chemistry, Second Edition offers a logical presentation of topics that can be scaled to meet the needs of introductory as well as more advanced courses in chemistry, materials science, and chemical engineering.
In the time of Freud, the typical psychoanalytic patient was afflicted with neurotic disorders; however, the modern-day psychotherapy patient often suffers instead from a variety of addictive disorders. As the treatment of neurotic disorders based on unconscious conflicts cannot be applied to treatment of addictive disorders, psychoanalysis has been unable to keep pace with the changes in the type of patient seeking help. To address the shift and respond to contemporary patients’ needs, Ulman and Paul present a thorough discussion of addiction that studies and analyzes treatment options. Their honest and unique work provides new ideas that will help gain access to the fantasy worlds of addicted patients. The Self Psychology of Addiction and Its Treatment emphasizes clinical approaches in the treatment of challenging narcissistic patients struggling with the five major forms of addiction. Ulman and Paul focus on six specific case studies that are illustrative of the five forms of addiction. They use the representative subjects to develop a self psychological model that helps to answer the pertinent questions regarding the origins and pathway of addiction. This comprehensive book links addiction and trauma in an original manner that creates a greater understanding of addiction and its foundations than any clinical or theoretical model to date.
While most abnormal psychology texts seem to aim solely for breadth, the acclaimed Oxford Textbook of Psychopathology aims for depth, with a focus on adult disorders and special attention given to the personality disorders. Almost a decade has passed since the first edition was published, establishing itself as an unparalleled guide for professionals and graduate students alike, and in this second edition, esteemed editors Paul H. Blaney and Theodore Millon have once again selected the most eminent researchers in abnormal psychology to cover all the major mental disorders, allowing them to discuss notable issues in the various pathologies which are their expertise. This collection exposes readers to exceptional scholarship, a history of psychopathology, the logic of the best approaches to current disorders, and an expert outlook on what future researchers and mental health professionals will be facing in the years to come. With extensive coverage of personality disorders and issues related to classification and differential diagnosis, this volume will be exceptionally useful for all mental health workers, clinical psychologists, psychiatrists, and social workers, and as a textbook focused on understanding psychopathology in depth, as well as a valuable guide for graduate psychology students and psychiatric residents.
Cereals, legumes, oilseeds, fruits, and vegetables are the most important food crops in the world, with cereal grains contributing the bulk of food calories and proteins worldwide. Generally, the supply of grains and other food can be enhanced by increasing production and by reducing postharvest losses. While food production has increased significa
Though many separation processes are available for use in todays analytical laboratory, chromatographic methods are the most widely used. The applications of chromatography have grown explosively in the last four decades, owing to the development of new techniques and to the expanding need of scientists for better methods of separating complex mixtures. With its comprehensive, unified approach, this book will greatly assist the novice in need of a reference to chromatographic techniques, as well as the specialist suddenly faced with the need to switch from one technique to another.
Quickly and decisively manage any medical emergency you encounter in the great outdoors with Wilderness Medicine! World-renowned authority and author, Dr. Paul Auerbach, and a team of experts offer proven, practical, visual guidance for effectively diagnosing and treating the full range of emergencies and health problems encountered in situations where time and resources are scarce. Every day, more and more people are venturing into the wilderness and extreme environments, or are victims of horrific natural disasters...and many are unprepared for the dangers and aftermath that come with these episodes. Whether these victims are stranded on mountaintops, lost in the desert, injured on a remote bike path, or ill far out at sea, this indispensable resource--now with online access at www.expertconsult.com for greater accessibility and portability-- equips rescuers and health care professionals to effectively address and prevent injury and illness in the wilderness! This textbook is widely referred to as "The Bible of Wilderness Medicine." Be able to practice emergency medicine outside of the traditional hospital/clinical setting whether you are in remote environments, underdeveloped but highly populated areas, or disaster areas, are part of search and rescue operations, or dealing with casualties from episodes of extreme sports and active lifestyle activities. Face any medical challenge in the wilderness with expert guidance: Dr. Auerbach is a noted author and the world's leading authority on wilderness medicine. He is a founder and Past President of the Wilderness Medical Society, consultant to the Divers Alert Network and many other agencies and organizations, and a member of the National Medical Committee for the National Ski Patrol System. Handle everything from frostbite to infection by marine microbes, not to mention other diverse injuries, bites, stings, poisonous plant exposures, animal attacks, and natural disasters. Grasp the essential aspects of search and rescue. Respond quickly and effectively by improvising with available materials. Improve your competency and readiness with the latest guidance on volcanic eruptions, extreme sports, splints and slings, wilderness cardiology, living off the land, aerospace medicine, mental health in the wilderness, tactical combat casualty care, and much more. Meet the needs and special considerations of specific patient populations such as children, women, elders, persons with chronic medical conditions, and the disabled. Make smart decisions about gear, navigation, nutrition, and survival. Be prepared for everything with expanded coverage on topics such as high altitude, cold water immersion, and poisonous and venomous plants and animals. Get the skills you need now with new information on global humanitarian relief and expedition medicine, plus expanded coverage of injury prevention and environmental preservation. Get guidance on the go with fully searchable online text, plus bonus images, tables and video clips - all available on ExpertConsult.com.
After nearly two decades, Paul Yoder's Opto-Mechanical Systems Design continues to be the reference of choice for professionals fusing optical and mechanical components into advanced, high-performance instruments. Yoder's authoritative systems-oriented coverage and down-to-earth approach fosters the deep-seated knowledge needed to continually push
In contrast to books on specific bioactive compounds, this book deals with the role of mevalonic acid metabolites (isoprenoids and their derived structures) in metabolism, development, and functions of organisms, which, though diverse, show various levels of communication. Different disciplines are brought together in a discussion of the messenger functions of terpenoids within and between organisms belonging to five biological kingdoms: bacteria, fungi, plants, insects, and vertebrates (including humans). The present volume covers evolutionary aspects of terpenoids in plant physiology, plant-insect relationships, semiochemicals, and in life sciences, with special emphasis on cancer research and treatment. The book provides proposals for multidisciplinary model systems for the study of interrelationships of organisms utilizing terpenoid messengers, and discusses novel strategies for insect control and multifactor treatments of cancer utilizing terpenoids. This book is of interest to scientists, and students at an advanced level: biologists, plant breeders, pharmacologists, specialists in medical fields, especially oncologists, physicians in general, and anyone with a basic biochemical and physiological knowledge.
P.J. van der Put offers students an original introduction to materials chemistry that integrates the full range of inorganic chemistry. Technologists who need specific chemical facts to manipulate matter will also find this work invaluable as an easy-to-use reference. The text includes practical subjects of immediate use for materials such as bonding, morphogenesis, and design that more orthodox materials science volumes often leave out.
A well-rounded and articulate examination of polymer properties at the molecular level, Polymer Chemistry focuses on fundamental principles based on underlying chemical structures, polymer synthesis, characterization, and properties. It emphasizes the logical progression of concepts and provide mathematical tools as needed as well as fully derived problems for advanced calculations. The much-anticipated Third Edition expands and reorganizes material to better develop polymer chemistry concepts and update the remaining chapters. New examples and problems are also featured throughout. This revised edition: Integrates concepts from physics, biology, materials science, chemical engineering, and statistics as needed. Contains mathematical tools and step-by-step derivations for example problems Incorporates new theories and experiments using the latest tools and instrumentation and topics that appear prominently in current polymer science journals. The number of homework problems has been greatly increased, to over 350 in all. The worked examples and figures have been augmented. More examples of relevant synthetic chemistry have been introduced into Chapter 2 ("Step-Growth Polymers"). More details about atom-transfer radical polymerization and reversible addition/fragmentation chain-transfer polymerization have been added to Chapter 4 ("Controlled Polymerization"). Chapter 7 (renamed "Thermodynamics of Polymer Mixtures") now features a separate section on thermodynamics of polymer blends. Chapter 8 (still called "Light Scattering by Polymer Solutions") has been supplemented with an extensive introduction to small-angle neutron scattering. Polymer Chemistry, Third Edition offers a logical presentation of topics that can be scaled to meet the needs of introductory as well as more advanced courses in chemistry, materials science, polymer science, and chemical engineering.
Organic Chemistry, Volume 28: Organic Syntheses with Noble Metal Catalysts provides information pertinent to the catalysis by noble metals, which is presented in a form as to be of use to those interested in organic synthesis. This book discusses the mechanistic aspects of reactions. Organized into nine chapters, this volume begins with an overview of catalytic dehydrogenation over platinum metals, which provides a convenient method for synthesis of organic compounds. This text then examines the mechanisms and kinetics of homogeneous hydrogenation. Other chapters consider the oxidation of organic compounds in the presence of noble metal catalysts that may affect a variety of changes, including introduction of alcohol, epoxide, carbonyl, and halogen functions into the molecule. This book discusses as well the differences between osmium tetroxide and ruthenium tetroxide in their reactions with organic compounds. The final chapter deals with noble metal catalysts. This book is a valuable resource for synthetic organic chemists.
The primary purpose of this textbook is to introduce the reader to a wide variety of elementary permutation statistical methods. Permutation methods are optimal for small data sets and non-random samples, and are free of distributional assumptions. The book follows the conventional structure of most introductory books on statistical methods, and features chapters on central tendency and variability, one-sample tests, two-sample tests, matched-pairs tests, one-way fully-randomized analysis of variance, one-way randomized-blocks analysis of variance, simple regression and correlation, and the analysis of contingency tables. In addition, it introduces and describes a comparatively new permutation-based, chance-corrected measure of effect size. Because permutation tests and measures are distribution-free, do not assume normality, and do not rely on squared deviations among sample values, they are currently being applied in a wide variety of disciplines. This book presents permutation alternatives to existing classical statistics, and is intended as a textbook for undergraduate statistics courses or graduate courses in the natural, social, and physical sciences, while assuming only an elementary grasp of statistics.
Chemistry and turnover of naturally occurring resistant organic compounds in soil; In situ analysis of soil components of biological origin; Oxidate coupling of aromatic compounds by ensymes from soil microorganisms; Control of urea transformations in soils; Chemistry and distribution of amino sugars in soils and soil organisms; Biochemistry, ecology, and microbiology of petroleum components in soil; Biological nitrogen fixation; Denitrification; Heavy metals in soil biology and biochemistry; Microbial biomass in soil: measurement and turnover.
The most comprehensive, multi-disciplinary text in the field, Cummings Otolaryngology: Head and Neck Surgery, 7th Edition, provides detailed, practical answers and easily accessible clinical content on the complex issues that arise for otolaryngologists at all levels, across all subspecialties. This award-winning text is a one-stop reference for all stages of your career—from residency and board certification through the challenges faced in daily clinical practice. Updated content, new otology editor Dr. Howard W. Francis, and new chapters and videos ensure that this 7th Edition remains the definitive reference in today’s otolaryngology. Brings you up to date with the latest minimally invasive procedures, recent changes in rhinology, and new techniques and technologies that are shaping patient outcomes. Contains 12 new chapters, including Chronic Rhinosinusitis, Facial Pain, Geriatric Otology, Middle Ear Endoscopic Surgery, Pediatric Speech Disorders, Pediatric Cochlear Implantation, Tongue-Ties and Lip Ties, Laryngotracheal Clefts, and more. Covers recent advances and new approaches such as the Draf III procedure for CRS affecting the frontal recess, endoscopic vidian and posterior nasal neurectomy for non-allergic rhinitis, and endoscopic approaches for sinonasal and orbital tumors, both extra- and intraconal. Provides access to 70 key indicator (Accreditation Council for Graduate Medical Education Key Indicator Procedures), and surgical videos – an increase of 43% over the previous edition. Offers outstanding visual support with 4,000 high-quality images and hundreds of quick-reference tables and boxes.
Whether used for aviation, manufacturing, oil and gas extraction, energy distribution, nuclear or fossil fuel power generation, surveillance or security, all control rooms share two common features. The people operating them are often remote from the processes that they are monitoring and controlling and the operations work 24/7. The twin demands o
Opto-Mechanical Systems Design, Fourth Edition is different in many ways from its three earlier editions: coauthor Daniel Vukobratovich has brought his broad expertise in materials, opto-mechanical design, analysis of optical instruments, large mirrors, and structures to bear throughout the book; Jan Nijenhuis has contributed a comprehensive new chapter on kinematics and applications of flexures; and several other experts in special aspects of opto-mechanics have contributed portions of other chapters. An expanded feature—a total of 110 worked-out design examples—has been added to several chapters to show how the theory, equations, and analytical methods can be applied by the reader. Finally, the extended text, new illustrations, new tables of data, and new references have warranted publication of this work in the form of two separate but closely entwined volumes. The first volume, Design and Analysis of Opto-Mechanical Assemblies, addresses topics pertaining primarily to optics smaller than 50 cm aperture. It summarizes the opto-mechanical design process, considers pertinent environmental influences, lists and updates key parameters for materials, illustrates numerous ways for mounting individual and multiple lenses, shows typical ways to design and mount windows and similar components, details designs for many types of prisms and techniques for mounting them, suggests designs and mounting techniques for small mirrors, explains the benefits of kinematic design and uses of flexures, describes how to analyze various types of opto-mechanical interfaces, demonstrates how the strength of glass can be determined and how to estimate stress generated in optics, and explains how changing temperature affects opto-mechanical assemblies. The second volume, Design and Analysis of Large Mirrors and Structures, concentrates on the design and mounting of significantly larger optics and their structures, including a new and important topic: detailed consideration of factors affecting large mirror performance. The book details how to design and fabricate very large single-substrate, segmented, and lightweight mirrors; describes mountings for large mirrors with their optical axes in vertical, horizontal, and variable orientations; indicates how metal and composite mirrors differ from ones made of glass; explains key design aspects of optical instrument structural design; and takes a look at an emerging technology—the evolution and applications of silicon and silicon carbide in mirrors and other types of components for optical applications.
Crisis management has become a defining feature of contemporary governance. In times of crisis, communities and members of organizations expect their leaders to minimize the impact of the crisis at hand, while critics and bureaucratic competitors try to seize the moment to blame incumbent rulers and their policies. In this extreme environment, policy makers must somehow establish a sense of normality, and foster collective learning from the crisis experience. In this uniquely comprehensive analysis, the authors examine how leaders deal with the strategic challenges they face, the political risks and opportunities they encounter, the errors they make, the pitfalls they need to avoid, and the paths away from crisis they may pursue. This book is grounded in over a decade of collaborative, cross-national case study research, and offers an invaluable multidisciplinary perspective. This is an original and important contribution from experts in public policy and international security.
Revised and updated for its Seventh Edition, this highly acclaimed volume is a complete, current, and practical guide to the diagnosis and treatment of allergic disorders. This comprehensive yet concise reference will remain the first choice for residents and practitioners who need guidance to identify an allergy, confirm a diagnosis, or find effective therapies. It will also be an excellent aid for board review. This edition includes discussions of clinical trials in asthma and significant updates on drug allergy, imaging, occupational allergy, and immune deficiency evaluation. A Companion Website will include the fully searchable text and additional illustrations and tables.
This issue of Clinics in Chest Medicine, Guest Edited by Carrie A. Redlich, MD, MPH, Paul Blanc, MD, MSPH, Mridu Gulati, MD, and Ware Kuschner, MD, will focus on Occupational and Environmental Lung Diseases, with article topics including: asthma, hypersensitivity pneumonitis, and other immune-mediated lung disease; Work-exacerbated asthma; Occupational COPD; Indoor fuel exposure and the lung in both the developed and developing worlds; New (and newly recognized) occupational and environmental causes of selected chronic parenchymal and terminal airway diseases; Occupational rhinitis and other work-related upper respiratory tract conditions; Military service and lung disease; Ambient air pollution; Protecting the lungs from microbes, particles and other inhalational exposures; and Exhaled breath and induce sputum analysis in assessing the effects of occupational and environmental exposures.
The years between 1550 and 1700 saw significant changes in the nature and scope of local government: sophisticated information and intelligence systems were developed; magistrates came to rely more heavily on surveillance to inform 'good government'; and England's first nationwide system of incarceration was established within bridewells. But while these sizeable and lasting shifts have been well studied, less attention has been paid to the important characteristic that they shared: the 'turning inside' of the title. What was happening beneath this growth in activity was a shift from 'open' to 'closed' management of a host of problems—from the representation of authority itself to treatment of every kind of local disorder, from petty crime and poverty to dirty streets. Information, Institutions, and Local Government in England, 1550-1700 explores the character and consequences of these changes for the first time. Drawing on wide-ranging archival research in 34 archives, the book examines the ways in which the notion of representing authority and ethics in public (including punishment) was increasingly called into question in early modern England, and how and why local government officials were involved in this. This 'turning inside' was encouraged by insistence on precision and clarity in broad bodies of knowledge, culture, and practice that had lasting impacts on governance, as well as a range of broader demographic, social, and economic changes that led to deeper poverty, thinner resources, more movement, and imagined or real crime-waves. In so doing, and by drawing on a diverse range of examples, the book offers important new perspectives on local government, visual representation, penal cultures, institutions, incarceration, and surveillance in the early modern period.
Addresses a range of analytical techniques that are provided within modern Geographic Information Systems and related geospatial software products. This guide covers: the principal concepts of geospatial analysis; core components of geospatial analysis; and, surface analysis, including surface form analysis, gridding and interpolation methods.
Contents: V. Zingel, C. Leschke and W. Schunack: Developments in research on histamine (H1) receptor agonists / P.D. Hoeprich: Antifungal chemotherapy / G. de Stevens: The diversity of heterocyclic compounds and their biological activities / R.M. Schultz: Newer antifolate compounds in cancer therapy / P.K. Mehrotra, S. Batra and A.P. Bhadun: Non-steroidal agents for regulation of the menstrual cycle / A.K. Saxena and M. Saxena: Developments in anti-convulsant drugs
Major advances have been made in recent years in clarifying the molecular properties of the cytochrome P-450 system. These advances stem, in practical terms, from the generally recognized importance of cytochrome P-450 in the metabolism of drugs and in the bioactivation of xenobiotics to toxic products. The fascinating multiplicity and differential regulation of cytochrome P-450 isozymes, and their ability to catalyze extraordinarily difficult chemical transformations, have independently drawn many chemists and biochemists into the P-450 circle. Progress in the field, from a technical point of view, has been propelled by the de velopment of reliable procedures for the purification of membrane-bound enzymes, by the growing repertoire of molecular biological techniques, and by the development of chemical models that mimic the catalytic action of P-450. As a result, our understanding of the P-450 system is moving from the descriptive, pharmacological level into the tangible realm of atomic detail. The rapid progress and multidisciplinary character of the cytochrome P-450 field, which cuts across the lines that traditionally divide disciplines as diverse as inorganic chemistry and genetics, have created a need for an up-to-date evaluation of the advances that have been made. It is hoped that this book, with its molecular focus on the cytochrome P-450 system, will alleviate this need. The authors of the individual chapters have strived to emphasize recent results without sacrificing the background required to make their chapters comprehensible to informed nonspecialists.
From the latest vaccination evidence, recommendations, and protocols . . . to new vaccine development and the use of vaccines in reducing disease, Plotkin’s Vaccines, 8th Edition, covers every aspect of vaccination. Now completely revised and updated from cover to cover, this award-winning text continues to provide reliable information from global authorities, offering a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as "an indispensable guide to the enhancement of the well-being of our world," Plotkin’s Vaccines is a must-have reference for current, authoritative information in this fast-moving field. Contains all-new chapters on COVID-19, vaccine hesitancy, and non-specific effects of vaccines, as well as significantly revised content on new vaccine technologies such as mRNA vaccines, emerging vaccines, and technologies to improve immunization. Presents exciting new data on evolution of adjuvants across the centuries, dengue vaccines, human papillomavirus vaccines, respiratory syncytial virus vaccines, tuberculosis vaccines, and zoster vaccines. Provides up-to-date, authoritative information on vaccine production, available preparations, efficacy and safety, and recommendations for vaccine use, with rationales and data on the impact of vaccination programs on morbidity and mortality. Provides complete coverage of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well as epidemiology and public health and regulatory issues. Keeps you up to date with information on each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. Covers vaccine-preventable diseases, vaccine science, and licensed vaccine products, as well as product technologies and global regulatory and public health issues. Analyzes the cost-benefit and cost-effectiveness of different vaccine options. Helps you clearly visualize concepts and objective data through an abundance of tables and figures.
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