In the case of water fluoridation, the chemicals used to fluoridate the water that more than 180 million people drink each day are not pharmaceutical grade, but rather hazardous waste products of the phosphate fertilizer industry; it is illegal to dump them into rivers and lakes or release them into the atmosphere. And water fluoridation is a prime example of one of the worst medical practices possible-forced medication with no control over the dose or who gets it. Perhaps most shocking of all, it is not subject to any federal regulation. At once painstakingly-documented and also highly-readable, The Case Against Fluoride brings new research to light, including links between fluoride and harm to the brain, bones, and kidneys, and argues that while there is possible value in topical applications like brushing your teeth with fluoride toothpaste, the evidence that swallowing fluoride reduces tooth decay is surprisingly weak.
Traditional Chinese medicine (TCM) has been used for centuries in the Orient to relieve or treat diseases. Its efficacy is now attracting worldwide attention. Chinese medicinal materials are traditionally identified by their organoleptic characteristics, such as the texture or the odor. To ensure consistency of quality and avoid misuse, reliable programs are urgently needed for authentication. Proper authentication also assists in the detection and conservation of endangered species. DNA molecules offer a more definitive means of authentication, as genetic composition is unique for each taxon and is less affected by age, physiological conditions and environmental factors. This book is the first of its kind to introduce and evaluate the molecular techniques that have been developed to authenticate Chinese medicinal materials.The contents of the book are divided into four parts. The first part reviews the current status of molecular authentication of Chinese medicinal materials. The second part describes the equipment and materials required for the work. In the third part, researchers in the field present the principles and step-by-step protocols for a wide spectrum of techniques used in the molecular authentication of TCM. The last part provides an overview of this field.
Metal Catalysed Reactions in Ionic Liquids is the first non-edited book on the subject of metal catalyzed reactions in ionic liquids to cover the literature from its origins until early 2005. Following a general introduction to the field of biphasic/multiphasic catalysis, the book moves on to describe the synthesis, the functionalisation, and fundamental properties of ionic liquids relevant to catalysis. It then analyses the catalysed reactions according to their type, encompassing hydrogenation, hydroformylation, oxidation, C-C coupling reactions, metathesis, dimerisation, polymerisation and more. Trends, generalisations, advantages and disadvantages of ionic liquids for specific reaction types are also examined as well as specific processes such as supported ionic liquid phase catalysis, continuous processes using CO2 extraction and nanoparticle catalysis. Metal Catalysed Reactions in Ionic Liquids is of interest to those working in catalysis/green chemistry, in particular to advanced level undergraduate and graduate students and researchers in bi- or multiphasic catalysis using ionic liquids.
This book is a comprehensive guide to the latest developments in data-driven additive manufacturing (AM). From data mining and pre-processing to signal processing, computer vision, and more, the book covers all the essential techniques for preparing AM data. Readers willl explore the key physical and synthetic sources of AM data throughout the life cycle of the process and learn about feature engineering techniques, pipelines, and resulting features, as well as their applications at each life cycle phase. With a focus on featurization efforts from reviewed literature, this book offers tabular summaries for major data sources and analyzes feature spaces at the design, process, and structure phases of AM to uncover trends and insights specific to feature engineering techniques. Finally, the book discusses current challenges and future directions, including AI/ML/DL readiness of AM data. Whether you're an expert or newcomer to the field, this book provides a broader summary of the status and future of data-driven AM technology.
This book represents the first complete and systematic guide to the virus-like particles (VLPs) and their applications as vaccines, therapeutic tools, nanomaterials, and nanodevices. The grouping of the VLPs follows the most recent virus taxonomy and the traditional Baltimore classification of viruses, which are based on the genome structure and mechanism of mRNA synthesis. Within each of the seven Baltimore classes, the order taxon serves as a framework of the chapter’s arrangement. The term "VLP" is used as a universal designation for the virus-, core-, or capsid-like structures, which became an important part of the modern molecular virology. The 3D structures, expression systems, and nanotechnological applications are described for VLPs in the context of the original viruses and uncover their evolving potential as novel vaccines and medical interventions. Key Features Presents the first full guide to the VLP nanotechnology, classified by current viral taxonomy Outlines specific structural properties and interconnection of the virions and VLPs Explains generation and characteristics of VLPs produced by various expression systems Offers up-to-date summary of VLPs designed as vaccines and delivery tools Unveils interconnection of VLPs with novel organic and inorganic nanomaterials
The book addresses the current demand for a scientific approach to advanced wireless technology and its future developments. It gives a clear presentation of both antennas and adaptive signal processing which is what makes antennas powerful, maneuverable and necessary for advanced wireless technology. The book presents electromagnetic signal processing techniques that both control the antenna beam and track the moving station, which is required for effective, fast, dynamic beamforming. The first part of the book presents a comprehensive description and analysis of basic antenna theory, starting from short dipole antennas to array antennas. This section also includes important concepts related to antenna parameters, electromagnetic wave propagation, the Friis equation, the radar equation and wave reflection and transmission through media. The second part of the book focuses on smart antennas, commencing from a look at the traditional approach to beamforming before getting into the details of smart antennas. Complete derivation and description of the techniques for electromagnetic field signal processing techniques for adaptive beamforming are also presented. Artificial Intelligence (AI) driven beamforming is presented using computationally fast and low-memory demanding technique for AI beamforming is presented with the different excitation functions available. A novel method for fast, low memory and accurate, maneuverable single beam generation is presented, as well as other methods for beamforming with fewer elements along with a simple method for tracking the mobile antenna and station. In this section, for completeness, the use of antenna signal processing for synthetic aperture techniques for imaging is also presented, specifically the Inverse Synthetic Aperture Imaging technique. The third part of the book presents technological aspects of advanced wireless technology, including the 5G wireless system and the various devices needed to construct it. While the books’ main emphasis is theoretical understanding and design, it includes applications, and legal matters are also presented.
Well-organized and vibrantly illustrated throughout, Handbook of Liver Disease is a comprehensive yet concise handbook providing authoritative guidance on key clinical issues in liver disease. The quick-reference outline format ensures that you'll find answers when you need them, and cover-to-cover updates keep you abreast of the recent rapid changes in the field. Written by leading international experts in hepatology, this reference is ideal for hepatologists, gastroenterologists, internists, family practitioners, trainees, and others who diagnose and manage patients with liver disorders. - Uses a highly templated outline format, key points in each chapter, alert symbols, and highlighted review points to provide a "just the facts" approach to daily clinical questions on liver disease. - Features expanded hepatitis chapters, including completely updated coverage of new, safe, and effective oral regimens for the treatment of hepatitis C. - Provides completely updated coverage of: alcoholic liver disease * autoimmune hepatitis * portal hypertension * primary biliary cholangitis * hepatic tumors * cirrhosis * nonalcoholic liver disease * liver transplantation * and more. - Includes the latest information on adolescents with liver disease moving into adult care. - Covers the revised criteria for prioritizing liver transplantation using the MELDNa score, new options for the treatment of hepatocellular carcinoma, and improved management of hepatorenal syndrome.
Since its first edition over 60 years ago, Rockwood and Green’s Fractures in Adults has been the go-to reference for treating a wide range of fractures in adult patients. The landmark, two-volume tenth edition continues this tradition with two new international editors, a refreshed mix of contributors, and revised content throughout, bringing you fully up to date with today’s techniques and technologies for treating fractures in orthopaedics. Drs. Paul Tornetta III, William M. Ricci, Robert F. Ostrum, Michael D. McKee, Benjamin J. Ollivere, and Victor A. de Ridder lead a team of experts who ensure that the most up-to-date information is presented in a comprehensive yet easy to digest manner.
This volume covers five emerging areas of advanced device technology: wide band gap devices, terahertz and millimeter waves, nanometer silicon and silicon-germanium devices, nanoelectronics and ballistic devices, and the characterization of advanced photonic and electronic devices. The papers by leading researchers in high speed and advanced electronic and photonic technology presented many firsts and breakthrough results, as has become a tradition with the Lester Eastman Conference, and will allow readers to obtain up-to-date information about emerging trends and future directions of these technologies. Key papers in each section present snap-shot and mini reviews of state-of-the-art and hot off the press results making the book required reading for engineers, scientists, and students working on advanced and high speed device technology.
Electrochemical Phenomena in the Cathode Impedance Spectrum of PEM Fuel Cells: Fundamentals, Modelling, and Applications establishes how the electrochemical and diffusion mechanisms of a polymer electrolyte membrane fuel cell (PEMFC) are related to electrochemical impedance spectroscopy (EIS) measurements using physics-based impedance models derived from fundamental electrode and diffusion theories. The contribution of the different phenomena occurring at the different layers comprising the cathode on the impedance response of the PEMFC is revealed through EIS-modelling analysis. The relation between EIS measurements and polarisation curves representing the performance of PEMFCs is established. Insight is gained into how the EIS response of the PEMFC changes at different operating conditions e.g. relative humidity, load demand, gas reactant stoichiometry and temperature using physics-based impedance models. The application of impedance models with EIS measurements carried out in the individual cells comprising a PEMFC stack is demonstrated, while recent modelling approaches and other impedance models reported in the literature to represent the EIS response of the PEMFC are also considered and discussed. - Provides further understanding of ambiguities during the interpretation of the electrochemical impedance spectrum of the PEMFC - Includes impedance models written in MATLAB® for replication or application to other PEMFC-EIS measurements - Includes impedance spectra of the PEMFC at different operating conditions, electro/diffusion pathways for derivation of the impedance models and flowcharts for application of the impedance models with real-world measured EIS data
Focusing on how conjugated polymers can be designed and made for use in efficient organic electronic devices, this book covers the tools for future development of more environmentally and economically friendly devices. Including examples of interdisciplinary science, it exemplifies how chemists and physicists work together to enable the design and synthesis of high-performance material in devices, allowing polymer-based electronic devices to become viable commercial products. It provides the main classes of conjugated polymers and their applications in organic electronic devices such as transistors, light-emitting diodes, and solar cells, making this a comprehensive introduction. This complete guide includes the methods for making conjugated polymers, the properties and specific structures that make them suitable for use, and how their synthesis can be optimised to improve device performance. Written by experts in the field, this is the ideal guide for researchers and practitioners across materials science, physics, chemistry, and electrical engineering.
This unique, full-color reference offers a total team approach to radiation oncology treatment planning, incorporating the newest imaging techniques and offering a comprehensive discussion of clinical, physical, biological and technical aspects. A clear focus on the application of physical and clinical concepts to solve treatment planning problems helps you provide effective, state-of-the-art care for cancer patients. With authoritative coverage of the latest in sophisticated radiation oncology treatment modalities, the 4th Edition of Khan’s Treatment Planning in Radiation Oncology is an essential resource for the radiation oncologist, medical physicist, dosimetrist, and radiation therapist.
From the latest vaccination evidence, recommendations, and protocols . . . to new vaccine development and the use of vaccines in reducing disease, Plotkin's Vaccines, 8th Edition, covers every aspect of vaccination. Now completely revised and updated from cover to cover, this award-winning text continues to provide reliable information from global authorities, offering a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as "an indispensable guide to the enhancement of the well-being of our world," Plotkin's Vaccines is a must-have reference for current, authoritative information in this fast-moving field. - Contains all-new chapters on COVID-19, vaccine hesitancy, and non-specific effects of vaccines, as well as significantly revised content on new vaccine technologies such as mRNA vaccines, emerging vaccines, and technologies to improve immunization. - Presents exciting new data on evolution of adjuvants across the centuries, dengue vaccines, human papillomavirus vaccines, respiratory syncytial virus vaccines, tuberculosis vaccines, and zoster vaccines. - Provides up-to-date, authoritative information on vaccine production, available preparations, efficacy and safety, and recommendations for vaccine use, with rationales and data on the impact of vaccination programs on morbidity and mortality. - Provides complete coverage of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well as epidemiology and public health and regulatory issues. - Keeps you up to date with information on each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. - Covers vaccine-preventable diseases, vaccine science, and licensed vaccine products, as well as product technologies and global regulatory and public health issues. - Analyzes the cost-benefit and cost-effectiveness of different vaccine options. - Helps you clearly visualize concepts and objective data through an abundance of tables and figures. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Wound healing and wound care technologies are an ever expanding field with the advancement of materials science, biomedicine and tissue engineering. In the year 2011 the global wound care market generated US$ 6,500 million with an annual growth rate of 7.5%. The global advanced wound care products market share in 2023 is predicted to be approximately US$ 16,300 million.This book discusses the evolution of wound care devices and protocol over the years and different technologies being used in the present day wound care treatment. New strategies involving engineered tissues and drug delivery to mimic the natural wound healing milieu are discussed. The use of cytokine growth factors enhances chronic wound healing particularly for burn wound healing. Prevention of scarring, keloid formation or contractures and a cosmetically acceptable healing is a challenge even now.Skin tissue engineering was the first successfully clinically applied product in regenerative medicine. Bioengineered skin seeded with fibroblast and keratinocyte cells could form a permanent solution that do not require skin grafting or as a temporary cover for burns prior to grafting. Cell attachment, proliferation and tissue formation in a three-dimensional porous scaffold can be engineered for specific application. These cell based skin substitutes had significant wound healing and scar reducing effect on patients.Gene-activated dermal equivalent is another emerging approach for the healing of full thickness incision wounds with good remodelling of the skin. The book also describes similar latest developments on wound healing science and research.The target audiences are wound care professionals, researchers working on wound healing technology and skin tissue engineering; as well as graduate students and industries that need to understand the aspects of wound healing and technological orientation towards successful commercialisation.
Now in its 7th edition, Auerbach's Wilderness Medicine continues to help you quickly and decisively manage medical emergencies encountered in any wilderness or other austere setting! World-renowned authority Dr. Paul Auerbach and 2 new associate editors have assembled a team of experts to offer proven, practical, visual guidance for effectively diagnosing and treating the full range of issues that can occur in situations where time and resources are scarce. This indispensable resource equips physicians, nurses, advanced practice providers, first responders, and rescuers with the essential knowledge and skills to effectively address and prevent injuries and illnesses – no matter where they happen! - Brand-new 2-volume format ensures all content is available in print and online to provide you easy access. - Face any medical challenge in the wilderness with expert guidance from hundreds of outstanding world experts edited by Dr. Auerbach and 2 new associate editors, Drs.Tracy Cushing and N. Stuart Harris - New and expanded chapters with hundreds of new photos and illustrative drawings help increase your visual understanding of the material - Acquire the knowledge and skills you need with revised chapters providing expanded discussions of high-altitude medicine, improvisation, technical rescue, telemedicine, ultrasound, and wilderness medicine education - Ten new chapters cover Acute High-Altitude Medicine and Pathophysiology; High Altitude and Pre-Existing Medical Conditions; Cycles, Snowmobiles, and other Wilderness Conveyances; Medical Wilderness Adventure Races (MedWAR); Canyoneering and Canyon Medicine; Evidence-Based Wilderness Medicine; National Park Service Medicine; Genomics and Personalized Wilderness Medicine; Forestry; and Earth Sciences - 30+ Expert Consult online videos cover survival tips, procedural demonstrations, and detailed explanations of diseases and incidents - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos, and references from the book on a variety of devices
This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure. It also sheds light on the relationship of this cluster with cancer. Tumor cells, in contrast to cells in cardiometabolic tissues, can regulate this cluster of non-coding RNAs to escape from oxidative stress and anti-tumor immunity and maintain insulin sensitivity, facilitating cancer progression. The book presents a cluster of non-coding RNAs that may be prospectively analyzed in extensive cohort studies to determine their value in risk-predicting machine learning algorithms. In addition, it emphasizes the role of microvesicles in communication between tumor-adjacent tissue, inflammatory cells, and tumor cells, with a special focus on the role of miR-155. The book intends to promote interdisciplinary research. Due to the comprehensive background information provided in each chapter, it is suitable for researchers in academia and industry and for graduate students in biology, bioengineering, and medicine.
Breeding Disease-Resistant Horticultural Crops is a complete and comprehensive resource for understanding the concept of breeding disease resistant crops, especially horticultural crops. Breeders of horticultural crops face distinct challenges that are different from agronomy/row crops, and these crops do not benefit from the vast body of literature available for agronomic crops. This book covers the basic theories that underpin breeding for disease resistance and features extensive real-world examples. Both classical and biotechnical breeding methods are covered, with an emphasis on how these methods are adapted for horticultural species. Presented in a logical flow for the reader, this book addresses historical perspectives and context as it relates to breeding for disease resistance. It highlights treatments of resistance in the context of the phenotype, the genotype, the pathogen, the environment interaction, sources of resistance, and the deployment of resistance to obtain a durable resistance. - Explores the definition of horticultural "resistance", how it is inherited, and how resistance can be manipulated through breeding - Highlights the importance of the interaction among crops, pathogens, and environmental elements - Provides the latest references and insights as a foundation for further research
Now in its 6th edition, Cummings Otolaryngology remains the world's most detailed and trusted source for superb guidance on all facets of head and neck surgery. Completely updated with the latest minimally invasive procedures, new clinical photographs, and line drawings, this latest edition equips you to implement all the newest discoveries, techniques, and technologies that are shaping patient outcomes. Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, multi-disciplinary text in the field! Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Overcome virtually any clinical challenge with detailed, expert coverage of every area of head and neck surgery, authored by hundreds of leading luminaries in the field. Experience clinical scenarios with vivid clarity through a heavily illustrated, full-color format which includes approximately 3,200 images and over 40 high quality procedural videos. Get truly diverse perspectives and worldwide best practices from a multi-disciplinary team of contributors and editors comprised of the world’s leading experts. Glean all essential, up-to-date, need-to-know information. All chapters have been meticulously updated; several extensively revised with new images, references, and content. Stay at the forefront of your field with the most updated information on minimally-invasive surgical approaches to the entire skull base, vestibular implants and vestibular management involving intratympanic and physical therapy-based approaches, radiosurgical treatment of posterior fossa and skull base neoplasms, and intraoperative monitoring of cranial nerve and CNS function. Apply the latest treatment options in pediatric care with new chapters on pediatric sleep disorders, pediatric infectious disease, and evaluation and management of the infant airway. Find what you need faster through a streamlined format, reorganized chapters, and a color design that expedites reference. Manage many of the most common disorders with treatment options derived from their genetic basis. Assess real-world effectiveness and costs associated with emergent technologies and surgical approaches introduced to OHNS over the past 10 years. Incorporate recent findings about endoscopic, microscopic, laser, surgically-implantable, radiosurgical, neurophysiological monitoring, MR- and CT-imaging, and other timely topics that now define contemporary operative OHNS. Take it with you anywhere! With Expert Consult, you'll have access the full text, video clips, and more online, and as an eBook - at no additional cost!
This volume will be summarized on the basis of the topics of Ionic Liquids in the form of chapters and sections. It would be emphasized on the synthesis of ILs of different types, and stabilization of amphiphilic self-assemblies in conventional and newly developed ILs to reveal formulation, physicochemical properties, microstructures, internal dynamics, thermodynamics as well as new possible applications. It covers: Topics of ionic liquid assisted micelles and microemulsions in relation to their fundamental characteristics and theories Development bio-ionic liquids or greener, environment-friendly solvents, and manifold interesting and promising applications of ionic liquid based micelles and micremulsions
This book brings together the most up-to-date information on the fabrication techniques, properties, and potential applications of low dimensional silicon carbide (SiC) nanostructures such as nanocrystallites, nanowires, nanotubes, and nanostructured films. It also summarizes the tremendous achievements acquired during the past three decades involving structural, electronic, and optical properties of bulk silicon carbide crystals. SiC nanostructures exhibit a range of fascinating and industrially important properties, such as diverse polytypes, stability of interband and defect-related green to blue luminescence, inertness to chemical surroundings, and good biocompatibility. These properties have generated an increasing interest in the materials, which have great potential in a variety of applications across the fields of nanoelectronics, optoelectronics, electron field emission, sensing, quantum information, energy conversion and storage, biomedical engineering, and medicine. SiC is also a most promising substitute for silicon in high power, high temperature, and high frequency microelectronic devices. Recent breakthrough pertaining to the synthesis of ultra-high quality SiC single-crystals will bring the materials closer to real applications. Silicon Carbide Nanostructures: Fabrication, Structure, and Properties provides a unique reference book for researchers and graduate students in this emerging field. It is intended for materials scientists, physicists, chemists, and engineers in microelectronics, optoelectronics, and biomedical engineering.
This is a comprehensive guide to single-stranded RNA phages (family Leviviridae), first discovered in 1961. These phages played a unique role in early studies of molecular biology, the genetic code, translation, replication, suppression of mutations. Special attention is devoted to modern applications of the RNA phages and their products in nanotechnology, vaccinology, gene discovery, evolutionary and environmental studies. Included is an overview of the generation of novel vaccines, gene therapy vectors, drug delivery, and diagnostic tools exploring the role of RNA phage-derived products in the revolutionary progress of the protein tethering and bioimaging protocols. Key Features Presents the first full guide to single-stranded RNA phages Reviews the history of molecular biology summarizing the role RNA phages in the development of the life sciences Demonstrates how RNA phage-derived products have resulted in nanotechnological applications Presents an up-to-date account of the role played by RNA phages in evolutionary and environmental studies
As a mature topic in chemical engineering, the book provides methods, problems and tools used in process control engineering. It discusses: process knowledge, sensor system technology, actuators, communication technology, and logistics, design and construction of control systems and their operation. The knowledge goes beyond the traditional process engineering field by applying the same principles, to biomedical processes, energy production and management of environmental issues. The book explains all the determinations in the "chemical systems" or "process systems", starting from the beginning of the processes, going through the intricate interdependency of the process stages, analyzing the hardware components of a control system and ending with the design of an appropriate control system for a process parameter or a whole process. The book is first addressed to the students and graduates of the departments of Chemical or Process Engineering. Second, to the chemical or process engineers in all industries or research and development centers, because they will notice the resemblance in approach from the system and control point of view, between different fields which might seem far from each other, but share the same control philosophy.
This updated and revised textbook provides comprehensive coverage of common polygenic and rare monogenic disorders, emphasising advances in bone cell biology and human skeletal disease. Accessible and well-illustrated, this concise account of metabolic bone disease is designed for postgraduates and clinicians.
Title: The Vacuum Interrupter: Theory, Design, and ApplicationShelving guide: Electrical Engineering Dr. Paul Slade draws from his nearly six decades of active experience to develop this second edition of The Vacuum Interrupter: Theory, Design, and Application. This book begins by discussing the design requirements for high voltage vacuum interrupters and then the contact requirements to interrupt the vacuum arc. It then continues by describing the various applications in which the vacuum interrupter is generally utilized. Part 1 of this book begins with a detailed review of the vacuum breakdown process. It continues by covering the steps necessary for the design and the manufacture of a successful vacuum interrupter. The vacuum arc is then discussed, including how it is affected as a function of current. An overview of the development and use of practical contact materials, along with their advantages and disadvantages, follows. Contact designs that are introduced to control the high current vacuum arc are also analyzed. Part 2, on application, begins with a discussion of the arc interruption process for low current and high current vacuum arcs. It examines the voltage escalation phenomenon that can occur when interrupting inductive circuits. The occurrence of contact welding for closed contacts subjected to the passage of high currents, and for contacts when closing on high currents, is explored. The general requirements for the successful manufacture and testing of vacuum circuit breakers is then presented. The general application of vacuum interrupters to switch load currents, especially when applied to capacitor circuits, is also given. The interruption of high short circuit currents is presented along with the expected performance of the two major contact designs. Owing to the ever-increasing need for environmentally friendly circuit protection devices, the development and application of the vacuum interrupter will only increase in the future. At present the vacuum circuit breaker is the technology of choice for distribution circuits (5kV to 40.5kV). It is increasingly being applied to transmission circuits (72.5kV to 242kV). In the future, its application for protecting high voltage DC networks is assured. Audience This is a practical source book for engineers and scientists interested in studying the development and application of the vacuum interrupter Research scientists in industry and universities Graduate students beginning their study of vacuum interrupter phenomena Design engineers applying vacuum interrupters in vacuum switches, vacuum contactors, vacuum circuit breakers, and vacuum contactors It provides a unique and comprehensive review of all aspects of vacuum interrupter technology for those new to the subject and for those who wish to obtain a deeper understanding of its science and application Scientists and engineers, who are beginning their research into vacuum breakdown and aspects of the vacuum arc, will find the extensive bibliography and phenomenological descriptions to be a useful introduction
An Integrated Guide to Human Drug Metabolism: From Basic Chemical Transformations to Drug-Drug Interactions uses the chemistry of each of the metabolic transformations to underpin the discussion of drug interactions with foods, herbal medicines and other drugs. Each of the human metabolic processes will be covered, employing examples drawn from known metabolic transformations of drugs used clinically. The clinical relevance of metabolism is discussed, focusing on appropriate prescribing (age-related dosage adjustments, routes of administration, and personalized medicines). Appropriate for use in the classroom or for self-study, An Integrated Guide to Human Drug Metabolism is useful for students and researchers needing a reference for interdisciplinary research in drug interactions. Metabolism is at the center of personalized medicine, as it is a governing factor in the response of the patient to a drug. For example, does the patient express the genes, and so enzymes, which are responsible for the metabolism of a drug? Do they express the genes responsible for the bioactivation of a prodrug into its active form? Examples of clinically used agents for which metabolic phenotyping is essential will be used to highlight the increasing necessity for understanding the genetic profile of individual patients. This book includes questions and answers to gauge learning of each chapter, real-life case studies, and the basic science as a basis for the discussion of clinical aspects. - Covers each of the human metabolic processes, employing examples drawn from known metabolic transformations of drugs used clinically - Provides an integrated approach, linking together the science and practice strands of human drug metabolism - Contains questions and answers to assess learning of material and real-life case studies
Offering expert, comprehensive guidance on the basic science, diagnosis, and treatment of acute musculoskeletal injuries and post-traumatic reconstructive problems, Skeletal Trauma, 6th Edition, brings you fully up to date with current approaches in this challenging specialty. This revised edition is designed to meet the needs of orthopaedic surgeons, residents, fellows, and traumatologists, as well as emergency physicians who treat patients with musculoskeletal trauma. International thought leaders incorporate the latest peer-reviewed literature, technological advances, and practical advice with the goal of optimizing patient outcomes for the full range of traumatic musculoskeletal injuries. - Offers complete coverage of relevant anatomy and biomechanics, mechanisms of injury, diagnostic approaches, treatment options, and associated complications. - Includes eight new chapters dedicated to advances in technology and addressing key problems and procedures, such as Initial Evaluation of the Spine in Trauma Patients, Management of Perioperative Pain Associated with Trauma and Surgery, Chronic Pain Management (fully addressing the opioid epidemic), Understanding and Treating Chronic Osteomyelitis, and more. - Features a complimentary one-year subscription to OrthoEvidence, a global online platform that provides high-quality, peer-reviewed and timely orthopaedic evidence-based summaries of the latest and most relevant literature. Contains unique, critical information on mass casualty incidents and war injuries, with contributions from active duty military surgeons and physicians in collaboration with civilian authors to address injuries caused by road traffic, armed conflict, civil wars, and insurgencies throughout the world. - Features important call out boxes summarizing key points, pearls and pitfalls, and outcomes. - Provides access to nearly 130 instructional videos that demonstrate principles of care and outline detailed surgical procedures. - Contains a wealth of high-quality illustrations, full-color photographs, and diagnostic images. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
This book presents an evaluation methodology to design future FPGA fabrics incorporating hard embedded blocks (HEBs) to accelerate applications. This methodology will be useful for selection of blocks to be embedded into the fabric and for evaluating the performance gain that can be achieved by such an embedding. The authors illustrate the use of their methodology by studying the impact of HEBs on two important bioinformatics applications: protein docking and genome assembly. The book also explains how the respective HEBs are designed and how hardware implementation of the application is done using these HEBs. It shows that significant speedups can be achieved over pure software implementations by using such FPGA-based accelerators. The methodology presented in this book may also be used for designing HEBs for accelerating software implementations in other domains besides bioinformatics. This book will prove useful to students, researchers, and practicing engineers alike.
Despite the numerous competitive advantages of one-of-a-kind production (OKP), the low efficiency and high costs associated with OKP companies threaten to push their business opportunities into the hands of cheaper overseas suppliers. One-of-a-Kind Production introduces a novel strategy and technology to help OKP companies to efficiently mass-produce customized products. In One-of-a-Kind Production, case studies from OKP companies are used to validate the feasibility and effectiveness of the OKP strategy and technology. These case studies include: a structural steel construction company, a manufacturer of specifically ordered compressors and refrigeration systems, a customized high pressure vessel manufacturing company, and a custom window and door manufacturer. To help readers understand OKP strategy and technology, the authors offer a year’s free access to the OKP Management and Control Software System. This system is based on a new integrated production control and management concept, namely product production structure. It is a useful tool – and One-of-a-Kind Production is a valuable guide – for production engineers and managerial staff in manufacturing companies, as well as for university researchers and graduate students.
The most comprehensive, multi-disciplinary text in the field, Cummings Otolaryngology: Head and Neck Surgery, 7th Edition, provides detailed, practical answers and easily accessible clinical content on the complex issues that arise for otolaryngologists at all levels, across all subspecialties. This award-winning text is a one-stop reference for all stages of your career—from residency and board certification through the challenges faced in daily clinical practice. Updated content, new otology editor Dr. Howard W. Francis, and new chapters and videos ensure that this 7th Edition remains the definitive reference in today's otolaryngology. - Brings you up to date with the latest minimally invasive procedures, recent changes in rhinology, and new techniques and technologies that are shaping patient outcomes. - Contains 12 new chapters, including Chronic Rhinosinusitis, Facial Pain, Geriatric Otology, Middle Ear Endoscopic Surgery, Pediatric Speech Disorders, Pediatric Cochlear Implantation, Tongue-Ties and Lip Ties, Laryngotracheal Clefts, and more. - Covers recent advances and new approaches such as the Draf III procedure for CRS affecting the frontal recess, endoscopic vidian and posterior nasal neurectomy for non-allergic rhinitis, and endoscopic approaches for sinonasal and orbital tumors, both extra- and intraconal. - Provides access to 70 key indicator (Accreditation Council for Graduate Medical Education Key Indicator Procedures), and surgical videos – an increase of 43% over the previous edition. - Offers outstanding visual support with 4,000 high-quality images and hundreds of quick-reference tables and boxes. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
The third edition of the bestselling Classification Methods for Remotely Sensed Data covers current state-of-the-art machine learning algorithms and developments in the analysis of remotely sensed data. This book is thoroughly updated to meet the needs of readers today and provides six new chapters on deep learning, feature extraction and selection, multisource image fusion, hyperparameter optimization, accuracy assessment with model explainability, and object-based image analysis, which is relatively a new paradigm in image processing and classification. It presents new AI-based analysis tools and metrics together with ongoing debates on accuracy assessment strategies and XAI methods. New in this edition: Provides comprehensive background on the theory of deep learning and its application to remote sensing data. Includes a chapter on hyperparameter optimization techniques to guarantee the highest performance in classification applications. Outlines the latest strategies and accuracy measures in accuracy assessment and summarizes accuracy metrics and assessment strategies. Discusses the methods used for explaining inherent structures and weighing the features of ML and AI algorithms that are critical for explaining the robustness of the models. This book is intended for industry professionals, researchers, academics, and graduate students who want a thorough and up-to-date guide to the many and varied techniques of image classification applied in the fields of geography, geospatial and earth sciences, electronic and computer science, environmental engineering, etc.
This book contains articles written by experts on a wide range oftopics that are associated with the analysis and management ofbiological information at the molecular level. It contains chapters onRNA and protein structure analysis, DNA computing, sequence mapping, genome comparison, gene expression data mining, metabolic networkmodeling, and phyloinformatics
Regularization becomes an integral part of the reconstruction process in accelerated parallel magnetic resonance imaging (pMRI) due to the need for utilizing the most discriminative information in the form of parsimonious models to generate high quality images with reduced noise and artifacts. Apart from providing a detailed overview and implementation details of various pMRI reconstruction methods, Regularized image reconstruction in parallel MRI with MATLAB examples interprets regularized image reconstruction in pMRI as a means to effectively control the balance between two specific types of error signals to either improve the accuracy in estimation of missing samples, or speed up the estimation process. The first type corresponds to the modeling error between acquired and their estimated values. The second type arises due to the perturbation of k-space values in autocalibration methods or sparse approximation in the compressed sensing based reconstruction model. Features: Provides details for optimizing regularization parameters in each type of reconstruction. Presents comparison of regularization approaches for each type of pMRI reconstruction. Includes discussion of case studies using clinically acquired data. MATLAB codes are provided for each reconstruction type. Contains method-wise description of adapting regularization to optimize speed and accuracy. This book serves as a reference material for researchers and students involved in development of pMRI reconstruction methods. Industry practitioners concerned with how to apply regularization in pMRI reconstruction will find this book most useful.
Legendary conservationists show us that we still have the power to prevent critical consequences of the sixth extinction in this game-changing book. Can we save threatened animals and ecosystems in the midst of a mass extinction? The answer is a resounding yes! Before They Vanish shows us how. In this wise and impassioned book, renowned conservation scientists Paul R. Ehrlich, Gerardo Ceballos, and Rodolfo Dirzo urge us to shift our thinking rather than succumb to grief over the losses that humanity faces. This comprehensive look at a crucial but often overlooked aspect of conservation—population extinction, or the loss of a species within a specific geographic location—guides us onto a new, hopeful path. The authors argue that conservationists have placed too much emphasis on the extinction of entire species, which occurs gradually enough that we only detect it in the direst of cases. By that time, meaningful action may be impossible. By shifting our focus to identifying extinction threats at the more localized population level, we can intervene more rapidly and effectively to prevent broader declines before it's too late. This change in perspective represents a critical step in saving these vanishing species; early detection and intervention may be our last, best hope for stemming the tide of this global crisis. Using examples from the worlds of vertebrates, invertebrates, plants, fungi, and microorganisms, the authors explain the concept of population extinction, its causes and consequences, and how to prevent the mass destruction of the amazing and unique creatures with whom we share our planet. This call to action is a must-read for anyone concerned with saving endangered and threatened species, our natural world—and ourselves.
This book presents how metasurfaces are exploited to develop new low-cost single sensor based multispectral cameras. Multispectral cameras extend the concept of conventional colour cameras to capture images with multiple color bands and with narrow spectral passbands. Images from a multispectral camera can extract significant amount of additional information that the human eye or a normal camera fails to capture and thus have important applications in precision agriculture, forestry, medicine, object identifications, and classifications. Conventional multispectral cameras are made up of multiple image sensors each externally fitted with a narrow passband wavelength filters, optics and multiple electronics. The need for multiple sensors for each band results in a number of problems such as being bulky, power hungry and suffering from image co-registration problems which in turn limits their wide usage. The above problems can be eliminated if a multispectral camera is developed using one single image sensor.
This impressive scientific resource presents up-to-date information on ten thousand years of volcanic activity on Earth. In the decade and a half since the previous edition was published new studies have refined assessments of the ages of many volcanoes, and several thousand new eruptions have been documented. This edition updates the book’s key components: a directory of volcanoes active during the Holocene; a chronology of eruptions over the past ten thousand years; a gazetteer of volcano names, synonyms, and subsidiary features; an extensive list of references; and an introduction placing these data in context. This edition also includes new photographs, data on the most common rock types forming each volcano, information on population densities near volcanoes, and other features, making it the most comprehensive source available on Earth’s dynamic volcanism.
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