This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure. It also sheds light on the relationship of this cluster with cancer. Tumor cells, in contrast to cells in cardiometabolic tissues, can regulate this cluster of non-coding RNAs to escape from oxidative stress and anti-tumor immunity and maintain insulin sensitivity, facilitating cancer progression. The book presents a cluster of non-coding RNAs that may be prospectively analyzed in extensive cohort studies to determine their value in risk-predicting machine learning algorithms. In addition, it emphasizes the role of microvesicles in communication between tumor-adjacent tissue, inflammatory cells, and tumor cells, with a special focus on the role of miR-155. The book intends to promote interdisciplinary research. Due to the comprehensive background information provided in each chapter, it is suitable for researchers in academia and industry and for graduate students in biology, bioengineering, and medicine.
This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure. It also sheds light on the relationship of this cluster with cancer. Tumor cells, in contrast to cells in cardiometabolic tissues, can regulate this cluster of non-coding RNAs to escape from oxidative stress and anti-tumor immunity and maintain insulin sensitivity, facilitating cancer progression. The book presents a cluster of non-coding RNAs that may be prospectively analyzed in extensive cohort studies to determine their value in risk-predicting machine learning algorithms. In addition, it emphasizes the role of microvesicles in communication between tumor-adjacent tissue, inflammatory cells, and tumor cells, with a special focus on the role of miR-155. The book intends to promote interdisciplinary research. Due to the comprehensive background information provided in each chapter, it is suitable for researchers in academia and industry and for graduate students in biology, bioengineering, and medicine.
This book constitutes the thoroughly refereed postproceedings of the Joint International Workshop on Multi-Agent and Multi-Agent-Based Simulation, MABS 2004, held in New York, NY, USA in July 2004. The 20 revised full papers presented have gone through two rounds of reviewing, selection, and improvement; they present state-of-the-art research results in agent-based simulation and modeling. The papers are organized in topical sections on simulation of multi-agent systems, techniques and technologies, methodology and modeling, social dynamics, and application.
This book covers recent advances in the field of nucleon resonances presented at the IX International Workshop on the Physics of Excited Baryons, NSTAR2004. A complete overview of the most recent experimental results obtained worldwide on baryon spectroscopy is presented together with theoretical progress on related topics ranging from resonance parameters extraction to lattice-QCD calculations through effective field theory. Of particular interest, a large part of the book is devoted to exotic states with quantum numbers of pentaquarks, whose recent discovery represents a new chapter in hadronic physics. The proceedings have been selected for coverage in: . OCo Index to Scientific & Technical Proceedings (ISTP CDROM version / ISI Proceedings). OCo CC Proceedings OCo Engineering & Physical Sciences.
Entrepreneurship in Western Europe: A Contextual Perspective looks to explain how different local cultural and historical contexts can yield radically different entrepreneurial scenarios in a heterogenous Europe. Over 20 countries are examined providing a comprehensive history of the evolution of entrepreneurship across western Europe. The book concludes with a look at the future implications of current policies on entrepreneurship and of symbiosis in western Europe. Richly illustrated, this book is perfect for undergraduate students or anyone with an interest in the business practices, economics or public policy of Europe.
Design for the Unexpected: From Holonic Manufacturing Systems Towards a Humane Mechatronics Society presents new, even revolutionary, ideas to managing production and production systems which may fundamentally shift the paradigm of manufacturing systems design. It provides guidelines for the design of complex systems that can deal with unexpected disturbances and presents a decentralized control methodology that goes far beyond the traditional hierarchical control approach that currently prevails. The benefits are illustrated by a variety of examples and case studies from different fields, with the book's well-established authors presenting Holonic Manufacturing Systems (HMS) as the framework for the ‘factory-of-the-future’, and suggesting that the application of biologically inspired control paradigms can control complex manufacturing systems, and that there are far wider applications for these systems than pure manufacturing. In addition, the book explores how this multi-agent control framework can be extended to other fields such as traffic, transport, services, and health care. Provides a practical control system architecture that can be applied to a wide variety of systems in manufacturing, transportation, logistics, and robotics Contains a wide range of case studies from different engineering disciplines Provides a decentralized control methodology that goes beyond the traditional hierarchical control approach that currently prevails A must-read resource for researchers and professionals alike
This is a comprehensive guide to single-stranded RNA phages (family Leviviridae), first discovered in 1961. These phages played a unique role in early studies of molecular biology, the genetic code, translation, replication, suppression of mutations. Special attention is devoted to modern applications of the RNA phages and their products in nanotechnology, vaccinology, gene discovery, evolutionary and environmental studies. Included is an overview of the generation of novel vaccines, gene therapy vectors, drug delivery, and diagnostic tools exploring the role of RNA phage-derived products in the revolutionary progress of the protein tethering and bioimaging protocols. Key Features Presents the first full guide to single-stranded RNA phages Reviews the history of molecular biology summarizing the role RNA phages in the development of the life sciences Demonstrates how RNA phage-derived products have resulted in nanotechnological applications Presents an up-to-date account of the role played by RNA phages in evolutionary and environmental studies
A must have resource for clinicians and investigators interested in pulmonary embolism and deep venous thrombosis Highly illustrated with numerous tables and graphs alongside clear concise text Includes chapters addressing pulmonary embolism (PE) and deep venous thrombosis (DVT) in relation to diseases and disorders such as; chronic heart failure, cancer, diabetes, stroke, chronic obstructive pulmonary disease (COPD) and many more Discusses the role the different tools offered in imaging for PE, including echocardiography, multidetector computed tomography (CT), single photon emission computed tomography (SPECT), ventilation-perfusion (V-Q) imaging, dual energy CT, and magnetic resonance angiography Contains 29 new chapters and includes new content on epidemiology of deep venous thrombosis; use of the new anticoagulants (dabigatran, rivaroxaban, and apixaban) for DVT and PE; indications and results with thrombolytic therapy and with vena cava filters; and information and indications for invasive mechanical thrombectomy and thrombolysis Written by an internationally recognized and respected expert in the field
This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. There is a broad consensus across European states and the EU that social and economic inequality is a problem that needs to be addressed. Yet inequality policy is notoriously complex and contested. This book approaches the issue from two linked perspectives. First, a focus on functional requirements highlights what policymakers think they need to deliver policy successfully, and the gap between their requirements and reality. We identify this gap in relation to the theory and practice of policy learning, and to multiple sectors, to show how it manifests in health, education, and gender equity policies. Second, a focus on territorial politics highlights how the problem is interpreted at different scales, subject to competing demands to take responsibility. This contestation and spread of responsibilities contributes to different policy approaches across spatial scales. We conclude that governments promote many separate equity initiatives, across territories and sectors, without knowing if they are complementary or contradictory. This outcome could reflect the fact that ambiguous policy problems and complex policymaking processes are beyond the full knowledge or control of governments. It could also be part of a strategy to make a rhetorically radical case while knowing that they will translate into safer policies. It allows them to replace debates on values, regarding whose definition of equity matters and which inequalities to tolerate, with more technical discussions of policy processes. Governments may be offering new perspectives on spatial justice or new ways to reduce political attention to inequalities.
First published in 1999. This book is written in four parts. Part I 'Foundations', starts with Chapter 1 'What is a multisensory environment?' and provides a general introduction to the field. The MSE can be different things to different people. It can describe an actual space, or the impact that space has on an individual. Furthermore, it can be for adults or children, for recreation, leisure, therapy or education. Part II 'Design and construction' explores the what, who, why and how of the open-minded, Part III 'Curriculum development' begins with Chapter 8 'Curriculum development in the MSE. The final section, Part IV 'Future developments', consists of two chapters. The goal of Chapter 11 'Conducting research in the MSE' is to demystify research and thereby encourage all members of the transdisciplinary team to become actively involved in MSE related research; Chapter 12 'Where are we going?', the MSE is re-examined to identify possible ways this development could contribute to the increased pluralities that will constitute education in the twenty-first century.
Of the thousands of papers and books about problematic sexual behaviors, most focus solely on sex crimes or so-called "hyper-sexuality" or "sexual addiction." Together, these publications present a grim and pessimistic prognosis for anyone who has unusual sexual interests of any type. This book challenges that view by providing a more informed and balanced review of what is known and what is not known about unconventional sexual interests. It is based on approximately thirty years of experience by the author concerning the assessment and treatment of paraphilias and unconventional sexual interests. The Paraphilias: Changing Suits in the Evolution of Sexual Interest Paradigms examines current and past perspectives concerning unconventional sexual interests associated with both criminal and non-criminal activities. Extensively referenced, it challenges the dogma that sexual interests are immutably determined during a single critical period and are thereafter unchangeable. The book provides extensive case histories and tables summarizing over 100 paraphilias and the latest research regarding them. It also reviews diagnostic criteria for the paraphilias. Analyses of current and past paradigms are presented together with new ways to understand, investigate, and provide meaningful and effective assistance to people with paraphilias. It is written for mental health clinicians and specialists in the fields of sexology and forensic psychiatry and psychology.
Impact evaluations are studies that attempt to measure the causal impact of a project, program or policy on one or more outcomes of. This book provides a comprehensive exposition of how to conduct impact evaluations. Part I provides an overview of impact evaluations and comprises five chapters which are accessible to readers who have few or none of the technical (statistical and econometric) skills that are needed to conduct impact evaluations. Parts II and III make use of statistical and econometric methods and are at a level similar to a graduate-student course but written to make them accessible to the ambitious reader whose skills are not at that level. Part II presents, in Chapters 6-10, a comprehensive discussion of the use of randomized controlled trials (RCTs) to conduct impact evaluations, including a general discussion of the ethical issues involved in conducting impact evaluations. Part III presents the main non-experimental methods that are used to implement impact evaluations when RCTs are not feasible or not recommended for other reasons. Chapters 11 and 12 present regression methods, including difference-in-differences estimation. Matching methods are described in Chapter 13, after which regression discontinuity methods are covered in Chapter 14. Instrumental variable methods, including the estimation of local average treatment effects (LATE), are discussed in detail in Chapter 15. Chapters 16 and 17 cover more advanced topics: quantile treatment effects and control function methods, respectively. Part IV then considers more practical issues when conducting impact evaluations, including designing questionnaires (Chapter 18), data collection methods and survey management (Chapters 19 and 20), and disseminating results to policymakers (Chapter 21). Finally, Part V addresses two topics in impact evaluation: qualitative methods for conducting impact evaluations (Chapter 22), and cost-benefit and cost-effectiveness analysis (Chapter 23).
This book describes the nature of trafficking in persons in West Africa, focusing on labor and sexual exploitation in the region, and recommends tailor-made solutions established by the Catholic Church in light of governmental authorities’ failure to effectively combat this scourge of humanity. While states’ efforts to fulfill their international obligations in developing anti-trafficking legislations are recognized, their failure to carry out prosecutions of offenders and ensure protection of the victims reveals that law alone is not a sufficient instrument for realizing human rights and improving people’s lives. Faced with the sobering background of less than successful efforts by governmental entities to end the trade in humans, this research study recommends adopting essential elements of Catholic social teaching, which rests on the inherent dignity of human beings allowing the development of political, socio-cultural, and religious reforms that will increase the effectiveness of existing legislation designed to combat trafficking. This faith-based approach highlights the role that religion may play in fulfilling the discretionary provisions of the Palermo Protocol by promoting the welfare and protecting the life and dignity of the victims. Additionally, religion is composed of sound moral ethics that determine people's behavior to refrain from the sinful conduct of trafficking. It also creates a sense of ethical responsibility that promotes supply chain transparency and ethical purchasing as well as advocating social reforms and anti-trafficking legislations initiatives. In fact, the author's approach, may be a model for other regions in the world and will be of interest to scholars, law and policy makers, human rights advocates and law enforcement agents working in the field of trafficking in persons.
The most comprehensive, multi-disciplinary text in the field, Cummings Otolaryngology: Head and Neck Surgery, 7th Edition, provides detailed, practical answers and easily accessible clinical content on the complex issues that arise for otolaryngologists at all levels, across all subspecialties. This award-winning text is a one-stop reference for all stages of your career—from residency and board certification through the challenges faced in daily clinical practice. Updated content, new otology editor Dr. Howard W. Francis, and new chapters and videos ensure that this 7th Edition remains the definitive reference in today’s otolaryngology. Brings you up to date with the latest minimally invasive procedures, recent changes in rhinology, and new techniques and technologies that are shaping patient outcomes. Contains 12 new chapters, including Chronic Rhinosinusitis, Facial Pain, Geriatric Otology, Middle Ear Endoscopic Surgery, Pediatric Speech Disorders, Pediatric Cochlear Implantation, Tongue-Ties and Lip Ties, Laryngotracheal Clefts, and more. Covers recent advances and new approaches such as the Draf III procedure for CRS affecting the frontal recess, endoscopic vidian and posterior nasal neurectomy for non-allergic rhinitis, and endoscopic approaches for sinonasal and orbital tumors, both extra- and intraconal. Provides access to 70 key indicator (Accreditation Council for Graduate Medical Education Key Indicator Procedures), and surgical videos – an increase of 43% over the previous edition. Offers outstanding visual support with 4,000 high-quality images and hundreds of quick-reference tables and boxes.
This issue of Endocrinology and Metabolism Clinics, guest edited by Dr. Paul Hruz, is devoted to HIV and Endocrine Disorders. Articles in this issue include: Dyslipidemia and cardiovascular risk in HIV infection; Changes in nutritional concerns in HIV/AIDS; HIV Lipodystrophy: Lessons learned about adipose tissue and metabolic disorders; Hypogonadism in the HIV infected male; Gonadal function and reproductive health in women with HIV; Osteopenia, osteoporosis, and fracture risk with HIV infection and treatment; HIV-associated calcium and vitamin D abnormalities; Alterations in pancreatic islet function in HIV; Insulin resistance, glucose intolerance, and diabetes in HIV; Thyroid abnormalities in HIV; HPA axis/adrenal pathology in HIV; and Endocrinopathies in HIV-infected children.
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