This book presents the reader with an understanding of the role played by matrix metalloproteinases (MMPs) in the normal and diseased central nervous system (CNS). These enzymes may be important to brain development, and may also contribute to tissue destruction, which is observed with inflammatory and degenerative conditions of the brain. The book provides a background on the biology of MMPs, and on the stimuli and conditions that are linked to an increase in their production and activity. It describes the targets of MMPs, which include matrix proteins such as collagen, soluble cytokines and chemokines, and cell surface receptors. Studies implicating MMPs in neuronal process outgrowth and cell migration in CNS development are covered. The book also touches on studies suggesting that, in certain situations, dysregulated MMP activity and/or production may be critical to blood-brain barrier breakdown and neuronal damage./a
Autism represents one of the biggest health challenges facing children today. Whilst experts around the globe strive to unravel and truly understand how autism develops and presents itself, relatively little is still known about the condition. Meanwhile, strong evidence has emerged that the diet in children on the autistic spectrum can have a significant role to play in the management of their symptoms. A growing body of research reveals that some challenging characteristics present in autism may be positively affected by the introduction of a gluten- and casein-free (GFCF) diet. Autism: Exploring the benefits of a gluten and casein free diet offers an easy-to-read alternative to sifting through the science. Written by experts in autism research, food, nutrition and dietetics, the book cuts through the science-speak to offer readers a no-nonsense overview of diet and autism together with a range of useful recipes and handy hints for making mealtimes fun for children with autism and related conditions.
In a world awash in screenwriting books, The Science of Screenwriting provides an alternative approach that will help the aspiring screenwriter navigate this mass of often contradictory advice: exploring the science behind storytelling strategies. Paul Gulino, author of the best-selling Screenwriting: The Sequence Approach, and Connie Shears, a noted cognitive psychologist, build, chapter-by-chapter, an understanding of the human perceptual/cognitive processes, from the functions of our eyes and ears bringing real world information into our brains, to the intricate networks within our brains connecting our decisions and emotions. They draw on a variety of examples from film and television -- The Social Network, Silver Linings Playbook and Breaking Bad -- to show how the human perceptual process is reflected in the storytelling strategies of these filmmakers. They conclude with a detailed analysis of one of the most successful and influential films of all time, Star Wars, to discover just how it had the effect that it had.
Master the essentials of anatomy and body movement to succeed as a physical therapist assistant! Essentials of Kinesiology for the Physical Therapist Assistant, 4th Edition provides you with a solid background in the structure and function of the musculoskeletal system, with clear explanations of normal movement setting the stage for discussions of abnormal movement patterns and treatment techniques. To clarify kinesiology concepts, full-color illustrations show bones, joints, supporting ligaments, and muscles. Written by experienced physical therapy practitioners Paul Jackson Mansfield and Donald A. Neumann, this concise guide prepares PTAs for success in both the classroom and the clinical setting. And it includes a fully searchable eBook version with each print purchase! - More than 600 full-color photos and drawings help you understand key concepts. - Expert author team of Paul Jackson Mansfield and Donald Neumann represents a combined 50 years of physical therapy practice and more than 40 years of teaching experience. - UNIQUE! Illustrations from Kinesiology of the Musculoskeletal System depict body anatomy and movement. - UNIQUE! Atlas-style muscle presentations pair the illustration of a specific muscle or group with the relevant attachments, innervations, and actions. - Study questions include 20-30 multiple-choice and true/false practice questions in each chapter, serving as a self-assessment tool for exam preparation. - UNIQUE! Goniometry boxes in joint-specific chapters show how the goniometer may be used to measure joint angle or range of motion. - Clinical Insight and Consider This boxes link the concepts of kinesiology with their clinical applications in physical therapy. - Summary tables and boxes pull content together into a concise, quick-reference format. - Learning objectives at the start of each chapter include a chapter outline, outcome objectives, and key terms. - NEW! Revised content and updated references provide the current information you need to be an effective clinician. - NEW! Discussion of Common Patterns of Joint Restriction is included in each chapter. - NEW! eBook version is included with print purchase. The eBook includes video clips, animations, flashcards, and labeling exercises, and allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. - NEW! Video clips help you interpret new concepts with visual demonstration.
From the development of each vaccine to its use in reducing disease, Plotkin's Vaccines, 7th Edition, provides the expert information you need to provide optimal care to your patients. This award-winning text offers a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as "an indispensable guide to the enhancement of the well-being of our world," Plotkin's Vaccines is a must-have reference for current, authoritative information in this fast-moving field. - Includes complete information for each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, epidemiology, and public health and regulatory issues – plus complete information for each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. - Analyzes the cost-benefit and cost-effectiveness of different vaccine options. - Helps you clearly visualize concepts and objective data through an abundance of tables and figures. - Covers the new oral cholera and zoster vaccines, as well as newly licensed meningococcal group B vaccines and a newly licensed dengue vaccine. - Brings you up to date on successful human trials of Ebola vaccines, an enterovirus 71 vaccine licensed in China, and new recommendations and changes to polio vaccines. - Features a new chapter on maternal immunization. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
From the latest vaccination evidence, recommendations, and protocols . . . to new vaccine development and the use of vaccines in reducing disease, Plotkin's Vaccines, 8th Edition, covers every aspect of vaccination. Now completely revised and updated from cover to cover, this award-winning text continues to provide reliable information from global authorities, offering a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as "an indispensable guide to the enhancement of the well-being of our world," Plotkin's Vaccines is a must-have reference for current, authoritative information in this fast-moving field. - Contains all-new chapters on COVID-19, vaccine hesitancy, and non-specific effects of vaccines, as well as significantly revised content on new vaccine technologies such as mRNA vaccines, emerging vaccines, and technologies to improve immunization. - Presents exciting new data on evolution of adjuvants across the centuries, dengue vaccines, human papillomavirus vaccines, respiratory syncytial virus vaccines, tuberculosis vaccines, and zoster vaccines. - Provides up-to-date, authoritative information on vaccine production, available preparations, efficacy and safety, and recommendations for vaccine use, with rationales and data on the impact of vaccination programs on morbidity and mortality. - Provides complete coverage of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well as epidemiology and public health and regulatory issues. - Keeps you up to date with information on each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. - Covers vaccine-preventable diseases, vaccine science, and licensed vaccine products, as well as product technologies and global regulatory and public health issues. - Analyzes the cost-benefit and cost-effectiveness of different vaccine options. - Helps you clearly visualize concepts and objective data through an abundance of tables and figures. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Drs. Paul L. Kaufman, Albert Alm, Leonard A Levin, Siv F. E. Nilsson, James Ver Hoeve, and Samuel Wu present the 11th Edition of the classic text Adler's Physiology of the Eye, updated to enhance your understanding of ocular function. This full-color, user-friendly edition captures the latest molecular, genetic, and biochemical discoveries and offers you unparalleled knowledge and insight into the physiology of the eye and its structures. A new organization by function, rather than anatomy, helps you make a stronger connection between physiological principles and clinical practice; and more than 1,000 great new full-color illustrations help clarify complex concepts. - Deepen your grasp of the physiological principles that underlie visual acuity, color vision, ocular circulation, the extraocular muscle, and much more. - Improve your understanding of physiology by referring to this totally updated volume--organized by function, rather than anatomy--and make a stronger connection between physiological principles and clinical practice. - Better visualize information with a new, revamped format that includes 1,000 illustrations presented in full-color to better clarify complex concepts and functions. - Access the most recent molecular, genetic, and biochemical discoveries affecting eye function, and gain fresh perspectives from a new, international editorial team. - Search the entire contents online and download all the illustrations at www.expertconsult.com.
Few criminologists have drawn attention to the fact that widespread and significant forms of harm such as green or environmental crimes are neglected by criminology. Others have suggested that green crimes present the most important challenge to criminology as a discipline. This book argues that criminology needs to take green harms more seriously and to be revolutionized so that it forms part of the solution to the large environmental problems currently faced across the world. It asks how criminology should be redesigned to consider green/environmental harm as a key area of study in an era where destruction of the earth and the world’s ecosystem is a major concern and examines why this has remained unaccomplished so far. The chapters in this book apply an environmental frame of reference underlying a green approach to issues which can be addressed from within criminology and which can encourage criminologists and environmentalists to respond and react differently to environmental crime.
In this book, well-known scholars describe new and exciting approaches to aesthetics, creativity and psychology of the arts, approaching these topics from a point of view that is biological or related to biology and answering new questions with new methods and theories. All known societies produce and enjoy arts such as literature, music and visual decoration or depiction. Judging from prehistoric archaeological evidence, this arose very early in human development. Furthermore, Darwin was explicit in attributing aesthetic sensitivity to lower animals. These considerations lead us to wonder whether the arts might not be evolutionarily based. Although such an evolutionary basis is not obvious on the face of it, the idea has recently elicited considerable attention. The book begins with a consideration of ten theories on the evolutionary function of specific arts such as music and literature. The theory of evolution was first drawn up in biology, but evolution is not confined to biology: genuinely evolutionary theories of sociocultural change can be formulated. That they need to be formulated is shown in several chapters that discuss regular trends in literature and scientific writings. Psychologists have recently rediscovered the obvious fact that thought and perception occur in the brain, so cognitive science moves ever closer to neuroscience. Several chapters give overviews of neurocognitive and neural network approaches to creativity and aesthetic appreciation. The book concludes with two exciting describing brain-scan research on what happens in the brain during creativity and presenting a close examination of the relationship between genetically transmitted mental disorder and creativity.
Now in its 6th edition, Cummings Otolaryngology remains the world's most detailed and trusted source for superb guidance on all facets of head and neck surgery. Completely updated with the latest minimally invasive procedures, new clinical photographs, and line drawings, this latest edition equips you to implement all the newest discoveries, techniques, and technologies that are shaping patient outcomes. Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, multi-disciplinary text in the field! Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Overcome virtually any clinical challenge with detailed, expert coverage of every area of head and neck surgery, authored by hundreds of leading luminaries in the field. Experience clinical scenarios with vivid clarity through a heavily illustrated, full-color format which includes approximately 3,200 images and over 40 high quality procedural videos. Get truly diverse perspectives and worldwide best practices from a multi-disciplinary team of contributors and editors comprised of the world’s leading experts. Glean all essential, up-to-date, need-to-know information. All chapters have been meticulously updated; several extensively revised with new images, references, and content. Stay at the forefront of your field with the most updated information on minimally-invasive surgical approaches to the entire skull base, vestibular implants and vestibular management involving intratympanic and physical therapy-based approaches, radiosurgical treatment of posterior fossa and skull base neoplasms, and intraoperative monitoring of cranial nerve and CNS function. Apply the latest treatment options in pediatric care with new chapters on pediatric sleep disorders, pediatric infectious disease, and evaluation and management of the infant airway. Find what you need faster through a streamlined format, reorganized chapters, and a color design that expedites reference. Manage many of the most common disorders with treatment options derived from their genetic basis. Assess real-world effectiveness and costs associated with emergent technologies and surgical approaches introduced to OHNS over the past 10 years. Incorporate recent findings about endoscopic, microscopic, laser, surgically-implantable, radiosurgical, neurophysiological monitoring, MR- and CT-imaging, and other timely topics that now define contemporary operative OHNS. Take it with you anywhere! With Expert Consult, you'll have access the full text, video clips, and more online, and as an eBook - at no additional cost!
Lessons in Perception seeks to clarify notoriously elusive themes of the avant-garde with the use of existing research from the field of psychology. There is a long-standing history of reference to psychological concepts in relation to avant-garde film, such as its unique relationship to memory, visual perception, narrative comprehension, and synesthesia. Yet direct analysis of these topics in light of existing psychological research remains largely unexplored until now. More broadly, the aim of the book is to frame avant-garde filmmaking practice as a form of "practical psychology." In doing so, two principal arguments are proposed: first, that many avant-garde filmmakers draw creative inspiration from their own cognitive and perceptual capacities, and touch on topics explored by actual psychologists; secondly, that as practical psychologists, avant-garde filmmakers provide "lessons in perception" that offer psychological experiences that are largely unrehearsed in commercial cinema
A novel economic interpretation of how religions have become so powerful in the modern world Religion in the twenty-first century is alive and well across the world, despite its apparent decline in North America and parts of Europe. Vigorous competition between and within religious movements has led to their accumulating great power and wealth. Religions in many traditions have honed their competitive strategies over thousands of years. Today, they are big business; like businesses, they must recruit, raise funds, disburse budgets, manage facilities, organize transportation, motivate employees, and get their message out. In The Divine Economy, economist Paul Seabright argues that religious movements are a special kind of business: they are platforms, bringing together communities of members who seek many different things from one another—spiritual fulfilment, friendship and marriage networks, even business opportunities. Their function as platforms, he contends, is what has allowed religions to consolidate and wield power. This power can be used for good, especially when religious movements provide their members with insurance against the shocks of modern life, and a sense of worth in their communities. It can also be used for harm: political leaders often instrumentalize religious movements for authoritarian ends, and religious leaders can exploit the trust of members to inflict sexual, emotional, financial or physical abuse, or to provoke violence against outsiders. Writing in a nonpartisan spirit, Seabright uses insights from economics to show how religion and secular society can work together in a world where some people feel no need for religion, but many continue to respond with enthusiasm to its call.
Human beings have constantly told stories, presented events and placed the world into narrative form. This activity suggests a very basic way of looking at the world, yet, this book argues, even the most seemingly simple of stories is embedded in a complex network of relations. Paul Cobley traces these relations, considering the ways in which humans have employed narrative over the centuries to ‘re-present’ time, space and identity. This second, revised and fully updated edition of the successful guidebook to narrative covers a range of narrative forms and their historical development from early oral and literate forms through to contemporary digital media, encompassing Hellenic and Hebraic foundations, the rise of the novel, realist representations, narratives of imperialism, modernism, cinema, postmodernism and new technologies. A final chapter reviews the way that narrative theory in the last decade has re-orientated definitions of narrative. Written in a clear, engaging style and featuring an extensive glossary of terms, this is the essential introduction to the history and theory of narrative.
P.J. van der Put offers students an original introduction to materials chemistry that integrates the full range of inorganic chemistry. Technologists who need specific chemical facts to manipulate matter will also find this work invaluable as an easy-to-use reference. The text includes practical subjects of immediate use for materials such as bonding, morphogenesis, and design that more orthodox materials science volumes often leave out.
Ever since the discovery of blood types early in the last century, transfusion medicine has evolved at a breakneck pace. This second edition of Blood Banking and Transfusion Medicine is exactly what you need to keep up. It combines scientific foundations with today's most practical approaches to the specialty. From blood collection and storage to testing and transfusing blood components, and finally cellular engineering, you'll find coverage here that's second to none. New advances in molecular genetics and the scientific mechanisms underlying the field are also covered, with an emphasis on the clinical implications for treatment. Whether you're new to the field or an old pro, this book belongs in your reference library. - Integrates scientific foundations with clinical relevance to more clearly explain the science and its application to clinical practice. - Highlights advances in the use of blood products and new methods of disease treatment while providing the most up-to-date information on these fast-moving topics - Discusses current clinical controversies, providing an arena for the discussion of sensitive topics. - Covers the constantly changing approaches to stem cell transplantation and brings you the latest information on this controversial topic.
Heaven is multiethnic, "a vast multitude from every nation, tribe, people, and language." But in this diverse community shouldn't have to wait until eternity to begin! It can be a reality now. Here, the authors give biblical warrant for such a community and show how multiethnic churches provide a unique apologetic for the gospel.
Completely revised and updated, this respected reference offers comprehensive and current coverage of every aspect of vaccination--from development to use in reducing disease. It also includes access to a companion Web site for more coverage.
The popularity of high-intensity interval training (HIIT), which consists primarily of repeated bursts of high-intensity exercise, continues to soar because its effectiveness and efficiency have been proven in use by both elite athletes and general fitness enthusiasts. Surprisingly, few resources have attempted to explain both the science behind the HIIT movement and its sport-specific application to athlete training. That’s why Science and Application of High-Intensity Interval Training is a must-have resource for sport coaches, strength and conditioning professionals, personal trainers, and exercise physiologists, as well as for researchers and sport scientists who study high-intensity interval training. Authors Paul Laursen and Martin Buchheit—both well-known, expert-level HIIT researchers as well as practitioners and endurance athletes—do a masterful job of blending science-based concepts of HIIT with practical application strategies. Laursen, Buchheit, and a team of highly qualified contributors—who bring hundreds of years of combined HIIT science and application experience from across all sports—have written Science and Application of High-Intensity Interval Training to provide practitioners and athletes an understanding of the foundational principles of HIIT programming. Chapters in the first section describe five types of training, how to manipulate HIIT variables to maximize improvements in physical performance, and how to incorporate HIIT into a general training program. Readers will also learn the influence HIIT can have on fatigue, stress, and an athlete’s overall health. The final 20 chapters each focus on a different sport and are written by leading coaches or practitioners who have successfully applied HIIT principles at an elite level in their respective sport. These chapters describe specific ways to incorporate HIIT into a training regimen for everything from combat sports to endurance events to the most popular U.S. and international individual and team sports. Each chapter also contains sport-specific preparation and competition phases, an overall one-year training program, and a brief story of how the coach or practitioner who authored the chapter used HIIT to successfully prepare an athlete for a competition. Knowing the proper ways to incorporate high-intensity interval training into a fitness or conditioning program is of vital importance: Not following proper protocols can lead to excessive and prolonged fatigue, illness, or injury. Science and Application of High-Intensity Interval Training is an essential guide for those who want to incorporate HIIT into their own training or their athletes’ programming. Earn continuing education credits/units! A continuing education course and exam that uses this book is also available. It may be purchased separately or as part of a package that includes all the course materials and exam.
Many of the systems built to serve people instead do more harm than good. In Broken, Dr. Paul LeBlanc, president of Southern New Hampshire University, draws on his experience working in one such system—education—to reconnect us to the human facets of serving people. In doing so, he charts a course for rebuilding and reinhabiting better systems across education, healthcare, criminal justice, government, and more. The United States spends enormous sums on helping people—$3.8 trillion on healthcare, $182 billion on prisons, and $604 billion on higher education—and yet these systems routinely fail us. When we seek to improve how they function, our efforts focus on policy debates, technical solutions, funding, and data. But if these systems are to truly improve, we have to start with the human values that fuel decision making. Broken explores the deeply human dimensions we must consider—aspiring, discovering, mattering—if we want to rebuild the policies, technologies, processes, and, most importantly, the heart we use to serve people. Over the course of 25 years as a college and university president and higher education innovator, Paul LeBlanc, PhD, has encountered innumerable wonderful people who want to do the right thing for students but whose efforts cannot overcome the shortcomings of the system. Now, he shares what he’s learned, and continues to learn, about the opportunities and necessity to put humanity and care at the center of all our systems. With Broken, LeBlanc outlines the distinctly human questions that education—and all systems that serve—must start asking to reframe what is broken in order to make lasting repairs and to better care for those they serve.
Drawing on the hugely successful campaign with Aardman Animations called What’s Up With Everyone? Paul Crawford provides an accessible, lively and creative entry point to mental health literacy and young people at a time of unprecedented challenges.
The proceedings of the 2nd International Congress on Energy Efficiency and Energy Related Materials include 73 peer-reviewed technical papers, submitted by leading academic and research institutions from over 20 countries and representing some of the most cutting-edge research available. The 73 papers are grouped into the following sections: - General Issues - Wind Energy - Solar Energy - Nuclear Energy - Biofuels and Bioenergy - Fossil Energy - Hydropower - Energy Storage, Conservation and Efficiency - Environmental Issues - Carbon Capture and Storage - Bio-Assessment and Toxicology - Air Pollution from Mobile and Stationary Sources - Transport of Air Pollutants - Environmentally Friendly Construction and Development - Energy Management Systems - Materials for Sustainable Energy - Materials for Renewable Energy Storage and Conversion - Fuel Cells - Hydrogen Storage - Photovoltaics and Solar Cells - Hydrogen Production and Fuel Generation from Renewables (Catalysis) - Carbon Dioxide Sequestration and Conversion - Energy-Saving Materials - Thermoelectrics - Saving Energy in Buildings - Modeling and Theoretical Aspects in Energy-Related Materials
What is the essence of martial arts? What is their place in or relationship with culture and society? Deconstructing Martial Arts analyses familiar issues and debates that arise in scholarly, practitioner and popular cultural discussions and treatments of martial arts and argues that martial arts are dynamic and variable constructs whose meanings and values regularly shift, mutate and transform, depending on the context. It argues that deconstructing martial arts is an invaluable approach to both the scholarly study of martial arts in culture and society and also to wider understandings of what and why martial arts are. Placing martial arts in relation to core questions and concerns of media and cultural studies around identity, value, orientalism, and embodiment, Deconstructing Martial Arts introduces and elaborates deconstruction as a rewarding method of cultural studies.
The medieval clergy, aristocracy, and commercial classes tended to regard peasants as objects of contempt and derision. In religious writings, satires, sermons, chronicles, and artistic representations peasants often appeared as dirty, foolish, dishonest, even as subhuman or bestial. Their lowliness was commonly regarded as a natural corollary of the drudgery of their agricultural toil. Yet, at the same time, the peasantry was not viewed as “other” in the manner of other condemned groups, such as Jews, lepers, Muslims, or the imagined “monstrous races” of the East. Several crucial characteristics of the peasantry rendered it less clearly alien from the elite perspective: peasants were not a minority, their work in the fields nourished all other social orders, and, most important, they were Christians. In other respects, peasants could be regarded as meritorious by virtue of their simple life, productive work, and unjust suffering at the hands of their exploitive social superiors. Their unrewarded sacrifice and piety were also sometimes thought to place them closest to God and more likely to win salvation. This book examines these conflicting images of peasants from the post-Carolingian period to the German Peasants’ War. It relates the representation of peasants to debates about how society should be organized (specifically, to how human equality at Creation led to subordination), how slavery and serfdom could be assailed or defended, and how peasants themselves structured and justified their demands. Though it was argued that peasants were legitimately subjugated by reason of nature or some primordial curse (such as that of Noah against his son Ham), there was also considerable unease about how the exploitation of those who were not completely alien—who were, after all, Christians—could be explained. Laments over peasant suffering as expressed in the literature might have a stylized quality, but this book shows how they were appropriated and shaped by peasants themselves, especially in the large-scale rebellions that characterized the late Middle Ages.
From basic science to clinical care, to epidemiological disease patters, The Neurology of AIDS is the only complete textbook available on AIDS neurology and the only one comprehensive enough to stand alone in each segment of study in brain disorders affected by the human immunodeficiency virus. It is an indispensable resource for students, resident physicians, practicing physicians, and for researchers and experts in the HIV/AIDS field. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.
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