Paul Deltenre's Books

Pediatric Neurology Part III

Chapter 158. Hearing loss and deafness in the pediatric population: causes, diagnosis, and rehabilitation

By: Paul Deltenre,Lionel Van Maldergem

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Pediatric Neurology Part III

Chapter 158. Hearing loss and deafness in the pediatric population: causes, diagnosis, and rehabilitation

By: Paul Deltenre,Lionel Van Maldergem

With prevalence figures close to 0.2% at birth and rising to 0.35% during adolescence, hearing loss is the most frequent sensory impairment in childhood. This silent handicap has to be actively sought for without delay as it will seriously interfere with the development of speech, language, cognitive and socio-emotional behavior. Objective physiological techniques (evoked potentials, oto-acoustic emissions, tympanometry) combined according to the cross-check principle allow early diagnosis. Objective testing yields invaluable information about the mechanism of the loss and the contribution of disruption of the neural code to the handicap. Among the acquired causes, cytomegalovirus (CMV) infections plays a major role and may take elusive forms. Aminoglycoside ototoxicity has a genetic determinant. Meningitis can lead to rapid endocochlear ossification prompting for rapid cochlear implantation. Genetic causes account for more than 60% of congenital hearing loss, new genetic causes being discovered at an amazing rate. The high number of genetic entities and their huge heterogeneity among them requires guidelines for requesting genetic testing when desirable. Several syndromes prone to request neuropediatricians’ attention as an early diagnosis followed by specific treatment can considerably limit the ensuing handicap. Whatever the type of assistive device fitted (amplifying hearing aid or cochlear implant) and the importance of associated handicaps, a multidisciplinary rehabilitation combined with educated parental commitment is necessary for optimal results.

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128084243

ISBN 13

9780128084243

How Scientists Explain Disease

By: Paul Thagard

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How Scientists Explain Disease

By: Paul Thagard

How do scientists develop new explanations of disease? How do those explanations become accepted as true? And how does medical diagnosis change when physicians are confronted with new scientific evidence? These are some of the questions that Paul Thagard pursues in this pathbreaking book that develops a new, integrative approach to the study of science. Ranging through the history of medicine, from the Hippocratic theory of humors to modern explanations of Mad Cow Disease and chronic fatigue syndrome, Thagard analyzes the development and acceptance of scientific ideas. At the heart of the book is a case study of the recent dramatic shift in medical understanding of peptic ulcers, most of which are now believed to be caused by infection by the bacterium Helicobacter pylori. When this explanation was first proposed in 1983, it was greeted with intense skepticism by most medical experts, but it became widely accepted over the next decade. Thagard discusses the psychological processes of discovery and acceptance, the physical processes involving instruments and experiments, and the social processes of collaboration, communication, and consensus that brought about this transformation in medical knowledge. How Scientists Explain Disease challenges both traditional philosophy of science, which has viewed science as largely a matter of logic, and contemporary science studies that view science as largely a matter of power. Drawing on theories of distributed computing and artificial intelligence, Paul Thagard develops new models that make sense of scientific change as a complex system of cognitive, social, and physical interactions. This is a book that will appeal to all readers with an interest in the development of science and medicine. It combines an engaging style, significant research, and a powerfully original argument.

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285

Publisher

Princeton University Press

Published Date

ISBN 10

0691187304

ISBN 13

9780691187303

Handbook of Liver Disease E-Book

By: Lawrence S. Friedman,Paul Martin

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Handbook of Liver Disease E-Book

By: Lawrence S. Friedman,Paul Martin

Well-organized and vibrantly illustrated throughout, Handbook of Liver Disease is a comprehensive yet concise handbook providing authoritative guidance on key clinical issues in liver disease. The quick-reference outline format ensures that you'll find answers when you need them, and cover-to-cover updates keep you abreast of the recent rapid changes in the field. Written by leading international experts in hepatology, this reference is ideal for hepatologists, gastroenterologists, internists, family practitioners, trainees, and others who diagnose and manage patients with liver disorders. - Uses a highly templated outline format, key points in each chapter, alert symbols, and highlighted review points to provide a "just the facts" approach to daily clinical questions on liver disease. - Features expanded hepatitis chapters, including completely updated coverage of new, safe, and effective oral regimens for the treatment of hepatitis C. - Provides completely updated coverage of: alcoholic liver disease * autoimmune hepatitis * portal hypertension * primary biliary cholangitis * hepatic tumors * cirrhosis * nonalcoholic liver disease * liver transplantation * and more. - Includes the latest information on adolescents with liver disease moving into adult care. - Covers the revised criteria for prioritizing liver transplantation using the MELDNa score, new options for the treatment of hepatocellular carcinoma, and improved management of hepatorenal syndrome.

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579

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323478824

ISBN 13

9780323478823

Antibacterial Agents

Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

By: Rosaleen Anderson,Paul W. Groundwater,Adam Todd,Alan Worsley

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Antibacterial Agents

Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

By: Rosaleen Anderson,Paul W. Groundwater,Adam Todd,Alan Worsley

Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

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Page Count

379

Publisher

John Wiley & Sons

Published Date

ISBN 10

0470972440

ISBN 13

9780470972441

Book's by Paul Deltenre

Pediatric Neurology Part III

Pediatric Neurology Part III

How Scientists Explain Disease

How Scientists Explain Disease

Handbook of Liver Disease E-Book

Handbook of Liver Disease E-Book

Antibacterial Agents

Antibacterial Agents

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