Just two years ago Alanis Morissette was a former teen pop star, dismissed by some as a footnote in Canadian pop history. Then her album Jagged Little Pill sold over 13 million copies worldwide, and a new queen of alternative rock was crowned. Here Paul Cantin tells the tale of how Morissette transformed herself from failed teenage star into an artist whose work speaks to an entire generation. With multiple Grammys and MTV Awards under her belt; this singer/songwriter has achieved what none thought possible. This is the story of that rare second chance. Included in this book are: Morissette's own account of her songwriting inspiration, exclusive interview material, a front-row account of the 1996 Grammy Awards, and never before-seen photos. This is the one book no Morrisette fan will want to be without.
Dr. Paul L. Marino’s concise, engaging writing style is just one of many reasons that Marino’s The ICU Book is the best-selling reference in critical care. This highly regarded, full-color resource contains the essential information needed to care for patients in any ICU, regardless of the specialty designation of the unit. The newly revised Fifth Edition continues the focus on practical aspects of patient care and will appeal to anyone with an interest in the care of critically ill patients. The intended audience incudes medical students, interns and residents in medicine, surgery, and anesthesiology, critical care physicians and nurses, physician’s assistants, respiratory therapists, and paramedics.
First published in 1990: The Endothelium: Modulator of Cardiovascular Function takes a comprehensive look at the role of the endothelium in cardiovascular control in health and disease. Experts offer detailed reviews on specific topics that address these roles of the endothelium: diffusion barrier, blood-brain barrier, regulator of capillary permeability, metabolic function (uptake and enzymatic destruction), conversion of vasoactive products, production of prostanoids, production and release of endothelium-derived relaxing factors, production of endothelium-derived contracting factors, production of coagulation factors, production of fibrinolytic factors, reticulo-endothelial function, role in atherosclerosis, and changes in function with aging and disease. This overview provides the reader with an update on the role of one of the most fascinating cells in cardiovascular biology. It focuses on the multiple functions of those cells and offers the first attempt to draw a parallel between these functions. Anyone studying the fields of physiology and pharmacology will benefit from this "must have" reference resource.
A Sprinkling of Stardust over the Outhouse is the long-awaited follow-up to Paul Brogan’s highly successful first book, Was That a Name I Dropped? released in 2011. Paul came out as gay when he was ten in the early 1960s and faced a number of obstacles for doing so. He approached them without losing sight of who he was, eventually winning over the naysayers who urged him to be someone other than himself. A Sprinkling of Stardust is a true story that is rich in detail as it tells Paul’s story with humor and heart as well as harsh and sometimes shockingly brutal reality. In the 1980s, playing the starring role in a musical production of Peter Pan, Paul Brogan sang the song “Never Never Land.” The lyrics “I have a place where dreams are born, and time is never planned. It’s not on any chart. You must find it with your heart. Never Never Land” had a great deal of meaning to Paul. Frequently he found himself getting choked up as he sang them. After coming out at the age of ten, Paul created his own Never Never Land. It represented a safe haven, a refuge where he could do and be himself. It was a place to which he escaped after being sexually abused, raped, and suffering a series of life-threatening health issues. His latest book is not a sequel to his 2011 best-seller, Was That a Name I Dropped? Instead, it is the rest of the story told in the same frank and honest manner that earned him kudos for the first book. It is funny, sexy, insightful, moving, and will have the viewer turning away in shock and horror in some instances. Ultimately, it is life. Enthusiastic Response to Paul Brogan’s Writing Was That a Name I Dropped? is even more rare. It is a must-read, and incredible journey and the fastest and most enticing 532 pages I have enjoyed in years. (Tommy Lightfoot Garrett, Canyon News, June 19, 2011) Paul has now written a top-flight memoir, which has the narrative flow of a Dickensian novel. (David Kaufman, celebrated New York author of Ridiculous! The Theatrical Life and Times of Charles Ludlam [2002] and Doris Day: The Untold Story of the Girl Next Door [2008], May 30, 2011) It was a nice mixture of personal tragedy and high-octane gossip, and of course we all love titillation.” (Rex Reed, columnist, June 8, 2011) I also HIGHLY recommend Was That a Name I Dropped? by Paul Brogan. Paul has known EVERYONE in Hollywood. It is an incredible memoir accounting an incredible journey! (Richard Skipper; celebrated producer, performer, and writer; December 10, 2011)
Aldosterone provides a comprehensive and detailed review of the problems that have arisen in the course of research on aldosterone, particularly with respect to their physiological roles and clinical implications. Topics covered include the biosynthesis, transport, and metabolism of aldosterone, as well as its biological activity and control of its secretion. A variety of pathological conditions, both acute and chronic, associated with aldosterone is also discussed. This volume is comprised of 10 chapters and opens with a historical background on aldosterone research, with emphasis on the discovery of the function of the adrenal cortex. The next chapter summarizes the methods suitable for the evaluation of aldosterone activity, from investigations of mineral metabolism to determination of the concentration of aldosterone or aldosterone metabolites; estimation of secretion of aldosterone; and examination of aldosterone metabolism. Subsequent chapters explore the biosynthesis, transport, and metabolism of aldosterone; secretion of aldosterone, factors affecting secretion, and how it can be controlled; pathological conditions caused by either an increase or a decrease in aldosterone secretion, including aldosteronism, Conn's syndrome, hypoaldosteronism, and hypomineralocorticism. The therapeutic uses of aldosterone are discussed in the last chapter. This book will appeal to biologists and biochemists.
This book represents the first complete and systematic guide to the virus-like particles (VLPs) and their applications as vaccines, therapeutic tools, nanomaterials, and nanodevices. The grouping of the VLPs follows the most recent virus taxonomy and the traditional Baltimore classification of viruses, which are based on the genome structure and mechanism of mRNA synthesis. Within each of the seven Baltimore classes, the order taxon serves as a framework of the chapter’s arrangement. The term "VLP" is used as a universal designation for the virus-, core-, or capsid-like structures, which became an important part of the modern molecular virology. The 3D structures, expression systems, and nanotechnological applications are described for VLPs in the context of the original viruses and uncover their evolving potential as novel vaccines and medical interventions. Key Features Presents the first full guide to the VLP nanotechnology, classified by current viral taxonomy Outlines specific structural properties and interconnection of the virions and VLPs Explains generation and characteristics of VLPs produced by various expression systems Offers up-to-date summary of VLPs designed as vaccines and delivery tools Unveils interconnection of VLPs with novel organic and inorganic nanomaterials
This book is a follow up to Goitre Monitor: The History of Iodine Deficiency in Tasmania, published in 2006. Since that time climate change has played a major role in the delivery and availability of iodine to land masses, along with the role of iodophors and the mandatory fortification of bread with iodised salt in Australia and New Zealand over the past 15 years. Several academic colleagues have been invited to discuss the status of iodine from the UK, NZ and Australian perspective in individual chapters, as well as a contribution to the final chapter which discusses 'What the Future Holds' for the delivery and availability of iodine to sustain sufficiency and avoid deficiency of iodine in a changing world.
We all want to understand the world around us, and the ancient Greeks were the first to try and do so in a way we can properly call scientific. Their thought and writings laid the essential foundations for the revivals of science in medieval Baghdad and renaissance Europe. Now their work is accessible to all, with this invaluable introduction to c.100 scientific authors active from 320 BCE to 230 CE. The book begins with an outline of a new socio-political model for the development and decline of Greek science, followed by eleven chapters that cover the main disciplines: * the science which the Greeks saw as fundamental - mathematics * astronomy * astrology and geography * mechanics * optics and pneumatics * the non-mathematical sciences of alchemy, biology, medicine and 'psychology'. Each chapter contains an accessible introduction on the origins and development of the topic in question, and all the authors are set in context with brief biographies.
One of the most turbulent periods in the history of prairie agriculture is chronicled in a new book about the life and times of Alexander "Mac" Runciman, the Saskatchewan farmer who led the United Grain Growers as president from 1961 to 1981. Mac Runciman earned the respect and admiration on both sides of the great agriculture debates of the 1960s and 1970s from individual farmers to Pierre Trudeau, who offered Runciman a cabinet post in 1980 (Mac turned him down). Mac Runciman: A Life in the Grain Trade tells the story of how Runciman rose through the ranks of the UGG to play a central role in the fierce debates over the modernization of grain handling, subsidized freight rates, and the role of The Canadian Wheat Board. Runciman's reminiscences give new insights into the events and personalities of that critical period in Canadian agricultural history, a time in which the rural community began to question highly centralized and regulated marketing and transportation systems. The events and decisions of those years continue to reverberate in today's controversies over grain marketing and grain transportation.
Interdisciplinary and Advanced Topics in Science and Engineering, Volume 3: Separation of Flow presents the problem of the separation of fluid flow. This book provides information covering the fields of basic physical processes, analyses, and experiments concerning flow separation. Organized into 12 chapters, this volume begins with an overview of the flow separation on the body surface as discusses in various classical examples. This text then examines the analytical and experimental results of the laminar boundary layer of steady, two-dimensional flows in the subsonic speed range. Other chapters consider the study of flow separation on the two-dimensional body, flow separation on three-dimensional body shape and particularly on bodies of revolution. This book discusses as well the analytical solutions of the unsteady flow separation. The final chapter deals with the purpose of separation flow control to raise efficiency or to enhance the performance of vehicles and fluid machineries involving various engineering applications. This book is a valuable resource for engineers.
This new book is by two knowledgeable and expert popularizers of chemistry and deals exclusively with molecules and compounds rather than with the simpler atoms and elements. It is based on the very successfulMolecule of the Month' website that was begun by Paul May fifteen years ago and to which his co-author Simon Cotton has been a frequent co
This new account of the pathogenesis of essential hypertension (EH) represents a detailed analysis of the main components of the circulatory control system. The latter's properties resemble those of man-made adaptive control systems in which regulatory parameters are altered when operating conditions exceed certain limits, often through neural mechanisms. Inheritance of EH depends on both genes and environment. The high blood pressure (BP) genes have not yet been definitively identified, whilst the main environmental causes are mental stress, high dietary salt intake and obesity. EH occurs as two major syndromes, each initiated by chronic stress: 1) Stress-and-salt related EH, and 2) Hypertensive obesity. Stress is perceived by the cortex, from which increased dopaminergic (DA) neuron activity stimulates the hypothalamic defense area, raising sympathetic neural activity (SNA) and BP. Normally these subside quickly when the stress is over, but in those susceptible to EH the DA synapses become sensitized so that the defense response is evoked by ever lower levels of stress. Sensitization is common in memory circuits, but not in autonomic neurons, so that this property in EH may be genetically determined. Stress-related hypertension increases hypothalamic responsiveness to high salt, resulting in further rises in SNA and BP. Later, non-neural functional changes (e.g. reduction in nitric oxide) and the structural remodeling of resistance vessels further enhance the vasoconstriction. In contrast, in those developing hypertensive obesity food consumption is excessive, which transiently alleviates stress-related anxiety. The brain ignores the leptin-mediated signals that normally curb appetite, contrasting with normal energy regulation in SSR-EH. In hypertensive obesity, the SNA pattern is similar to that in SSR-EH, but vasoconstriction is masked by vasodilatation and fluid retention due to hyperinsulinemia. This syndrome is a volume overload hypertension, where high cardiac output, renal impairment and other non-neural factors contribute to the elevation of BP. Other topics include the role of various transmitters in autonomic regulation; the place of baroreflexes in the intact organism; why exercise training lowers resting BP; obstructive sleep apnea; non-pharmacological and drug treatment of EH; the role of the kidney in EH and in different types of renal hypertension and the pathogenesis of the Japanese spontaneously hypertensive rat, which provides a valuable animal model for EH. The work suggests that physiological systems analysis in a complex disorder like EH is a valuable tool for using the great advances in molecular biology to best advantage.
Deforestation is frequently a topic of discussion in the environmental arena, but it is not just the number of trees that matters; the quality of the forest is also important. Even where the forest area is stable or increasing, there are often rapid changes in its character. Natural forests are being replaced by plantations or by intensively managed forests. Around the world, forests are becoming younger and less diverse, in both species and structure; this has important impacts for biodiversity and also affects many human values. In this groundbreaking text, forest quality is discussed as a useful new concept in forest conservation and management. Three main assessment criteria are used: authenticity; environmental benefits; and social and economic benefits. The book describes a methodology and protocol for collecting and analysing data, and outlines in detail the approach required with each indicator. The authors advocate a landscape approach to assessment and demonstrate how assessment works through a series of case studies that show how this approach can be used in many ways to help forest conservation management. This hands-on manual is for professionals involved in forestry, conservation and resource management worldwide, and contains case study material from Europe, Asia, Africa and Latin America that demonstrates practical uses of the new 'landscape' approach to forest conservation. Published with IUCN and WWF
This unique work from acclaimed author Dr. Paul Marino (Marino’s The ICU Book, The Little ICU Book) challenges the traditional notion that the human body thrives on oxygen, and that promoting tissue oxygenation is necessary for promoting life. This concept fails to recognize that oxygen is a destructive molecule that also damages the human body. Instead of welcoming oxygen, the human body limits exposure of the tissues to oxygen, and employs an army of chemical antioxidants to combat the damaging effects of oxygen. This “oxygen protective” human design represents a new paradigm for the relationship between oxygen and human survival, and it has important implications for the excessive and unregulated use of oxygen in clinical practice.
Despite having been made into three TV movies, a radio drama, a stage play, a Broadway musical, a feature-film remake in color, and a book adaptation, the 1947 black-and-white film of Miracle on 34th Street still remains the favorite version of this modern Christmas classic. The American public seems to echo what Macy’s stated when declining to participate in the 1994 remake: “We felt there was nothing to be improved upon.” In many ways, it is a perfect film in the sense that there really is nothing that could have been done better: the story, the casting, the acting were all spot-on. The decade from 1941–1951 saw a bumper crop of classic Christmas including Christmas in Connecticut, Holiday Inn, and It’s a Wonderful Life, but with the exception of the latter film none have had the staying power of Miracle on 34th Street. This book describes the origins of the story, the casting and production of the film, its marketing and publicity, and even how it elevated the Macy’s Thanksgiving Day Parade from a local New York event to a national celebration. Finally, it looks at the film’s legacy, including its high ranking among best Christmas movies of all time as well as its placement as ninth overall on the American Film Institute’s list of the most inspiring films.
At the gates of Moscow, Napoleon's Grand Army prepares to enter in triumphal procession. But what it finds is a city abandoned by its inhabitants save only the men who emerge to fan the flames as incendiary fuses hidden throughout the empty buildings of Moscow set the city alight. For three days Moscow burned, while looters dodged the fires to plunder and pillage. And so begins 1812: Napoleon in Moscow, Paul Britten Austin's atmospheric second volume in his acclaimed trilogy on Napoleons catastrophic invasion of Russia. After the fires died down the army settled in the ruins of Moscow; for five weeks Napoleon waited at the Kremlin, expecting his 'brother the Tsar' in St Petersburg to capitulate and make peace, while in fact the Russian Army was gathering its strength. At the same time Murat's cavalry, the advance guard, was encamped in dreadful conditions three days' march away at Winkowo, where it was being starved to death. When Napoleon eventually realized the futility of his plans and prepared to leave Moscow, his advance guard was surprised by a Russian attack. The most astounding exodus in modern times ensued. 1812: Napoleon in Moscow follows on from the brilliant 1812: The March on Moscow, which took Napoleon's army across Europe to the great city. Paul Britten Austin brings this next phase of the epic campaign to life with characteristic verve. Drawing on hundreds of eyewitness accounts by French and allied soldiers of Napoleon's army, this brilliant study recreates this disastrous military campaign in all its death and glory.
This best-selling resource provides a general overview and basic information for all adult intensive care units. The material is presented in a brief and quick-access format which allows for topic and exam review. It provides enough detailed and specific information to address most all questions and problems that arise in the ICU. Emphasis on fundamental principles in the text should prove useful for patient care outside the ICU as well. New chapters in this edition include hyperthermia and hypothermia syndromes; infection control in the ICU; and severe airflow obstruction. Sections have been reorganized and consolidated when appropriate to reinforce concepts.
The field of microporous solids in solid state chemistry has seen a huge expansion over the last decades with new developments in a diverse range of directions and applications. Drawing upon nature as an inspiration, scientists are continually extending known families and preparing porous solids with novel structures. In turn, the novel properties that these possess stimulate further research and applications. Microporous Framework Solids describes fundamental principles and experimental practices of the synthetic chemistry and physical characterisation of crystalline microporous solids. It al.
Fatigue in Friction Stir Welding provides knowledge on how to design and fabricate high performance, fatigue resistance FSW joints. It summarizes fatigue characterizations of key FSW configurations, including butt and lap-shear joints. The book's main focus is on fatigue of aluminum alloys, but discussions of magnesium, steel, and titanium alloys are also included. The FSW process-structure-fatigue performance relationships, including tool rotation, travel speeds, and pin tools are covered, along with sections on extreme fatigue conditions and environments, including multiaxial, variable amplitude, and corrosion effects on fatigue of the FSW. From a practical design perspective, appropriate fatigue design guidelines, including engineering and microstructure-sensitive modeling approaches are discussed. Finally, an appendix with numerous representative fatigue curves for design and reference purposes completes the work. - Provides a comprehensive characterization of fatigue behavior for various FSW joints and alloy combinations, along with an in-depth presentation on crack initiation and growth mechanisms - Presents the relationships between process parameters and fatigue behavior - Discusses modeling strategies and design recommendations, along with experimental data for reference purposes
Machine learning, and specifically deep learning, has been hugely disruptive in many fields of computer science. The success of deep learning techniques in solving notoriously difficult classification and regression problems has resulted in their rapid adoption in solving real-world problems. The emergence of deep learning is widely attributed to a virtuous cycle whereby fundamental advancements in training deeper models were enabled by the availability of massive datasets and high-performance computer hardware. This text serves as a primer for computer architects in a new and rapidly evolving field. We review how machine learning has evolved since its inception in the 1960s and track the key developments leading up to the emergence of the powerful deep learning techniques that emerged in the last decade. Next we review representative workloads, including the most commonly used datasets and seminal networks across a variety of domains. In addition to discussing the workloads themselves, we also detail the most popular deep learning tools and show how aspiring practitioners can use the tools with the workloads to characterize and optimize DNNs. The remainder of the book is dedicated to the design and optimization of hardware and architectures for machine learning. As high-performance hardware was so instrumental in the success of machine learning becoming a practical solution, this chapter recounts a variety of optimizations proposed recently to further improve future designs. Finally, we present a review of recent research published in the area as well as a taxonomy to help readers understand how various contributions fall in context.
An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical applications. After heart disease, cancer is the number one killer worldwide, and the tumor microenvironment is forever changing, creating an ever-greater demand for safer, more effective anticancer agents. In response to that demand, the $100 billion cancer drug market continues to grow, with our increased understanding of cancer leading to new drugs being used clinically almost every year. Anticancer Therapeutics is divided into three sections. Section 1 is an introduction to cancer and therapeutics, and covers the etiology and cellular and molecular basis of cancer. In Section 2, the authors focus on the anticancer agents — their discovery, synthesis, mode of action, mechanisms of resistance, and adverse reactions. Section 3 focuses on specific cancers, explaining how and why the various agents discussed in Section 2 are used, both individually and in combination, to treat different cancers. Integrates aspects of basic science, including chemistry and pharmacology and clinical medicine in relation to cancer therapeutics Written by an author team comprising specialists in medicinal chemistry, pharmacology, and oncology Features full-color images throughout illustrating how drugs bind to cellular targets and exert their pharmacological effect Divided into three sections, covering the etiology and cellular and molecular basis of cancer, anticancer agents, and drug applications for different cancers. Providing the reader with an integrated understanding of all aspects of the science of anticancer agents, this is an ideal textbook for undergraduates studying medicine, nursing, medicinal chemistry, pharmacy, pharmacology and other allied heath / life sciences. It is also a valuable bench reference for pharmacists, medics, and pharmaceutical researchers working in both academia and industry.
There is increasing awareness that the autonomic nervous system, through its central and peripheral pathways, plays a critical role in the regulation of the circulation. Peripherally, the autonomic representation, largely that of sympathetic nerves, innervate virtually all segments of the vascular tree as well as the adrenal medulla. Through the interaction of nerve terminals, their transmitters, receptors and intracellular mediators in smooth muscle, sympathetic neurons control vascular tone as well as the basal performance of the heart. In turn, the performance of the autonomic nervous system is highly controlled by the brain. Once viewed as a black box with only a vague influence on cardiovascular performance, the introduction of concepts and techniques of neuroscience into the field of cardiovascular medicine has led to the realization of the critical role of this organ in cardiovascular control. It is now well recognized that within the brain, the represenation of cardiovascular function is highly restricted anatomically, engages a number of specific transmitters for its actions, and has highly selective and topographically restricted functions to influence circulatory performance.
Paul Coby here proposes a new system for the recording and mapping of Roman forts and fortifications that integrates all the data, including size, dating and identification of occupying units. Application of these methods allows analysis that brings new insights into the placement of these forts, the units garrisoning them and the strategy of conquest and defense they underpinned. This is a new and original contribution to the long-running debate over whether the Roman Empire had a coherent grand strategy or merely reacted piecemeal to emerging needs. Although the author focuses on several major campaigns in Britain as case studies, the author stresses that his method's are also applicable to elsewhere in the Empire. Lavishly illustrated with color maps, the book is also supported by a website and blogs, encouraging further investigation and discussion.
This book provides comprehensive coverage of the scientific aspects of cheese, emphasizing fundamental principles. The book's updated 22 chapters cover the chemistry and microbiology of milk for cheesemaking, starter cultures, coagulation of milk by enzymes or by acidification, the microbiology and biochemistry of cheese ripening, the flavor and rheology of cheese, processed cheese, cheese as a food ingredient, public health and nutritional aspects of cheese, and various methods used for the analysis of cheese. The book contains copious references to other texts and review articles.
The 21 species of sea ducks are one of the larger subgroups (Tribe Mergini) of the waterfowl family Anatidae, and the 16 species (one historically extinct) that are native to North America represent the largest number to be found on any continent, and also the largest number of endemic sea duck species native to any continent. Although generally not important as game birds, the sea ducks include some economically important birds such as the eiders, the basis for the Arctic eiderdown industry and a historically important food source for some Native American cultures. They also include what is probably the most northerly breeding species of all waterfowl and an icon of Arctic bird life, the long-tailed duck. The sea ducks also include species having some of the most complex and diverse pair-forming postural and acoustic displays of all waterfowl (goldeneyes and bufflehead), and some of the deepest diving species of all waterfowl (scoters and long-tailed duck). Sea ducks are highly prone to population disasters caused by oil spills and other water contaminants and, like other seabirds, are among the first bird groups that are being affected by current global warming trends in polar regions. This book is an effort to summarize succinctly our current knowledge of sea duck biology and to provide a convenient survey of the vast technical literature on the group, with over 900 literature references. It also includes 90,000 words of text (more than 40 percent of which is new), 15 updated range maps, 11 black & white and 20 color photographs, over 30 ink drawings, and nearly 150 sketches. Lastly, the North American sea ducks include the now extinct Labrador duck, the only northern hemisphere waterfowl species to have gone extinct in modern times. I have gratefully reprinted a Labrador duck watercolor by Sir Peter Scott. Considering recent population crashes in other sea ducks, such as the Steller's eider and spectacled eider, it should also offer a sobering reminder of the fragility of our natural world and its inhabitants, including us.
The public holds many misconceptions about criminal justice and prison life. Prisons do not resemble country clubs, even though the material amenities have improved over the years. Incarceration is not a deterrent to crime, but instead often reinforces a criminal lifestyle. The deprivation of liberty is basically counterproductive, as it is an impediment to the reintegration of the offender into society, a prerequisite to sound crime prevention. In Criminal Justice: Pros and Cons, author Paul Williams seeks to dispel these common myths about the criminal justice system. Relying on five decades of experience as a penitentiary psychologist and parole board member, he explores some of the problems and challenges of the current system as it stands now. He includes personal anecdotes from his many years dealing with the system firsthand. Williams examines the parole process, which is contingent upon an institutional experience directed toward future, crime-free living in the community rather than directed at suppression and control. He also states that the predominant bureaucratic approach, bolstered by technological advance, must be constrained so as not to supplant the personal element in this complex people business. A vibrant, autonomous, community-based sector is essential to the development and maintenance of a healthy criminal justice system. Learn the ins and outs of the criminal justice system from an insiders personal experiences in Criminal Justice: Pros and Cons.
It is an exciting task to be the editor of the first monograph covering a new area of the biomedical sciences. Since the first report in 1980 by Robert Furchgott and colleagues (see Chapter 1) of the evidence of endothelium-dependent relaxation in isolated arteries, there are ever increasing numbers of vascular physiologists and pharmacologists who are scraping away the endothelium to look into its role in cardiovascular con trol. And the more one looks, the more one discovers. Not only is the list of substances that can induce endothelium-dependent relaxations im pressively long, but these intriguing cells can also secrete vasoconstrictor substances. The ability of the endothelium to modulate the degree of con traction of the underlying smooth muscle is an ancestral property of the blood vessel wall, illustrating the logic of nature, since the endothelial cells are located in the best possible strategic location to continuously monitor the properties (chemical or physical) of the blood. And more and more data emerge suggesting that in several cardiovascular diseases per turbations in endothelium-dependent responses are one of the early signs of the abnormal process. Thus, the importance of endothelium-dependent responses, triggered by the intellectual curiosity of one of the pioneers of vascular physiology and pharmacology, is now recognized not only by basic scientists, but also by all concerned with the cardiovascular diseases. The purpose of this monograph is to provide them with a reference work, so that they know where to start.
Safe Water in Healthcare: A Practical and Clinical Guide enables users from different disciplines to understand all types of waterborne hazards that can pose a risk to those who might be exposed, the events which cause them to be present, what may precipitate an increase in their levels that may cause harm, and how they can be avoided or managed to reduce risk. The handbook highlights microorganisms that can cause infections, modes of transmission, the infections they cause, and risks. The book's authors draw from their extensive practical experience assisting with day-to-day problems that range from minor issues to outbreaks. The book includes case studies on the growth of biofilms and where they cause problems in water systems as well as providing practical answers to a majority of issues that arise in healthcare water and drainage systems. This is an accessible handbook that fills the gaps for those without technical knowledge for a complex but important area of infection control. It provides practical guidance for professionals who are required to design, manage and maintain water systems and help them manage associated infection outbreaks. - Discusses waterborne pathogens, their detection, identification and surveillance and describes the extent and range of recognized and emerging waterborne microorganisms as well as the diseases that occur and consequences to patients and staff - Covers hazards that can cause harm within water systems and associated equipment, the circumstances or factors that increase the risks, and the multiple modes of transmission of waterborne pathogens - Explains the importance of good design, including the type of design, management, hardware and software that can help manage and control the presence of waterborne pathogens. - Highlights who needs to be involved at each stage to ensure that patients are kept safe from waterborne pathogens, taking into account current legislation and best practices guidance
This textbook provides authoritative and up-to-date coverage of the classification, causes, treatment and prevention of psychological disorders in children.
Religion is usually thought of as inconsequential to contemporary Canadian politics. Religion and Canadian Party Politics takes a hard look at just how much influence faith continues to have in federal, provincial, and territorial political arenas. Drawing on case studies from across the country, this book explores three important axes of religiously based contention in Canada. Early on, there were the denominational distinctions between Catholics and Protestants that shaped party oppositions. Since the 1960s, a newly politicized divide opened between religious conservatives and political reformers. Then from the 1990s on, sporadic controversy has centred on the recognition of non-Christian religious minority rights. Although the extent of partisan engagement with each of these sources of conflict has varied across time and region, this book shows that religion still matters in shaping party politics . This detailed look at the play of religiously based conflict and accommodation in Canada fills a large gap and pulls us back from overly simplified comparisons with the United States. More broadly, this book also compares the role of faith in politics in Canada to that of other Western industrialized societies.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.