From small beginnings in the early 1970s, the study of complement regulatory proteins has grown in the last decade to the point where it dominates the complement field. This growth has been fueled by the discovery of new regulators, the cloning of old and new regulators, the discovery that many of the regulators are structurally and evolutionarily related to each other and the development of recombinant forms for use in therapy. There are now more proteins known to be involved in controlling the complement system than there are components of the system and the list continues to grow. The time is ripe for a comprehensive review of our current knowledge of these intriguing proteins. This book does just that. The first few chapters discuss the "nuts-and-bolts" of the complement regulators, describing their structures, functional roles and modes of action. The roles of the complement regulators in vivo are then described, focusing on the consequences of deficiency, roles in the reproductive system, interactions with pathogens and exploitation for therapy. The interesting developments in defining the complement regulators expressed in other species are also discussed. The book is written as a monograph, albeit by two people. The text is as readable as possible without compromising on scientific accuracy and completeness. The conversational style very evident in some sections is deliberate! Placing all references in a single bibliography at the end of the text further improves readability. The reader will go to the book to discover a specific fact but be persuaded to read more and derive pleasure from the process. The authors' enthusiasm for the subject comes over strongly in the text, and this enthusiasm proves infectious. - Complement regulators--structure, functional roles and mode of action - Comprehensive reviews of each of the individual regulators - Roles of Complement regulators in vivo,in health and disease: - Consequences of deficiency - Roles in the reproductive system - Interactions with pathogens - Exploitation for therapy - Complement regulators in other species
It was my original intention to write a reasonably advanced psycho physiology text that would go beyond cardiovascular activity. This I believed would require a collaborative effort since my expertise outside of cardiovascular psychophysiology is too limited. After some initial limited efforts to organize such a venture, it became apparent that a text of this nature was not feasible. Thus, the effort was dropped. I did, however, receive encouragement to write the present monograph, which is more a personalized document than a text. As will become apparent, this monograph relies heavily on research from my laboratory and details the manner in which our conceptualizations of the issues have developed. At first, I believed such an effort premature since such a personalized document was something one composes upon retire ment. However, I was persuaded by some individuals (who shall re main anonymous, just in case they end up regretting their actions) to undertake the present effort. There are several people, who have rendered assistance in the preparation of this monograph, for whose efforts I am extremely grate ful. Extensive editorial assistance and encouragement were provided by Kathleen C. Light and Alberto Grignolo. Also assisting editorially were Ellen Z. Curtin, Allison Cahill, and Carolyn Williams. I wish also to thank my long-time secretary, Virginia Hodson, and Jenny Adams, for their typing assistance. There are six people to whom I would like to dedicate this book.
This book is a follow up to Goitre Monitor: The History of Iodine Deficiency in Tasmania, published in 2006. Since that time climate change has played a major role in the delivery and availability of iodine to land masses, along with the role of iodophors and the mandatory fortification of bread with iodised salt in Australia and New Zealand over the past 15 years. Several academic colleagues have been invited to discuss the status of iodine from the UK, NZ and Australian perspective in individual chapters, as well as a contribution to the final chapter which discusses 'What the Future Holds' for the delivery and availability of iodine to sustain sufficiency and avoid deficiency of iodine in a changing world.
The Measurement of Health and Health Status: Concepts, Methods and Applications from a Multidisciplinary Perspective presents a unifying perspective on how to select the best measurement framework for any situation. Serving as a one-stop shop that unifies material currently available in various locations, this book illuminates the intuition behind each method, explaining how each method has special purposes, what developments are occurring, and how new combinations among methods might be relevant to specific situations. It especially emphasizes the measurement of health and health states (quality-of-life), giving significant attention to newly developed methods. The book introduces technically complex, new methods for both introductory and technically-proficient readers. - Assumes that the best measure depends entirely on the situation - Covers preference-based methods, classical test theory, and item response theory - Features illustrations and animations drawn from diverse fields and disciplines
A pioneering critic, educator, and poet, I. A. Richards (1893-1979) helped the English-speaking world decide not only what to read but how to read it. Acknowledged "father" of New Criticism, he produced the most systematic body of critical writing in the English language since Coleridge. His method of close reading dominated the English-speaking classroom for half a century. John Paul Russo draws on close personal acquaintance with Richards as well as on unpublished materials, correspondence, and interviews, to write the first biography (originally published in 1989) of one of last century’s most influential and many-sided men of letters.
Pharmacology, in its own right, is a massive subject area and has been the focus of several major textbooks. Human Pharmacology is a readable, introductory text covering all of the main aspects of pharmacology in a way that enthuses the reader to study the subject further. Each chapter includes line drawings and figures to illustrate concepts and mechanisms of action. Each chapter ends with a selection of recommended reading and multiple choice revision questions. The author introduction to the science of pharmacology allows readers to appreciate why and how certain drugs alleviate the symptoms of disease.
Essential Dental Public Health, Second Edition is an ideal introduction for undergraduate dental students to the field of public health. With a strong emphasis on evidence-based medicine, this guide puts clinical practice in context with the help of a problem based approach to learning, illustrations and lists of further reading.
JC Smith's The Law of Contract is a classic text revised with the needs of modern students in mind. With a strong focus on helping students understand and apply case law, the book guides the reader through the intricacies of contract law in an accessible way.
Written by a team of high profile, international authors, this exciting new text successfully combines theory and practice, making it a must-have for all students of Events Management. Events Management: An International Approach provides comprehensive coverage of all the most common types of events, preparing students for a future career in Events Management. Covering key issues such as fundraising, sponsorship and globalization, this text addresses the challenges and examines the realities of events management in an international context. A wide range of case studies and examples look at sporting, music, catering and fundraising events across the UK, Europe, Asia, Australia and the Middle East.
Throughout its human history, New Zealand has been interpreted and experienced in often radically different ways. Each wave of arrivals to its shores has left its own set of views of New Zealand on the country – applying a new coat of mythology and understanding to the landscape, usually without fully removing the one that lies beneath it.' Encounters is the wide-ranging, audacious and gripping story of New Zealand's changing national identity, how it has emerged and evolved through generations. In this genre-busting book, historian Paul Moon delves into how the many and conflicting ideas about New Zealand came into being. Along the way, he explores forgotten crevices of the nation's character, and exposes some of the mythology of its past and present. These include, for example, the earliest Maori myths and the 'mock sacredness' of the All Blacks in the twenty-first century; the role of nostalgia in our national character, both Maori and Pakeha; whether the explorer Kupe existed; the appeal of the Speight's 'Southern Man'; and ruminations on New Zealand art and landscape. What results is an absorbing piece of scholarship, an imaginative and exuberant epic that will challenge preconceptions about what it means to be a New Zealander, and how our country is understood. Lyrical, breathtaking and provocative, and illustrated with artworks throughout, Encounters offers an extraordinary insight into the beginnings of our country.
The first history of the Congres Internationaux d'Architecture Moderne traces the development and promotion of its influential concept of the "Functional City.
Introduces major topics in ancient Greek civilization through the development of eleven characteristic city states, ranging from prehistoric Cnossos through Byzantion, and including the future Marseilles as well as Athens and Sparta.
The law of human rights permeates every area of law. This title focuses on the impact of human rights law at every stage of the criminal process. It addresses the principal human rights issues that apply during an investigation and prior to a suspect knowing that they are a suspect, powers of arrest and search, and treatment at the police station. It considers every stage of the criminal process, including appeal before the domestic courts and the European Court of Human Rights. Part 1 covers the fundamental principles of the European Convention on Human Rights and the Human Rights Act 1998 and their application in domestic law, particularly in relation to criminal appeals, as well as taking a case to the European Court of Human Rights. Parts 2 to 4 address the three broad phases of a criminal case – investigation, pre-trial and trial – providing an analysis of human rights law as it applies in each phase. This book offers a comprehensive analysis of the often complex interactions between criminal law and human rights; with a wide range of experienced contributors drawn from the legal profession and academia, under the general editorship of Ben Douglas-Jones KC, Daniel Bunting, Paul Mason and Benjamin Newton.
A superbly clear, direct, and detailed explanation of the rule that underpin the law of evidence. The Modern Law of Evidence is well-established as a lucid, engaging, authoritative and comprehensive exploration of the law of evidence. The emphasis is on critical focused analysis, setting the rules in context and drawing upon both modern practice and a wealth of relevant legal and non-legal research. An ideal text for undergraduate and postgraduate students, including students undertaking the bar course or solicitors' training courses. The Modern Law of Evidence is also an authoritative resource for legal practitioners and judges, including appellate judges in England and Wales and across the Commonwealth. Book jacket.
Accessory liability in the private law is of great importance. Claimants often bring claims against third parties who participate in wrongs. For example, the 'direct wrongdoer' may be insolvent, so a claimant might prefer a remedy against an accessory in order to obtain satisfactory redress. However, the law in this area has not received the attention it deserves. The criminal law recognises that any person who 'aids, abets, counsels or procures' any offence can be punished as an accessory, but the private law is more fragmented. One reason for this is a tendency to compartmentalise the law of obligations into discrete subjects, such as contract, trusts, tort and intellectual property. This book suggests that by looking across such boundaries in the private law, the nature and principles of accessory liability can be better understood and doctrinal confusion regarding the elements of liability, defences and remedies resolved. Winner of the Joint Second SLS Peter Birks Prize for Outstanding Legal Scholarship 2015.
Paul Davies and Graham Virgo present the most engaging and student-focused text, cases, and materials approach to equity and trusts, providing an authoritative account of the law in a single volume.
Need the go-to reference on adult bone and joint injuries? Get the definitive guide on fracture treatment, written by the world’s top orthopaedic surgeons: Rockwood and Green’s Fractures in Adults. This fully updated and expanded 8th edition offers up-to-the-minute research and recommendations from more than 80 leading orthopaedic experts from around the world. An essential resource on fractures for every orthopaedic surgeon or resident.. Features: NEW chapters on: Management of the Geriatric or Elderly Patient; Management of Bone Defects;; Psychological Aspect of Trauma NEW authors from countries including India, China, Columbia, Greece, and Denmark NEW 10 new full length videos added to the video library. All videos feature easy navigation so you can go directly to specific steps in the procedure, or watch the entire procedure from start to finish Pearls and Pitfalls and preventive measures listed for all procedures NEW Time-saving outline template for easy quick-reference “Before the Case” checklists of all necessary equipment for each surgical procedure Preferred Technique section provides algorithms explaining each author’s choice of preferred procedure Full-color operative photos, tables, x-rays, diagrams, and more than 500 line drawings of surgical procedures
Argues that technological imperatives like rationalization, universalism, monism, and autonomy have transformed the humanities and altered the relation between humans and nature. Examines technology and its impact on education, historical memory, and technological and literary values in criticism and theory, concluding with an analysis of the fiction of Don DeLillo"--Provided by publisher.
This book focuses on the fiction of four postcolonial authors: V.S. Naipaul, Anita Desai, Timothy Mo and Salman Rushdie. It argues that meals in their novels act as sites where the relationships between the individual subject and the social identities of race, class and gender are enacted. Drawing upon a variety of academic fields and disciplines — including postcolonial theory, historical research, food studies and recent attempts to rethink the concept of world literature — it dedicates a chapter to each author, tracing the literary, cultural and historical contexts in which their texts are located and exploring the ways in which food and the act of eating acquire meanings and how those meanings might clash, collide and be disputed. Not only does this book offer suggestive new readings of the work of its four key authors, but it challenges the reader to consider the significance of food in postcolonial fiction more generally.
Roberts and Zuckerman's Criminal Evidence is the eagerly-anticipated third of edition of the market-leading text on criminal evidence, fully revised to take account of developments in legislation, case-law, policy debates, and academic commentary during the decade since the previous edition was published.With an explicit focus on the rules and principles of criminal trial procedure, Roberts and Zuckerman's Criminal Evidence develops a coherent account of evidence law which is doctrinally detailed, securely grounded in a normative theoretical framework, and sensitive to the institutional and socio-legal factors shaping criminal litigation in practice. The book is designed to be accessible to the beginner, informative to the criminal court judge or legal practitioner, and thought-provoking to the advanced student and scholar: a textbook and monograph rolled into one.The book also provides an ideal disciplinary map and work of reference to introduce non-lawyers (including forensic scientists and other expert witnesses) to the foundational assumptions and technical intricacies of criminal trial procedure in England and Wales, and will be an invaluable resource for courts, lawyers and scholars in other jurisdictions seeking comparative insight and understanding of evidentiary regulation in the common law tradition.
Drawing on original international research by a cross-European social science team, this book makes an important contribution to the discussion about the future of arts and humanities research. It explores the responses of these fields to the growing range of questions being asked about the value, impact and benefit of publicly-funded research. The objective is to better understand what really matters rather than what is easily measured. The book increases our understanding of the contribution which university-based arts and humanities research makes to society and the economy by exploring how it is defined, appreciated and accounted for by researchers, policymakers and civil society. It identifies appropriate practices and methodologies to assess and demonstrate quality and value beyond the academy. The book will be essential reading for researchers and policymakers, as well as research organisations and anyone interested in the arts and humanities.
If 'prevention is better than cure', why isn't policy more preventive? Policymakers only have the ability to pay attention to, and influence, a tiny proportion of their responsibilities, and they engage in a policymaking environment of which they have limited understanding and even less control. This simple insight helps explain the gap between stated policymaker expectations and actual policy outcomes. Why Isn't Government Policy more Preventive? uses these insights to produce new empirical studies of 'wicked' problems with practical lessons. The authors find that the UK and Scottish governments both use a simple idiom - prevention is better than cure - to sell a package of profound changes to policy and policymaking. Taken at face value, this focus on 'prevention' policy seems like an idea 'whose time has come'. Yet, 'prevention' is too ambiguous until governments give it meaning. No government has found a way to turn this vague aim into a set of detailed, consistent, and defendable policies. This book examines what happens when governments make commitments without knowing how to deliver them. It compares their policymaking contexts, roles and responsibilities, policy styles, language, commitments, and outcomes in several cross-cutting policy areas (including health, families, justice, and employability) to make sense of their experiences. The book uses multiple insights from policy theory to help research and analyse the results. The results help policymakers reflect on how to avoid a cycle of optimism and despair when trying to solve problems that their predecessors did not.
Originally published in 1989, Karst Geomorphology and Hydrology became the leading textbook on karst studies. This new textbook has been substantially revised and updated. The first half of the book is a systematic presentation of the dissolution kinetics, chemical equilibria and physical flow laws relating to karst environments. It includes details of the many environmental factors that complicate their chemical evolution, with a critique of measurement of karst erosion rates. The second half of the book looks at the classification system for cave systems and the influence of climate and climatic change on karst development. The book ends with chapters on karst water resource management and a look at the important issues of environmental management, including environmental impact assessment, environmental rehabilitation, tourism impacts and conservation values. Practical application of karst studies are explained throughout the text. "This new edition strengthens the book's position as the essential reference in the field. Karst geoscientists will not dare to stray beyond arm's reach of this volume. It is certain to remain the professional standard for many decades." Journal of Cave and Karst Studies, August 2007
Focused on the key themes of an undergraduate course in trusts and with an analytical approach to the subject, this book has been thoroughly updated and re-worked to enhance accessibility whilst stimulating thought and insight for students. Complex issues are explained clearly but without over-simplification in this comprehensive account of trusts law which mirrors the focus of trusts teaching in universities, and seeks to engage students critically through real-life issues, key scholarship and theoretical considerations. To further help students excel in this subject, expanded further reading sections and end of-chapter questions are included alongside analysis of selected readings to guide the interested reader to relevant sources and ideas. Real-life examples of the application of the law of trusts are highlighted throughout. Alongside reference to the latest scholarship in trusts, consideration of theoretical perspectives has been expanded to provide a fresh and stimulating exposition. Online Resource Centre The Online Resource Centre provides updates, web links, essay questions and answer guidance, and summaries of selected further reading.
Mormonism is one of the few homegrown religions in the United States, one that emerged out of the religious fervor of the early nineteenth century. Yet, members of the Church of Jesus Christ of Latter-day Saints have struggled for status and recognition. In this book, W. Paul Reeve explores the ways in which nineteenth century Protestant white America made outsiders out of an inside religious group. Much of what has been written on Mormon otherness centers upon economic, cultural, doctrinal, marital, and political differences that set Mormons apart from mainstream America. Reeve instead looks at how Protestants racialized Mormons, using physical differences in order to define Mormons as non-White to help justify their expulsion from Ohio, Missouri, and Illinois. He analyzes and contextualizes the rhetoric on Mormons as a race with period discussions of the Native American, African American, Oriental, Turk/Islam, and European immigrant races. He also examines how Mormon male, female, and child bodies were characterized in these racialized debates. For instance, while Mormons argued that polygamy was ordained by God, and so created angelic, celestial, and elevated offspring, their opponents suggested that the children were degenerate and deformed. The Protestant white majority was convinced that Mormonism represented a racial-not merely religious-departure from the mainstream and spent considerable effort attempting to deny Mormon whiteness. Being white brought access to political, social, and economic power, all aspects of citizenship in which outsiders sought to limit or prevent Mormon participation. At least a part of those efforts came through persistent attacks on the collective Mormon body, ways in which outsiders suggested that Mormons were physically different, racially more similar to marginalized groups than they were white. Medical doctors went so far as to suggest that Mormon polygamy was spawning a new race. Mormons responded with aspirations toward whiteness. It was a back and forth struggle between what outsiders imagined and what Mormons believed. Mormons ultimately emerged triumphant, but not unscathed. Mormon leaders moved away from universalistic ideals toward segregated priesthood and temples, policies firmly in place by the early twentieth century. So successful were Mormons at claiming whiteness for themselves that by the time Mormon Mitt Romney sought the White House in 2012, he was labeled "the whitest white man to run for office in recent memory." Ending with reflections on ongoing views of the Mormon body, this groundbreaking book brings together literatures on religion, whiteness studies, and nineteenth century racial history with the history of politics and migration.
Since the 1990 publication of Goodwin and Jamison's classic text on mania and bipolar and unipolar depression, Manic-Depressive Illness, there have been a number of significant advances in the research, diagnosis, and treatment of mania and bipolar disorder. Developed and written by experts at the forefront of these advances, Mania: Clinical and Research Perspectives provides a comprehensive overview of all recent developments on all aspects of mania. Mania is divided into three sections: diagnostic considerations, biological aspects, and treatment. "Diagnostic Considerations" includes coverage of the diagnostic revisions in DSM-IV, special comorbidity issues in children and substance abuse, the differentiation of mood swing from bipolar disorder, and generational change and genetic linkage. "Biological Aspects" reviews the current state of knowledge in biochemistry and biological techniques such as gamma-aminobutyric acid (GABA) and brain imaging. "Treatment" thoroughly surveys all major treatment regimens for mania, including new drug therapies such as carbamazepine, valproate, clozapine, risperidone, verapamil, and nimodipine. This section also details new findings on the use of lithium and the risks for pregnant women and advances in psychotherapy. The book concludes with a summary that provides a historical perspective and directions for further research. With the comprehensive coverage provided in Mania: Clinical and Research Perspectives, readers will be able to improve patient care through advanced diagnosis and treatment.
Contents: V. Zingel, C. Leschke and W. Schunack: Developments in research on histamine (H1) receptor agonists / P.D. Hoeprich: Antifungal chemotherapy / G. de Stevens: The diversity of heterocyclic compounds and their biological activities / R.M. Schultz: Newer antifolate compounds in cancer therapy / P.K. Mehrotra, S. Batra and A.P. Bhadun: Non-steroidal agents for regulation of the menstrual cycle / A.K. Saxena and M. Saxena: Developments in anti-convulsant drugs
The third volume of The U.S. Navy Warship Series covers the fifty-year period from 1883-1922. In 1883, Congress authorized the first ships of the "New Navy" and ordered removal of all obsolete ships. All US Navy ships since that time have stemmed from these first three cruisers. The numbering system in effect since 1920 was effectively begun in 1886. The ships built during the next few years fought in the Spanish-American War. The success and popularity of the naval victories of that war together with the acquisition of overseas territories were the impetus for a large naval shipbuilding program. The voyage around the world of the "Great White Fleet" was a prime example of the excitement felt by the American people about the Navy. This led naturally into the fleet of World War I and its vast expansion, terminating with its demobilization after the war and the succeeding naval disarmament treaty of 1992. This book will be arranged following the standard format with sections on Capital Ships, Cruisers, Destroyers, Submarines, Mines Vessels, Patrol Vessels, Tenders, Supply & Transport Ships, Naval Overseas Transportation Service (NOTS), and other government departments (Coast Guard, etc.). A further article about Paul Silverstone and the Navy Warships series can be found at: http://www.thejc.com/home.aspxParentId=m11s18s180&SecId=180&AId=58892&ATypeId=1
How can the EU's community of welfare states adapt their public policies to economic globalization? What happens when the economic and social aims of the EU come into conflict? This book examines the developing legal regimes and regulation of public services in the UK and other European countries. Public services are examined though a case-study of the complex area of public employment services. These are job-placement and vocational training services which aim to maximize employment and minimize unemployment within EU member States' Active Labour Market policies. Employment services are at the centre of a complex web of rules in both hard and soft forms of law deriving from the EU, national public law and from private, and at times contractual, agreements. They also lie at the crossroads of a series of trends in regulation, and priorities have been inspired by an array of conflicting policy rationales. These policy rationales include the establishment of an open and competitive European internal market, the establishment of an efficient welfare state, the scaling down of state administrative machinery, the fulfilment of core public service responsibilities, and the creation of public-private partnerships. Public employment services provide a highly informative and novel case study of the interaction and conflict between the economic and social aims of the EU and between regulation at national and supranational levels, and the changing forms which this regulation has taken.
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