This book analyzes how news discourse was shaped over time by external factors, such as the historical context, news production, technological innovation and current affairs, and as such both conformed to and deviated from generic conventions. Using data from a newspaper corpus, it offers the first empirical study into the development of style in early mass media. In this analysis, media style appears as a dynamic concept which is highly sensitive to innovative approaches towards making news not only informative but also entertaining to read. This cutting-edge survey will be of interest to academics researching corpus linguistics, media discourse and stylistics.
This book explores the dynamics of language and social change in central Europe in the context of the end of the Cold War and eastern expansion of the European Union. One outcome of the profound social transformations in central Europe since the Second World War has been the reshaping of the relationship between particular languages and linguistic varieties, especially between 'national' languages and regional or ethnic minority languages. Previous studies have investigated these transformed relationships from the macro perspective of language policies, while others have taken more fine-grained approaches to individual experiences with language. Combining these two perspectives for the first time--and focusing on the German language, which has a uniquely complex and problematic history in the region--the authors offer an understanding of the complex constellation of language politics in central Europe. Stevenson and Carl's analysis draws on a range of theoretical, conceptual and analytical approaches - language ideologies, language policy, positioning theory, discourse analysis, narrative analysis and life histories - and a wide range of data sources, from European and national language policies to individual language biographies. The authors demonstrate how the relationship between German and other languages has played a crucial role in the politics of language and processes of identity formation in the recent history of central Europe.
Natural Attenuation: CERCLA, RBCAs, and the Future of Environmental Remediation presents the concept of "natural attenuation"-the tendency of soils to severly limit the toxicity of many types of hazardous waste. It reviews and updates the most recent findings from the field and lab and shows how natural attenuation is rapidly changing the direction and focus of environmental remediation. Outlining the legal and regulatory framework that has made waste remediation so costly, this book shows how applying an understanding of natural attenuation can decrease cleanup outlays while lowering risks to human health. Natural Attenuation: CERCLA, RBCAs, and the Future of Environmental Remediation makes it clear why natural attenuation will be relied upon more and more in the future.
Encompassing interviews with managing directors and CEOs, this book explores the role of business outsiders as leaders. Viewing the term ‘outsider’ in a broad sense, the book considers leader background, perspective, gender, training and family membership and examines the implications, challenges and benefits brought by outsider leaders to their respective business environments. The authors explore questions and themes such as how outsider leaders can enrich an organisation, the importance of relationships and adopting a ‘hybrid’ approach, illuminated by interviewee perspectives. Introducing discussion and analysis through these narratives, Outsider Leadership distils commonalities to frame understanding of their experiences.
The second edition of Introduction to Microfluidics captures all the new exciting developments in the field of microfluidics over the last twenty years. While maintaining the same clear structure, and accessible explanations of the basic theory, this new edition is a complete revision of the first edition and makes use of the considerable data collected in the field over the last two decades. The book describes the applications, the market, and attempts to envision the future of microfluidics. It covers the physics of miniaturization, the hydrodynamics of microfluidics in channels and with droplets, transport phenomena in microsystems, electrokinetic phenomena, and an introduction to microfabrication. The basic principles are explored in depth and with rigor, and their main applications are clearly presented. Many examples are provided and discussed simply, most often from a physical perspective, and the book includes 415 figures and 600 references. Offering a cross-disciplinary view of the field embracing biological, chemical, physical and engineering perspectives, this book is an ideal resource for students and researchers at any level.
Written for high school or beginning undergraduate students, this four-volume reference valiantly attempts to provide a historical framework for the perhaps overly broad concept of world trade. Entry topics were selected on trade organizations, influential people, commodities, events that affected trade, trade routes, navigation, religion, communic
Aphasia Rehabilitation: Challenging Clinical Issues focuses on specific aphasia symptoms and clinical issues that present challenges for rehabilitation professionals. These topics are typically not addressed as separate topics, even in clinical texts. This heavily clinical text will also include thorough discussions of theoretical underpinnings. For chapters that focus on specific clinical challenges, practical suggestions to facilitate clinical application and maximize clinical usefulness. This resource integrates theoretical and practical information to aid a clinician in planning treatment for individuals with aphasia.
This book, a combination of theory and practice, provides comprehensive knowledge in the field of radiation curing and support for your daily work. It offers guidance on how to select raw materials and features a troubleshooting chapter which provides concrete answers to possible problems." "This book is aimed towards formulators in the field of radiation curing, students and young professionals in coatings and printing inks with no previous experience of radiation curing and all readers who have an interest in and enjoy reading about the theory and practice of one of the fastest-growing technologies." --Book Jacket.
In this work, Patrick Whitworth explores the writings of Basil of Caesarea, Gregory of Nyssa, and Gregory Nazianzen and shares their understanding of the purpose and scope of theology.
Aphasia and Related Neurogenic Communication Disorders, Third Edition reviews the definition, terminology, classification, symptoms, and neurology of aphasia, including the theories of plasticity and recovery.
Direct Democracy in Canada: The History and Future of Referendums surveys Canada’s century-long record of plebiscites and referendums. J. Patrick Boyer analyzes the effects of the three national referendums and the development of a consensus. This companion volume to The People’s Mandate studies some of the major provincial and municipal referendums, examines existing legal frameworks and speculates on the future of direct democracy in Canada.
Taking you to the forefront of the emerging field of Nanofluidics, this cutting-edge book details the physics and applications of fluid flow in nanometer scale channels. You gain a solid understanding of the fundamental aspects of transport processes and force interactions in microscale. Moreover, this unique resource presents the latest research on nanoscale transport phenomena. You find a comprehensive overview of fabrication technologies for nanotechnologies, including detailed technology recipes and parameters. The book concludes with a look at future trends and the possible directions this new field could take.
The frozen-hydrated specimen is the principal element that unifies the subject of low temperature microscopy, and frozen-hydrated specimens are what this book is all about. Freezing the sample as quickly as possible and then further preparing the specimen for microscopy or microanalysis, whether still embedded in ice or not: there seem to be as many variations on this theme as there are creative scientists with problems of structure and composition to investigate. Yet all share a body of com mon fact and theory upon which their work must be based. Low-Temperature Micros copy and Analysis provides, for the first time, a comprehensive treatment of all the elements to which one needs access. What is the appeal behind the use of frozen-hydrated specimens for biological electron microscopy, and why is it so important that such a book should now have been written? If one cannot observe dynamic events as they are in progress, rapid specimen freezing at least offers the possibility to trap structures, organelles, macro molecules, or ions and other solutes in a form that is identical to what the native structure was like at the moment of trapping. The pursuit of this ideal becomes all the more necessary in electron microscopy because of the enormous increase in resolution that is available with electron-optical instruments, compared to light optical microscopes.
Nonlinear is a buzzword for every broadcaster and facility house worldwide. Systems range from the humble to the exotic, and despite the growing acceptance of the technology, many users, both new and experienced, find the complexity of the operation and the time spent loading the material and rendering effects difficult to manage at first. Non-linear editing also comes with its own specialist language, requiring each editor to be conversant with a new range of skills from day one. As desktop systems improve the role of the traditional editor is constantly evolving and expanding. This is an operational manual for professional trainees and students in the post-production industry. It will also serve as a useful reference tool for producers and directors. Written in a concise and clear manner, the book serves as a practical guide to the efficient management and operation of non-linear editing systems. It describes the technology involved, the essential techniques to be mastered including on-line and off-line editing, project management, rendering effects, working with graphics and audio, and adding third party applications. Designed for quick and easy reference, this is a practical user guide to non-linear editing that comes complete with an extensive jargon buster that will get you fully conversant with the technology in a short space of time. Patrick Morris is a Trainer in Post-Production for the Television Corporation of Singapore and the Singapore Broadcasting Authority as well as Chairman of the South East Asia User Group. He is an AVID Certified Trainer with a working knowledge of Lightworks, Media 100, Quantel, D Vision and other systems. Formerly a consultant and Senior Editor for BBC, ITV and SKY TV, he also spent many years a Training Manager for BBC Wood Norton and as Senior Video-Tape Editor for Television South West.
A mood of anger with the political system has been stirring across Canada; yet rather than turning away from the system, many Canadians are actually seeking a greater say in matters that affect them. they want to become more effective participants in the political process. In this timely book, Patrick Boyer examines the important role that direct democracy -- through the occasional use of referendums, plebscites, and inniatives -- can play in concert with our existing institutions of representative democracy. This concept is not alien to our country, says Boyer, pointing to the two national plebiscites (on prohibition of alcohol in 1898 and consciption for overseas military service in 1942), some sixty provincial plebscites (on everything from sovereignty-association to abortion, medicare to women's suffrage, prohibition to ownership of power companies), and several thousand at the municipal level. Direct voting is an important instrument in a truly democratic society, Boyer argues, and it has a more important rold in the current reformation of Canada than some in the comfortable growing governing classes want to admit. In addition to clarifying an issue, it is an educational tool, as the plebiscite campaign becomes a national teach-in. Canadians can become participants, rathe rthan mere spectators, in the major changes and transcending isues that affect the future of our country. The People's Mandate is a helpful guide to understanding the distinctions between plebiscites and referendums in a purely Canadian context. It addresses some of the concerns about this unparliamentary practice, and makes a powerful and logical statement about democracy. In sum, Boyer believes it is essential to govern with the trust of the people.
The Iditarod may be the only race that awards a prize for last place. But then how many people can even complete a course that ranges across 1,000 miles of Alaska's ice fields, mountains, and canyons at temperatures that sometimes plunges to 100 degrees below zero? In conditions like these, anything can go wrong. For Brian Patrick O'Donoghue, nearly everything did. In My Lead Dog Was a Lesbian, his reporter and intrepid novice musher tells what happened when he entered the 1991 Iditarod, along with seventeen sled dogs with names like Harley, Screech, and Rainy, his sexually confused lead dog. O'Donoghue braved snowstorms and sickening wipeouts, endured the contempt of more experienced racers (one of whom was daft enough to use poodles), and rode herd of four-legged companions who would rather be fighting or having sex. It's all here, narrated with self-deprecating wit, in a true story of heroism, cussedness and astonishing dumb luck.
The creator of the hit podcast series Tides of History and Fall of Rome explores the four explosive decades between 1490 and 1530, bringing to life the dramatic and deeply human story of how the West was reborn. In the bestselling tradition of The Swerve and A Distant Mirror, The Verge tells the story of a period that marked a decisive turning point for both European and world history. Here, author Patrick Wyman examines two complementary and contradictory sides of the same historical coin: the world-altering implications of the developments of printed mass media, extreme taxation, exploitative globalization, humanistic learning, gunpowder warfare, and mass religious conflict in the long term, and their intensely disruptive consequences in the short-term. As told through the lives of ten real people—from famous figures like Christopher Columbus and wealthy banker Jakob Fugger to a ruthless small-time merchant and a one-armed mercenary captain—The Verge illustrates how their lives, and the times in which they lived, set the stage for an unprecedented globalized future. Over an intense forty-year period, the seeds for the so-called "Great Divergence" between Western Europe and the rest of the globe would be planted. From Columbus's voyage across the Atlantic to Martin Luther's sparking the Protestant Reformation, the foundations of our own, recognizably modern world came into being. For the past 500 years, historians, economists, and the policy-oriented have argued which of these individual developments best explains the West's rise from backwater periphery to global dominance. As The Verge presents it, however, the answer is far more nuanced.
The history of the Lone Star state is a narrative dominated by larger-than-life personalities and often-contentious legends, presenting interesting challenges for historians. Perhaps for this reason, Texas has produced a cadre of revered historians who have had a significant impact on the preservation (some would argue creation) of our state’s past. An anthology of biographical essays, Writing the Story of Texas pays tribute to the scholars who shaped our understanding of Texas’s past and, ultimately, the Texan identity. Edited by esteemed historians Patrick Cox and Kenneth Hendrickson, this collection includes insightful, cross-generational examinations of pivotal individuals who interpreted our history. On these pages, the contributors chart the progression from Eugene C. Barker’s groundbreaking research to his public confrontations with Texas political leaders and his fellow historians. They look at Walter Prescott Webb’s fundamental, innovative vision as a promoter of the past and Ruthe Winegarten’s efforts to shine the spotlight on minorities and women who made history across the state. Other essayists explore Llerena Friend delving into an ambitious study of Sam Houston, Charles Ramsdell courageously addressing delicate issues such as racism and launching his controversial examination of Reconstruction in Texas, Robert Cotner—an Ohio-born product of the Ivy League—bringing a fresh perspective to the field, and Robert Maxwell engaged in early work in environmental history.
This book tackles the challenges of designing mm-wave circuits in 16nm FinFET, from the elementary transistor level to a measured D-band transmitter. The design of crucial building blocks such as oscillators and power amplifiers are covered through theoretical limitations, design methodology and measurement. Offers first book on design of mm-wave circuits above 100GHz in an advanced 16nm FinFET digital technology; Covers fundamentals of transistor layout, circuit implementation and measurements; Provides single-source reference to information otherwise only available in disparate literature.
This volume was primarily intended to present selected papers from the workshop on Theory and Applications of Nested Relations and Complex Objects, held in Darmstadt, FRG, from April 6-8, 1987. Other papers were solicited in order to provide a picture of the field as general as possible. Research on nested relations and complex objects originates in the late seventies. The motivation was to obtain data models and systems which would provide support for so-called complex objects or molecular structures, i.e., for hierarchically organized data, thereby overcoming severe shortcomings of the relational model. This theme of research is now maturing. Systems based on those ideas are beginning to be available. Languages of various natures (algebras, calculi, graphical, logic-oriented) have been designed and a theory is slowly emerging. Finally, new developments in database technology and research are incorporating features of models involving complex objects. A variety of approaches is represented in this volume. The first three papers give overviews of major pioneering implementation efforts. The fourth paper is devoted to the important issue of implementation of storage structures. The next three papers propose excursions in the foundations of nested relations and complex objects. The following six contributions are all devoted to modeling of complex objects. The area of database design is represented by the last four papers.
This innovative monograph explores a new mathematical formalism in higher-order temporal logic for proving properties about the behavior of systems. Developed by the authors, the goal of this novel approach is to explain what occurs when multiple, distinct system components interact by using a category-theoretic description of behavior types based on sheaves. The authors demonstrate how to analyze the behaviors of elements in continuous and discrete dynamical systems so that each can be translated and compared to one another. Their temporal logic is also flexible enough that it can serve as a framework for other logics that work with similar models. The book begins with a discussion of behavior types, interval domains, and translation invariance, which serves as the groundwork for temporal type theory. From there, the authors lay out the logical preliminaries they need for their temporal modalities and explain the soundness of those logical semantics. These results are then applied to hybrid dynamical systems, differential equations, and labeled transition systems. A case study involving aircraft separation within the National Airspace System is provided to illustrate temporal type theory in action. Researchers in computer science, logic, and mathematics interested in topos-theoretic and category-theory-friendly approaches to system behavior will find this monograph to be an important resource. It can also serve as a supplemental text for a specialized graduate topics course.
Atomic force microscopy (AFM) is part of a range of emerging microscopic methods for biologists which offer the magnification range of both the light and electron microscope, but allow imaging under the 'natural' conditions usually associated with the light microscope. To biologists, AFM offers the prospect of high resolution images of biological material, images of molecules and their interactions even under physiological conditions, and the study of molecular processes in living systems. This book provides a realistic appreciation of the advantages and limitations of the technique and the present and future potential for improving the understanding of biological systems.The second edition of this bestseller has been updated to describe the latest developments in this exciting field, including a brand new chapter on force spectroscopy. The dramatic developments of AFM over the past ten years from a simple imaging tool to the multi-faceted, nano-manipulating technique that it is today are conveyed in a lively and informative narrative, which provides essential reading for students and experienced researchers alike./a
Known for its readability, portability, and global perspectives, Holcomb and Ashcraft's Pediatric Surgery remains the most comprehensive, up-to-date, single-volume text in its field. As technology and techniques continue to evolve, the 7th Edition provides state-of-the-art coverage—both in print and on video—of the full range of general surgical and urological problems in infants, children, and adolescents, equipping you to achieve optimal outcomes for every patient. - Provides authoritative, practical coverage to help you implement today's best evidence-based open and minimally invasive techniques, with guidance from internationally recognized experts in the field. - Features more than 1,000 high-quality images depicting the visual nuances of surgery for the full range of pediatric and urologic conditions you're likely to see. - Delivers comprehensive updates throughout including the latest advances in managing Inguinal Hernias and Hydroceles; Imperforate Anus and Cloacal Malformations; Hirschsprung Disease; Duodenal and Intestinal Atresia and Stenosis; Esophageal Atresia; and more. - Offers access to more than 50 videos that help you improve and refine your surgical skills. New videos cover Fetal Endoluminal Tracheal Occlusion (FETO); Laparoscopic Inguinal Hernia Repair; Robotic Extravesical Ureteral Reimplantation; Laparoscopic Management of Ovarian Torsion; and Laparoscopic Sleeve Gastrectomy. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices
The human brain is the inner universe through which all external events are perceived. That fact alone should ensure that neuroscience will eventually receive top priority in the list of human endeavors. The brain represents the pinnacle of sophistication in the realm of living systems. Yet it is an imperfect organ, whose failures in disease processes lead to the occupation of more than half of all hospital beds and whose variable performance in the healthy state contributes in undetermined degree to the world's social problems. Every significant advance in our understanding of the brain has yielded enormous practical dividends. There is every reason to believe the future holds even greater promise. It can be said that brain research took root near the end of the last century when Ram6n y Cajal proved beyond doubt that the neuron is the basic functioning unit of the brain and Sherrington revealed its method of transmitting impulses. But it is only in the past two decades that neuroscience has been established as a recognized discipline where the anatomical, physiological, and chemical aspects of neuronal function are treated in a unified fashion. It can be anticipated that this logical advance'will allow brain research to reach new levels of sophistication. Already it has resulted in the establishment of graduate programs at dozens of universities, and the found ing of numerous journals devoted to reports of interdisciplinary research on the brain.
Geechi Suede and Sonny Cheeba are Camp Lo. These two emcees from the Bronx, NY entered the American hip hop scene with an insider slang that bewildered listeners as they radiated the look of a bygone era of black culture. In 1996, they collaborated with producer Ski and a host of other contributors to create Uptown Saturday Night, featuring the seminal single “Luchini (a.k.a. This is It).” While other 1990s rappers referred to 1970s Blaxploitation culture, Camp Lo were self-described “time travelers” who weaved the slang and style of a soulful past into state-of-the-art lyrical flows. Uptown Saturday Night is a tapestry of 1970s black popular culture and 1990s New York City hip hop. This volume will detail how the album's fantastic world of “Coolie High” reflected classic films like Cooley High and the Sidney Poitier film from which the album's title is derived, and promoted vintage slang and fashion. The book features new interviews with Camp Lo, producer Ski, Trugoy the Dove from De La Soul, Ish from Digable Planets, and others, and offers musical and cultural analyses that detail the development of the album and its essential contributions to a post-soul aesthetic.
Today a deepening global recession is causing economic hardships for all kinds of businesses. Earth Capitalism attributes the crisis to inappropriate macroeconomic policies and excessive expansion of financial institutions in blind pursuit of profit, lack of self-discipline among financial institutions, and the failure of supervision and regulation to keep up with financial innovations. Collectively, these are some of the main causes of the current global economic malaise. Petit argues that human greed and insatiability are the true source of disparities around the world. Greed is the reason why we are depleting the Earth's natural resources and destroying its ecosystems. He argues that instead, a good life should be based on balanced give-and-take. When we take something from society or the Earth, we have to maintain a balance by giving something equivalent back. Happiness is founded on gratitude for what one has, and one should engage in an overall appraisal of life, not what one lacks. He believes the same principle should be applied to management of the Earth's natural resources and goods. The current global crisis impels us to create a responsible capitalism, one that benefits all living beings on this planet. It reminds us to live a simpler life based on true well-being and life-satisfaction, but simple living is not about living in poverty. As its subtitle suggests, Earth Capitalism's contributors present leading edge economic concepts, business models, and best practices that show the path toward creation of responsible capitalism?a viable scenario emerging from the current global economic and financial crisis.
“I don’t know how to say what the grace of God is. What I can say is what it’s like for me.” We all know about grace being amazing—after all, there’s a whole song about it—but Patrick Henry reminds us that that’s not all it is. It’s also intimidating, disorienting, demanding, reassuring, and sometimes even just downright mind-boggling. Describing thirty-three different aspects of grace based on his everyday experiences, Henry tells the story of a grace that is wide-ranging and comprehensive—if not always comprehensible. Rather than trying to capture and tame his encounters with God, he lets the mystery of memory speak for itself, exemplifying his mantra that being a Christian is about being “an explorer, not a colonizer.” Flashes of Grace is wise and grounded, earnest and light, faithful and quirky. Henry describes encountering grace in airports, baseball, hazelnuts, and just about anywhere else you can imagine, while engaging with dialogue partners ranging from King Saul and Saint Augustine to Yogi Berra and Captain Picard. For anyone longing to connect (or reconnect) with God, this book provides a surprising journey that broadens perspectives and explores strange new worlds, while loosening stiff spiritual joints so movement can be free and spontaneous.
In early Pennsylvania, translation served as a utopian tool creating harmony across linguistic, religious, and ethnic differences. Patrick Erben challenges the long-standing historical myth--first promulgated by Benjamin Franklin--that language diversity posed a threat to communal coherence. He deftly traces the pansophist and Neoplatonist philosophies of European reformers that informed the radical English and German Protestants who founded the "holy experiment." Their belief in hidden yet persistent links between human language and the word of God impelled their vision of a common spiritual idiom. Translation became the search for underlying correspondences between diverse human expressions of the divine and served as a model for reconciliation and inclusiveness. Drawing on German and English archival sources, Erben examines iconic translations that engendered community in colonial Pennsylvania, including William Penn's translingual promotional literature, Francis Daniel Pastorius's multilingual poetics, Ephrata's "angelic" singing and transcendent calligraphy, the Moravians' polyglot missions, and the common language of suffering for peace among Quakers, Pietists, and Mennonites. By revealing a mystical quest for unity, Erben presents a compelling counternarrative to monolingualism and Enlightenment empiricism in eighteenth-century America.
We have come to know that our ability to survive and grow as a nation to a very large degree depends upon our scientific progress. Moreover, it is not enough simply to keep 1 abreast of the rest of the world in scientific matters. We must maintain our leadership. President Harry Truman spoke those words in 1950, in the aftermath of World War II and in the midst of the Cold War. Indeed, the scientific and engineering leadership of the United States and its allies in the twentieth century played key roles in the successful outcomes of both World War II and the Cold War, sparing the world the twin horrors of fascism and totalitarian communism, and fueling the economic prosperity that followed. Today, as the United States and its allies once again find themselves at war, President Truman’s words ring as true as they did a half-century ago. The goal set out in the Truman Administration of maintaining leadership in science has remained the policy of the U. S. Government to this day: Dr. John Marburger, the Director of the Office of Science and Technology (OSTP) in the Executive Office of the President, made remarks to that effect during his 2 confirmation hearings in October 2001. The United States needs metrics for measuring its success in meeting this goal of maintaining leadership in science and technology. That is one of the reasons that the National Science Foundation (NSF) and many other agencies of the U. S.
This book represents a classic compilation of current knowledge about mouse development and its correlates to research in cell biology, molecular biology, genetics, and neuroscience. Emphasis is placed on the research strategy, experimental design, and critical analysis of the data, disguishing this from other books that only focus on protocols for mouse developmental research. Selected chapters are indexed to electronic databases such as GeneBank, GenBank, Electronic Mouse Atlas, and Transgenic/Knockout, further increasing the utility of this book as a reference.*Broad-based overview of mouse development from fundamental to specialist levels*Extensive coverage of a wide range of developmental mutations of the mouse*Excellent benchmark illustrations of brain, craniofacial, gut and heart development*In-depth experiment-based assessment of concepts in mammalian development*Focus on models of specific relevance to human development*Comprehensive reference to key literature and electronic databases related to mouse development*High-quality full-color production
Evidence-Based Practice of Critical Care, 2nd Edition, presents objective data and expert guidance on managing critically ill patients in unique question-based chapters that focus on best practices. Now thoroughly updated by Drs. Clifford S. Deutschman, Patrick J. Neligan, and nearly 200 critical-care experts, this highly regarded title remains the only book of its kind that provides a comprehensive framework for translating evidence into practice, making it a valuable resource for both residents and practitioners. Tap into the expertise of nearly 200 critical-care experts who discuss the wide variety of clinical options in critical care, examine the relevant research, and provide recommendations based on a thorough analysis of available evidence. Think through each question in a logical, efficient manner, using a practical, consistent approach to available management options and guidelines. Find the information you need quickly with tables that summarize the available literature and recommended clinical approaches. Navigate a full range of challenges from routine care to complicated and special situations. Stay up to date with new issues and controversies such as the redefinition of sepsis • changing approaches to fluid administration • immune suppression in sepsis • monitoring the microcirculation • the long-term sequelae of critical illness • minimizing ventilator associated lung injury • the benefits of evidence-based medicine management guidelines • rapid response teams • and more. Benefit from all-new sections covering persistent critical illness and the role of advanced practice nurses and physician assistants in the ICU.
Evidence-Based Practice of Critical Care, 2nd Edition, presents objective data and expert guidance on managing critically ill patients in unique question-based chapters that focus on best practices. Now thoroughly updated by Drs. Clifford S. Deutschman, Patrick J. Neligan, and nearly 200 critical-care experts, this highly regarded title remains the only book of its kind that provides a comprehensive framework for translating evidence into practice, making it a valuable resource for both residents and practitioners. Tap into the expertise of nearly 200 critical-care experts who discuss the wide variety of clinical options in critical care, examine the relevant research, and provide recommendations based on a thorough analysis of available evidence. Think through each question in a logical, efficient manner, using a practical, consistent approach to available management options and guidelines. Find the information you need quickly with tables that summarize the available literature and recommended clinical approaches. Navigate a full range of challenges from routine care to complicated and special situations. Stay up to date with new issues and controversies such as the redefinition of sepsis . changing approaches to fluid administration . immune suppression in sepsis . monitoring the microcirculation . the long-term sequelae of critical illness . minimizing ventilator associated lung injury . the benefits of evidence-based medicine management guidelines . rapid response teams . and more. Benefit from all-new sections covering persistent critical illness and the role of advanced practice nurses and physician assistants in the ICU.
This work describes the essential aspects of enantioselective catalysis, with chapters organised by concept rather than by reaction type. Each concept is supported by examples to give the reader broad exposure to a wide range of catalysts, reactions and reaction mechanisms.
The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. - Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders - Describes the clinical background and underlying molecular processes for Alzheimer's disease, Parkinson's, Prion, Motor Neuron, Huntington's, and Multiple Sclerosis - Highlights the state-of-the-art treatment options for each disorder - Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models
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