Patrick McGeer's Books

Molecular Neurobiology of the Mammalian Brain

By: Patrick McGeer

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Molecular Neurobiology of the Mammalian Brain

By: Patrick McGeer

The human brain is the inner universe through which all external events are perceived. That fact alone should ensure that neuroscience will eventually receive top priority in the list of human endeavors. The brain represents the pinnacle of sophistication in the realm of living systems. Yet it is an imperfect organ, whose failures in disease processes lead to the occupation of more than half of all hospital beds and whose variable performance in the healthy state contributes in undetermined degree to the world's social problems. Every significant advance in our understanding of the brain has yielded enormous practical dividends. There is every reason to believe the future holds even greater promise. It can be said that brain research took root near the end of the last century when Ram6n y Cajal proved beyond doubt that the neuron is the basic functioning unit of the brain and Sherrington revealed its method of transmitting impulses. But it is only in the past two decades that neuroscience has been established as a recognized discipline where the anatomical, physiological, and chemical aspects of neuronal function are treated in a unified fashion. It can be anticipated that this logical advance'will allow brain research to reach new levels of sophistication. Already it has resulted in the establishment of graduate programs at dozens of universities, and the found ing of numerous journals devoted to reports of interdisciplinary research on the brain.

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646

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Springer Science & Business Media

Published Date

ISBN 10

1461574919

ISBN 13

9781461574910

Integrating Functional and Temporal Domains in Logic Design

The False Path Problem and Its Implications

By: Patrick C. McGeer,Robert K. Brayton

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Integrating Functional and Temporal Domains in Logic Design

The False Path Problem and Its Implications

By: Patrick C. McGeer,Robert K. Brayton

This book is an extension of one author's doctoral thesis on the false path problem. The work was begun with the idea of systematizing the various solutions to the false path problem that had been proposed in the literature, with a view to determining the computational expense of each versus the gain in accuracy. However, it became clear that some of the proposed approaches in the literature were wrong in that they under estimated the critical delay of some circuits under reasonable conditions. Further, some other approaches were vague and so of questionable accu racy. The focus of the research therefore shifted to establishing a theory (the viability theory) and algorithms which could be guaranteed correct, and then using this theory to justify (or not) existing approaches. Our quest was successful enough to justify presenting the full details in a book. After it was discovered that some existing approaches were wrong, it became apparent that the root of the difficulties lay in the attempts to balance computational efficiency and accuracy by separating the tempo ral and logical (or functional) behaviour of combinational circuits. This separation is the fruit of several unstated assumptions; first, that one can ignore the logical relationships of wires in a network when considering timing behaviour, and, second, that one can ignore timing considerations when attempting to discover the values of wires in a circuit.

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227

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1461539609

ISBN 13

9781461539605

The Molecular and Clinical Pathology of Neurodegenerative Disease

By: Patrick A. Lewis,Jennifer E. Spillane

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The Molecular and Clinical Pathology of Neurodegenerative Disease

By: Patrick A. Lewis,Jennifer E. Spillane

The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. - Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders - Describes the clinical background and underlying molecular processes for Alzheimer's disease, Parkinson's, Prion, Motor Neuron, Huntington's, and Multiple Sclerosis - Highlights the state-of-the-art treatment options for each disorder - Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models

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276

Publisher

Academic Press

Published Date

ISBN 10

0128110708

ISBN 13

9780128110706

Neuroscience for Neurologists

By: Patrick F. Chinnery

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Neuroscience for Neurologists

By: Patrick F. Chinnery

The last decade has seen major advances in our understanding of the basic scientific principles that underpin clinical neurology. Many of these advances have already had a major impact on routine clinical practice, and this is likely to continue in the future. Although this makes it an exciting time to practice neurology, it also presents new challenges. How can established general neurologists keep up-to-date with clinically relevant scientific advances, and how can the specialist remain competent outside his own field? What should trainee neurologists learn to prepare themselves for the future career?. Written by experts in the field, this timely book presents the scientific principles behind neurology. It aims to take the reader from the human genome, through gene expression, to molecular and cellular pathology, and subsequently to contemporary clinical investigations and clinical trials. Each contribution includes a discussion about the future of the field and highlights areas of potential growth and their relevance to routine clinical practice over the next decade. The succinctly written chapters will be easily accessible to both neurologists and trainees who have no expertise in the area. Many of the chapters are co-written by a clinician and a basic scientist, and each has been subject to peer review OCo both by experts in the field and a OC jobbingOCO general neurologist. This has ensured that the contributions reflect contemporary scientific thinking which is presented in a way that is easy to digest. The book includes generous use of diagrams to help explain difficult concepts, a glossary explaining the terminology, and provides information on links to web-based resources for further information. Sample Chapter(s). Chapter 1: Neurogenetics -- Single Gene Disorders (761 KB). Contents: Neurogenetics OCo Single Gene Disorders; Neurogenetics II: Complex Disorders; Functional Genomics and Proteomics: Application in Neurosciences; Mitochondria; Nanotechnology for Neuronal Ion Channels; Molecular and Cellular Pathways of Neurodegeneration in Motor Neurone Disease; Neurodegenerative Disorders: Parkinson''s Disease and Huntington''s Disease; Molecular Pathogenesis of Neuroinflammation; Neurovirology; Molecular Neurology of Prion Disease; Monitoring and Interpretation of Intracranial Pressure; Cerebral Perfusion and Stroke; A Review of Structural Magnetic Resonance Neuroimaging; Applications of Positron Emission Tomography (PET) in Neurology; Functional Magnetic Resonance Imaging; How to Spot Bias and Other Potential Problems in Randomised Controlled Trials. Readership: Neurologists, trainees/interns in neurology and related disciplines, neurobiologists.

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Page Count

468

Publisher

Imperial College Press

Published Date

ISBN 10

1860948960

ISBN 13

9781860948961

Evidence-Based Practice of Critical Care

By: Clifford S. Deutschman, MS, MD, FCCM,Patrick J. Neligan

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Evidence-Based Practice of Critical Care

By: Clifford S. Deutschman, MS, MD, FCCM,Patrick J. Neligan

Evidence-Based Practice of Critical Care, 2nd Edition, presents objective data and expert guidance on managing critically ill patients in unique question-based chapters that focus on best practices. Now thoroughly updated by Drs. Clifford S. Deutschman, Patrick J. Neligan, and nearly 200 critical-care experts, this highly regarded title remains the only book of its kind that provides a comprehensive framework for translating evidence into practice, making it a valuable resource for both residents and practitioners. Tap into the expertise of nearly 200 critical-care experts who discuss the wide variety of clinical options in critical care, examine the relevant research, and provide recommendations based on a thorough analysis of available evidence. Think through each question in a logical, efficient manner, using a practical, consistent approach to available management options and guidelines. Find the information you need quickly with tables that summarize the available literature and recommended clinical approaches. Navigate a full range of challenges from routine care to complicated and special situations. Stay up to date with new issues and controversies such as the redefinition of sepsis . changing approaches to fluid administration . immune suppression in sepsis . monitoring the microcirculation . the long-term sequelae of critical illness . minimizing ventilator associated lung injury . the benefits of evidence-based medicine management guidelines . rapid response teams . and more. Benefit from all-new sections covering persistent critical illness and the role of advanced practice nurses and physician assistants in the ICU.

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Page Count

691

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323299954

ISBN 13

9780323299954

Evidence-Based Practice of Critical Care E-Book

By: Clifford S. Deutschman,Patrick J. Neligan

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Evidence-Based Practice of Critical Care E-Book

By: Clifford S. Deutschman,Patrick J. Neligan

Evidence-Based Practice of Critical Care, 2nd Edition, presents objective data and expert guidance on managing critically ill patients in unique question-based chapters that focus on best practices. Now thoroughly updated by Drs. Clifford S. Deutschman, Patrick J. Neligan, and nearly 200 critical-care experts, this highly regarded title remains the only book of its kind that provides a comprehensive framework for translating evidence into practice, making it a valuable resource for both residents and practitioners. Tap into the expertise of nearly 200 critical-care experts who discuss the wide variety of clinical options in critical care, examine the relevant research, and provide recommendations based on a thorough analysis of available evidence. Think through each question in a logical, efficient manner, using a practical, consistent approach to available management options and guidelines. Find the information you need quickly with tables that summarize the available literature and recommended clinical approaches. Navigate a full range of challenges from routine care to complicated and special situations. Stay up to date with new issues and controversies such as the redefinition of sepsis • changing approaches to fluid administration • immune suppression in sepsis • monitoring the microcirculation • the long-term sequelae of critical illness • minimizing ventilator associated lung injury • the benefits of evidence-based medicine management guidelines • rapid response teams • and more. Benefit from all-new sections covering persistent critical illness and the role of advanced practice nurses and physician assistants in the ICU.

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691

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323394175

ISBN 13

9780323394178

Pharmacotherapy Principles and Practice, Third Edition

By: Marie Chisholm-Burns,Terry Schwinghammer,Barbara G. Wells,Patrick Malone,Joseph T. DiPiro

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Pharmacotherapy Principles and Practice, Third Edition

By: Marie Chisholm-Burns,Terry Schwinghammer,Barbara G. Wells,Patrick Malone,Joseph T. DiPiro

Learn the essential principles of pharmacotherapy and how they apply to today’s healthcare Pharmacotherapy Principles & Practice, Third Edition uses a solid evidence-based approach to teach you how to design, implement, monitor, and evaluate medication therapy. This trusted text provides everything you need to gain an in-depth understanding of the principles essential optimal pharmacotherapy of disease. In order to be as clinically relevant as possible, the disease states and treatments discussed focus on disorders most often seen in clinical practice. Chapters were written or reviewed by pharmacists, nurse practitioners, physician assistants, and physicians who are authorities in their fields. The book opens with an introductory chapter followed by chapters on pediatrics, geriatrics, and palliative care. The remainder of the text consists of ninety-eight disease-based chapters that review etiology, epidemiology, pathophysiology, and clinical presentation, followed by therapeutic recommendations for drug selection, dosing, and patient monitoring.

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Page Count

1969

Publisher

McGraw Hill Professional

Published Date

ISBN 10

0071804234

ISBN 13

9780071804233

Molecular Neurobiology of the Mammalian Brain

By: Patrick McGeer

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Molecular Neurobiology of the Mammalian Brain

By: Patrick McGeer

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646

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Springer Science & Business Media

Published Date

ISBN 10

1461574919

ISBN 13

9781461574910

Molecular Neurobiology of the Mammalian Brain

By: Patrick McGeer

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Molecular Neurobiology of the Mammalian Brain

By: Patrick McGeer

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648

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Springer

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ISBN 10

1461574935

ISBN 13

9781461574934

Integrating Functional and Temporal Domains in Logic Design

The False Path Problem and Its Implications

By: Patrick C. McGeer,Robert K. Brayton

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Integrating Functional and Temporal Domains in Logic Design

The False Path Problem and Its Implications

By: Patrick C. McGeer,Robert K. Brayton

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227

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Springer Science & Business Media

Published Date

ISBN 10

1461539609

ISBN 13

9781461539605

Little Book of St Patrick

By: Saint Patrick,Don Mullan

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Little Book of St Patrick

By: Saint Patrick,Don Mullan

Capturing in simple format the very essence of Saint Patrick, the quotations gathered here provide a profound insight into his thinking, offering the reader food for thought and substance for prayerful reflection.

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128

Published Date

ISBN 10

1856074269

ISBN 13

9781856074261

POEM FOR ST PATRICKS DAY 1870

By: Patrick Martin King

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POEM FOR ST PATRICKS DAY 1870

By: Patrick Martin King

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

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Publisher

Wentworth Press

Published Date

ISBN 10

1374335088

ISBN 13

9781374335080

Book's by Patrick McGeer

Molecular Neurobiology of the Mammalian Brain

Molecular Neurobiology of the Mammalian Brain

Integrating Functional and Temporal Domains in Logic Design

Integrating Functional and Temporal Domains in Logic Design

The Molecular and Clinical Pathology of Neurodegenerative Disease

The Molecular and Clinical Pathology of Neurodegenerative Disease

Neuroscience for Neurologists

Neuroscience for Neurologists

Evidence-Based Practice of Critical Care

Evidence-Based Practice of Critical Care

Evidence-Based Practice of Critical Care E-Book

Evidence-Based Practice of Critical Care E-Book

Pharmacotherapy Principles and Practice, Third Edition

Pharmacotherapy Principles and Practice, Third Edition

Molecular Neurobiology of the Mammalian Brain

Molecular Neurobiology of the Mammalian Brain

Molecular Neurobiology of the Mammalian Brain

Molecular Neurobiology of the Mammalian Brain

Integrating Functional and Temporal Domains in Logic Design

Integrating Functional and Temporal Domains in Logic Design

Little Book of St Patrick

Little Book of St Patrick

POEM FOR ST PATRICKS DAY 1870

POEM FOR ST PATRICKS DAY 1870

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