The reign of Alexander I was a pivotal moment in the construction of Russia's national mythology. This work examines this crucial period focusing on the place of the Russian nobility in relation to their ruler, and the accompanying debate between reform and the status quo, between a Russia old and new, and between different visions of what Russia could become. Drawing on extensive archival research and placing a long-neglected emphasis on this aspect of Alexander I's reign, this book is an important work for students and scholars of imperial Russia, as well as the wider Napoleonic and post-Napoleonic period in Europe.
Artemia is widely used in both life-sciences research and aquaculture. Although there are over 4000 references regarding Artemia, the literature is widely scattered. Artemia Biology provides a comprehensive, state-of-the-art review of this literature, containing a considerable amount of previously unpublished data. Although all aspects of Artemia biology are covered, the book emphasizes whole-organism approaches. Topics covered include molecular genetics, ontogeny, clonal diversity, mitochondrial DNA-based phylogeny, and comparisons of Artemia and Parartemia (including a taxonomic key to Parartemia species). The book also contains the latest information on Artemia culturing in fertilized ponds and culture tanks, as well as the use of the organism as a food source. Researchers investigating basic biological questions involving molecular genetics, biochemistry, enzymatic and developmental activities, physiology, ecological genetics and adaptation, ecology, and aquaculture production will find this book indispensable.
This book surveys the current knowledge concerning the expression and function of small stress proteins (sHsps) in different organisms, ranging from prokaryotes to humans. It provides an overview of the diversity and complex evolutionary history of sHsps and describes their function and expression in different eukaryote models. Additional chapters discuss the involvement of sHsps in pathological conditions and gene therapy approaches towards a control of sHsp expression levels.
This book discusses the mutual relationship between service and sustainability. It covers methodologies and approaches and describes measurements and tools that can promote sustainability on the service market. Lastly, it presents the different applications of sustainability, together with examples of sustainable services. Environmental concerns have become integral to any decision-making process in the design and implementation of goods and services. With the increasing dominance of the service sector, and as service systems become more complex and interdisciplinary, the focus must move from the exchange of products to that of services. Newly created services should thus aim to incorporate sustainability into their designs while viewing sustainability as a service in its own right. Integrating sustainability in the service design and development process is essential to improving the sustainability of our society and preserving the environment. Moreover, doing so shifts the service boundaries from values that are focused only on personal, local, and current needs and economic profit to those that are broader and more future oriented, ultimately placing greater social and environmental responsibility on all stakeholders. In addition, it advances the current state-of-the-art in sustainable development and service design and contributes to improving the quality of life on a global scale.
New York Times bestselling author Patrick A. Davis spins a gripping tale of deadly intrigue in a time of national crisis that races to the explosive final act. A LONG DAY FOR DYING When General Michael Garber, the newly appointed Chairman of the Joint Chiefs of Staff, is discovered dead in the private compartment of his airplane, Air Force investigator Martin Collins finds himself thrust into the most dangerous case of his career. What initially appears to be an accidental death turns out to be a near-perfect murder -- and three members of the Joint Chiefs are the prime suspects. As Martin weaves his way through a puzzling maze of blood and deceit, he finds himself in the firing line of Garber's enemies, including a half-mad rival general who collects the ears of the men he's killed, and the ruthless female secretary of defense, whose hatred for Garber knows no bounds. With his life and the honor of the military at stake, Martin has only twenty-four hours to uncover a legacy of secrets that no one wants brought to light -- secrets that the most powerful forces in Washington will kill to keep buried....
Dedicated to the late Juan Carlos Simo, this volume contains the proceedings of a workshop held at the Fields Institute in October 1993. The articles focus on current algorithms for the integration of mechanical systems, from systems in celestial mechanics to coupled rigid bodies to fluid mechanics. The scope of the articles ranges from symplectic integration methods to energy-momentum methods and related themes.
Complexity is an intrinsic property of natural systems. In the oceanic system, it is linked to many interactions with the atmosphere, geosphere and biosphere with which it exchanges energy and matter. Complexity of the ocean system has, at different spatial and temporal scales, hydrodynamic mechanisms of these exchanges and dynamics of elements and compounds, they are involved in biogeochemical cycles or used as tracers. By its pedagogical approach, it defines the terms, methods, techniques and analytical tools used. Then, it analyzes the consequences of climate change, future projections, human impact and the concept introduced with planktonic pelagic ecosystem component.
This Georgia Rising is a study of Georgia's political changes in the decade of the Second World War and in the postwar years of the 1940s. Georgia's political establishment underwent challenges in the 1940s in everything from Georgians defending the state's university system from attacks by Governor Eugene Talmadge to challenges by Georgia's larger cities and towns to the state's county unit system to the early postwar stirrings of the modern civil rights movement. An array of progressive forces--including Georgia's veterans of the Second World War, college and university students, newspaper editors and reporters in the state's larger circulating newspapers and smaller town newspapers--fought for change in some of the state's political institutions, culminating in the 1942 election of Governor Ellis Arnall and in 1945 the changes to the state constitution. This Georgia Rising is a detailed study of the gubernatorial races of the 1940s as they are interwoven with the larger political and social changes of wartime and then postwar Georgia. This book draws not only from Georgia's larger circulation newspapers but also focuses on its smaller circulation newspapers and especially its African-American newspapers, including The Atlanta Daily World and The Savannah Tribune. This Georgia Rising offers a detailed and rich narrative of a decade of far-reaching change in twentieth-century Georgia. --Publisher description.
Evidence-Based Practice of Critical Care, 2nd Edition, presents objective data and expert guidance on managing critically ill patients in unique question-based chapters that focus on best practices. Now thoroughly updated by Drs. Clifford S. Deutschman, Patrick J. Neligan, and nearly 200 critical-care experts, this highly regarded title remains the only book of its kind that provides a comprehensive framework for translating evidence into practice, making it a valuable resource for both residents and practitioners. Tap into the expertise of nearly 200 critical-care experts who discuss the wide variety of clinical options in critical care, examine the relevant research, and provide recommendations based on a thorough analysis of available evidence. Think through each question in a logical, efficient manner, using a practical, consistent approach to available management options and guidelines. Find the information you need quickly with tables that summarize the available literature and recommended clinical approaches. Navigate a full range of challenges from routine care to complicated and special situations. Stay up to date with new issues and controversies such as the redefinition of sepsis . changing approaches to fluid administration . immune suppression in sepsis . monitoring the microcirculation . the long-term sequelae of critical illness . minimizing ventilator associated lung injury . the benefits of evidence-based medicine management guidelines . rapid response teams . and more. Benefit from all-new sections covering persistent critical illness and the role of advanced practice nurses and physician assistants in the ICU.
The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. - Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders - Describes the clinical background and underlying molecular processes for Alzheimer's disease, Parkinson's, Prion, Motor Neuron, Huntington's, and Multiple Sclerosis - Highlights the state-of-the-art treatment options for each disorder - Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models
Meeting the need for a textbook for classroom use after first year Hebrew grammar, Waltke and O'Connor integrate the results of modern linguistic study of Hebrew and years of experience teaching the subject in this book. In addition to functioning as a teaching grammar, this work will also be widely used for reference and self-guided instruction in Hebrew beyond the first formal year. Extensive discussion and explanation of grammatical points help to sort out points blurred in introductory books. More than 3,500 Biblical Hebrew examples illustrate the points of grammar under discussion. Four indexes (Scripture, Authorities cited, Hebrew words, and Topics) provide ready access to the vast array of information found in the 40 chapters. Destined to become a classic work, this long-awaited book fills a major gap among modern publications on Biblical Hebrew.
Topically organized, Adult Development and Aging: Growth, Longevity and Challenges provides students with a comprehensive understanding of the aging process in adulthood from multiple perspectives. The authors use principles of lifespan development to show readers the directionality of changes in early, middle, and late adulthood. Within its framework of scientific literacy, the text charts four key themes to guide learners: a focus on aging as development; a global perspective on contexts; a vibrant, integrated approach to diverse coverage; and psychological science that translates into real-life experiences. A final chapter focuses on ways to improve the experience of aging for all adults. Included with this title: The password-protected Instructor Resource Site (formally known as SAGE Edge) offers access to all text-specific resources, including a test bank and editable, chapter-specific PowerPoint® slides.
This new edition of Evaluation and Treatment of Myopathies is written for the clinician who sees patients with muscle disease, or the patient with complaints of pain or weakness of muscle. Like the original, this new edition is divided in to 3 primary sections: Approach to the Patient with Muscle Disease, Specific Myopathies, and General Strategies of Clinical Management, each section providing practical guidance to eliciting key histories and demonstrate findings upon examination. This new edition also provides guidance on the next steps in diagnoses as well as the latest information on pathogenesis, diagnosis, and treatment, in an integrated manner, so as to give trainees, practicing clinicians and others who see neuromuscular disease perspective on how to evaluate and care for patients. New and revised tables, figures, and references are selected and organized to present information of clinical importance to provide the most up-to-date resource on the myopathies.
Aphasia and Related Neurogenic Communication Disorders is designed for the graduate course on Aphasia. Part 1 of the textbook covers aphasiology, while part 2 addresses related disorders. Overall, the textbook offers an overview of aphasia and related neurogenic communication disorders by presenting important recent advances and clinically relevant information. It emphasizes Evidence Based Practice by critically reviewing the pertinent literature and its relevance for best clinical practices. Case studies in all clinical chapters illustrate key topics, and a "Future Directions" section in each chapter provides insight on where the field may be headed. The WHO ICF Framework is introduced in the beginning of the text and then reinforced and infused throughout"--
This book covers important biological, immunological, and molecular information essential for understanding the rationale and results of experiments and clinical observations on cell-cell and cell substrate adhesion; hydrolytic activities, cell motility; immunological and other host elements of the host-tumor ecosystem (at different sites of the metastic process); genetic and epigenetic elements of the acquisition and the expression of invasive phenotypes. 38 tables and 60 computer-drawn figures provide comprehensive overviews, and a methodological chapter emphasizing the differences and similarities between assays and their relevance for natural situations has also been included. Clinical and experimental cancer researchers, as well as as post-graduate students interested in cancer research, will find this book to be an indispensable reference resource.
Evidence-Based Practice of Critical Care, 2nd Edition, presents objective data and expert guidance on managing critically ill patients in unique question-based chapters that focus on best practices. Now thoroughly updated by Drs. Clifford S. Deutschman, Patrick J. Neligan, and nearly 200 critical-care experts, this highly regarded title remains the only book of its kind that provides a comprehensive framework for translating evidence into practice, making it a valuable resource for both residents and practitioners. Tap into the expertise of nearly 200 critical-care experts who discuss the wide variety of clinical options in critical care, examine the relevant research, and provide recommendations based on a thorough analysis of available evidence. Think through each question in a logical, efficient manner, using a practical, consistent approach to available management options and guidelines. Find the information you need quickly with tables that summarize the available literature and recommended clinical approaches. Navigate a full range of challenges from routine care to complicated and special situations. Stay up to date with new issues and controversies such as the redefinition of sepsis • changing approaches to fluid administration • immune suppression in sepsis • monitoring the microcirculation • the long-term sequelae of critical illness • minimizing ventilator associated lung injury • the benefits of evidence-based medicine management guidelines • rapid response teams • and more. Benefit from all-new sections covering persistent critical illness and the role of advanced practice nurses and physician assistants in the ICU.
Based on graduate lectures given by the authors, Smectic and Columnar Liquid Crystals: Concepts and Physical Properties Illustrated by Experiments examines lamellar (smectic) and columnar liquid crystals, which, in addition to orientational order, possess 1D, 2D or 3D positional order. Topics include rheology and plasticity, ferroelectricity, analogies with superconductors, hexatic order and 2D-melting, equilibrium shapes, facetting, and the Mullins-Sekerka instability, as well as phase transitions in free films and membrane vibrations. Nematic and cholesteric liquid crystals are covered by the authors in a separate volume entitled Nematic and Cholesteric Liquid Crystals: Concepts and Physical Properties Illustrated by Experiments.
The age of Elizabeth I exercises a fascination unmatched by other periods of English history. Yet while the leading figures may seem familiar, many Elizabethan personalities, including the queen herself, remain enigmatic; their attitudes to life, politics and religion often difficult to comprehend. Patrick Collinson redraws the main features of the political and religious struggle of the reign. In engaging with the virgin queen herself he tackles the old conundrum: was she a religious woman? He also investigates the no less inscrutable religious position adopted by the by the notorious turncoat, Andrew Perne, the reliability as a historian of the martyrologist John Foxe (whose religion is in no doubt) and the religious environment which shaped William Shakespeare.
Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The unique orientation to pharmacotherapy found in the landmark Pharmacotherapy: A Pathophysiologic Approach distilled to a concise clinically focused full-color resource Pharmacotherapy Principles & Practice, Fifth Edition uses a solid evidence-based approach to teach readers how to design, implement, monitor, and evaluate medication therapy. This trusted text provides everything readers need to gain an in-depth understanding of the underlying principles of the pharmacotherapy of disease―and their practical application. In order to be as clinically relevant as possible, the disease states and treatments discussed focus on disorders most often seen in clinical practice, and laboratory values are expressed as both conventional units and SI units. Importantly, all chapters were written or reviewed by pharmacists, nurse practitioners, physician assistants, and physicians widely recognized as authorities in their fields. The Fifth Edition begins with an insightful introductory chapter, followed by chapters on geriatrics, pediatrics, and palliative care. Each of the subsequent 98 disease-based chapters cover disease epidemiology, etiology, pathophysiology, clinical presentation and diagnosis, nonpharmacologic therapy, followed by therapeutic recommendations for medication selection, desired outcomes, dosing, and patient monitoring. Features: • The acclaimed patient encounter cases sharpen critical thinking skills and lend clinical relevance to scientific principles • Chapter-opening structured learning objectives enable you to rapidly locate related content • Icon-identified key concepts highlight the disease, patient assessment, and treatment • A newly designed patient care process section models the Joint Commission of Pharmacy Practitioners (JCPP) Pharmacists’ Patient Care Process • Up-to-date literature citations support treatment recommendations • Tables, figures, algorithms, and defined medical abbreviations reinforce comprehension throughout • Includes valuable table of common laboratory tests and reference ranges
Viability theory designs and develops mathematical and algorithmic methods for investigating the adaptation to viability constraints of evolutions governed by complex systems under uncertainty that are found in many domains involving living beings, from biological evolution to economics, from environmental sciences to financial markets, from control theory and robotics to cognitive sciences. It involves interdisciplinary investigations spanning fields that have traditionally developed in isolation. The purpose of this book is to present an initiation to applications of viability theory, explaining and motivating the main concepts and illustrating them with numerous numerical examples taken from various fields.
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