Neuro-Oncology-a new title in the Blue Books of Practical Neurology series-is a concise and clinically applicable guide to this dynamic subspecialty. Jeremy Rees, PhD, MRCP and Patrick Y. Wen, MD present the most current information on the treatment and management of primary CNS tumors, secondary brain tumors, and the neurological complications of other cancers and their therapies in a format and scope appealing to both the general neurologist and the subspecialist. Access comprehensive coverage of treatment for adult and pediatric conditions-including tumors of the spinal cord as well as the brain. Find coverage of recent advances easily thanks to the emphasis on the latest clinical and laboratory findings and their implications for clinical management and treatment. Apply the possibilities and outcomes of neuro-oncologic surgery within the context of neurologic practice. Address the neurologic complications of cancer and its treatment as well as of primary and secondary tumors. Tap into the global perspectives of experts from all around the world for a multi-disciplinary approach to practice.
The main purpose of this paper is to contribute to the discussion about the design of computer and communication systems that can aid the management process. 1.1 Historical Overview We propose that Decision Support System can be considered as a design conception conceived within the computer industry to facilitate the use of computer technology in organisations (Keen, 1991). This framework, built during the late 1970s, offers computer and communication technology as support to the decision process which constitutes, in this view, the core of the management process. The DSS framework offers the following capabilities: • Access: ease of use, wide variety of data, analysis and modelling capacity. • Technological: software gel)eration tools. • Development modes: interactive and evolutionary. Within this perspective, computer and communication technologies are seen as an amplification of the human data processing capabilities which limit the decision process. Thus, the human being is understood metaphorically as a data processing machine. Mental processes are associated with the manipulation of symbols aOO human communication to signal transmission.
Drawing on his vast knowledge and direct experience of most of the key events in astronomy and space exploration during this century, Patrick Moore takes a sideways look at the historical reports and contemporary thought behind a wide range of astronomical topics. The Wandering Astronomer presents his personal accounts of the towering characters of 20th-century astronomy, intriguing facts about puzzling astronomical phenomena, and amusing stories about the quirkier side of astronomy and space exploration. This collection of essays covers everything from the case of vanishing planets to UFOs over Selsey. Entertaining and informative, it will be enjoyable reading for both seasoned and amateur astronomers as well as general science readers. About the Author Author and broadcaster Patrick Moore is a lunar specialist who makes observations from his home in Selsey on most clear nights. He has written more than 100 books, and for the past 43 years he has presented BBC TV's Sky at Night program without missing a single episode. Moore served in the RAF during WWII and has been involved in astronomy since he was a boy. In 1967 he was awarded the OBE for his services to astronomy, and in 1988 he received the CBE. He also recently received a knighthood in the New Years Honours list.
Introductory textbook using the entire range of tropical ecosystems - terrestrial, freshwater and marine - to illustrate and explain major ecological concepts.
A richly illustrated account of the story of ancient viniculture The history of civilization is, in many ways, the history of wine. This book is the first comprehensive account of the earliest stages of the history and prehistory of viniculture, which extends back into the Neolithic period and beyond. Elegantly written and richly illustrated, Ancient Wine opens up whole new chapters in the fascinating story of wine by drawing on recent archaeological discoveries, molecular and DNA sleuthing, and the writings and art of ancient peoples. In a new afterword, the author discusses exciting recent developments in the understanding of ancient wine, including a new theory of how viniculture came to central and northern Europe.
Perspectives in Life Cycle Impact Assessment: A Structured Approach to Combine Models of the Technosphere, Ecosphere, and Valuesphere presents a proposal for a second generation framework and method for Life Cycle Impact Assessment. Many of the suggested elements are either based on other tools for environmental analysis, e.g. risk assessment, or fit in well with tools and concepts such as industrial ecology, technology assessment, or environmental impact assessment. The research presented in this book goes beyond the scope of presently used methods for Life Cycle Assessment and may stimulate new developments in a variety of areas.
In this innovative comparison of Gadamer and Wittgenstein, the author explores their common concern with the relation of language to reality. Patrick Horn's starting point is the widely accepted view that both philosophers rejected a certain metaphysical account of that relation in which reality determines the nature of language. Horn proceeds to argue that Gadamer never completely escaped metaphysical assumptions in his search for the unity of language. In this respect, argues Horn, Gadamer's work is nearer to the earlier rather than to the later Wittgenstein. The final chapter of the book highlights the work of Wittgenstein’s pupil Rush Rhees, who shows that Wittgenstein's own later emphasis on language games, while doing justice to the variety of language, does less than justice to the dialogical relation between speakers of a language, wherein the unity of language resides. Contrasting Rhees's account of the unity of language with those given by Gadamer and the early Wittgenstein brings out the importance of understanding reality in terms of the life that people share rather than in terms of what philosophers say about reality.
Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology. Provides coverage of gene therapy for a variety of infections, including HBV, HCV, HIV, hemorrhagic fever viruses, and respiratory and other viral infections Bridges the gap between the basic science and the important medical applications of this technology Features a broad approach to the topic, including an essential overview and the applications of gene therapy, synthetic RNA, and other antiviral strategies that involve nucleic acid engineering Presents perspectives on the future use of nucleic acids as a novel class of antiviral drugs Arms the reader with the cutting-edge information needed to stay abreast of this developing field
The First Detailed Account of Statistical Analysis That Treats Models as Approximations The idea of truth plays a role in both Bayesian and frequentist statistics. The Bayesian concept of coherence is based on the fact that two different models or parameter values cannot both be true. Frequentist statistics is formulated as the problem of estimating the "true but unknown" parameter value that generated the data. Forgoing any concept of truth, Data Analysis and Approximate Models: Model Choice, Location-Scale, Analysis of Variance, Nonparametric Regression and Image Analysis presents statistical analysis/inference based on approximate models. Developed by the author, this approach consistently treats models as approximations to data, not to some underlying truth. The author develops a concept of approximation for probability models with applications to: Discrete data Location scale Analysis of variance (ANOVA) Nonparametric regression, image analysis, and densities Time series Model choice The book first highlights problems with concepts such as likelihood and efficiency and covers the definition of approximation and its consequences. A chapter on discrete data then presents the total variation metric as well as the Kullback–Leibler and chi-squared discrepancies as measures of fit. After focusing on outliers, the book discusses the location-scale problem, including approximation intervals, and gives a new treatment of higher-way ANOVA. The next several chapters describe novel procedures of nonparametric regression based on approximation. The final chapter assesses a range of statistical topics, from the likelihood principle to asymptotics and model choice.
Evidence-Based Practice of Critical Care, 2nd Edition, presents objective data and expert guidance on managing critically ill patients in unique question-based chapters that focus on best practices. Now thoroughly updated by Drs. Clifford S. Deutschman, Patrick J. Neligan, and nearly 200 critical-care experts, this highly regarded title remains the only book of its kind that provides a comprehensive framework for translating evidence into practice, making it a valuable resource for both residents and practitioners. Tap into the expertise of nearly 200 critical-care experts who discuss the wide variety of clinical options in critical care, examine the relevant research, and provide recommendations based on a thorough analysis of available evidence. Think through each question in a logical, efficient manner, using a practical, consistent approach to available management options and guidelines. Find the information you need quickly with tables that summarize the available literature and recommended clinical approaches. Navigate a full range of challenges from routine care to complicated and special situations. Stay up to date with new issues and controversies such as the redefinition of sepsis • changing approaches to fluid administration • immune suppression in sepsis • monitoring the microcirculation • the long-term sequelae of critical illness • minimizing ventilator associated lung injury • the benefits of evidence-based medicine management guidelines • rapid response teams • and more. Benefit from all-new sections covering persistent critical illness and the role of advanced practice nurses and physician assistants in the ICU.
List of Figures. List of Tables. List of Symbols. List of Country Acronyms. Foreword and Acknowledgements. I. The Transition Economies. II. Saving, by Plan and in the Market. III. Considering the Competing Explanations of Transition in Inflation and Economic Growth. IV. The Inflationary Explosion Following Price Liberalization. V. The Crisis Years. VI. Directed Credits and Financial Repression in Belarus. VII. Stabilization in Transition Economies. VIII. Ukraine in the Stabilization Phase. IX. Georgia: from Crisis to Stabilization .. and Then? X. The Fallout of the Russian Financial C.
Evidence-Based Practice of Critical Care, 2nd Edition, presents objective data and expert guidance on managing critically ill patients in unique question-based chapters that focus on best practices. Now thoroughly updated by Drs. Clifford S. Deutschman, Patrick J. Neligan, and nearly 200 critical-care experts, this highly regarded title remains the only book of its kind that provides a comprehensive framework for translating evidence into practice, making it a valuable resource for both residents and practitioners. Tap into the expertise of nearly 200 critical-care experts who discuss the wide variety of clinical options in critical care, examine the relevant research, and provide recommendations based on a thorough analysis of available evidence. Think through each question in a logical, efficient manner, using a practical, consistent approach to available management options and guidelines. Find the information you need quickly with tables that summarize the available literature and recommended clinical approaches. Navigate a full range of challenges from routine care to complicated and special situations. Stay up to date with new issues and controversies such as the redefinition of sepsis . changing approaches to fluid administration . immune suppression in sepsis . monitoring the microcirculation . the long-term sequelae of critical illness . minimizing ventilator associated lung injury . the benefits of evidence-based medicine management guidelines . rapid response teams . and more. Benefit from all-new sections covering persistent critical illness and the role of advanced practice nurses and physician assistants in the ICU.
This work describes the essential aspects of enantioselective catalysis, with chapters organised by concept rather than by reaction type. Each concept is supported by examples to give the reader broad exposure to a wide range of catalysts, reactions and reaction mechanisms.
Cooperation among humans is one of the keys to our great evolutionary success. This book examines this phenomena with a fusion of theoretical work on the evolution of cooperation, ethnographic descriptions of social behavior, and a range of other experimental results.
This book surveys the current knowledge concerning the expression and function of small stress proteins (sHsps) in different organisms, ranging from prokaryotes to humans. It provides an overview of the diversity and complex evolutionary history of sHsps and describes their function and expression in different eukaryote models. Additional chapters discuss the involvement of sHsps in pathological conditions and gene therapy approaches towards a control of sHsp expression levels.
Uneven Zimbabwe examines the influence of domestic and international financial markets and financiers in uneven development in Zimbabwe, using - and contributing to - the tools of radical political economy. Theoretically, Bond begins with criticism of the classical Marxist concepts of "finance capital" for focusing on institutional characteristics and failing to grasp underlying dynamics. Instead, as economic crisis tendencies emerge, the power of finance periodically intensifies, temporarily displacing crisis through time and space and across geographical scales. But the limits of the financial solution become evident when paper assets delink from the productive assets they are meant to represent, as well as in the role that finance plays in amplifying uneven development across different economic sectors, spaces and scales.
Neurologic side effects of cancer therapy can inhibit treatment, can be dose-limiting and can diminish quality-of-life. Neurotoxicity related to cancer therapy is a common problem in oncology practice and in clinical neurology. Recognition of neurologic complications of anticancer therapy is necessary due to potential confusion with metastatic disease, paraneoplastic syndromes or comorbid neurologic disorders that do not require reduction or discontinuation of therapy. Neurologic Complications of Cancer Therapy provides comprehensive coverage of the recognition and management of neurologic symptoms related to cancer therapy. The book includes sections on systemic therapy discussed by both agent and adverse event. The section on adverse events is particularly valuable to clinicians, allowing them to consult by symptom in cases where multiple agents have been administered and the source of the complication is uncertain. The systemic therapy section includes coverage of immunologic agents, biologics, and targeted therapies. The book also features sections on the complications of radiation therapy, complications of surgery and high-dose chemotherapy, and stem cell transplantation. Neurologic Complications of Cancer Therapy Features: A widely recognized team of editors Systemic therapy covered by therapeutic agent and by adverse event, enabling a "problem-oriented" approach for the clinician Coverage of newer modalities including immunologic agents, biologics, and targeted therapies Complete sections on complications of radiation therapy, surgery, high-dose chemotherapy, and stem-call transplantion
The nuclear shell model has had much success when describing nuclear structure. It is able to describe the single-particle states of nuclei, and gives understanding as to how nuclear structure evolves as the number of nucleons changes in a nucleus. This led to the discovery of the so-called magic numbers, which designate particularly stable configurations of protons and neutrons in nuclei. With the advent of radioactive ion beams, it has become possible to probe exotic nuclei to test current theories of nuclear structure. These investigations have led to the discovery of exotic nuclear phenomena, with structures different to those found in stable nuclei. One of these is the N=20 island of inversion, where configurations that appear in stable nuclei become less bound than more exotic particle-hole configurations across a shell gap. Another is the weakening of the magic N=20 shell gap to N=16 as the number of protons is reduced in this isotonic chain. Of particular interest are the magnesium isotopes, which exhibit a swift transition into the island of inversion with 29Mg lying outside and 31Mg lying inside. In addition, 29Mg lies one neutron outside N=16, so is also able to give insight on the weakening of the N=16 shell gap. Mapping this region of the chart of nuclides helps in the understanding of the evolution of this nuclear structure. A useful probe for this task is single-particle transfer reactions. However, these reactions have been hindered by low yields from radioactive ion beams, as well as suffering from kinematic effects that obscure the states that need to be observed. The ISOLDE Solenoidal Spectrometer (ISS), that measures these transfer reactions in a solenoidal magnetic field, was designed to counteract these effects. With the high-yield radioactive ion beams at ISOLDE, CERN, these transfer reactions became viable. Therefore, the nuclear structure of 29Mg was probed using the d(28Mg,p) reaction using this device. This work marks the first measurement using the ISOLDE Solenoidal spectrometer and the first time that a solenoidal spectrometer has been used at an ISOL radioactive beam facility. The measurements highlight the interplay of nucleon-nucleon interactions and the geometry of the nuclear potential in driving observed trends in single-particle structure, in particular the changes in closed shells towards doubly magic 24O
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