Written by experts in the field, this timely book presents the scientific principles behind neurology. It aims to take the reader from the human genome, through gene expression, to molecular and cellular pathology, and subsequently to contemporary clinical investigations and clinical trials. Each contribution includes a discussion about the future of the field and highlights areas of potential growth and their relevance to routine clinical practice over the next decade. The succinctly written chapters will be easily accessible to both neurologists and trainees who have no expertise in the area.
This delightfully eclectic book, part comedy, part travelogue, and part cultural history, uncovers the story of the British delegations that were invited to China in 1954 - a full eighteen years before President Nixon's more famous 1972 mission.
This new edition of Evaluation and Treatment of Myopathies is written for the clinician who sees patients with muscle disease, or the patient with complaints of pain or weakness of muscle. Like the original, this new edition is divided in to 3 primary sections: Approach to the Patient with Muscle Disease, Specific Myopathies, and General Strategies of Clinical Management, each section providing practical guidance to eliciting key histories and demonstrate findings upon examination. This new edition also provides guidance on the next steps in diagnoses as well as the latest information on pathogenesis, diagnosis, and treatment, in an integrated manner, so as to give trainees, practicing clinicians and others who see neuromuscular disease perspective on how to evaluate and care for patients. New and revised tables, figures, and references are selected and organized to present information of clinical importance to provide the most up-to-date resource on the myopathies.
It has often been said that the nineteenth century was a relatively stagnant period for Chinese fiction, but preeminent scholar Patrick Hanan shows that the opposite is true: the finest novels of the nineteenth century show a constant experimentation and evolution. In this collection of detailed and insightful essays, Hanan examines Chinese fiction before and during the period in which Chinese writers first came into contact with western fiction. Hanan explores the uses made of fiction by westerners in China; the adaptation and integration of western methods in Chinese fiction; and the continued vitality of the Chinese fictional tradition. Some western missionaries, for example, wrote religious novels in Chinese, almost always with the aid of native assistants who tended to change aspects of the work to "fit" Chinese taste. Later, such works as Washington Irving's "Rip Van Winkle," Jonathan Swift's "A Voyage to Lilliput," the novels of Jules Verne, and French detective stories were translated into Chinese. These interventions and their effects are explored here for virtually the first time.
A “hard to solve and easy to read” mystery from the Edgar Award–winning author of the Peter Duluth series (Kirkus Reviews). Patrick Quentin, best known for the Peter Duluth puzzle mysteries, also penned outstanding detective novels from the 1930s through the 1960s under other pseudonyms, including Q. Patrick and Jonathan Stagge. Anthony Boucher wrote: “Quentin is particularly noted for the enviable polish and grace which make him one of the leading American fabricants of the murderous comedy of manners; but this surface smoothness conceals intricate and meticulous plot construction as faultless as that of Agatha Christie.” Lewis Denham has always been the black sheep of the family. Adopted into the “proper” Denham household after his working-class parents died, Lew never quite fit in with the rest of the clan—or maybe he simply couldn’t keep his nose elevated that high for that long without getting frostbite. Either way, when he announces his marriage to a British girl without checking how blue her blood is, the family is aghast. But things become truly appalling when Lew finds a dead man in his apartment—and it seems the lower-class victim had a connection with his upper-crust family. Now, feeling more outside the Denham ranks than ever, Lew will have to look past his family’s elite façade and find out who they really are. And he’s about to learn that none of them are too good to get a little blood on their hands . . .
In family rooms across America, millions of children and teenagers are playing video games, such as Call of Duty, Halo, and Grand Theft Auto, roaming violent virtual worlds—with virtual guns in their hands. In what sometimes seems like an increasingly violent world, it's only natural to worry about the effects of all this pixelated gore. But is that concern misplaced? Authors and psychologists Patrick M. Markey and Christopher J. Ferguson say it is. The media and politicians have been sounding the alarm for years, and with every fresh tragedy involving a young perpetrator comes another flurry of articles about the dangers of violent media. The problem is this: Their fear isn't supported by the evidence. In fact, unlike the video game–trained murder machines depicted in the press, school shooters are actually less likely to be interested in violent games than their peers. In reality, most well-adjusted children and teenagers play violent video games, all without ever exhibiting violent behavior in real life. What's more, spikes in sales of violent games actually correspond to decreased rates of violent crime. If that surprises you, you're not alone—the national dialogue on games and violence has been hopelessly biased. But that's beginning to change. Scholars are finding that not only are violent games not one of society's great evils, they may even be a force for good. In Moral Combat, Markey and Ferguson explore how video games—even the bloodiest—can have a positive impact on everything from social skills to stress, and may even make us more morally sensitive. Tracing the rise of violent games from arcades to online deathmatches, they have spent years on the front lines of the video game debate and now offer a comprehensive overview of the scientific research on gaming. With humor, complete honesty, and extensive research, they separate the myth from the medium. Moral Combat is an irreverent and informative guide to the worries—and wonders—of our violent virtual world.
The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. - Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders - Describes the clinical background and underlying molecular processes for Alzheimer's disease, Parkinson's, Prion, Motor Neuron, Huntington's, and Multiple Sclerosis - Highlights the state-of-the-art treatment options for each disorder - Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models
From the mid-eighteenth century onwards, British women started traveling in any numbers to the East Indies, mostly to accompany husbands, brothers or fathers. Very little about them is recorded from the earlier years, about the remarkable journeys that they made and what drove them to travel those huge distances. Some kept journals, others wrote letters, and for the first time Patrick Wheeler tells their story in this fascinating and colorful history, exploring the little-known lives of these women and their experiences of life in India before the Raj.With a perceptive approach, Ribbons Among the Rajahs considers all aspects of women's lives in India, from the original discomfort of traversing the globe and the complexities of arrival through to creating a home in a tight-knight settlement community. It considers, too, the effects of the subservience of women to the needs of men and argues for the greater fusion of European cultures that existed prior to imperial times.
In this gripping behind-the-scenes account, acclaimed journalist Aaron Patrick examines how the Coalition came back from the brink, and what that means for Australia. Disunity is said to be death in politics – but not for Scott Morrison’s Liberal Party. The Surprise Party tells how Morrison and his team took their chance and won a remarkable victory. Patrick interviews key insiders to reveal the turning points and the cunning schemes. What did Shorten’s Labor get so wrong? How good is Morrison at plotting? When did the Coalition realise they might win? And is chaos behind them now, or is there more to come? This is the pacy story of how politics was turned on its head – several times.
This book highlights the field of youth mental health and why it is a specialty distinct from both child and adolescent and adult mental health. Youth Mental Health: Approaches to Emerging Mental Ill-Health in Young People examines issues such as mental health literacy, e-Health, family, psychological, vocational and pharmacological interventions. The authors also discuss issues that are particularly pertinent to young people, such as suicidality, substance abuse, gender identity and sexuality, attention deficit disorder and eating disorders. Taking a preventative focus, this book presents evidence for youth mental health as an important and growing field, makes the case for the reform of existing service structures to better serve this group and outlines the latest specialised approaches to treatment. Drawing on the knowledge and expertise of leading thinkers in youth mental health, this book is instrumental for mental health professionals who wish to design new specialised mental health systems for young people.
Genetics and Genomics in Medicine is a new textbook written for undergraduate students, graduate students, and medical researchers that explains the science behind the uses of genetics and genomics in medicine today. Rather than focusing narrowly on rare inherited and chromosomal disorders, it is a comprehensive and integrated account of how geneti
Genetics and Genomics in Medicine is a new textbook written for undergraduate students, graduate students, and medical researchers that explains the science behind the uses of genetics and genomics in medicine today. Rather than focusing narrowly on rare inherited and chromosomal disorders, it is a comprehensive and integrated account of how geneti
This new edition of Evaluation and Treatment of Myopathies is written for the clinician who sees patients with muscle disease, or the patient with complaints of pain or weakness of muscle. Like the original, this new edition is divided in to 3 primary sections: Approach to the Patient with Muscle Disease, Specific Myopathies, and General Strategies of Clinical Management, each section providing practical guidance to eliciting key histories and demonstrate findings upon examination. This new edition also provides guidance on the next steps in diagnoses as well as the latest information on pathogenesis, diagnosis, and treatment, in an integrated manner, so as to give trainees, practicing clinicians and others who see neuromuscular disease perspective on how to evaluate and care for patients. New and revised tables, figures, and references are selected and organized to present information of clinical importance to provide the most up-to-date resource on the myopathies.
At his best, George Chinnery was a splendid artist. For a living he painted portraits of swaggering lieutenants, hoary governors and their beribboned wives, American sea-captains, and Chinese and Parsi merchants. George Chinnery immersed himself in these
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