After reviewing the mechanisms of androgen action, we will look at the main clinical features of androgen insensitivity, as well as the biological, cellular, and molecular tools used to investigate the AR. Numerous AR mutations have been described over the past 20 years. We will consider the challenges for diagnosis and prognosis by examining the genotype–phenotype relationship and the possibility of somatic mutations. Last, we will address the role of genetic counseling and the elements that should be taken into account for the difficult decision of sex assignment in children affected with AIS.
There is one fundamental thing that has changed in our societies since 1950: life has got longer. Over the last few generations, 20 or 30 years have been added to the duration of our lives. But after the age of 50, human beings experience a kind of suspension: no longer young, not really old, they are, as it were, weightless. It is a reprieve that leaves life open like a swinging door. The increase in life expectancy is a tremendous step forward that upsets everything: relations between generations, patterns of family life, the very meaning of our identity and our destiny. This reprieve is both exciting and frightening. The deadlines are getting shorter, the possibilities are shrinking, but there are still discoveries, surprises and upsetting love affairs. Time has become a paradoxical ally: instead of killing us, it carries us forward. What to do with this ambiguous gift? Is it only a question of living longer or living more intensely? To continue along the same path or to branch out and start again? What about remarriage, a new career? How to avoid the weariness of living, the melancholy of the twilight years, how to get through great joys and great pains? Nourished by both reflections and statistics, drawing on the sources of literature, the arts and history, this book proposes a philosophy of longevity based not on resignation but on resolution. In short, an art of living this life to the full. Is there not a profound joy in being alive at the age when our ancestors already had one foot in the grave? This book is dedicated to all those who dream of a new spring in the autumn of life, and want to put off winter as long as they can.
After reviewing the mechanisms of androgen action, we will look at the main clinical features of androgen insensitivity, as well as the biological, cellular, and molecular tools used to investigate the AR. Numerous AR mutations have been described over the past 20 years. We will consider the challenges for diagnosis and prognosis by examining the genotype–phenotype relationship and the possibility of somatic mutations. Last, we will address the role of genetic counseling and the elements that should be taken into account for the difficult decision of sex assignment in children affected with AIS.
The exhibition at the Dahesh Museum that the publication of this book celebrates is the first in a century to feature Dagnan Bouveret's work. Against the Modern pays special attention to the evolution of this artist's style and subject matter and brings to the public gaze the real diversity, accessibility - and surprising modernity - that has made Dagnan-Bouveret worthy of our attention today."--BOOK JACKET.
The effects of the French Revolution reached far beyond the confines of France itself. The Ottoman Empire, ancient ally and major trading partner of France, was not immune from the repercussions of the 'Age of Revolutions', especially since it was home to permanent French communities with a certain legal autonomy. French Revolutionaries in the Ottoman Empire examines, for the first time, the political and cultural impact of the French Revolution on Franco-Ottoman relations, as well as on the French communities of the Ottoman Empire. The modern interpretation of revolutionary ideological expansionism is strongly influenced by the famous propaganda decree of 19 November 1792 which promised 'fraternity and help to all peoples who wish to recover their liberty', as well as the well-studied efforts to export the Revolution into the territories conquered by the revolutionary armies and to the various Sister Republics. Against all expectations, however, French revolutionaries in the Ottoman Empire exhibited neither a 'crusading mentality' nor a heightened readiness to use force in order to achieve ideological goals. Instead, as this volume shows, in matters of diplomacy as well as in the administration of French expatriate communities, revolutionary policies were applied in an extremely circumspect fashion. The focus on the effects of the French regime change outside of France offers valuable new insights into the revolutionary process itself, which will revise common assumptions about French revolutionary diplomacy. In addition, Pascal Firges takes a close look at the establishment of the new political culture of the French Revolution within the transcultural context of the French expatriate communities of the Ottoman Empire, which serves as a thought-provoking point of comparison for the emergence and development of French revolutionary political culture.
Originally published in France in 2012, Pascal Mégeau's definitive biography of legendary film director Jean Renoir is a landmark work-the winner of a Prix Goncourt, France's top literary achievement. Now available in the English language for the first time, Jean Renoir: A Biography, is the definitive study of one of the most fascinating and creative artistic figures of the twentieth century. The French filmmaker made more than forty films from the silent era to the late '60s and today he is revered by filmmakers and seen by many as one of the greatest of all time. Renoir made acclaimed movies in France, America, India, and Italy and became a writer during the last part of his life. An estimated 75 percent of the book details previously unknown information about the filmmaker, including Renoir's close affiliation with Communism in the '30s (when he was the Party's official director) and his work with the fascist regimes during World War II; his previously uncredited Hollywood film, The Amazing Mrs. Holiday; and new information on the making of his most famous films. Drawing from unpublished or little known sources, this biography is a completely fresh approach to the maker of Grand Illusion and The Rules of the Game, redefining the very function of the movie director and simultaneously recounting the history of a century.
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