Paolo Zatta's Books

Metal Ions and Neurodegenerative Disorders

By: Paolo Zatta

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Metal Ions and Neurodegenerative Disorders

By: Paolo Zatta

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Page Count

538

Publisher

World Scientific

Published Date

ISBN 10

9812383980

ISBN 13

9789812383983

Aluminium Toxicity in Infants' Health and Disease

By: Paolo Zatta,Allen C. Alfrey

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Aluminium Toxicity in Infants' Health and Disease

By: Paolo Zatta,Allen C. Alfrey

Aluminium is the most abundant metal ion in the biosphere and we are continuously exposed to it in our everyday life through food, beverages, pharmaceutical products, etc. This book is a current and comprehensive review of the biochemistry, metabolism and toxicity of aluminium undertaken by an international group of authors, many of whom are outstanding authorities in their respective fields. In contrast with previous books on this topic, much of the subject matter is unique, in that it is primarily directed at aluminium nutrition and toxicity in infants and children. This book covers many aspects of aluminium toxicity in infants including for instance the embryo-fetal as well as the neurodevelopmental effects of this element, contamination of pharmaceutical products, and individual sensitivity through vaccines using aluminium as an adjuvant.This book will be especially useful to paediatricians, paediatric nephrologists & neurologists, nutritionists, toxicologists, biochemical toxicologists and postgraduate students.

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Page Count

270

Publisher

World Scientific

Published Date

ISBN 10

9810229143

ISBN 13

9789810229146

Non-neuronal Cells in Alzheimer's Disease

By: Paolo Zatta,Marino Nicolini

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Non-neuronal Cells in Alzheimer's Disease

By: Paolo Zatta,Marino Nicolini

Alzheimer's disease (AD) is a devastating pathology of the central nervous system (CNS) of unknown etiology which represents the most common neurodegenerative disorder. AD is the major cause of senile dementia, affecting approximately 5% of the population over 70. This syndrome is characterized by loss of short-term memory and progressive impairment of intellectual functions. No established therapeutic strategy has been found so far.Until recently, much of the literature on AD discussed the effects of this syndrome on the CNS. In the last few years, however, a large amount of information has appeared which underscored the importance of studying AD from other perspectives with the view of identifying reliable biological markers. The amyloid precursor proteins (APPs), for instance, constitute a complex family of membrane-bound and soluble glycoproteins that are derived by alternative splicing of a gene on chromosome 21. In the hemopoietic system, APPs have been detected in a number of cell types, such as leukocytes, megakaryocytes and platelets. In addition plasma contains picomolar concentrations of APP isoforms most likely derived from platelets. Abnormalities were also detected in the electrophoretic profile of erythrocytic membranes from AD patients. Numerous abnormalities have been proposed as peripheral markers for AD and several laboratories around the world are deeply involved in this challenging research.This book provides up-to-date information, as review chapters, on non-neuronal cells, with the aim of stimulating the formulation of potential diagnostic-therapeutic strategies.

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Page Count

257

Publisher

World Scientific

Published Date

ISBN 10

9810220928

ISBN 13

9789810220921

Metallothioneins in Biochemistry and Pathology

By: Paolo Zatta

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Metallothioneins in Biochemistry and Pathology

By: Paolo Zatta

Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer's and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events.

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Page Count

335

Publisher

World Scientific

Published Date

ISBN 10

9812778942

ISBN 13

9789812778949

Minority Language Planning and Micronationalism in Italy

An Analysis of the Situation of Friulian, Cimbrian and Western Lombard with Reference to Spanish Minority Languages

By: Paolo Coluzzi

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Minority Language Planning and Micronationalism in Italy

An Analysis of the Situation of Friulian, Cimbrian and Western Lombard with Reference to Spanish Minority Languages

By: Paolo Coluzzi

Issues of language planning and minority nationalism or «micronationalism» are becoming increasingly important in a globalized world. Yet minority language planning in Italy and its relation to minority nationalism has so far attracted relatively limited academic attention, despite the particularly interesting changes that have taken place since Law 482 on the protection of minority languages was passed in 1999. This book presents the situation in Italy in three case studies and compares them with similar cases in Spain: Friulian (compared with Galician), Cimbrian (compared with Aranese) and Western Lombard (compared with Asturian). Analysis of these case studies is preceded by a clear and thorough introduction to terminology, legislation in the two countries, nationalism, the discipline of language planning and bilingual education, both in general terms and with specific reference to the Italian and Spanish cases. This first part introduces and defines the crucial distinction between minority and regional languages, between macro and micronationalism, both in their conservative and progressive strands, and between majority and minority language planning, among other things.

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Page Count

356

Publisher

Peter Lang

Published Date

ISBN 10

3039110411

ISBN 13

9783039110414

Metal Ions and Neurodegenerative Disorders

By: Paolo Zatta

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Metal Ions and Neurodegenerative Disorders

By: Paolo Zatta

Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer''s disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer''s, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena. Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on OC Metals and the Brain: From Neurochemistry to NeurodegenerationOCO (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa. This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy. Contents: Metal-Catalyzed Redox Activity in Neurodegenerative Disease (M A Taddeo et al.); Aluminum and Central Nervous System Morphology in Hemodialysis (E Reusche); Transition Metals, Oxidation, Lipoproteins, and Amyloid-: Major Players in Alzheimer''s Disease (A Kontush); Molecular Basis of Copper Transport: Cellular and Physiological Functions of Menkes and Wilson Disease Proteins (ATP7A and ATP7B) (D R Kramer et al.); Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis (M B Yim et al.); Copper and Prion Disease (J Sasson & D Brown); Metallothioneins in Neurodegeneration (M Aschner et al.); Iron and Neurodegeneration (S L Grab & J R Connor); Iron, Neuromelanin, and -Synuclein in Neuropathogenesis of Parkinson''s Disease (K L Double et al.); Iron and Epilepsy (W-Y Ong et al.); Role of Iron Metabolism in Multiple Sclerosis (M J Kotze et al.); Neuroprotective Effects of Lithium (S Ermidiou-Pollet & S Pollet); and other articles. Readership: Academics, graduate students and researchers in neurology, psychiatry, neuroscience and environmental health.

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Page Count

546

Publisher

World Scientific

Published Date

ISBN 10

981279669X

ISBN 13

9789812796691

Aluminium Toxicity in Infants' Health and Disease

By: Paolo Zatta,Allen C. Alfrey

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Aluminium Toxicity in Infants' Health and Disease

By: Paolo Zatta,Allen C. Alfrey

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Solve jigsaw puzzle

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Page Count

270

Publisher

World Scientific

Published Date

ISBN 10

9810229143

ISBN 13

9789810229146

Book's by Paolo Zatta

Metal Ions and Neurodegenerative Disorders

Metal Ions and Neurodegenerative Disorders

Aluminium Toxicity in Infants' Health and Disease

Aluminium Toxicity in Infants' Health and Disease

Non-neuronal Cells in Alzheimer's Disease

Non-neuronal Cells in Alzheimer's Disease

Metallothioneins in Biochemistry and Pathology

Metallothioneins in Biochemistry and Pathology

Minority Language Planning and Micronationalism in Italy

Minority Language Planning and Micronationalism in Italy

Metal Ions and Neurodegenerative Disorders

Metal Ions and Neurodegenerative Disorders

Aluminium Toxicity in Infants' Health and Disease

Aluminium Toxicity in Infants' Health and Disease

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