CP violation is a well-established phenomenon in particle physics, but until 2001 it was only observed in kaons. In the last decade, several matter-antimatter asymmetries have been observed in neutral B mesons in line with the expectations of the Standard Model of the weak interaction. Direct CP violation is also expected in the decay rates of charged B+ mesons versus that of B- mesons, though the greatest effects are present in a decay that occurs just twice in 10 million decays. Such rarity requires huge samples to study and this is exactly what the LHC, and its dedicated B-physics experiment LHCb provide. This thesis presents an analysis of the first two years of LHCb data. The author describes the first observation of the rare decay, B- → DK-, D → π-K+ and the first observation of direct CP violation in this B decay. The work constitutes essential information on the experiment’s measurement of a fundamental parameter of the theory and stands as a benchmark against which subsequent analyses of this type will be compared.
This book aims to cast light on all aspects of tunnel fires, based on experimental activities and theoretical and computational fluid dynamics (CFD) analyses. In particular, the authors describe a transient full-scale fire test (~15 MW), explaining how they designed and performed the experimental activity inside the Morgex North tunnel in Italy. The entire organization of the experiment is described, from preliminary evaluations to the solutions found for management of operational difficulties and safety issues. This fire test allowed the collection of different measurements (temperature, air velocity, smoke composition, pollutant species) useful for validating and improving CFD codes and for testing the real behavior of the tunnel and its safety systems during a diesel oil fire with a significant heat release rate. Finally, the fire dynamics are compared with empirical correlations, CFD simulations, and literature measurements obtained in other similar tunnel fire tests. This book will be of interest to all engineers and public officials who are concerned with the nature, prevention, and management of tunnel fires.
I think this is an excellent book–I recommend it to anyone involved in molecular epidemiology... The 26 chapters are written by topic specialists, in an explanatory, east to read style." –BTS Newsletter, Summer 2009 "This text provides an accessible and useful handbook for the epidemiologist who wants to survey the field, to become better informed, to look at recent developments and get some background on these or simply to appreciate further the relatively rapid changes in informatic and analytical technologies which increasingly will serve and underpin future epidemiological studies. One of the strengths in this book is the extensive array of practical illustrative examples, and it would also in my opinion have useful potential as a teaching text." –American Journal of Human Biology, March 2009 With the sequencing of the human genome and the mapping of millions of single nucleotide polymorphisms, epidemiology has moved into the molecular domain. Scientists can now use molecular markers to track disease-associated genes in populations, enabling them to study complex chronic diseases that might result from the weak interactions of many genes with the environment. Use of these laboratory generated biomarker data and an understanding of disease mechanisms are increasingly important in elucidating disease aetiology. Molecular Epidemiology of Disease crosses the disciplinary boundaries between laboratory scientists, epidemiologists, clinical researchers and biostatisticians and is accessible to all these relevant research communities in focusing on practical issues of application, rather than reviews of current areas of research. Covers categories of biomarkers of exposure, susceptibility and disease Includes chapters on novel technologies: genomics, transcriptomics, proteomics and metabonomics, which are increasingly finding application in population studies Emphasizes new statistical and bioinformatics approaches necessitated by the large data sets generated using these new methodologies Demonstrates the potential applications of laboratory techniques in tackling epidemiological problems while considering their limitations, including the sources of uncertainty and inaccuracy Discusses issues such as reliability (compared to traditional epidemiological methods) and the timing of exposure Explores practical elements of conducting population studies, including biological repositories and ethics Molecular Epidemiology of Disease provides an easy-to-use, clearly presented handbook that allows epidemiologists to understand the specifics of research involving biomarkers, and laboratory scientists to understand the main issues of epidemiological study design and analysis. It also provides a useful tool for courses on molecular epidemiology, using many examples from population studies to illustrate key concepts and principles.
Grounded in more than a decade of field research, this book uses empirical examples, quantitative data, and qualitative interviews with young music consumers as well as music industry professionals to understand how the platforms behind music production, distribution and listening work in our digital society. Bringing together the perspectives from science and technology studies, media studies, and the political economy of digital platforms, the book outlines the process of mutual construction between music digital platforms and the cultural value of music in today’s society, and also reflects on the complicated relationship between the power of platforms and the agency of listeners.
Imaging in Endocrinology will provide endocrinologists and radiologists of all levels with an outstanding diagnostic imaging atlas to aid them in the diagnosis and management of all the major endocrine diseases they are likely to encounter. In full colour throughout, the 300 high-quality images consist of CT scans, MRI, NMR and histopathology slides, and are arranged by each specific endocrine condition, resulting in a visually outstanding and easily accessible tool that guides the user through exactly what to look out for and provides a practical and extremely useful aid in helping them formulate a diagnosis. Every major endocrine condition is covered in a specific section, including diseases of the thyroid, pituitary, reproductive and adrenal glands, the pancreas, bone metabolism problems, and the various forms of endocrine cancers. Each disease covered will offer a comparison of the normal findings so as to further assist in diagnosis. An accompanying website contains an online slide-atlas of all the figures in the book, to allow users to download all figures for use in presentations. Led by Paolo Pozzilli, an internationally-recognised expert in this field, the authors have assembled a wonderful collection of images that will be greatly valued by endocrinologists and radiologists alike, ensuring this is the perfect tool to consult when assessing patients with endocrine disease.
The goal we have set ourselves with this series of four volumes, written in four hands, is to give an overall picture of the Divisions formed by the Army of the R.S.I. to the departments used in the fight against the partisans by the Republican National Army, starting from the last months of 1943, offering a purely military point of view, free from judgments of any kind. The purpose of "continuing the war" had always been present since the beginning of autumn 1943 in the military authorities of the Social Republic. During talks between three Mussolini and Hitler it was agreed to form a new fascist army, which, in the intentions of the Fuhrer, was to be made up of an army of 10/15 divisions. In reality, only 4 were planned and formed by the Republican National Army: 1st Bersaglieri Division "Italy", 2nd Grenadiers Division "Littorio", 3rd Marine Division "San Marco", 4th Alpine Division "Monterosa". This first volume is dedicated to the Division “Italy”, which operated on the southern front in Garfagnana, against the Allies, until the end of the conflict.
This book covers the history of plastic surgery from the remarkable achievements of such ancient civilizations as India and Egypt up to the revolutionary techniques developed at the end of the Middle Age, the Renaissance and beyond. Coverage details how the knowledge of wound healing has changed and influenced plastic surgery, describes the development of various surgical reconstructive procedures and details the birth of Cosmetic Surgery.
This book illustrates a new quantitative risk analysis model for road tunnels that is capable of evaluating the role of infrastructure measures, equipment and management procedures as prescribed by EU Directive 2004/54/EC. The risk assessment draws on the typical F-N curves of societal risk, evaluated with the help of event tree analysis, vehicle queue formation dynamics, and users’ egress and tenability models. In addition, the model considers the reliability of the safety measures. The work provides essential guidance on the following aspects: how a quantitative model can be implemented to evaluate risk in road tunnels; how to build an event tree for the accident scenarios considered; how to simulate the vehicle queue formation; how to simulate the evolution of accident scenarios; and how to simulate the users’ egress. Given its scope and depth of coverage, the book will be of interest to all engineers whose work involves fire protection and safety in tunnels, all persons engaged in safety and transport engineering or risk analysis for road tunnels, as well as public and private bodies involved in the application of Directive 2004/54/EC.
A Quick Guide to Cancer Epidemiology is an ideal addition to Springer Briefs in Cancer Research. The Brief provides core concepts in cancer epidemiology and also gives a snapshot of the epidemiology of seventeen human cancers. The Brief aims to provide-with quantitative focus-estimates of the global burden of neoplasms, of recent and likely future trends, distribution, causes and strategies for prevention for major groups of cancers. Finally, the Brief will give an overview of severals factors that cause cancer including dietary factors, tobacco smoking, obesity and alcohol consumption.
In recent years, smartphones and digital platforms have become essential to our lives and are now inextricably interwoven into the everyday practices of millions, especially young people. Focusing on smartphone practices and experiences of youth today, this volume is the result of empirical research based on focus groups and in-depth interviews with young people aged 18-30. Grounded in media theory and analyzed through a blended lens of media and science and technology studies, the book offers detailed and fascinating insights into the everyday use of smartphones. Topics covered include the role of the smartphone as material technology, its use in interpersonal relationships, photographic practices, music and consumer practices, along with the deconstruction of the notion of smartphone ‘addiction’.
CP violation is a well-established phenomenon in particle physics, but until 2001 it was only observed in kaons. In the last decade, several matter-antimatter asymmetries have been observed in neutral B mesons in line with the expectations of the Standard Model of the weak interaction. Direct CP violation is also expected in the decay rates of charged B+ mesons versus that of B- mesons, though the greatest effects are present in a decay that occurs just twice in 10 million decays. Such rarity requires huge samples to study and this is exactly what the LHC, and its dedicated B-physics experiment LHCb provide. This thesis presents an analysis of the first two years of LHCb data. The author describes the first observation of the rare decay, B- → DK-, D → π-K+ and the first observation of direct CP violation in this B decay. The work constitutes essential information on the experiment’s measurement of a fundamental parameter of the theory and stands as a benchmark against which subsequent analyses of this type will be compared.
This book aims to cast light on all aspects of tunnel fires, based on experimental activities and theoretical and computational fluid dynamics (CFD) analyses. In particular, the authors describe a transient full-scale fire test (~15 MW), explaining how they designed and performed the experimental activity inside the Morgex North tunnel in Italy. The entire organization of the experiment is described, from preliminary evaluations to the solutions found for management of operational difficulties and safety issues. This fire test allowed the collection of different measurements (temperature, air velocity, smoke composition, pollutant species) useful for validating and improving CFD codes and for testing the real behavior of the tunnel and its safety systems during a diesel oil fire with a significant heat release rate. Finally, the fire dynamics are compared with empirical correlations, CFD simulations, and literature measurements obtained in other similar tunnel fire tests. This book will be of interest to all engineers and public officials who are concerned with the nature, prevention, and management of tunnel fires.
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