Meningitis is an uncommon but serious illness at any age, and during the first few weeks of life it poses a particular hazard with high mortality and a considerable risk to survivors of permanent damage to the developing brain. This book comprehensively reviews bacterial, fungal and viral forms of the illness. Epidemiology and comparisons of maternally and environmentally derived infections are included, along with a view of the developing brain and host defence mechanisms. A review of experimental bacterial meningitis is provided, together with a discussion of its relevance for clinical and laboratory diagnosis, and for antimicrobial and supportive management. Prospects for the future in terms of early diagnosis, management and prevention are also addressed. In its collation of material from such a wide range of literature sources, this is a vital reference for all clinicians with an interest in the problems of meningitis in early life.
Newly available in paperback, this landmark volume is the definitive study of the work of visionary American artist Nancy Holt (1938–2014). Since the late 1960s, Holt’s wide-ranging production has included Land art—particularly the monumental Sun Tunnels (1973–76)—as well as significant projects in sculpture, installation, photography, film, and video. A comprehensive representation of Holt’s working process in both word and image, Alena J. Williams’s momentous publication illuminates the artist’s interest in physical space and reveals how the geographic variety and boundlessness of the American landscape afforded her numerous opportunities to develop large-scale projects beyond the confines of New York City’s gallery walls. Contributions by a distinguished group of writers—including Pamela M. Lee, Lucy R. Lippard, Ines Schaber, and Matthew Coolidge—chart Holt’s fascinating trajectory from her initial experiments with sound, light, and industrial materials to major site interventions and environmental sculpture. James Meyer’s valuable interview with Holt and Julia Alderson’s illustrated chronology expand our knowledge of this groundbreaking artist and the crucial contexts in which she worked. More than twenty original writings by the artist and a rare selection of her concrete poetry, documentary photographs, and preparatory drawings reveal Holt’s revolutionary concepts of space, time, optics, and scale.
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