Designed as a text for students and professionals pursuing careers in the fields of molecular biology, pharmacy and bioinformatics, the fourth edition continues to offer a fascinating and authoritative treatment of the entire spectrum of bioinformatics, covering a wide range of high-throughput technologies. In this edition, four new chapters are included and two chapters are updated. As a student-friendly text, it embodies several pedagogic features such as detailed examples, chapter-end problems, numerous tables, a large number of diagrams, flow charts, a comprehensive glossary and an up-to-date bibliography. This book should prove an invaluable asset to students and researchers in the fields of bioinformatics, biotechnology, computer-aided drug design, information technology, medical diagnostics, molecular biology and pharmaceutical industry. NEW TO THE FOURTH EDITION: • Includes four new chapters—Introduction to Biological Databases, Introduction to Phylogenetic, Methods of Phylogenic analysis and RNA Predict. • Updates chapters on Information Search and Data Retrieval and Alignment of Multiple Sequences. • Incorporates Problem Sets containing more than 250 problems and Multiple Choice Questions so that students can test their knowledge and understanding. Key Features • State-of-the-art technologies for gene identification, molecular modeling and monitoring of cellular processes • Data mining, analysis, classification, interpretation and efficient structure determination of genomes and proteomes • Importance of cell cycle for discovering new drug targets and their ligands • Computer-aided drug design and ADME-Tox property prediction Companion website www.phindia.com/rastogi provides useful resources for the teachers as well as for the students.
Designed as a comprehensive text for students and professionals pursuing careers in the fields of bioinformatics, molecular biology, pharmacy and drug research, the Fifth Edition continues to offer a fascinating and authoritative treatment of the entire spectrum of bioinformatics, covering a wide range of high-throughput technologies. The content can be used for four core courses: bioinformatics fundamentals, genomics, proteomics and drug discovery and design. The Fifth Edition takes a completely new pedagogical approach and the book is divided into eight distinct Units for the ease of learning: Bioinformatics Fundamentals, Sequence Alignment, Phylogenetic Analysis, Genomics, Protein Structure and Function, Drug Discovery Methods, Drug Design and Development and Integrative Topics. Accordingly, all the chapters are revised and updated in the new edition, besides introduction of seven new chapters and another seven completely re-written chapters. As a student-friendly text, it embodies several pedagogical features such as detailed examples, numerous tables, a large number of diagrams, flow charts and web resources. The book in its present edition should prove an invaluable asset to the students and researchers in the fields of bioinformatics, biotechnology, computer-aided drug design, information technology, medical diagnostics, molecular biology and pharmaceutical sciences. NEW TO THE FIFTH EDITION • Re-written chapters — Biological database search and data retrieval, Pair-wise alignment of sequences, PSSMs and Hidden Markov Models, Gene Mapping, Gene Prediction, Protein Structure Overview and Protein Structure Prediction. • Inclusion of new chapters—Scoring Matrices, Gene Sequencing, Regulatory Elements Prediction, Comparative Genomics, Protein Structure Databases, Protein Function Prediction and Potential Drug Targets. KEY FEATURES • Covers the field of bioinformatics in a complete and integrated approach – moving from the fundamentals to theory and practical applications. • State-of-the-art technologies for gene identification, molecular modeling and monitoring of cellular processes. • Data mining, data curation and analysis, classification, interpretation and efficient structure determination of genomes and proteomes. • Companion website provides useful resources for the teachers as well as for the students. So, visit Learning Centre https:// www.phindia.com/bioinformatics_mendiratta_rastogi to have access of Lecture notes, solutions manual, MCQs, problems set for practice, glossary of important terms, etc. TARGET AUDIENCE • UG and PG Students of Bioinformatics, Biotechnology, Molecular Biology and Pharmacy.
The book is an unstructured data mining quest, which takes the reader through different features of unstructured data mining while unfolding the practical facets of Big Data. It emphasizes more on machine learning and mining methods required for processing and decision-making. The text begins with the introduction to the subject and explores the concept of data mining methods and models along with the applications. It then goes into detail on other aspects of Big Data analytics, such as clustering, incremental learning, multi-label association and knowledge representation. The readers are also made familiar with business analytics to create value. The book finally ends with a discussion on the areas where research can be explored.
Section 1: Science of Arthroplasty 1. How to Establish a Successful Arthroplasty Practice 2. Critical Surgical Anatomy for Safe Total Knee Arthroplasty 3. Surgical Anatomy for Total Hip Arthroplasty 4. Kinematics of Knee Arthroplasty 5. Biomechanics of the Hip Joint 6. Modern Cement Technology in Arthroplasty 7. Bearing Surfaces for Total Hip Arthroplasty: Material and Design 8. Mechanical Failure of Hard-on-Hard Bearings in Arthroplasty and Preventive Measures 9. Alternative Bearings in Total Hip Arthroplasty 10. Essential Knowledge about Polyethylene 11. The Science of Ligament Balancing 12. Scientific Basis for Unicompartmental Knee Replacement: Technical Implications 13. Thromboprophylaxis in Total Joint Arthroplasty 14. Patellofemoral Kinematics in Total Knee Arthroplasty Design 15. Understanding Mid-Flexion Instability in Total Knee Arthroplasty Section 2: Primary Knee Arthroplasty 16. Surgical Approaches to the Knee 17. Concepts Underlining Balancing in Total Knee Arthroplasty 18. Components Rotational Alignment in Total Knee Arthroplasty 19. Posterior Cruciate Ligament in Total Knee Arthroplasty: Balancing the Controversy 20. Algorithm for Dealing with Varus Deformity 21. Algorithm for Dealing with Fixed Flexion Deformity 22. Classification and Treatment Algorithm of a Valgus Knee 23. Total Knee Replacement in Valgus Knees: An Algorithmic Approach 24. Dealing with Severe Valgus Knee 25. Total Knee Arthroplasty after High Tibial Osteotomy 26. Total Knee Replacement in Complex Multiplanar and Segmental Knee Deformities 27. Rotating Mobile-bearing Total Knee Arthroplasty 28. High-flexion TKA: View through the Mist 29. Navigation in Total Knee Replacement 30. Extensor Mechanism Deficiency in Total Knee Arthroplasty 31. Patellofemoral Arthroplasty 32. Noncemented Primary Total Knee Arthroplasty 33. Current Role of Patient-specific Instrumentation in Total Knee Arthroplasty 34. UKA: The Mobile-bearing Option 35. Fixed-bearing Unicondylar Knee Arthroplasty 36. Minimal Invasive Unicondylar Knee Arthroplasty 37. Multicompartment UKR and ACL Reconstruction Section 3: Revision Total Knee Arthroplasty 38. Surgical Approaches for Revision Total Knee Arthroplasty 39. Evaluation of Painful Total Knee Arthroplasty 40. Management of Major Bone Defects in Revision TKR: Unility of Cones and Sleeves 41. Dealing with Bone Loss in Total Knee Arthroplasty 42. Knee Balancing in Revision Total Knee Arthroplasty 43. Rationale for Stem Extension Selection in Revision TKA 44. Management of the Disrupted Quadriceps Mechanism in Revision Total Knee Arthroplasty Section 4: Primary Total Hip Arthroplasty 45. Surgical Approaches for the Hip Replacement 46. Modern Cementing Techniques 47. Restoration of Center of Rotation and Balance of THR 48. Altered Hip Center in Total Hip Arthroplasty 49. Cemented Total Hip Arthroplasty 50. Cementless Stem: The Scientific Basis of Choice 51. Tapered Cementless Stem in THR 52. S-ROM in Primary and Revision THA: Technical Details and Surgical Tips 53. Cups and Diametric Considerations in Primary Total Hip Arthroplasty 54. Total Hip Arthroplasty for Developmental Dysplasia of the Hip 55. Total Hip Arthroplasty in High Grade Developmental Dysplasia of Hip 56. Role of Dual Mobility Cup in Total Hip Arthroplasty 57. Surgical Management of Hip Dislocations following Total Hip Arthroplasty 58. Minimally Invasive Surgery: Posterior Approach Variant 59. Bipolar Hip Arthroplasty 60. Total Hip Arthroplasty in Acetabular Fractures Section 5: Revision Total Hip Arthroplasty 61. Principles of Revision Total Hip Arthroplasty 62. Pathomecha
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