Drs. Christopher P. Crum, Marisa R. Nucci, and Kenneth R. Lee help you diagnose neoplastic and non-neoplastic lesions of the female reproductive tract with their comprehensive update of Diagnostic Gynecologic and Obstetric Pathology. This 2nd Edition provides all of the latest guidance needed to accurately evaluate pathologic features and morphologic patterns. With 650+ new color images, an appendix with algorithms for the use of biomarkers, key points, diagnostic pearls, and more... this title is a must-have for today’s pathologist. Find distinct diagnostic/differential diagnostic criteria for any potential obstetric/gynecologic specimen encountered in practice. Integrate exfoliative cytology, immunohistochemistry, and molecular/genetic testing together with findings gleaned from the traditional open surgical biopsy. Examine the cytologic features of specimens taken from the uterine cervix and corpus, following the Bethesda classification of these lesions. View more than 2,250 full-color photographs and photomicrographs, ideal for side-by-side comparison to the specimens seen in the laboratory. Make better decisions regarding complex pregnancy situations with a new chapter devoted to the "Placental Correlates of Unanticipated Fetal Death." Experience easier reference with key points and diagnostic pearls at the end of each chapter, and a new appendix on algorithms for the use of biomarkers. Update your cancer assessment skills with the restructured section on pelvic epithelial malignancies, including a new chapter on "Assessing Pelvic Cancer Risk and Intercepting Early Malignancy." Gain the professional insights of new co-editor Dr. Marissa Nucci, an associate professor in pathology at the Harvard Medical School.
Dairy Processing and Quality Assurance, Second Edition describes the processing and manufacturing stages of market milk and major dairy products, from the receipt of raw materials to the packaging of the products, including the quality assurance aspects. The book begins with an overview of the dairy industry, dairy production and consumption trends. Next are discussions related to chemical, physical and functional properties of milk; microbiological considerations involved in milk processing; regulatory compliance; transportation to processing plants; and the ingredients used in manufacture of dairy products. The main section of the book is dedicated to processing and production of fluid milk products; cultured milk including yogurt; butter and spreads; cheese; evaporated and condensed milk; dry milks; whey and whey products; ice cream and frozen desserts; chilled dairy desserts; nutrition and health; sensory evaluation; new product development strategies; packaging systems; non-thermal preservation technologies; safety and quality management systems; and dairy laboratory analytical techniques. This fully revised and updated edition highlights the developments which have taken place in the dairy industry since 2008. The book notably includes: New regulatory developments The latest market trends New processing developments, particularly with regard to yogurt and cheese products Functional aspects of probiotics, prebiotics and synbiotics A new chapter on the sensory evaluation of dairy products Intended for professionals in the dairy industry, Dairy Processing and Quality Assurance, Second Edition, will also appeal to researchers, educators and students of dairy science for its contemporary information and experience-based applications.
This issue of Emergency Medicine Clinics focuses on Pediatric Emergency Medicine, with topics including: BRUE/ALTE; Pediatric Minor Head Injury; PAIN MANAGEMENT and PAIN ALTERNATIVES; DEHYDRATION - ORT and IVF FLUID SELECTION; PEDIATRIC SYNCOPE - High Risk Conditions and Reasonable Approach; INBORN ERRORS OF METABOLISM IN THE ED; BRONCHIOLITIS - From Guideline to Clinical Practice; PED NON-INVASIVE VENTILATION; PED VENT MANAGEMENT; POST-OP TONSILLECTOMY HEMORRHAGE; UNDIFFERENTIATED SHOCK MANAGEMENT; PEDIATRIC BURN MANAGEMENT; MAJOR HEAD TRAUMA: Not a Minor Problem; and PEDIATRIC THORACIC TRAUMA.
Dealing with general problems in fluid mechanics, convection diffusion, compressible and incompressible laminar and turbulent flow, shallow water flows and waves, this is the leading text and reference for engineers working with fluid dynamics in fields including aerospace engineering, vehicle design, thermal engineering and many other engineering applications. The new edition is a complete fluids text and reference in its own right. Along with its companion volumes it forms part of the indispensable Finite Element Method series.New material in this edition includes sub-grid scale modelling; artificial compressibility; full new chapters on turbulent flows, free surface flows and porous medium flows; expanded shallow water flows plus long, medium and short waves; and advances in parallel computing. - A complete, stand-alone reference on fluid mechanics applications of the FEM for mechanical, aeronautical, automotive, marine, chemical and civil engineers. - Extensive new coverage of turbulent flow and free surface treatments
The development of graphene-related nanomaterials and nanocomposite has shown immense utility in the areas of science, engineering, and technology. These materials include graphene derivatives, graphene-supported inorganic nanomaterials and films, graphene-metal decorated nanostructures, core–shell structures of nanocarbon-graphene, and graphene-doped polymer hybrid nanocomposites. They have been prepared by various methods like chemical vapor deposition, exfoliation of graphite, chemical reduction of GO, silver mirror reaction, catalysis, in situ hydroxylation, and sono sol–gel route.
Integrative Oncology explores a comprehensive, evidence-based approach to cancer care that addresses all individuals involved in the process, and can include the use of complementary and alternative medicine (CAM) therapies alongside conventional modalities such as chemotherapy, surgery, and radiation therapy. The number of integrative care programs is increasing worldwide and this book forms a foundation text for all who want to learn more about this growing field. This guide provides a thoughtful and generous perspective on integrative care, an outstanding overview of the exciting clinical opportunities these techniques can offer, and a guide to the new territories that all oncologists and CAM practitioners need to explore and understand.
Advanced manufacturing via computer numerical machining is the art of producing mechanical components employed in aerospace, automobile, and industrial applications where a high level of accuracy is needed. This book focuses on the nano-machining of aluminum alloy and its optimization. The application of aluminum alloy in the manufacturing industry has increased tremendously due to its lightweight to high strength ratio and high-level resistance to corrosion. However, aluminum alloy has some challenges during the machining and manufacturing stage in order to solve real-life manufacturing challenges in advanced machining operation for sustainable production processes. Therefore, it is a need for the implementation of a general algebraic modeling system (GAMS) and other metaheuristic techniques for problem solving and to effectively develop mathematical models for high accuracy prediction and optimization under nano-lubrication machining conditions. This book discusses majorly on the major three responses in machining such as surface roughness, cutting force, and material removal rate, which will give an excellent guide to undergraduate and postgraduate students, senior research fellows in academia, operational, and strategic staff in manufacturing industries.
Why do so many people suffer the slings and arrows of outrageous angst? Some twenty percent of us are afflicted with common Anxiety and Depressive disorders. That's not just nervous or scared or sad - that is painful dysfunction without obvious benefit. A new theoretical synthesis suggests that while animals share a set of evolved social instincts, we humans experience commonplace Anxiety and Depressive disorders when we use our reason to defy that biology.
Theory of Modeling and Simulation: Discrete Event & Iterative System Computational Foundations, Third Edition, continues the legacy of this authoritative and complete theoretical work. It is ideal for graduate and PhD students and working engineers interested in posing and solving problems using the tools of logico-mathematical modeling and computer simulation. Continuing its emphasis on the integration of discrete event and continuous modeling approaches, the work focuses light on DEVS and its potential to support the co-existence and interoperation of multiple formalisms in model components. New sections in this updated edition include discussions on important new extensions to theory, including chapter-length coverage of iterative system specification and DEVS and their fundamental importance, closure under coupling for iteratively specified systems, existence, uniqueness, non-deterministic conditions, and temporal progressiveness (legitimacy). - Presents a 40% revised and expanded new edition of this classic book with many important post-2000 extensions to core theory - Provides a streamlined introduction to Discrete Event System Specification (DEVS) formalism for modeling and simulation - Packages all the "need-to-know" information on DEVS formalism in one place - Expanded to include an online ancillary package, including numerous examples of theory and implementation in DEVS-based software, student solutions and instructors manual
A practical guide that allows access to the advances made in recent years in acute treatment and maintenance therapy. The authors have written a unique reference for the management of patients with these gastrointestinal disorders. Comprehensive and user-friendly, the topics covered in the treatment of acid, peptic disorders and motility disorders range from daily medication to on-demand programs. Highlights clinical advances made in the care of patients, including a focus on symptoms, causes, evaluation, and treatment. As part of "The Clinician's Guide to Gl" Series, this text serves as a concise reference that allows clinicians to quickly access and evaluate the necessary information for treating and managing patients with acid/peptic and motility disorders.
Biology of Female Cancers explores what can be learned about female cancers by summarizing what is known about the mechanisms of growth regulation and genetic features associated with common forms of female cancers, including malignancies of the breast, ovary, uterus, cervix, vulva, and gestational trophoblastic disease. The book describes the etiology, incidence, pathology, staging, and treatment of each type of cancer. The risk of developing particular tumor types and how their growth may be influenced by hormones, growth factors, and cytokines is also discussed. For oncologists, gynecologists and obstetricians, cell biologists, and everyone interested in learning more about female cancers, the Biology of Female Cancers offers a comprehensive, unique approach.
This book provide useful information in the area of spinal infections, particularly with regard to those that receive delayed treatment. The book first deals with various spinal infections and their manifestations. It is strong in the areas of tuberculosis and the structural problems that ensue when spinal infections are not diagnosed and treated early. Structural diagrams are helpful. Apart from surgical techniques, adequate emphasis has been laid on clinical features, value of modern diagnostic facilities and appropriate drug therapy. This book will be a useful reference book with more infor.
Dear Readers, We live in a remarkable era of rapid technological advancement, where innovation is reshaping our world at an unprecedented pace. From artificial intelligence to renewable energy, emerging technologies are driving transformative changes across various sectors, promising to revolutionize the way we live, work, and interact. Artificial intelligence (AI) is a prime example of a groundbreaking technology that is already making a significant impact. Machine learning algorithms and deep neural networks are enabling computers to learn, reason, and make decisions like never before. AI is being employed in fields as diverse as healthcare, finance, transportation, and entertainment, revolutionizing processes, improving efficiency, and unlocking new possibilities. The Internet of Things (IoT) is another revolutionary concept that is steadily permeating our daily lives. By connecting everyday objects to the internet and allowing them to communicate and share data, IoT is creating a seamlessly interconnected environment. Smart homes, autonomous vehicles, and industrial automation are just a few examples of how IoT is reshaping industries and enhancing our quality of life. Advancements in biotechnology and genetic engineering hold the promise of tackling some of the most pressing challenges in healthcare, agriculture, and environmental conservation. Gene editing technologies like CRISPR-Cas9 have the potential to cure genetic diseases, increase crop yields, and preserve endangered species. The ability to manipulate DNA is opening up new frontiers in scientific discovery and paving the way for a more sustainable and healthier future. Renewable energy technologies are revolutionizing the global energy landscape. Solar, wind, and hydroelectric power are becoming increasingly affordable and efficient, driving the transition towards a clean energy economy. With each passing day, we are moving closer to achieving energy independence, mitigating climate change, and ensuring a sustainable future for generations to come. Blockchain technology, initially popularized by cryptocurrencies like Bitcoin, is now being recognized for its potential in transforming various industries. Its decentralized and transparent nature offers new possibilities for secure and efficient transactions, data management, and supply chain optimization. Blockchain is poised to disrupt finance, healthcare, logistics, and other sectors, driving efficiency, reducing fraud, and fostering trust. These emerging technologies are not just isolated advancements; they are interconnected and synergistic. The convergence of AI, IoT, biotechnology, renewable energy, and blockchain holds the potential for even more profound transformations. Combined, they can create smart cities with optimized energy consumption, personalized medicine tailored to individual genomes, and sustainable ecosystems that benefit both human society and the planet. However, as we embrace the promises of emerging technologies, we must also acknowledge the challenges they present. Ethical considerations, privacy concerns, and the potential for job displacement are all aspects that require careful consideration. As society navigates these transformative waters, policymakers, researchers, and citizens alike must work together to ensure responsible and equitable deployment of emerging technologies. The future is being shaped by the incredible potential of emerging technologies. As we witness their integration into our daily lives, it is imperative that we approach their development and deployment with responsibility, foresight, and empathy. By doing so, we can harness their power to create a better, more sustainable, and inclusive future for all. Sincerely, Dr K Parish Venkata Kumar Mr.Prasad Devarasetty Dr.Muralidhar Vejendla Dr N Raghvendra Sai Dr.K Gurnadha Gupta Dr P Dileep Kumar Reddy
This MIE volume covers methods for a multitude of topics among which are computational methods, laboratory methods, enzyme optimization, binding proteins/antibodies, and screening technologies.Table of Contents-Methodology-Applications-Opzimization and Screening-Applications-Directed Evolution of Enzymatic Function-Applications-Evolution of Biosynthetic Pathways-Devices, Antibodies and Vaccines
This two-volume text demonstrates the progress towards a better and more rational use of blood kproducts. The major topics of transfusion therapy are covered from both a laboratory and a clinical perspective. Discipline lines are crossed, involving such topics as biochemistry, hematology and infectiious disease. This reference serves as an important resource for clinicians involved in transfusion, blood bank personnel, and scientists working with the development of improved blood components.
Completely revised text focuses on use of spectral methods to solve boundary value, eigenvalue, and time-dependent problems, but also covers Hermite, Laguerre, rational Chebyshev, sinc, and spherical harmonic functions, as well as cardinal functions, linear eigenvalue problems, matrix-solving methods, coordinate transformations, methods for unbounded intervals, spherical and cylindrical geometry, and much more. 7 Appendices. Glossary. Bibliography. Index. Over 160 text figures.
Current Trends and Future Developments on (Bio-) Membranes: Carbon Dioxide Separation/Capture by Using Membranes explores the unique property of membranes to separate gases with different physical and chemical properties. The book covers both polymeric and inorganic materials for CO2 separation and explains their mechanism of action, allowing for the development and most appropriate and efficient processes. It also lists the advantages of using membranes instead of other separation techniques, i.e., their low operating costs and low energy consumption. This book offers a unique opportunity for scientists working in the field of membrane technology for CO2 separation and capture. - Outlines numerous membrane-based technologies for CO2 separation and capture - Lists new, advanced separation techniques and production processes - Includes various applications, modelling, and the economic considerations of each process - Covers advanced techniques for the separation of CO2 in natural gas
The second of two volumes concentrating on the dynamics of slender bodies within or containing axial flow, Volume 2 covers fluid-structure interactions relating to shells, cylinders and plates containing or immersed in axial flow, as well as slender structures subjected to annular and leakage flows. This volume has been thoroughly updated to reference the latest developments in the field, with a continued emphasis on the understanding of dynamical behaviour and analytical methods needed to provide long-term solutions and validate the latest computational methods and codes, with increased coverage of computational techniques and numerical methods, particularly for the solution of non-linear three-dimensional problems. - Provides an in-depth review of an extensive range of fluid-structure interaction topics, with detailed real-world examples and thorough referencing throughout for additional detail - Organized by structure and problem type, allowing you to dip into the sections that are relevant to the particular problem you are facing, with numerous appendices containing the equations relevant to specific problems - Supports development of long-term solutions by focusing on the fundamentals and mechanisms needed to understand underlying causes and operating conditions under which apparent solutions might not prove effective
Fundamentals of Dairy Chemistry has always been a reference text which has attempted to provide a complete treatise on the chemistry of milk and the relevant research. The third edition carries on in that format which has proved successful over four previous editions (Fun damentals of Dairy Science 1928, 1935 and Fundamentals of Dairy Chemistry 1965, 1974). Not only is the material brought up-to-date, indeed several chapters have been completely re-written, but attempts have been made to streamline this edition. In view of the plethora of research related to dairy chemistry, authors were asked to reduce the number of references by eliminating the early, less significant ones. In addition, two chapters have been replaced with subjects which we felt deserved attention: "Nutritive Value of Dairy Foods" and "Chemistry of Processing. " Since our society is now more attuned to the quality of the food it consumes and the processes necessary to preserve that quality, the addition of these topics seemed justified. This does not minimize the importance of the information in the deleted chapters, "Vitamins of Milk" and "Frozen Dairy Products. " Some of the mate rial in these previous chapters has been incorporated into the new chapters; furthermore, the information in these chapters is available in the second edition, as a reprint from ADSA (Vitamins in Milk and Milk Products, November 1965) or in the many texts on ice cream manufac ture.
This volume is proceedings of the international conference of the Parallel Computational Fluid Dynamics 2002. In the volume, up-to-date information about numerical simulations of flows using parallel computers is given by leading researchers in this field. Special topics are "Grid Computing" and "Earth Simulator". Grid computing is now the most exciting topic in computer science. An invited paper on grid computing is presented in the volume. The Earth-Simulator is now the fastest computer in the world. Papers on flow-simulations using the Earth-Simulator are also included, as well as a thirty-two page special tutorial article on numerical optimization.
Presents state-of-the-art research and case studies from over 150 Design & Manufacturing professionals across the globe in the areas of CAD/CAM; Product Design; Rapid Prototyping and Tooling; Manufacturing Processes; Micromachining and Miniaturisation; Mechanism and Robotics; Artificial Intelligence; and Material Handling Systems.
Current pharmaceutical and clinical approaches to the treatment of disease suffer from the inherent limitations in the specialization of drugs introduced to physiological systems. The interface of clinical and material sciences has allowed for a broad spectrum of creative approaches with the potential to alleviate these shortcomings. However, the synergy of these disciplines also presents problems in which nascent technology lacks the necessary evaluation within its intended clinical environment. Given the growing potential for materials science to address a number of unanswered therapeutic needs, it remains even more pressing to validate emerging drug delivery technologies in actual clinical environments. Drug Delivery: Materials Design and Clinical Perspective addresses the core fundamentals of drug delivery using material science and engineering principles, and then applies this knowledge using prominent examples from both the scientific literature and clinical practice. Each chapter focuses on a specific drug delivery technology, such as controlled-release materials, thin-film materials, or smart materials. Within each chapter, an initial section on “Engineering Concepts” reviews the relevant fundamental principles that guide rational design. The following section on “Materials Design” discusses how the design process applies engineering concepts for use in physiological systems. A third section on “Implementation” discusses current approaches in the literature which have demonstrated effective drug delivery in controlled environments. Finally, each chapter contains several sections on “Clinical Applications” which describe the validity of materials approaches from a clinical perspective; these sections review the safety and efficacy of drug delivery systems for specific, compelling medical applications. The book thereby bridges materials science with clinical medicine, and provides the reader with a bench-to-bedside view of novel drug delivery systems. · Provides a comprehensive description of drug delivery systems from a materials perspective · Includes a wide-ranging discussion of clinical applications of drug delivery systems · Presents separate chapters on controlled release materials, thin film materials, self-microemulsifying materials, smart materials, etc. · Covers fundamental engineering principles, rational materials design, implementation testing, and clinical applications for each material type
Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by internationally renowned experts Drs. Scott P. Bruder and Roy K. Aaron, Orthobiologics: Scientific and Clinical Solutions for Orthopaedic Surgeons provides authoritative, comprehensive coverage of this fast-growing field. This one-stop reference is an ideal resource, covering technology and basic science through specific clinical applications.
Part of the highly regarded Braunwald's family of cardiology references, Clinical Arrhythmology and Electrophysiology, 3rd Edition, offers complete coverage of the latest diagnosis and management options for patients with arrhythmias. Expanded clinical content and clear illustrations keep you fully abreast of current technologies, new syndromes and diagnostic procedures, new information on molecular genetics, advances in ablation, and much more. - Key topics such as inherited channelopathies; atrial fibrillation; ventricular tachycardia; hypertrophic cardiomyopathy, arrhythmogenic cardiomyopathy, and congenital heart disease. - Dozens of videos depicting key mapping techniques, and fluoroscopy images illustrating techniques for electrophysiologic catheter positioning, atrial septal puncture, and pericardial access, cryoablation, and left atrial appendage exclusion procedures. - Grounds clinical techniques in basic science for managing complex patients. - Consistent organization, showing every arrhythmia in a similar manner for quick reference. - New management options with increased clinical content. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Comprehensive, concise, and readable, Textbook of Critical Care, 7th Edition, brings you fully up to date with the effective management of critically ill patients, providing the evidence-based guidance you need to overcome a full range of practice challenges. Drs. Jean-Louis Vincent, Edward Abraham, Frederick A. Moore, Patrick Kochanek, and Mitchell P. Fink are joined by other international experts who offer a multidisciplinary approach to critical care, sharing expertise in anesthesia, surgery, pulmonary medicine, and pediatrics. This highly acclaimed text offers ICU clinicians a new understanding of the pathophysiology of critical illness and new therapeutic approaches to critical care. - Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. - Features a wealth of tables, boxes, algorithms, diagnostic images, and key points that clarify important concepts and streamline complex information for quick reference. - Includes many new chapters on echocardiography, antibiotic stewardship, antiviral agents, coagulation and anti-coagulation, , telemedicine, extracorporeal membrane oxygenation (ECMO), and more. - Offers new coverage of biomarkers, bedside ultrasound, and the management of increasingly complex critically ill patients. - Provides new approaches to sepsis, acute kidney injury, and management of acute respiratory distress syndrome (ARDS), and other forms of respiratory failure.
Polymers from natural sources are particularly useful as biomaterials and in regenerative medicine, given their similarity to the extracellular matrix and other polymers in the human body. This important book reviews the wealth of research on both tried and promising new natural-based biomedical polymers, together with their applications as implantable biomaterials, controlled-release carriers or scaffolds for tissue engineering.The first part of the book reviews the sources, processing and properties of natural-based polymers for biomedical applications. Part two describes how the surfaces of polymer-based biomaterials can be modified to improve their functionality. The third part of the book discusses the use of natural-based polymers for biodegradable scaffolds and hydrogels in tissue engineering. Building on this foundation, Part four looks at the particular use of natural-gelling polymers for encapsulation, tissue engineering and regenerative medicine. The penultimate group of chapters reviews the use of natural-based polymers as delivery systems for drugs, hormones, enzymes and growth factors. The final part of the book summarises research on the key issue of biocompatibility.Natural-based polymers for biomedical applications is a standard reference for biomedical engineers, those studying and researching in this important area, and the medical community. - Examines the sources, processing and properties of natural based polymers for biomedical applications - Explains how the surfaces of polymer based biomaterials can be modified to improve their functionality - Discusses the use of natural based polymers for hydrogels in tissue engineering, and in particular natural gelling polymers for encapsulation and regenerative medicine
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
Obtain all the core knowledge in pain management you need from one of the most trusted resources in the field. The new edition of Practical Management of Pain gives you completely updated, multidisciplinary overview of every aspect of pain medicine, including evaluation, diagnosis of pain syndromes, rationales for management, treatment modalities, and much more. In print and online, it is all the expert guidance necessary to offer your patients the best possible relief. "In summary, this is the best explanation of what lies behind MRI that I have read, taking what can be a dry subject and making it readily understandable and really interesting. I would recommend it to anyone starting their MRI training and anyone trying to teach MRI to others." Reviewed by RAD Magazine, June 2015 Understand and apply the latest developments in pain medicine with brand-new chapters covering disability assessment, central post-stroke pain, chronic widespread pain, and burn pain. Effectively ease your patients' pain with today's best management techniques, including joint injections, ultrasound-guided therapies, and new pharmacologic agents (such as topical analgesics). Access up-to-the-minute knowledge on all aspects of pain management, from general principles to specific management techniques, with contributions from renowned experts in the field. Read the full text and view all the images online at expertconsult.com. Understand and apply the latest developments in pain management with brand-new chapters covering disability assessment, central post-stroke pain, widespread chronic pain, and burn pain. Effectively ease your patients' pain with today's best management techniques, including joint injections, ultrasound-guided therapies, and new pharmacologic agents (such as topical analgesics).
Written by key experts in the field of nanomedicine, this book provides a broad introduction to the important field of nanomedicine and application of nanotechnology for drug delivery. It covers up-to-date information regarding various nanoparticulate drug delivery systems, describes the various opportunities for the application of nanoparticular drug carriers in different areas of clinical medicine, and analyzes already available information on their clinical applications.This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry, molecular biology, biomedical engineering, physiology, experimental and clinical medicine, and pharmaceutical sciences, who are interested in general problems of drug delivery and drug targeting, as well as in more specialized topics of using nanoparticulate-mediated drug delivery approaches in the individual areas of clinical medicine.Prof Torchilin is an expert in Nanomedicine and a recipient of numerous awards including the Lenin Prize in Science & Technology of the former USSR, membership in the European Academy of Sciences, and AAPS Research Achievement Award in Pharmaceutics and Drug Delivery. He served as an Associate Professor of Radiology at Harvard Medical School before joining Northeastern University as the Chairman of the Department of Pharmaceutical Sciences./a
Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. - Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. - Disease pathways are based on computational models from Elsevier's Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. - Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.
Reagents in Mineral Technology provides comprehensive coverage of both basic as well asapplied aspects of reagents utilized in the minerals industry.This outstanding, single-source reference opens with an explicit account of flotation fundamentals,including coverage of wetting phenomena, mineral/water interfacial phenomena, flo tationchemistry, and flocculation and dispersion of mineral suspensions.It then discusses flotation of sulfide and nonsulfide minerals, with attention to formation ofclithiolates, formation of metal thiol compounds, application of fatty acids, sulfosuccinic acids,amines, and other collectors.Reagents in Mineral Technology also reviews adsorption of surfactants on minerals .. .details adsorption of polymers .. . and considers the chemistry and application of chelation agentsin minerals separations.Additional chapters consider grinding aids, frothers, inorganic and polymeric depressants,dewatering and filtering aids, analytical techniques, and much more.Unique in its depth of coverage, Reagents in Mineral Technology will prove an invaluablereference for mineral engineers and processors; analytical, surface, colloid, and physical chemists;petroleum, petrochemical, metallurgical, and mining engineers; and for use in advancedundergraduate- and graduate-level courses in these and related fields.
Peripheral nerve entrapments are frequent. They usually appear in anatomical tunnels such as the carpal tunnel. Nerve compressions may be due to external pressure such as the fibular nerve at the fibular head. Malignant or benign tumors may also damage the nerve. For each nerve from the upper and lower limbs, detailed clinical, electrophysiological, imaging, and therapeutic aspects are described. In the upper limbs, carpal tunnel syndrome and ulnar neuropathy at the elbow are the most frequent manifestations; the radial nerve is less frequently involved. Other nerves may occasionally be damaged and these are described also. In the lower limbs, the fibular nerve is most frequently involved, usually at the fibular head by external compression. Other nerves may also be involved and are therefore described. The clinical and electrophysiological examination are very important for the diagnosis, but imaging is also of great use. Treatments available for each nerve disease are discussed.
With each passing day, Pakistan becomes an even more crucial player in world affairs. Home of the world's second-largest Muslim population, epicenter of the global jihad, location of perhaps the planet's most dangerous borderlands, and armed with nuclear weapons, this South Asian nation will go a long way toward determining what the world looks like ten years from now. The Future of Pakistan presents and evaluates several scenarios for how the country will develop, evolve, and act in the near future, as well as the geopolitical implications of each. Led by renowned South Asia expert Stephen P. Cohen, a team of authoritative contributors looks at several pieces of the Pakistan puzzle. The book begins with Cohen's broad yet detailed overview of Pakistan, placing it within the context of current-day geopolitics and international economics. Cohen's piece is then followed by a number of shorter, more tightly focused essays addressing more specific issues of concern. Cohen's fellow contributors hail from America, Europe, India, and Pakistan itself, giving the book a uniquely international and comparative perspective. They address critical factors such as the role and impact of radical groups and militants, developments in specific key regions such as Punjab and the rugged frontier with Afghanistan, and the influence of—and interactions with—India, Pakistan's archrival since birth. The book also breaks down relations with other international powers such as China and the United States. The all-important military and internal security apparatus come under scrutiny, as do rapidly morphing social and gender issues. Political and party developments are examined along with the often amorphous division of power between Islamabad and the nation's regions and local powers. Uncertainty about Pakistan's trajectory persists. The Future of Pakistan helps us understand the current circumstances, the relevant actors and their motivation, the crit
Longtime Brookings economist and former presidential adviser Barry Bosworth examines why saving rates in the United States have fallen so precipitously over the past quarter century, why the initial consequences were surprisingly benign, and how reduced saving will affect the future well-being of Americans. The Decline in Saving provides an extensive and unparalleled account of the complexity of present saving patterns, an issue made even more serious by the 2008–09 global economic and financial crises. It objectively examines saving at both the individual household and the aggregate economy levels to understand whether the U.S. decline in saving is truly a threat to American prosperity. Highlights from The Decline in Saving: "The magnitude of the two-decade-long fall in household saving has been truly astonishing; it is even more surprising in view of the fact that the large cohort of baby boomers should have been in their peak saving years." "If Americans save so little, why are they so rich? This divergence emerges because the conventional measure of saving excludes all forms of capital gains...." "Saving behavior appears to be influenced in important ways by country-specific institutional factors along with a few common determinants, such as income growth, demographic changes, and variations in private wealth." "In the aggregate, the United States has had a negative net national saving rate since the onset of the financial crisis, and it now relies on foreign resource inflows to finance all its capital accumulation and a portion of its consumption." "The optimistic projections of just a few years ago about the future well-being of retirees now seem seriously dated.
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