Who hasn't had a wild dream about finding treasure? Bobby Wright, Charter Boat Captain and expert Scuba diver, touched that dream, only to have it turn into a nightmare. Four divers find a chest of old gold coins in a sea cave, and everyone wants their share. Well, maybe some of them want part of someone else's share, too. They might have worked out their differences, but things swiftly become more complicated when word of the discovery reaches the family who originally lost the coins in a shipwreck. Intrigue and betrayal ensue as everyone fights for a share of the coins. As euphoria dissolves into disappointment and greed, the characters are forced to cope with their own personal shortcomings and motivations, but a few discover a different sort of treasure. The ending isn't what you'd expect.......or would you?
Frank Schmitt has for two thirds of a century been searching for -- and in many cases finding -- explanations of major biomedical importance. His is a very human story -- of a youth in high school doing experiments in a make-shift chemical laboratory in the attic of the family home; of a young university student who organized a students' science society and whose undergraduate research on cell structure was published in major professional journals; of a medical school student who wrote a thesis that attracted the attention of cardiologists for many years; of a devoted husband who, with his young wife, spent two postdoctoral years in Berkeley, London and Berlin and later made two trips around the world with her as he set up a worldwide network of neuroscientists. As a young scientist at Washington University, Schmitt investigated polarization optical and x-ray diffraction methods to discover the molecular structure of living tissues -- this, long before molecular biology was established as a scientific discipline. Schmitt was called to head biology at MIT in 1941. There he added electron microscopy to his ultrastructural repertoire and used much of it in wartime research. As an Institute Professor (MIT's highest rank), he became a leader in the founding and characterization of the fields of biophysic and neuroscience. Schmitt was also deeply committed to music, along with his wife, and had an interest in theology. Photos.
Otto Brunner contends that prevailing notions of medieval social and constitutional history had been shaped by the nineteenth-century nation state and its "liberal" order. Whereas a sharp distinction between the public and the private might be appropriate to descriptions of contemporary society, such a dichotomy could not be projected back onto the Middle Ages. Focusing particularly on forms of lordship in late medieval Austria, Brunner found neither a "state" in the modern sense nor any distinction between the public and private spheres. Behind the apparent disorder of late medieval political life, however, Brunner discovered a coherent legal and constitutional order rooted in the the rights and obligations of noble lordship. In carefully reconstructing this order, Brunner's study weaves together social, legal, constitutional, and intellectual history.
Existing international law is capable to govern the “war on terror” also in the aftermath of September 11, 2001. The standards generally applicable to targeted killings are those of human rights law. Force may be used in order to address immediate threats, preventive killings are permitted under strict preconditions but targeted killings are prohibited. In the context of armed conflicts, these standards are complemented by international humanitarian law as lex specialis. Civilians may only be targeted while directly taking part in hostilities and posing a threat to the adversary. Also in Israel and the Occupied Territory, these standards apply. Contrary to the Israeli Supreme Court’s view, international humanitarian law is not complemented by human rights law, but human rights law is – to some degree – complemented by international humanitarian law. According to these standards, many killings which would be legal according to the Israeli Supreme Court violate international law.
Completely revised and updated, Dermatology covers all the classical and related fields of dermatology, providing a wealth of information on clinical features, pathophysiology, and differential diagnosis. Over 900 color photographs acquaint the reader with a variety of dermatological diseases. Each chapter contains detailed proposals for comprehensive therapy.
This book grew-how could it be otherwise?-out of a series oflectures which the author held at the University of Heidelberg. The purpose ofthese lectures was to give an introduction to the phenomenology of elementary particles for students both of theoretical and experimental orientation. With the present book the author has set himself the same aim. The reader is assumed to be familiar with ordinary nonrelativistic quantum mechanics as presented, e.g., in the following books: Quantum Mechanics, by L.1. Schiff (McGraw-Hill, New York, 1955); Quantum Mechanics, Vol. I, by K. Gottfried (W.A. Benjamin, Reading, Ma., 1966). The setup of the present book is as follows. In the first part we present some basic general principles and concepts which are used in elementary particle physics. The reader is supposed to learn here the "language" of particle physics. An introductory chapter deals with special relativity, of such funda mental importance for particle physics, which most ofthe time is high energy, i.e., highly relativistic physics. Further chapters of this first part deal with the Dirac equation, with the theory of quantized fields, and with the general definitions of the scattering and transition matrices and the cross-sections.
Most medical doctors have probably during their studies heard of the `Magnus and De Kleijn reflexes' and may have been aware of their relation to posture. But they know little about their significance and nothing about the man who unravelled the complex physiology of these reflexes and about his work. Rudolf Magnus lived from 1873 until 1927. His work on the physiology of posture was initiated during a short period of work with Sherrington in Liverpool in 1908. Though Magnus was also an authority in the field of pharmacology, it was particularly his neurophysical work on posture which made him known worldwide. It led to his nomination, together with De Kleijn, for the Nobel Prize in 1927. Unfortunately he died before the decision was made. In this illustrated biography Magnus' family background and his student years are described in a lively way. Fragments of the diary of his journey to England in 1898 and the description of his scientific career in Heidelberg will enlighten those interested in the history of how science was conducted during his lifetime. His lectures on Goethe as a scientist are also included. This is followed by Magnus' life as Professor of Pharmacology in Utrecht, and his studies on animal postures and experimental pharmacology. Finally Magnus' legacy is described.
The present exegitical study of the Hebrew and Greek texts of Sirach 50 provides an impressive illustration of Israels religion from 200-132 BCE, offering two pictures of Simon the High Priest, one by Ben Sira and one by his grandson.
WOLFGANG AMADE MOZART came of a family belonging originally to the artisan class. We find his ancestors settled in Augsburg early in the seventeenth century, and following their calling there without any great success. His grandfather, Johann Georg Mozart, a bookbinder, married, October 7, 1708, Anna Maria Peterin, the widow of another bookbinder, Augustin Banneger. From this union sprang two daughters and three sons, viz.: Fr. Joseph Ignaz, Franz Alois (who carried on his father's trade in his native town), and Johann Georg Leopold Mozart, bom on November 14, 1719, the father of the Mozart of our biography. Gifted with a keen intellect and firm will he early formed the resolution of raising himself to a higher position in the world than that hitherto occupied by his family; and in his later years he could point with just elation to his own arduous efforts, and the success which had crowned them, when he was urging his son to the same steady perseverance. When Wolfgang visited Augsburg in 1777, he gathered many particulars of his father's youth which refreshed the recollections of Leopold himself. We find him writing to his son (October 10, 1777) how, as a boy, he had sung a cantata at the monastery of St. Ulrich, for the wedding of the Hofrath Oefele, and how he had often climbed the broken steps to the organ loft, to sing treble at the Feast of the Holy Cross (November 29, 1777). He afterwards became an excellent organist: a certain Herr von Freisinger, of Munich, told Wolfgang (October 10, 1777) that he knew his father well, he had studied with him, and "had the liveliest recollections of Wessobrunn where my father (this was news to me) played the organ remarkably well. He said: 'It was wonderful, to see his hands and feet going together, but exceedingly fine—yes, he was an extraordinary man. My father thought very highly of him. And how he used to jeer at the priests, when they wanted him to turn monk.'" This last must have been of peculiar interest to Wolfgang, who knew his father only as a devout and strict observer of the Catholic religion. But Leopold remembered the days of his youth, and wrote to his wife (December 15, 1777): "Let me ask, if Wolfgang has not of late neglected to go to confession? God should ever be first in our thoughts! to Him alone must we look for earthly happiness, and we should ever keep eternity in view; young people, I know, are averse to hearing of these things; I was young myself once; but God be thanked, I always came to myself after my youthful follies, fled from all dangers to my soul, and kept steadily in view God, and my honour, and the dangerous consequences of indulgence in sin." Long-continued exertions and self-denial laid the foundation of Leopold Mozart's character in a conscientious earnestness and devotion to duty in great things as in small; they had the effect also of rendering his judgment of others somewhat hard and uncompromising. This is observable in his relations as an official, and as a teacher, and in his dealings on matters of religion. He was a strict Catholic, and feared nothing so much for his children as the influence which a prolonged stay in Protestant countries might exert on their faith; he remarked with surprise that his travelling companions, Baron Hopfgarten and Baron Bose, had often edified him with their discourse, although they were Lutherans (Paris, April 1, 1764).
This is the updated version of Dr. Otto Warburg’s classic “The Metabolism of Tumours.” The updated version is in epub format, which is easier to read on smartphones and tablets. It also includes photos and a brief biography of Dr. Warburg. In his own words: There are prime and secondary causes of diseases. For example, the prime cause of the plague is the plague bacillus, but secondary causes of the plague are filth, rats, and the fleas that transfer the plague bacillus from rats to man. By a prime cause of a disease I mean one that is found in every case of the disease...Cancer, above all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar. All normal body cells meet their energy needs by respiration of oxygen, whereas cancer cells meet their energy needs in great part by fermentation. All normal body cells are thus obligate aerobes, whereas all cancer cells are partial anaerobes. From the standpoint of the physics and chemistry of life this difference between normal and cancer cells is so great that one can scarcely picture a greater difference. Oxygen gas, the donor of energy in plants and animals is dethroned in the cancer cells and replaced by an energy yielding reaction of the lowest living forms, namely, a fermentation of glucose… If a lowered oxygen pressure during cell growth may cause cancer, or, more generally, if any inhibition of respiration during growth may cause cancer, then a next problem is to show why reduced respiration induces cancer. Since we already know that with a lowering of respiration fermentation results, we can re- express our question: Why does cancer result if oxygen-respiration is replaced by fermentation? The early history of life on our planet indicates that life existed on earth before the earth’s atmosphere contained free oxygen gas. The living cells must therefore have been fermenting cells then, and, as fossils show, they were undifferentiated single cells. Only when free oxygen appeared in the atmosphere - some billion years ago - did the higher development of life set in, to produce the plant and animal kingdoms from the fermenting, undifferentiated single cells. What the philosophers of life have called "Evolution créatrice" has been and is therefore the work of oxygen. The reverse process, the dedifferentiation of life, takes place today in greatest amount before our eyes in cancer development, which is another expression for dedifferentiation. To be sure, cancer development takes place even in the presence of free oxygen gas in the atmosphere, but this oxygen may not penetrate in sufficient quantity into the growing body cells, or the respiratory apo-enzymes of the growing body cells may not be saturated with the active groups. In any case, during the cancer development the oxygen-respiration always falls, fermentation appears, and the highly differentiated cells are transformed to fermenting anaerobes, which have lost all their body functions and retain only the now useless property of growth. Thus, when respiration disappears, life does not disappear, but the meaning of life disappears, and what remains are growing machines that destroy the body in which they grow.
This collection includes the original cancer research papers by Dr. Otto Warburg and his colleagues in their original text. It includes additional articles NOT found in “The Metabolism of Tumours.” The collection includes these articles: —The Prime Cause and Prevention of Cancer —On the Origin of Cancer Cells —The Metabolism of Tumours in the Body —On the Respiratory Impairment of Cancer Cells —The Chemical Constitution of Respiration Ferment —The Oxygen Transferring Ferment of Respiration —The Metabolism of Carcinoma Cells —The Carbohydrate Metabolism of Tumours —Observation on the Carbohydrate Metabolism of Tumours —Enzymic Studies on Ascitic Tumours and Their Host’s Blood Plasmas If a lowered oxygen pressure during cell growth may cause cancer, or, more generally, if any inhibition of respiration during growth may cause cancer, then a next problem is to show why reduced respiration induces cancer. Since we already know that with a lowering of respiration fermentation results, we can re- express our question: Why does cancer result if oxygen-respiration is replaced by fermentation? The early history of life on our planet indicates that life existed on earth before the earth’s atmosphere contained free oxygen gas. The living cells must therefore have been fermenting cells then, and, as fossils show, they were undifferentiated single cells. Only when free oxygen appeared in the atmosphere - some billion years ago - did the higher development of life set in, to produce the plant and animal kingdoms from the fermenting, undifferentiated single cells. What the philosophers of life have called "Evolution créatrice" has been and is therefore the work of oxygen. The reverse process, the dedifferentiation of life, takes place today in greatest amount before our eyes in cancer development, which is another expression for dedifferentiation. To be sure, cancer development takes place even in the presence of free oxygen gas in the atmosphere, but this oxygen may not penetrate in sufficient quantity into the growing body cells, or the respiratory apo-enzymes of the growing body cells may not be saturated with the active groups. In any case, during the cancer development the oxygen-respiration always falls, fermentation appears, and the highly differentiated cells are transformed to fermenting anaerobes, which have lost all their body functions and retain only the now useless property of growth. Thus, when respiration disappears, life does not disappear, but the meaning of life disappears, and what remains are growing machines that destroy the body in which they grow.
This is book 2 of 5 of the “Understand Cancer” series. It is based on the best-available science. The SECONDARY causes of cancer were discussed in book one. This book continues from book one and discusses the PRIME cause of cancer as discovered by Nobel Prize Laureate Dr. Otto Warburg—considered by many as the founder of modern biochemistry. “There are prime and secondary causes of diseases. For example, the prime cause of the plague is the plague bacillus, but secondary causes of the plague are filth, rats, and the fleas that transfer the plague bacillus from rats to man. By a prime cause of a disease I mean one that is found in every case of the disease...Cancer, above all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar. All normal body cells meet their energy needs by respiration of oxygen, whereas cancer cells meet their energy needs in great part by fermentation. All normal body cells are thus obligate aerobes, whereas all cancer cells are partial anaerobes. From the standpoint of the physics and chemistry of life this difference between normal and cancer cells is so great that one can scarcely picture a greater difference. Oxygen gas, the donor of energy in plants and animals is dethroned in the cancer cells and replaced by an energy yielding reaction of the lowest living forms, namely, a fermentation of glucose.” —Dr. Otto Warburg
This updated and revised second edition of “Alcohol and Tobacco” reflects the new ICD 11 and DSM V classifications and provides comprehensive descriptions of new therapeutic approaches, outlining the different interactions between personality, environment and the effects of the respective substance. In addition to new data on prevention-based therapies, especially for smoking addiction, the book also presents essential psychological and sociological strategies, and medication-based therapies. Particular attention is given to new medications and new compounds for e-cigarettes, while a broad overview of the American and European epidemiology of alcohol and nicotine addictions rounds out the coverage. Given the breadth and depth of its coverage, the book will appeal to a wide readership, from professionals to researchers and students.
Otto Treumann (1919-2001) is a major pioneer in the modernization of graphic design in the Netherlands. Inspired by Swiss typography and Bauhaus aesthetics, Treumann's oeuvre combines easy-to-read visual elements with iconoclastic color treatment, enhanced by his wide knowledge of printing techniques acquired during the Second World War when he forged documents for the resistance. Treumann enjoyed a special relationship with industrial clients, devising house styles and logos for the publishing house Wolters Noordhoff, the Kröller-Müller Museum, the Royal Institute of Dutch Architects and El Al Airlines; he also designed posters for the Industries Fair in Utrecht, the Rotterdam Ahoy and Tattoo in Delft. Based on materials from the Otto Treumann Archive at the Stedelijk Museum, and designed by Irma Boom, this volume surveys Treumann's career.
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