The biological world operates on a multitude of scales - from molecules to tissues to organisms to ecosystems. Throughout these myriad levels runs a common thread: the communication and onward passage of information, from cell to cell, from organism to organism and ultimately, from generation to generation. But how does this information come alive to govern the processes that constitute life? The answer lies in the molecular components that cooperate through a series of carefully-regulated processes to bring the information in our genome to life. These components and processes lie at the heart of one of the most fascinating subjects to engage the minds of scientists today: molecular biology. Molecular Biology: Principles of Genome Function, Second Edition, offers a fresh approach to the teaching of molecular biology by focusing on the commonalities that exist between the three kingdoms of life, and discussing the differences between the three kingdoms to offer instructive insights into molecular processes and components. This gives students an accurate depiction of our current understanding of the conserved nature of molecular biology, and the differences that underpin biological diversity. Additionally, an integrated approach demonstrates how certain molecular phenomena have diverse impacts on genome function by presenting them as themes that recur throughout the book, rather than as artificially separated topics As an experimental science, molecular biology requires an appreciation for the approaches taken to yield the information from which concepts and principles are deduced. Experimental Approach panels throughout the text describe research that has been particularly valuable in elucidating difference aspects of molecular biology. Each panel is carefully cross-referenced to the discussion of key molecular biology tools and techniques, which are presented in a dedicated chapter at the end of the book. Molecular Biology further enriches the learning experience with full-color artwork, end-of-chapter questions and summaries, suggested further readings grouped by topic, and an extensive glossary of key terms. Features: A focus on the underlying principles of molecular biology equips students with a robust conceptual framework on which to build their knowledge An emphasis on their commonalities reflects the processes and components that exist between bacteria, archae, and eukaryotes Experimental Approach panels demonstrate the importance of experimental evidence by describing research that has been particularly valuable in the field
It has never been easier to publish a book, but publishing a book is never easy. Creative Self-Publishing is a comprehensive guide to every step in the publishing process, written by the director of the Alliance of Independent Authors (ALLi), and drawing on the experience of thousands of ALLi members. The book's focus is how to apply your creativity to publishing, as much as to writing. It takes an individual approach, beginning with you—your passion, mission and sense of purpose as a publisher and creative business owner—then guiding you through the seven processes of publishing, in ways that empower you to reach more readers and sell more books. In an engaging, easy-to-read format, you’ll learn: - Which creative practices and business models the most successful authors are using today - Where you fit in the history of authorship and self-publishing - How to overcome publishing resistance and block by fostering creative flow. - Where to find your ideal readers and how to ensure they find your books - A proven planning method that marries your passion, mission and purpose as writer and publisher Whether you write fiction, nonfiction, or poetry books, the principles and practices outlined in this book will work for you. You’ll make better books, find more readers, turn them into keener fans, and grow your income, impact and influence as a self-directed and empowered indie author–the creative way.
A provocative and deeply important study of women’s lives, women’s choices—and an ‘unspoken taboo’—that questions the societal pressures forcing women into motherhood Women who opt not to be mothers are frequently warned that they will regret their decision later in life, yet we rarely talk about the possibility that the opposite might also be true—that women who have children might regret it. Drawing on years of research interviewing women from a variety of socioeconomic, educational, and professional backgrounds, sociologist Orna Donath treats regret as a feminist issue: as regret marks the road not taken, we need to consider whether alternative paths for women currently are blocked off. She asks that we pay attention to what is forbidden by rules governing motherhood, time, and emotion, including the cultural assumption that motherhood is a “natural” role for women—for the sake of all women, not just those who regret becoming mothers. If we are disturbed by the idea that a woman might regret becoming a mother, Donath says, our response should not be to silence and shame these women; rather, we need to ask honest and difficult questions about how society pushes women into motherhood and why those who reconsider it are still seen as a danger to the status quo. Groundbreaking, thoughtful, and provocative, this is an especially needed book in our current political climate, as women's reproductive rights continue to be at the forefront of national debates.
An expanded and updated edition of a comprehensive presentation of the theory and practice of model checking, a technology that automates the analysis of complex systems. Model checking is a verification technology that provides an algorithmic means of determining whether an abstract model—representing, for example, a hardware or software design—satisfies a formal specification expressed as a temporal logic formula. If the specification is not satisfied, the method identifies a counterexample execution that shows the source of the problem. Today, many major hardware and software companies use model checking in practice, for verification of VLSI circuits, communication protocols, software device drivers, real-time embedded systems, and security algorithms. This book offers a comprehensive presentation of the theory and practice of model checking, covering the foundations of the key algorithms in depth. The field of model checking has grown dramatically since the publication of the first edition in 1999, and this second edition reflects the advances in the field. Reorganized, expanded, and updated, the new edition retains the focus on the foundations of temporal logic model while offering new chapters that cover topics that did not exist in 1999: propositional satisfiability, SAT-based model checking, counterexample-guided abstraction refinement, and software model checking. The book serves as an introduction to the field suitable for classroom use and as an essential guide for researchers.
This presentation of the theory and practice of model checking includes basic as well as state-of-the-art techniques, algorithms and tools, and can be used as an introduction to the subject or a reference for researchers.
The story of the false entries, good-faith errors, retractions, and mistakes that occurred during the formation of the Periodic Table of Elements as we know it.
Improving access to justice has been an ongoing process, and on-demand justice should be a natural part of our increasingly on-demand society. What can we do for example when Facebook blocks our account, we're harassed on Twitter, discover that our credit report contains errors, or receive a negative review on Airbnb? How do we effectively resolve these and other such issues? Digital Justice introduces the reader to new technological tools to resolve and prevent disputes bringing dispute resolution to cyberspace, where those who would never look to a court for assistance can find help for instance via a smartphone. The authors focus particular attention on five areas that have seen great innovation as well as large volumes of disputes: ecommerce, healthcare, social media, labor, and the courts. As conflicts escalate with the increase in innovation, the authors emphasize the need for new dispute resolution processes and new ways to avoid disputes, something that has been ignored by those seeking to improve access to justice in the past.
Women’s military service in Israel presents a compelling case study to explore the meaning of gendered citizenship. Lomsky-Feder and Sasson-Levy compellingly argue that women’s mandatory military service during an active ongoing violent conflict, occurring at a formative age, becomes an initiation process into gendered citizenship, where the women learn their marginal place in relation to the state. By analyzing the life stories and testimonies of young women from varied social backgrounds, the authors ask: How do young women soldiers manage their expectations vis-à-vis the hyper-masculine military institution? How do women experience their gendered citizenship as daily embodied and emotional practices in different military roles? How do women soldiers understand and cope with daily sexual harassment? And finally, how do women cope with the gendered silencing mechanisms of the violence of war and occupation, and what can women soldiers know about this violence when they choose to speak out? The book offers a new conceptualization of citizenship as gendered encounters with the state. These encounters can be analyzed through three interrelated concepts: Multi-level contracts; Contrasting gendered experiences; Dis/acknowledging the military’s (external and internal) violence. Applying these three thought-provoking concepts, the authors depict the intricate, non-deterministic relationships between citizenship, military service and multiple gendered experiences.
This work explores the social foundation of evidence law in a specific historical social and cultural context - the debate concerning the proof of the crime of witchcraft in early modern England. In this period the question of how to prove the crime of witchcraft was the centre of a public debate and even those who strongly believed in the reality of witchcraft had considerable concerns regarding its proof. In a typical witchcraft crime there were no eyewitnesses, and since torture was not a standard measure in English criminal trials, confessions could not be easily obtained. The scarcity of evidence left the fact-finders with a pressing dilemma. On the one hand, using the standard evidentiary methods might have jeopardized any chance of prosecuting and convicting extremely dangerous criminals. On the other hand, lowering the evidentiary standards might have led to the conviction of innocent people. Based on the analysis of 157 primary sources, the book presents a picture of a diverse society whose members tried to influence evidentiary techniques to achieve their distinct goals and to bolster their social standing. In so doing this book further uncovers the interplay between the struggle with the evidentiary dilemma and social characteristics (such as class, position along the centre/periphery axis and the professional affiliation) of the participants in the debate. In particular, attention is focused on the professions of law, clergy and medicine. This book finds clear affinity between the professional affiliation and the evidentiary positions of the participants in the debate, demonstrating how the diverse social players and groups employed evidentiary strategies as a resource, to mobilize their interests. The witchcraft debate took place within the formative era of modern evidence law, and the book highlights the mutual influences between the witch trials and major legal developments.
Ethics of Cinematic Experience: Screens of Alterity deals with the relationship between cinema and ethics from a philosophical perspective, finding an intrinsic connection between film spectatorship and the possibility of being open to different modes of alterity. The book’s main thesis is that openness to otherness is already found in the basic structures of cinematic experience. Through a close examination of the ethical relevance of the philosophy of Maurice Merleau-Ponty, Stanley Cavell, Emmanuel Levinas and Gilles Deleuze to cinema studies, Ethics of Cinematic Experience: Screens of Alterity pursues the question of how film can open the viewer to what is not her, and so bring her to encounter otherness in a way that is unique to cinematic experience. The book sees ethics as not just the subject, content or story of a film but part of its aesthetic structure. Accompanied by readings of films mainly from mainstream cinema, each chapter focuses on a different aspect of the encounter with alterity through cinema. The book gives particular attention to how theoretical discussion of the cinematic close-up can lead to ethical insights into the status of both the human and the non-human in film, and thus lead to an understanding of the relationships the viewer makes with them. The book is a helpful resource for students and scholars interested in the relationship between philosophy, film and ethics, and is appropriate for students of philosophy and media and cultural studies.
This book explores the fascinating role that language plays in the construction of non-verbal objects by mapping out the ontological meaning of the specialised concepts and the domain-specific knowledge embedded in them. In doing so, it provides a comprehensive linguistic insight into the discourse of professional domain-specific communities and hence, into the communication practices and procedures of those communities. In this respect, the book offers a response to the claims made by many of the most influential applied linguists today, such as Vijay Bhatia (1993, 2004), John Swales (1990, 2004) or Ken Hyland (2002), among others, who have consistently defended the need for applied linguistic research into the textual, generic and social perspectives on the under-researched interrelatedness of the discoursal and professional practices of a discipline. Specifically, this book provides readers with an integrative multi-perspective approach to the study of professional, domain-specific discourses. While it mainly draws on the tenets of genre theory and discourse semantics, it also nurtures from the theoretical and empirical foundations of applied linguistics, cognitive linguistics, corpus linguistics and ontological engineering. The book starts from the analysis of domain specific texts as final written products with specific lexico-grammatical, semantic and rhetorical features to later enquire into the written products as textual artefacts closely linked to the social context of production and interpretation of the text. This integrative approach provides fresh new insights into the way the processes of writing are affected by the community-specific, institutional and socio-historical circumstances in which domain-specific texts are produced.
Israel's half-a-century long rule over the West Bank and Gaza Strip, and some of its surrounding legal issues, have been the subject of extensive academic literature. Yet, to date, there has been no comprehensive, theoretically-informed, and empirically-based academic study of the role of various legal mechanisms, norms, and concepts in shaping, legitimizing, and responding to the Israeli control regime. This book seeks to fill this gap, while shedding new light on the subject. Through the format of an A-Z legal lexicon, it critically reflects on, challenges, and redefines the language, knowledge, and practices surrounding the Israeli control regime. Taken together, the entries illuminate the relation between global and local forces - legal, political, and cultural - in Israel and Palestine. The study of the terms involved provides insights that are relevant to other situations elsewhere in the world, particularly with regard to belligerent occupation, the law's role in relation to state violence, and justice.
SelfPub3 is a concept and a publishing era defined by the concept: that any author (with the requisite skills) now has the means to establish a sustainable and scalable business. It is also a campaign from the Alliance of Independent Authors (#selfpub3.0) that works with authors, readers, literary organizations, and creative industries to support independent authors in acquiring the three necessary skills: writing, publishing and creative business. The SelfPub3 era, the era of author enterprise, began around 2018. In this era, writers are moving beyond exclusively signing all rights to a single 3rd-party publisher, or exclusively self-publishing with one platform or service, into true creative and commercial independence. This short book outlines both the concept and campaign and aims to explain to self-publishing authors why SelfPub3 is important, the tools and techniques driving this trend, and how to take part in this movement that is enabling authors in more number than ever before to earn a living from writing and publishing books.
Take a colorful walk through human ingenuity. Humans have been unpacking the earth to use pigments since cavemen times. Starting out from surface pigments for cave paintings, we’ve dug deep for minerals, mined oceans for colors and exploited the world of plants and animals. Our accidental fumbles have given birth to a whole family of brilliant blues that grace our museums, mansions and motorcars. We’ve turned waste materials into a whole rainbow of tints and hues to color our clothes, our food and ourselves. With the snip of a genetic scissor, we’ve harnessed bacteria to gift us with “greener” blue jeans and dazzling dashikis. As the pigments march on into the future, who knows what new and exciting inventions will emerge? Mary Virginia Orna, a world-recognized expert on color, will lead you through an illuminating journey exploring the science behind pigments. Pausing for reflections en route to share stories around pigment use and discoveries informed by history, religion, sociology and human endeavour, this book will have you absorbing science and regaling tales. Jam packed with nuggets of information, March of the Pigments will have the curiously minded and the expert scientist turning pages to discover more.
A Research-Driven Resource on Building Biochemical Systems to Perform Information Processing Functions Information Processing by Biochemical Systems describes fully delineated biochemical systems, organized as neural network–type assemblies. It explains the relationship between these two apparently unrelated fields, revealing how biochemical systems have the advantage of using the "language" of the physiological processes and, therefore, can be organized into the neural network–type assemblies, much in the way that natural biosystems are. A wealth of information is included concerning both the experimental aspects (such as materials and equipment used) and the computational procedures involved. This authoritative reference: Addresses network-type connectivity, considered to be a key feature underlying the information processing ability of the brain Describes novel scientific achievements, and serves as an aid for those interested in further developing biochemical systems that will perform information-processing functions Provides a viable approach for furthering progress in the area of molecular electronics and biocomputing Includes results obtained in experimental studies involving a variety of real enzyme systems Information Processing by Biochemical Systems is intended for graduate students and professionals, as well as biotechnologists.
A literary family drama with patricide at its heart. When Mercy Mulcahy was 40 years old, she was accused of killing her elderly and tyrannical father. Now, at the end of her life, she has completed a book about what really happened on that fateful night of Christmas Eve, 1989. The tragic and beautiful Mercy has devoted her life to protecting Star from her grandfather. His behavior so blighted her own life as a child – she never wanted it to touch her darling daughter. Yet Star refuses to read a word. Her contempt for Mercy is as painful as it is inexplicable. What has Mercy done? What is she hiding? Was her father's death, as many believe, an assisted suicide? Or something even more sinister? In this book, nothing is what it seems on the surface, and everywhere there are emotional twists and surprises. Set in Ireland and California, Blue Mercy is a compelling family mystery, combing lyrical description with a page-turning style. Praise for Orna Ross and Blue Mercy “A lyrical, gripping and heartbreakingly beautiful tale of love, loss and the ever-present possibility of redemption.” — WE Magazine for Women “Epic sweep...ambitious scope... an intelligent book”. — Sunday Tribune “A riveting story...vividly brought to life.” — Emigrant Online
Throughout the world, schizophrenia is a diagnosis now in decline, representing a radical shift in our historical and medical understanding of madness and mental distress. But what does this medical term, first coined by a Swiss psychiatrist in 1908, mean? And why is it increasingly unpopular among patients and the medical establishment? Historian and clinician Orna Ophir unearths the stories of patients and doctors as they struggle to make sense of this debilitating condition. At different times, patients have been depicted as possessed by demons, or simply “inspired,” as hearing voices, suffering from a “split-mind,” or merely having difficulty in “integrating” experiences. Now, a century after its birth, schizophrenia is increasingly viewed not as a radical, abnormal disease defined by an ever-changing cluster of symptoms, but the extreme end of a spectrum on which we are all located. The story Ophir tells is a hopeful one: As patients and doctors sought to overcome stigma and improve therapeutic outcomes, they have shown ever-greater sensitivity to diversity and difference. Schizophrenia: An Unfinished History gestures toward a future in which clinicians and patients will collaborate in the search for better outcomes.
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