Alzheimer's disease is a major health problem. The disease is clinically characterized by the progressive mental decline of the patients and pathologically by the accumulation of amyloid plaques and tangles and neurodegenerative changes in the brain. The cause of the disease remains unclear but in some cases, genetic (missense) mutations in the Amyloid Precursor Protein (APP) and in the Presenilin genes (PS1 & PS2) are sufficient to initiate the whole disease cascade. All these mutations cause in essence an increase in the generation or a change of the characteristics of the AB peptide making it more prone to produce amyloid plaques. The AB peptide is generated from the APP protein and the question how Presenilin influences APP processing and AB production is the main topic of our work.
Alzheimer's disease is a major health problem. The disease is clinically characterized by the progressive mental decline of the patients and pathologically by the accumulation of amyloid plaques and tangles and neurodegenerative changes in the brain. The cause of the disease remains unclear but in some cases, genetic (missense) mutations in the Amyloid Precursor Protein (APP) and in the Presenilin genes (PS1 & PS2) are sufficient to initiate the whole disease cascade. All these mutations cause in essence an increase in the generation or a change of the characteristics of the AB peptide making it more prone to produce amyloid plaques. The AB peptide is generated from the APP protein and the question how Presenilin influences APP processing and AB production is the main topic of our work.
This book is composed of short essays (stories) based on true events that the author experienced since his childhood. Many people read these poignant essays at the time when they were written and told the author they laughed and cried at the same time. These short stories reflect the sense of humor of the author as he described painful events. His journey from the Middle East to the USA was summarized in the story entitled Go West, Young Man. There are funny stories in this book, such as Neighbors in Bellbrook, Ohio, City of Outlaws, How a Puerto Rican Policeman Changed My Attitude and Ethics, and Clashes of Cultures. On the other hand, there are sad stories such as Go to Your Cousins in the East, Memories, When I Die, Bury Me in Yageen, and the Tragedy of Multiple Sclerosis. The author grew up in a very small town in Palestine called Bani Naim. This town was the subject of many of his stories, such as I Left My Soul in Bani Naim, Antiquity of Bani Naim, and Lonesome Without You. The author left his hometown (Bani Naim) at the age of sixteen, then he went back for a visit after forty-four years later to see the town was transformed into a small-sized city. In this visit, he wrote the story Bani Naim Gave Me Back My Soul to close the cycle of his painful journey. The author wrote several essays in this book that are related to the brouhaha status of the Middle East. The stories in this book were randomly listed, since the author believes there are opportunities in chaos.
A powerful and essential memoir of self-discovery . . . Brimming with beautiful remembrances of his grandfather and terrifying stories of abuse and homophobia, this is an essential book that shines a much-needed light on the intersection of Arab and queer identity." —Abdi Nazemian, Lambda Literary Award–winning author of Like a Love Story, a Stonewall Honor Book The grandson of Hollywood royalty on his father’s side and Holocaust survivors on his mother’s, Omar Sharif Jr. learned early on how to move between worlds, from the Montreal suburbs to the glamorous orbit of his grandparents’ Cairo. His famous name always protected him wherever he went. When, in the wake of the Arab Spring, he made the difficult decision to come out in the pages of The Advocate, he knew his life would forever change. What he didn’t expect was the backlash that followed. From bullying, to illness, attempted suicide, becoming a victim of sex trafficking, death threats by the thousands, revolution and never being able to return to a country he once called home, Omar Sharif Jr. has overcome more challenges than one might imagine. Drawing on the lessons he learned from both sides of his family, A Tale of Two Omars charts the course of an iconoclastic life, revealing in the process the struggles and successes that attend a public journey of self-acceptance and a life dedicated in service to others.
This is a book of facts in a time of ‘simple lies’, where propaganda plays a major role in falsifying history. Wasn’t Palestine a "state without people”? Lies weaved in the darkness cast a shadow on the minds unknowing of the facts, soon before these lies become their undeniable "reality". The people claimed to be "non-existent" continue to have a snowball effect. You need not ask where they come from, or how their existence thrusts down the throat of the “people without a state”, Palestine is that phoenix.
The late President of Egypt, Gamal Abdel Nasser (1918-1970), has been represented in many major works of Egyptian literature and film, and continues to have a presence in everyday life and discourse in the country. Omar Khalifah's analysis of these representations focuses on how the historical character of Nasser has emerged in the Egyptian imaginary. He explores the recurrent images of Nasser in literature and film and shows how Nasser constitutes a perfect site for plural interpretations. He argues that Nasser has become a rhetorical device, a figure of speech, a trope that connotes specific images constantly invoked whenever he is mentioned. His study makes a case for literature and art to be seen as alternative archives that question, erase, distort and add to the official history of Nasser.
Une nouvelle guerre a éclaté aux États-Unis opposant le Nord aux États sudistes rebelles à tout contrôle des énergies fossiles. Sarat Chestnut a six ans quand son père est tué et qu’elle doit rejoindre un camp de réfugiés avec sa famille. Cette tragédie signe la fin d’une enfance ensoleillée près du Mississippi. D’une fillette curieuse et vive, Sarat se mue au fil des épreuves et des injustices en une héroïne insaisissable, féroce, révoltée. Bientôt, sous l’influence d’un homme qui la prend sous son aile, elle se transformera en une impitoyable machine de guerre. Portrait d’un conflit dévastateur qui détruit l’espoir et l’humain sur son passage, American War fait écho à toutes les luttes fratricides qui naissent aux quatre coins du monde.
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