Emphasizing model choice and model averaging, this book presents up-to-date Bayesian methods for analyzing complex ecological data. It provides a basic introduction to Bayesian methods that assumes no prior knowledge. The book includes detailed descriptions of methods that deal with covariate data and covers techniques at the forefront of research, such as model discrimination and model averaging. Leaders in the statistical ecology field, the authors apply the theory to a wide range of actual case studies and illustrate the methods using WinBUGS and R. The computer programs and full details of the data sets are available on the book's website.
The study of ecological systems is often impeded by components that escape perfect observation, such as the trajectories of moving animals or the status of plant seed banks. These hidden components can be efficiently handled with statistical modeling by using hidden variables, which are often called latent variables. Notably, the hidden variables framework enables us to model an underlying interaction structure between variables (including random effects in regression models) and perform data clustering, which are useful tools in the analysis of ecological data. This book provides an introduction to hidden variables in ecology, through recent works on statistical modeling as well as on estimation in models with latent variables. All models are illustrated with ecological examples involving different types of latent variables at different scales of organization, from individuals to ecosystems. Readers have access to the data and R codes to facilitate understanding of the model and to adapt inference tools to their own data.
The fascination with gold is a story which spans millennia, however scientists have recently found a new interest for gold when it is divided into miniscule grains, such as gold nanoparticles. This scientific enthusiasm started in various fields of science in the middle of the 1980s and the present book offers a panorama of the major scientific achievements obtained with gold nanoparticles.Various topics are reviewed such as: gold nanoparticle preparation methods, their plasmon resonance and thermo-optical properties, their catalytic properties, their use in biology and medicine as well as their possible toxicity and, finally, their future technological applications. The book also contains an in-depth study of the use of gold nanoparticles throughout the ages, starting from times where the concept of nanoparticles was beyond the realm of human imagination. All these topics are presented by world-class scientists within a set of self-contained chapters.This book may be used as an advanced textbook by graduate students and scientists who need an introduction to gold nanoparticles. It is also suitable for experts in the related areas of chemistry, biology, material science, optics and physics, who are interested in broadening their knowledge and who wish to have an overview of the subject. Each chapter gradually leads the reader from the basics of a topic towards some of the current scientific challenges in the area. The necessary background material to achieve a solid understanding of each topic and the scientific literature to go further in the field is provided./a
Primarily intended for physicians and health care professionals who are treating obese patients, this book explores current and future options for drug treatment of obesity puts them into perspective against available alternative treatments. Distinguished scientists and clinical investigators provide reviews of each individual topic, covering a wide range of subjects from pathophysiology of obesity to the benefits of weight loss. The core sections on pharmacotherapy deal with currently available drugs and drugs in pre-clinical development. These sections are complemented with sections on non-drug treatment and general therapeutic aspects. This design provides an integrated view of therapeutic approaches to the treatment of obesity and its associated syndromes.
From the contents: · C. Brater and M. D. Murray: The effects of NSAIDs on the kidney · G. Edwards and A. H. Weston: Latest developments in potassium channel modulator drugs · M.R. Juchau and Y. Huang: Chemical teratogenesis in humans: Biochemical and molecular mechanisms · S.P. Gupta: Studies on cardiovascular drugs · G. Polak: Antifungal chemotherapy: An everlasting battle · O. Valdenaire: New insights into the bioamine receptor family.
This wonderful, profusely illustrated book provides a concise and thoughtful review of all the important diseases of the child's brain. The lesions are well organized into logical categories that help the reader to remember the information conveyed. The important features of each entity are discussed thoroughly. Data from the literature are documented by selected references and are clearly distinguished from the authors' personal experience. The gross pathology of each disease is illustrated by well selected, high quality CT scans and supporting neuroradiological studies. Each caption begins with the relevant clinical data, so the reader understands the clinical context in which the study was obtained. The caption then describes the specific CT features of the case, so the reader learns to interpret the images correctly to arrive at the final diagnosis. By this technique, the authors provide the reader with a large experience in all aspects of pediatric cranial CT and teach him to distinguish properly among the diverse disease states. The authors must be congratulated for their excellence and their me ticulous attention to detail. They have written an important book that brings together the fields of pediatric neurology and pediatric cranial CT, enhancing both. This volume is a necessary addition to the personal and professional libraries of all physicians who care for children: pediatri cians, neurologists, neurosurgeons and radiologists. I feel I am a better physician for having read this text.
For more than 30 years, Skeel’s Handbook of Cancer Therapy (formerly Handbook of Cancer Chemotherapy) has been the resource of choice for current, reliable information on cancer treatment for most adults. The 9th Edition reflects recent significant advances in the systemic treatment of cancer, including innovations in immunotherapy, oncology genomics, and molecular targeted therapy. An invaluable reference for all levels of physicians, nurses, and allied health professionals who provide care to cancer patients, this bestselling guide combines the most current rationale and the details necessary to safely administer pharmacologic therapy, offering a balanced synthesis between science and clinical practice.
Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.
The study of ecological systems is often impeded by components that escape perfect observation, such as the trajectories of moving animals or the status of plant seed banks. These hidden components can be efficiently handled with statistical modeling by using hidden variables, which are often called latent variables. Notably, the hidden variables framework enables us to model an underlying interaction structure between variables (including random effects in regression models) and perform data clustering, which are useful tools in the analysis of ecological data. This book provides an introduction to hidden variables in ecology, through recent works on statistical modeling as well as on estimation in models with latent variables. All models are illustrated with ecological examples involving different types of latent variables at different scales of organization, from individuals to ecosystems. Readers have access to the data and R codes to facilitate understanding of the model and to adapt inference tools to their own data.
Emphasizing model choice and model averaging, this book presents up-to-date Bayesian methods for analyzing complex ecological data. It provides a basic introduction to Bayesian methods that assumes no prior knowledge. The book includes detailed descriptions of methods that deal with covariate data and covers techniques at the forefront of research, such as model discrimination and model averaging. Leaders in the statistical ecology field, the authors apply the theory to a wide range of actual case studies and illustrate the methods using WinBUGS and R. The computer programs and full details of the data sets are available on the book's website.
Picasso Black and White: Examines the artist's lifelong exploration of a black-and-white leitmotif through paintings and a selection of sculptures and works on paper. Picasso continued the tradition of engaging the color black that had been employed throughout a centuries-long history of Spanish painting by fellow artists José de Ribera, Diego Velázquez, Francisco de Zurbarán, and Francisco de Goya. Moreover, he made highly effective use of isolated black, white, and gray hues in a nod to monochromatic grisaille painting and to drawing, line, and form. As this volume attests, the recurrent motif of black and white appears throughout Picasso's oeuvre, including his blue and rose periods, his investigations into Cubism and Surrealism, his interpretations of historical subject studies for his celebrated painting 'Guernica', World War II, and an homage to old masters, as well as the powerful paintings of his last years. Featuring reproductions of more than 150 works, this book examines the extraordinary complexity and power of these expressive artworks, which purge color in order to highlight their formal structure. Including essays by leading Picasso scholars, this book is a unique and coherent perspective on one of the world's most innovative and influential artists.
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