Since early Greek and Roman times, atoms were assumed-after un dergoing their various interactions-to take on the stable configurations of either the living or the inanimate world. This simple and unitary theory has evolved markedly, even while maintaining its validity over several centuries of vicissitudes, and in essence constitutes the first ex ample of a synthesis between the physical and the life sciences. In modern times, a similar relationship between the structure of various macromolecules and the function of living cells has also emerged as one of the most striking findings of those scientists active at the con vergence of the physical and life sciences. This fundamental result is re ported in the first two sections of the present work, namely those on "Oncogenes and Cancer" and "Lower-to-Higher-Order DNA Struc ture," in many cases by those recent Nobelists who themselves have been major contributors to work at the intersection of these fields. Many other significant areas of forefront scientific inquiry today (for example, research on the brain and vision), as well as some of the most exciting technological developments (e.g., work on renewable fuels and materials, biotechnology, and NMR and X-ray tomography) and method ological advances (e.g., studies in the fields of statistical mechanics and cancer chemotherapy) depend on the complex but harmonious collabora tions of physicists, chemists, mathematicians, engineers, biologists, and physicians.
Since the early times of the Greek philosophers Leucippus and Democritus, and later of the Roman philosopher Lucretius, a simple, fundamental idea emerged that brought the life sciences into the realm of the physical sciences. Atoms, after various interactions, were assumed to acquire stable configurations that corresponded either to the living or to the inanimate world. This simple and unitary theory, which has evolved in successive steps to our present time, remarkably maintained its validity despite several centuries of alternative vicissitudes, and is the foundation of modern biophysics. Some of the recent developments of this ancient idea are the discovery of the direct relationship between spatial structures and chemical activity of such molecules as methane and benzene, and the later discovery of the three-dimensional structure of double-helical DNA, and of its relationship with biological activity. The relationship between the structure of various macromolecules and the function of living cells was one of the most striking advancements of modern science, obtained by the cooperation of physicists, chemists, mathematicians, engineers, biologists, and physicians. This crossing of the life and physical sciences has given rise to new and exciting frontiers, and to a new synthesis where there is a frequent interconnection of expertise, and where there is an exchange of roles among traditionally separated soft and hard sciences. Even if knowledge is still transmitted to new generations within univer sities as separate disciplines, new knowledge is acquired today in the laboratory by truly interdisciplinary teams.
Molecular bioelectronics is a field in strong evolution at the frontier of life and materials sciences. The term is utilized in a broad context to emphasize a unique blend of electronics and biotechnology which is seen as the best way to achieve many objectives of industrial and scientific relevance, including biomolecular engineering, bioelectronic devices, materials and sensors capable of optimal hardware efficiency and intelligence and molecular miniaturization.
This volume introduces, in a coherent and comprehensive fashion, the Pan Stanford Series on Nanobiotechnology by defining and reviewing the major sectors of nanobiotechnology and nanobiosciences with respect to the most recent developments. It covers the basic principles and main applications of nanobiotechnology as an emerging field at the frontiers of biotechnology and nanotechnology, with contributions from leading scientists active in their respective specialties.
This unique contribution to the growing field of western Indian Ocean studies brings new light and new perspective on the early 19th century expansion of both Omani Sultan and the British. The important role played by the Baluch in East Africa is here discussed thanks to little known archive documents integrated with field work.
The book addresses the most recent developments in structural and functional proteomics underlying the recent contributions given in these areas by our laboratory to the instrumentations, the methods and the procedures as mutuated from the nanoscale sciences and technologies. These developments introduced in the last few years make now possible protein massive identification (mass spectrometry and biomolecular arrays down to nanoamounts) and protein structural characterization in solution and in crystals down to the atomic scale to an extent and to a degree so far unmatched. Emphasis is placed in the growth by nanobiofilm template of protein crystals of any type and size from millimeter to micron, leading in combination with microfocus synchrotron technology and atomic force microscopy to the definition of a new field called nanocrystallography. The few useful examples being shown, concerning yet structurally unsolved proteins, point this very promising approach nanotechnology-based in structural proteomics using highly focused X-rays. This has not to be confused with the important study of nanocrystals, both organic and inorganic, and novel diamond like nanocomposite materials and devices having 3D protein crystals as matrices to be equilibrated with nanoparticles/gold/silver to be utilized in the most diversified electronic applications here also summarized. vii Acknowledgments We are particularly grateful to Giuseppe Zanotti at the University of Padova for his fundamental collaboration during all the crystallographic studies.
The Missionary Dynamism of the Church of the East It would be an attractive undertaking for the historian to be able to follow in the footsteps of those heralds of the Gospel, who went forth from Antioch with firmness and tenacity in those early days making their way to the East . . . building new centers of Christian irradiation, creating communities and spreading the doctrine of Jesus everywhere. The interest would certainly grow if we were familiar with the challenges faced by these first evangelizers on their way to the Far East. Gaining that knowledge, however, is no easy task. Christ's teaching had to cover immense distances on its road from Antioch towards the East. . . . The details of this diffusion, however, remain obscure. There are no Acts of the Apostles, no Letters of Saint Paul, no contemporary or near-contemporary documents that might tell us how and when Christianity from the region of the Euphrates and the Tigris crossed over the mountainous regions of the Orient, how through Media and Parthia it went south to Herat and Segestan, and how it penetrated eastward, crossing the Margiana (Merv), into the region of the Oxus and the Jaxartes, and finally how it entered today's Russian province of Semireč'e, then Turfan, and then further south into the heart of China"--
These memories, handwritten by Elmo Cermaria (Nonno Peppe) for his grandson Checco (Francesco Nicolini), tell of when, as a young man of 20, he found himself hurled into the inferno of the First World War. In those days, you could cry your heart out for a bread roll denied, then miraculously regained thanks to the compassion of a German soldier, “the hated enemy”. These recollections are terse, without a trace of rhetoric and devoid of recriminations. Nonno Peppe tells the facts just as he experienced them first hand, without expressing any condemnation of those responsible for them, even though an awareness of the large-scale massacre he witnessed transpires from his account. When Nonno Peppe delivered the manuscript to his grandson on his wedding day, he asked him to make a promise: “Let the President of the Republic know what we did for Italy.” A hundred years ago, whole generations of young Italian men were stripped of human honor and dignity. Only a few of these young men would live on and become our grandfathers; and only a few of us would be fortunate enough to become “grandchildren of the Great War” and bear witness to their ordeal.
The contribution of monks to the evangelization of lands not yet reached by the preaching of the Gospel has certainly been remarkable. The specific witness that the monastic community gives is of a radical Christian life naturally radiating outward, and thus it is implicitly missionary. The process of inculturation of Christian monasticism in China required a bold spiritual attitude of openness to the future and a willingness to accept the transformation of monastic forms that had been received. In Christian Monks on Chinese Soil, Matteo Nicolini-Zani highlights the willingness of foreign monks to encounter the cultural and spiritual realities of China and the degree of acceptance by the Chinese of the form of monastic life that was presented to them by the missionaries.
This work explores the relationship among knowing, learning, and practice in the development of organizational knowledge. It explores the implications for intervention growing out of the notion that organizational knowledge cannot be conceived as a mental process residing in members' heads.
This volume introduces, in a coherent and comprehensive fashion, the Pan Stanford Series on Nanobiotechnology by defining and reviewing the major sectors of nanobiotechnology and nanobiosciences with respect to the most recent developments. It covers the basic principles and main applications of nanobiotechnology as an emerging field at the frontiers of biotechnology and nanotechnology, with contributions from leading scientists active in their respective specialties.
Since the early times of the Greek philosophers Leucippus and Democritus, and later of the Roman philosopher Lucretius, a simple, fundamental idea emerged that brought the life sciences into the realm of the physical sciences. Atoms, after various interactions, were assumed to acquire stable configurations that corresponded either to the living or to the inanimate world. This simple and unitary theory, which has evolved in successive steps to our present time, remarkably maintained its validity despite several centuries of alternative vicissitudes, and is the foundation of modern biophysics. Some of the recent developments of this ancient idea are the discovery of the direct relationship between spatial structures and chemical activity of such molecules as methane and benzene, and the later discovery of the three-dimensional structure of double-helical DNA, and of its relationship with biological activity. The relationship between the structure of various macromolecules and the function of living cells was one of the most striking advancements of modern science, obtained by the cooperation of physicists, chemists, mathematicians, engineers, biologists, and physicians. This crossing of the life and physical sciences has given rise to new and exciting frontiers, and to a new synthesis where there is a frequent interconnection of expertise, and where there is an exchange of roles among traditionally separated soft and hard sciences. Even if knowledge is still transmitted to new generations within univer sities as separate disciplines, new knowledge is acquired today in the laboratory by truly interdisciplinary teams.
Molecular bioelectronics is a field in strong evolution at the frontier of life and materials sciences. The term is utilized in a broad context to emphasize a unique blend of electronics and biotechnology which is seen as the best way to achieve many objectives of industrial and scientific relevance, including biomolecular engineering, bioelectronic devices, materials and sensors capable of optimal hardware efficiency and intelligence and molecular miniaturization.
Nanocomposites are currently defined "as a multiphase solid material where one of the phases has one, two or three dimensions of less than 100 nanometers or structures having nano-scale repeat distances between the different phases that make up the material". The use of nanocomposites with polymer, metal or ceramic matrices has increased in various areas of engineering and technology due to their special properties, with applications in bioengineering, battery cathodes, automotives, sensors and computers, as well other advanced industries. The present volume aims to provide recent information on nanocomposites (materials manufacturing and engineering) in six chapters. The chapter 1 of the book provides information on synthesis and characterization of ceramic hollow nanocomposites and nanotraps. Chapter 2 is dedicated to recent advances on preparation, properties and applications polyurathene nanocomposites. Chapter 3 described preparation, characterization and properties of organoclays, carbon nanofibers and carbon nanotubes based polymer nanocomposites. Chapter 4 contains information on mechanical and wear properties of multi-scale phase reinforced composites. Chapter 5 described modeling mechanical properties of nanocomposites Finally, chapter 6 is dedicated to polyanaline derivates and carbon nanotubes and their characterization. This book is the essential reference for academics, materials and physics researchers, materials, mechanical and manufacturing engineers, and professionals in nanocomposite-related industries.
The book addresses the most recent developments in structural and functional proteomics underlying the recent contributions given in these areas by our laboratory to the instrumentations, the methods and the procedures as mutuated from the nanoscale sciences and technologies. These developments introduced in the last few years make now possible protein massive identification (mass spectrometry and biomolecular arrays down to nanoamounts) and protein structural characterization in solution and in crystals down to the atomic scale to an extent and to a degree so far unmatched. Emphasis is placed in the growth by nanobiofilm template of protein crystals of any type and size from millimeter to micron, leading in combination with microfocus synchrotron technology and atomic force microscopy to the definition of a new field called nanocrystallography. The few useful examples being shown, concerning yet structurally unsolved proteins, point this very promising approach nanotechnology-based in structural proteomics using highly focused X-rays. This has not to be confused with the important study of nanocrystals, both organic and inorganic, and novel diamond like nanocomposite materials and devices having 3D protein crystals as matrices to be equilibrated with nanoparticles/gold/silver to be utilized in the most diversified electronic applications here also summarized. vii Acknowledgments We are particularly grateful to Giuseppe Zanotti at the University of Padova for his fundamental collaboration during all the crystallographic studies.
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