This first detailed historical treatment of the electron microscope in biology advances an original philosophical argument on the relation of experimental technology to scientific change.
The scientific scramble to discover the first generation of drugs created through genetic engineering. The biotech arena emerged in the 1970s and 1980s, when molecular biology, one of the fastest-moving areas of basic science in the twentieth century, met the business world. Gene Jockeys is a detailed study of the biotech projects that led to five of the first ten recombinant DNA drugs to be approved for medical use in the United States: human insulin, human growth hormone, alpha interferon, erythropoietin, and tissue plasminogen activator. Drawing on corporate documents obtained from patent litigation, as well as interviews with the ambitious biologists who called themselves gene jockeys, historian Nicolas Rasmussen chronicles the remarkable, and often secretive, work of the scientists who built a new domain between academia and the drug industry in the pursuit of intellectual rewards and big payouts. In contrast to some who critique the rise of biotechnology, Rasmussen contends that biotech was not a swindle, even if the public did pay a very high price for the development of what began as public scientific resources. Within the biotech enterprise, the work of corporate scientists went well beyond what biologists had already accomplished within universities, and it accelerated the medical use of the new drugs by several years. In his technically detailed and readable narrative, Rasmussen focuses on the visible and often heavy hands that construct and maintain the markets in public goods like science. He looks closely at how science follows money, and vice versa, as researchers respond to the pressures and potential rewards of commercially viable innovations. In biotechnology, many of those engaged in crafting markets for genetically engineered drugs were biologists themselves who were in fact trying to do science. This book captures that heady, fleeting moment when a biologist could expect to do great science through the private sector and be rewarded with both wealth and scientific acclaim.
Shakespeare's tragedies are among the greatest works of tragic art and have attracted a rich range of commentary and interpretation from leading creative and critical minds. This Reader's Guide offers a comprehensive survey of the key criticism on the tragedies, from the 17th century through to the present day. In this book, Nicolas Tredell: - Introduces essential concepts, themes and debates. - Relates Shakespeare's tragedies to fi elds of study including psychoanalysis, gender, race, ecology and philosophy. - Summarises major critical texts from Dryden and Dr Johnson to Janet Adelman and Julia Reinhard Lupton, and covers influential critical movements such as New Criticism, New Historicism and poststructuralism. - Demonstrates how key critical approaches work in practice, with close reference to Shakespeare's texts. Informed and incisive, this is an indispensable guide for anyone interested in how the category of Shakespeare's tragedies has been constructed, contested and changed over the years.
This book traces the evolution of environmental principles from their origins as vague political slogans reflecting fears about environmental hazards to their embodiment in enforceable laws. Since the early 1970s environmental issues have taken on an ever increasing profile. This has been duein part to a fundamental change in the type and scale of risk posed by industry. Issues such as global warming, GM food, and mad cow disease typify the new kinds of risk: potentially catastrophic consequences could ensue yet there is no scientific agreement over their precise causation, duration andother concerns. Environmental law has always responded to risks posed by industrial society but the new generation of risks have required a new set of environmental principles, emerging from a combination of public fears, science, ethics and established legal practice. This book shows how three ofthe most important principles of modern environmental law grew out of this new age of ecological risk: the polluter pays principle, the preventive principle and the precautionary principle. The author examines the legal force of these principles and in the process offers a novel theory of normformation in environmental law by unearthing new grounds of legality.The book will be of interest to all with an interest in environmental law and policy, in the relationship between law and science, and in the ways in which political and ethical values can become embodied in laws.
Providing comprehensive insight into the use of copper in cross-coupling reactions, Copper-Mediated Cross-Coupling Reactions provides a complete up-to-date collection of the available reactions and catalytic systems for the formation of carbon-heteroatom and carbon-carbon bonds. This essential reference covers a broad scope of copper-mediated reactions, their variations, key advances, improvements, and an array of academic and industrial applications that have revolutionized the field of organic synthesis. The text also discusses the mechanism of these transformations, the use of copper as cost-efficient alternative to palladium, as well as recently developed methods for conducting copper-mediated reactions with supported catalysts.
Africa faces numerous challenges relating to good governance due to its vast and diverse landscape, as well as its history. This book explores the role of space-based applications in supporting African good governance by strengthening civil society, bolstering democratic processes and advancing socio-economic development. The increased use of such applications can accelerate Africa's progress towards the United Nations Agenda 2030 Sustainable Development Goals, as well as the African Union's Agenda 2063 aspirations This book examines key challenges facing governance within African to provide an accurate account of the current African context. It discusses specific examples of e-governance and digital solutions that leverage space-based technologies and have been successfully implemented in both the developed and developing world. In the context of the numerous satellite constellations being deployed to provide affordable Internet connectivity globally, it examines the major actors in this sector and presents additional governance solutions based on remote sensing and Earth observation data. Given its scope, the book will be of interest to professionals and students in the fields of development, governance and space studies.
This book provides an extensive introduction to numerical computing from the viewpoint of backward error analysis. The intended audience includes students and researchers in science, engineering and mathematics. The approach taken is somewhat informal owing to the wide variety of backgrounds of the readers, but the central ideas of backward error and sensitivity (conditioning) are systematically emphasized. The book is divided into four parts: Part I provides the background preliminaries including floating-point arithmetic, polynomials and computer evaluation of functions; Part II covers numerical linear algebra; Part III covers interpolation, the FFT and quadrature; and Part IV covers numerical solutions of differential equations including initial-value problems, boundary-value problems, delay differential equations and a brief chapter on partial differential equations. The book contains detailed illustrations, chapter summaries and a variety of exercises as well some Matlab codes provided online as supplementary material. “I really like the focus on backward error analysis and condition. This is novel in a textbook and a practical approach that will bring welcome attention." Lawrence F. Shampine A Graduate Introduction to Numerical Methods and Backward Error Analysis” has been selected by Computing Reviews as a notable book in computing in 2013. Computing Reviews Best of 2013 list consists of book and article nominations from reviewers, CR category editors, the editors-in-chief of journals, and others in the computing community.
A stimulating and comprehensive critical survey of the responses to A Midsummer Night's Dream, as well as the key debates and developments, from the seventeenth century to the present day. Leading the reader through material chronologically, the Guide explores the main themes and interpretations and draws on a rich range of critical writings.
The Mythic Mind follows the tradition of works which insist on the necessity for a comparative dimension in the study of ancient Israel. The Israelite world-view was essentially a West Semitic world-view in origin, with additional deeply embedded influences from Egypt and Mesopotamia, though it produced its own distinctive character by way of synthesis and reaction. The essays in this volume explore various aspects of this process, historically and cosmologically, commonly challenging received views developed in the treatment of Israel in isolation. The importance of the Ugaritic texts in particular, as reflecting the cultural context in which ancient Israel developed into two symbiotic kingdoms, heirs to a common 'Canaanite' tradition, emerges clearly from such studies as chapter 5: 'Sea and Desert', chapter 7: 'Of Calves and Kings', chapter 9: 'The Significance of Spn' and chapter 10: 'The Vocabulary and Neurology of Orientation.
Neuropsychedelia examines the revival of psychedelic science since the "Decade of the Brain." After the breakdown of this previously prospering area of psychopharmacology, and in the wake of clashes between counterculture and establishment in the late 1960s, a new generation of hallucinogen researchers used the hype around the neurosciences in the 1990s to bring psychedelics back into the mainstream of science and society. This book is based on anthropological fieldwork and philosophical reflections on life and work in two laboratories that have played key roles in this development: a human lab in Switzerland and an animal lab in California. It sheds light on the central transnational axis of the resurgence connecting American psychedelic culture with the home country of LSD. In the borderland of science and religion, Neuropsychedelia explores the tensions between the use of hallucinogens to model psychoses and to evoke spiritual experiences in laboratory settings. Its protagonists, including the anthropologist himself, struggle to find a place for the mystical under conditions of late-modern materialism.
This book explores social cohesion in rural settlements in western Europe from 700–1050, asking to what extent settlements, or districts, constituted units of social organisation. It focuses on the interactions, interconnections and networks of people who lived side by side – neighbours. Drawing evidence from most of the current western European countries, the book plots and interrogates the very different practices of this wide range of regions in a systematically comparative framework. It considers the variety of local responses to the supra-local agents of landlords and rulers and the impact, such as it was, of those agents on the small-scale residential group. It also assesses the impact on local societies of the values, instructions and demands of the wider literate world of Christianity, as delivered by local priests.
It is common to regard rights and wrongs as mirror images: to be wronged is to have one's rights violated. Nicolas Cornell rejects this view. Drawing on diverse real-world examples, he argues that rights determine how we ought to shape our interpersonal conduct, while wrongs alone tell us what corrective action is appropriate after a violation.
This book provides a comprehensive overview of recent advances in the analysis and design of health management systems for cooperating unmanned aerial vehicles. Such systems rely upon monitoring and fault adaptation schemes. Motivation for their study comes from the fact that, despite the use of fault-tolerant control software and hardware embedded onboard air vehicles, overall fleet performance may still be degraded after the occurrence of anomalous events such as systems faults and failures. Cooperative health management (CHM) systems seek to provide adaptation to the presence of faults by capitalizing on the availability of interconnected computing, sensing and actuation resources.This monograph complements the proposed CHM concepts by means of case studies and application examples. It presents fundamental principles and results encompassing optimization, systems theory, information theory, dynamics, modeling and simulation. Written by pioneers in cooperative control, health management and fault-tolerant control for unmanned systems, this book is a unique source of information for designers, researchers and practitioners interested in the field.
The young people of the Cameroon Grassfields have been subject to a long history of violence and political marginalization. For centuries the main victims of the slave trade, they became prime targets for forced labor campaigns under a series of colonial rulers. Today’s youth remain at the bottom of the fiercely hierarchical and polarized societies of the Grassfields, and it is their response to centuries of exploitation that Nicolas Argenti takes up in this absorbing and original book. Beginning his study with a political analysis of youth in the Grassfields from the eighteenth century to the present, Argenti pays special attention to the repeated violent revolts staged by young victims of political oppression. He then combines this history with extensive ethnographic fieldwork in the Oku chiefdom, discovering that the specter of past violence lives on in the masked dance performances that have earned intense devotion from today’s youth. Argenti contends that by evoking the imagery of past cataclysmic events, these masquerades allow young Oku men and women to address the inequities they face in their relations with elders and state authorities today.
This book focuses on the development of multi-variant products using modular product structures and thus addresses the reduction of complexity from a product development perspective. These modular product structures allow for a greater variety of demand with a smaller, internal variety of components and processes. As a supplement to the common product development methodology, the necessary basics of modularity and variant diversity as well as the corresponding methods are presented comprehensively. The book thus summarizes the current state of science as well as the research activities of the past ten years at the Institute of Product Development and Design Technology at the TU Hamburg-Harburg. The target groups This book is aimed at product developers and decision makers in practice. Science is offered a helpful reference book and interested engineering students can immerse themselves in the development of modular product families with the necessary basics. This book is a translation of the original German 1st edition Methodische Entwicklung modularer Produktfamilien by Dieter Krause & Nicolas Gebhardt, published by Springer Fachmedien Wiesbaden GmbH, part of Springer Nature in 2018. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.
Mathematical Modeling: Branching Beyond Calculus reveals the versatility of mathematical modeling. The authors present the subject in an attractive manner and flexibley manner. Students will discover that the topic not only focuses on math, but biology, engineering, and both social and physical sciences. The book is written in a way to meet the needs of any modeling course. Each chapter includes examples, exercises, and projects offering opportunities for more in-depth investigations into the world of mathematical models. The authors encourage students to approach the models from various angles while creating a more complete understanding. The assortment of disciplines covered within the book and its flexible structure produce an intriguing and promising foundation for any mathematical modeling course or for self-study. Key Features: Chapter projects guide more thorough investigations of the models The text aims to expand a student’s communication skills and perspectives WThe widespread applications are incorporated, even includinge biology and social sciences Its structure allows it to serve as either primary or supplemental text Uses Mathematica and MATLAB are used to develop models and computations
This book investigates how foreign subsidiaries of multinational corporations expand their presence and functional scope into foreign territories. It thereby focuses on how cross-border subsidiary mandates are obtained and how they develop over time. Multiple case-studies based on in-depth interviews with HQ and subsidiary management suggest that subsidiary internationalization represents a select MNC phenomenon and that associated foreign market mandates are only of temporary nature. Foreign subsidiaries appear to receive cross-border responsibility if their value proposition for overcoming liability of inter-regional foreignness is capable of more than offsetting any risk increase that stems from principal-agent relationships between corporate headquarters and foreign subsidiaries. Following the initial mandate gain, the subsidiary’s restrained access to HQ-like functions, intra-MNC competition and altering localization degrees in the market covered by the mandate puts the sustainability of cross-border responsibilities at risk. As a consequence, internationalization trajectories of foreign subsidiaries often follow discontinuous rather than gradual evolutionary paths. In addition, cross-border subsidiary mandates often appear to be predefined and temporary in nature. They might actually have a limited life span from their very conception.
This book reviews current knowledge of the etiopathogenesis, pathophysiology, and molecular biology of tympanic membrane retraction pockets and provides clear guidance on clinical assessment and treatment. A new diagnostic approach based on clinicoradiologic correlations is presented, and the ability of computer tomography to offer objective criteria for improved differentiation between stable and unstable or unsafe retraction pockets is explained. Surgical options are discussed, and on the basis of their own clinical and surgical experiences the authors propose a novel procedure, masto-atticotomy with anterior epitympanotomy (AER surgery), which addresses the causative factors underlying a retraction pocket. This surgery aims to restore adequate aeration routes for the middle ear compartments situated above the tympanic diaphragm; it results in better control of the pathology and in most cases prevents its recurrence. The book will assist otologists and surgeons in ensuring that retraction pockets are effectively diagnosed and treated, avoiding progression to cholesteatoma.
This book provides a general introduction to Sequential Monte Carlo (SMC) methods, also known as particle filters. These methods have become a staple for the sequential analysis of data in such diverse fields as signal processing, epidemiology, machine learning, population ecology, quantitative finance, and robotics. The coverage is comprehensive, ranging from the underlying theory to computational implementation, methodology, and diverse applications in various areas of science. This is achieved by describing SMC algorithms as particular cases of a general framework, which involves concepts such as Feynman-Kac distributions, and tools such as importance sampling and resampling. This general framework is used consistently throughout the book. Extensive coverage is provided on sequential learning (filtering, smoothing) of state-space (hidden Markov) models, as this remains an important application of SMC methods. More recent applications, such as parameter estimation of these models (through e.g. particle Markov chain Monte Carlo techniques) and the simulation of challenging probability distributions (in e.g. Bayesian inference or rare-event problems), are also discussed. The book may be used either as a graduate text on Sequential Monte Carlo methods and state-space modeling, or as a general reference work on the area. Each chapter includes a set of exercises for self-study, a comprehensive bibliography, and a “Python corner,” which discusses the practical implementation of the methods covered. In addition, the book comes with an open source Python library, which implements all the algorithms described in the book, and contains all the programs that were used to perform the numerical experiments.
Un panorama general, básico y didáctico sobre la singularidad genética y biológica de la especie humana. Tras la creación del universo con el big-bang hace 13.700 millones de años brotó la vida en un planeta idóneo para su expansión y diversificación. En el libro se detallan los mecanismos de la evolución y de la aparición del Homo sapiens a partir de unos ancestros prehomínidos en el centro de África, hasta su expansión por todo el mundo. Se describen los procesos de la hominización y humanización y las especiales características del ser humano. Se explica el significado del “fenómeno humano” y el por qué y el cómo del resurgir de una especie tan singular. La única que asciende al mundo de la racionalidad y que en consecuencia vive su vida de forma consciente, se comunica con sus congéneres, crea la cultura y domina su entorno con un sentido ético y de trascendencia. En el libro se describen los fundamentos genéticos de nuestros rasgos biológicos, los determinantes genéticos y ambientales que influyen en el comportamiento humano, las enfermedades hereditarias y los detalles de nuestro genoma en relación con el de los demás seres vivos. Se distingue entre lo innato y lo adquirido. Se derriban los mitos y se asientan las pruebas de lo que es genuinamente humano y lo que no lo es. También se aborda el futuro de la humanidad en la era de las tecnologías emergentes, con los desafíos éticos de la manipulación genética y las corrientes materialistas que tratan de conducir a nuestra singular especie a la utopía transhumanista y posthumanista.
In multi-agent-based simulation (MABS) the behavior of individual actors is modeled in detail. The analysis and validation of these models is rated as difficult and requires support by innovative techniques and tools. Problems include model complexity, the amount and often qualitative representation of simulation results, and the typical dichotomy between microscopic modeling and macroscopic observation perspectives. In recent years, data mining has been increasingly applied as a support technique in this context. A particularly promising approach is found in the field of process mining. Due to its rooting in business process analysis, process mining shares several process- and organization-oriented analysis perspectives and use cases with agent-based modeling. This thesis proposes a conceptual framework for the systematic application of process mining to the analysis and validation of MABS. As a foundation, agent-oriented analysis perspectives and simulation-specific use cases are identified and complemented with methods, techniques, and results from the literature. A partial formalization of perspectives and use cases is sketched by utilizing concepts from process modeling and software engineering. Beyond the conceptual work, process mining is applied in two case studies related to different modeling and simulation approaches.
A beautiful volume that brings to light the forgotten Le Nain brothers, a trio of 17th-century French master painters who specialized in portraiture, religious subjects, and scenes of everyday peasant life In France in the 17th century, the brothers Antoine (c. 1598-1648), Louis (c. 1600/1605-1648), and Mathieu (1607-1677) Le Nain painted images of everyday life for which they became posthumously famous. They are celebrated for their depictions of middle-class leisure activities, and particularly for their representations of peasant families, who gaze out at the viewer. The uncompromising naturalism of these compositions, along with their oddly suspended action, imparts a sense of dignity to their subjects. Featuring more than sixty paintings highlighting the artists' full range of production, including altarpieces, private devotional paintings, portraits, and the poignant images of peasants for which the brothers are best known, this generously illustrated volume presents new research concerning the authorship, dating, and meaning of the works by well-known scholars in the field. Also groundbreaking are the results of a technical study of the paintings, which constitutes a major contribution to the scholarship on the Le Nain brothers.
The environmental and economic importance of monitoring forests and agricultural resources has allowed remote sensing to be increasingly in the development of products and services responding to user needs.This volume presents the main applications in remote sensing for agriculture and forestry, including the primary soil properties, the estimation of the vegetation's biophysical variables, methods for mapping land cover, the contribution of remote sensing for crop and water monitoring, and the estimation of the forest cover properties (cover dynamic, height, biomass).This book, part of a set of six volumes, has been produced by scientists who are internationally renowned in their fields. It is addressed to students (engineers, Masters, PhD), engineers and scientists, specialists in remote sensing applied to agriculture and forestry.Through this pedagogical work, the authors contribute to breaking down the barriers that hinder the use of radar imaging techniques. - Provides clear and concise descriptions of modern remote sensing methods - Explores the most current remote sensing techniques with physical aspects of the measurement (theory) and their applications - Provides chapters on physical principles, measurement, and data processing for each technique described - Describes optical remote sensing technology, including a description of acquisition systems and measurement corrections to be made
This volume surveys the spectral properties of the spin Dirac operator. After a brief introduction to spin geometry, it presents the main known estimates for Dirac eigenvalues on compact manifolds with or without boundaries.
A riveting history of the rise and fall of the obesity epidemic during 1950s and 1960s America. Metropolitan Life Insurance Company identified obesity as the leading cause of premature death in the United States in the 1930s, but it wasn't until 1951 that the public health and medical communities finally recognized it as "America's Number One Health Problem." The reason for MetLife's interest? They wanted their policyholders to live longer and continue paying their premiums. Early postwar America responded to the obesity emergency, but by the end of the 1960s, the crisis waned and official rates of true obesity were reduced— despite the fact that Americans were growing no thinner. What mid-century factors and forces established obesity as a politically meaningful and culturally resonant problem in the first place? And why did obesity fade from public—and medical—consciousness only a decade later? Based on archival records of health leaders as well as medical and popular literature, Fat in the Fifties is the first book to reconstruct the prewar origins, emergence, and surprising disappearance of obesity as a major public health problem. Author Nicolas Rasmussen explores the postwar shifts that drew attention to obesity, as well as the varied approaches to its treatment: from thyroid hormones to psychoanalysis and weight loss groups. Rasmussen argues that the US government was driven by the new Cold War and the fear of atomic annihilation to heightened anxieties about national fitness. Informed by the latest psychiatric thinking—which diagnosed obesity as the result of oral fixation, just like alcoholism—health professionals promoted a form of weight loss group therapy modeled on Alcoholics Anonymous. The intervention caught on like wildfire in 1950s suburbia. But the sense of crisis passed quickly, partly due to cultural changes associated with the later 1960s and partly due to scientific research, some of it sponsored by the sugar industry, emphasizing particular dietary fats, rather than calorie intake. Through this riveting history of the rise and fall of the obesity epidemic, readers gain an understanding of how the American public health system—ambitious, strong, and second-to-none at the end of the Second World War—was constrained a decade later to focus mainly on nagging individuals to change their lifestyle choices. Fat in the Fifties is required reading for public health practitioners and researchers, physicians, historians of medicine, and anyone concerned about weight and weight loss.
Pseudo-differential operators were initiated by Kohn, Nirenberg and Hörmander in the sixties of the last century. Beside applications in the general theory of partial differential equations, they have their roots also in the study of quantization first envisaged by Hermann Weyl thirty years earlier. Thanks to the understanding of the connections of wavelets with other branches of mathematical analysis, quantum physics and engineering, such operators have been used under different names as mathematical models in signal analysis since the last decade of the last century. The volume investigates the mathematics of quantization and signals in the context of pseudo-differential operators, Weyl transforms, Daubechies operators, Wick quantization and time-frequency localization operators. Applications to quantization, signal analysis and the modern theory of PDE are highlighted.
The scientific scramble to discover the first generation of drugs created through genetic engineering. The biotech arena emerged in the 1970s and 1980s, when molecular biology, one of the fastest-moving areas of basic science in the twentieth century, met the business world. Gene Jockeys is a detailed study of the biotech projects that led to five of the first ten recombinant DNA drugs to be approved for medical use in the United States: human insulin, human growth hormone, alpha interferon, erythropoietin, and tissue plasminogen activator. Drawing on corporate documents obtained from patent litigation, as well as interviews with the ambitious biologists who called themselves gene jockeys, historian Nicolas Rasmussen chronicles the remarkable, and often secretive, work of the scientists who built a new domain between academia and the drug industry in the pursuit of intellectual rewards and big payouts. In contrast to some who critique the rise of biotechnology, Rasmussen contends that biotech was not a swindle, even if the public did pay a very high price for the development of what began as public scientific resources. Within the biotech enterprise, the work of corporate scientists went well beyond what biologists had already accomplished within universities, and it accelerated the medical use of the new drugs by several years. In his technically detailed and readable narrative, Rasmussen focuses on the visible and often heavy hands that construct and maintain the markets in public goods like science. He looks closely at how science follows money, and vice versa, as researchers respond to the pressures and potential rewards of commercially viable innovations. In biotechnology, many of those engaged in crafting markets for genetically engineered drugs were biologists themselves who were in fact trying to do science. This book captures that heady, fleeting moment when a biologist could expect to do great science through the private sector and be rewarded with both wealth and scientific acclaim.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.