After stroke, reorganization of surviving neural networks appears to be important for recovery of function. Noninvasive techniques such as functional magnetic resonance imaging allow some aspects of this reorganization to be studied in humans. In these experiments reorganization is apparent in cerebral networks in human stroke patients. For example, initial attempts to move a paretic limb following stroke are associated with widespread activity within the distributed motor system in both cerebral hemispheres, more so in patients with greater impairment. Disruption of activity in premotor areas using transcranial magnetic stimulation prior to movement can impair motor performance in stroke patients, suggesting that these new patterns of brain activity can support what recovered function there is. In other words, this reorganization is functionally relevant. This opens the way for functional brain imaging to become a clinically useful tool in rehabilitation. Understanding the dynamic process of systems-level reorganization will allow greater understanding of the mechanisms of recovery and potentially improve our ability to deliver effective restorative therapy.
From the first pitch at the original Polo Grounds on May 1, 1883, to the night of August 9, 2002, at Pacific Bell Park, where Barry Bonds crushed his 600th career home run -- and beyond -- the New York and San Francisco Giants have been one of the most successful -- and popular -- franchises in Major League Baseball. They have won five World Series championships (plus three 19th-century titles) and 20 National League pennants. Some 50 Giants are enshrined in the National Baseball Hall of Fame in Cooperstown, New York (more than any other franchise). Now, all the highlights and the individuals who provided them are captured in this comprehensive history of the club. The Giants Encyclopedia is more than just a running narrative of the franchise's history. It chronicles all 120 seasons in minute detail (the world championships, pennant winners, near-misses and disappointments). The book features biographies of more than 100 players (from Hall of Famers like Willie Mays and Christy Mathewson to present-day stars like Barry Bonds and Robb Nen), plus prominent owners (such as John Day, Horace and Charles Stoneham, Bob Lurie and Peter Magowan); front office executives (like Chub Feeney, Al Rosen and Brian Sabean); managers (such as John McGraw, Leo Durocher, Roger Craig and Dusty Baker); and broadcasters (Russ Hodges, Lon Simmons and Hank Greenwald).
Pandemics, epidemics and food borne diseases are a major global challenge. Focusing on the food and farming sector, and mobilising social theory as well as empirical enquiry, Pathological Lives investigates current approaches to biosecurity and ask how pathological lives can be successfully ‘regulated’ without making life more dangerous as a result. Uses empirical and social theoretical resources developed in the course of a 40-month research project entitled ‘Biosecurity borderlands’ Focuses on the food and farming sector, where the generation and subsequent transmission of disease has the ability to reach pandemic proportions Demonstrates the importance of a geographical and spatial analysis, drawing together social, material and biological approaches, as well as national and international examples The book makes three main conceptual contributions, reconceptualising disease as situated matters, the spatial or topological analysis of situations and a reformulation of biopolitics Uniquely brings together conceptual development with empirically and politically informed work on infectious and zoonotic disease, to produce a timely and important contribution to both social science and to policy debate
Exam Board: AQA Level: AS/A-level Subject: History First Teaching: September 2015 First Exam: June 2016 AQA approved Enhance and expand your students' knowledge and understanding of their AQA breadth study through expert narrative, progressive skills development and bespoke essays from leading historians on key debates. - Builds students' understanding of the events and issues of the period with authoritative, well-researched narrative that covers the specification content - Introduces the key concepts of change, continuity, cause and consequence, encouraging students to make comparisons across time as they advance through the course - Improves students' skills in tackling interpretation questions and essay writing by providing clear guidance and practice activities - Boosts students' interpretative skills and interest in history through extended reading opportunities consisting of specially commissioned essays from practising historians on relevant debates - Cements understanding of the broad issues underpinning the period with overviews of the key questions, end-of-chapter summaries and diagrams that double up as handy revision aids Democracy, Empire and War: Britain 1851-1964 This title explores political and social reform 1851-1914, the impact of both World Wars, the creation of the Welfare State and the transformational social changes of the 1950s and 1960s. It considers breadth issues of change, continuity, cause and consequence in this period through examining key questions on themes such as democracy, ideology, economy, society, Britain's' position in the world and the impact of key individuals.
The impact of information technology (IT) on government in the last five years has been profound. Using the governments of Canada and Ontario (both recognized as international leaders in the use of IT) as case studies, Digital State at the Leading Edge is the first attempt to take a comprehensive view of the impact of IT upon the whole of government, including politics and campaigning, public consultation, service delivery, knowledge management, and procurement. Using the concepts of channel choice, procurement market analysis, organizational integration, and digital leadership, this study explores the inter-relationships among all these aspects of the application of IT to government and politics. The authors seek to understand how IT is transforming government and what the nature of that transformation is. In the process, they offer an explanation of Canada's relative success, and conclude with practical advice to politicians and public servants about how to manage IT in government more effectively. Based on new and original research undertaken over the last five years, the findings of this intriguing study will be of interest to those studying or working in the fields of public administration, political science, and information technology.
President Obama and the UK Labour and Coalition governments have all backed the renewed momentum for serious progress towards a world free of nuclear weapons, whilst the UK finds itself embarked on a controversial and expensive programme to renew its Trident nuclear weapons system. What does the UK process tell about the prospects for disarmament?
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