A bold and controversial manifesto on where information technology is headed, how its role in business strategy will dramatically change, and what this all means for business managers and IT suppliers Does IT Matter provides the first cogent explanation of IT’s dramatically changing business role, its levelling influence on competition, and the practical implications for business managers and IT suppliers. A convincing manifesto on one of the most important business phenomena of our time, “Does IT Matter?” will play a central role in our ongoing debate about the future of IT.
Sand dunes are a globally important depositional landform and sedimentary system. Their origins and dynamics are important in understanding how deserts have evolved in response to climate change and changes in sand supply and mobility, and how they will continue to evolve in the future. This book provides a state-of-the-art review of the characteristics of desert dunes and their sediments, and explores their dynamics on timescales from days to millennia as they respond to changes in wind speed and direction, precipitation and sand supply. This extensively revised edition reflects the advances in our understanding of desert dunes, their dynamics and history; and covers recent developments including the luminescence dating revolution, ground penetrating radar and advances in numerical modeling. Also covering dunes on Mars and Titan, this authoritative reference is a must-have for researchers and graduate students working on desert dunes and aeolian geomorphology.
This unique archaeological account from Nicholas Saunders tells the story of the origins of modern guerrilla warfare during the Arab Revolt of 1916-18. The discovery of an unknown conflict landscape reveals the dramatic exploits of T. E. Lawrence, Emir Feisal, Bedouin warriors, and their attacks on the Hejaz Railway during the First World War.
Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.
New York Times bestseller • Finalist for the Pulitzer Prize "This is a book to shake up the world." —Ann Patchett Nicholas Carr’s bestseller The Shallows has become a foundational book in one of the most important debates of our time: As we enjoy the internet’s bounties, are we sacrificing our ability to read and think deeply? This 10th-anniversary edition includes a new afterword that brings the story up to date, with a deep examination of the cognitive and behavioral effects of smartphones and social media.
Notes for the MRCGP This classic book has been providing help for candidates of the MRCGP exam for over 20 years. Now fully updated for UK trained doctors wishing to obtain a Certificate of Completion of Training in General Practice, this new edition covers all three required components of the integrated assessment programme. It provides sample questions for the Applied Knowledge Test (AKT), practice cases for Clinical Skill Assessment (CSA) and a guide to Workplace Based Assessment (WPBA). The chapters follow the 16 sections of the RCGP curriculum and include summaries of the current evidence base with clinical guidelines, examination tips, revision tactics, and advice on where to get support – but not just at the crucial time of exams – it includes invaluable information for GPs starting their first year in practice and helps provide the “life skills” needed to be a GP, including topics relevant for the rest of a GP’s career and their “continuing professional development” – appraisal, revalidation, managing change, teamwork, burnout, and other areas of self care.
Future Shock for the Web-apps era.... Compulsively readable—for nontechies, too."—Fast Company Building on the success of his industry-shaking Does IT Matter? Nicholas Carr returns with The Big Switch, a sweeping look at how a new computer revolution is reshaping business, society, and culture. Just as companies stopped generating their own power and plugged into the newly built electric grid some hundred years ago, today it's computing that's turning into a utility. The effects of this transition will ultimately change society as profoundly as cheap electricity did. The Big Switch provides a panoramic view of the new world being conjured from the circuits of the "World Wide Computer." New for the paperback edition, the book now includes an A–Z guide to the companies leading this transformation.
In this ground-breaking and compelling book, Nicholas Carr argues that not since Gutenberg invented printing has humanity been exposed to such a mind-altering technology. The Shallows draws on the latest research to show that the Net is literally re-wiring our brains inducing only superficial understanding.
Over the last decade, and even since the bursting of the technology bubble, pundits, consultants, and thought leaders have argued that information technology provides the edge necessary for business success. IT expert Nicholas G. Carr offers a radically different view in this eloquent and explosive book. As IT's power and presence have grown, he argues, its strategic relevance has actually decreased. IT has been transformed from a source of advantage into a commoditized "cost of doing business"--with huge implications for business management. Expanding on Carr's seminal Harvard Business Review article that generated a storm of controversy, Does IT Matter? provides a truly compelling--and unsettling--account of IT's changing business role and its leveling influence on competition. Through astute analysis of historical and contemporary examples, Carr shows that the evolution of IT closely parallels that of earlier technologies such as railroads and electric power. He goes on to lay out a new agenda for IT management, stressing cost control and risk management over innovation and investment. And he examines the broader implications for business strategy and organization as well as for the technology industry. A frame-changing statement on one of the most important business phenomena of our time, Does IT Matter? marks a crucial milepost in the debate about IT's future. An acclaimed business writer and thinker, Nicholas G. Carr is a former executive editor of the Harvard Business Review.
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