The Triassic period is generally viewed as the beginning of the Age of Dinosaurs. For paleontologists, however, it also marks the rise of the world's first modern land ecosystems. Over the past three decades, extensive, worldwide fieldwork has led to the discovery of many new species of Triassic animals and plants, suggesting that faunal and floral changes already began in the Middle Triassic and were more protracted than previously thought. The Late Triassic is a pivotal time in the evolution of life on land, with many of the major groups of present-day vertebrates and insects first appearing in the fossil record. This book provides the first detailed overview of life on land during the Triassic period for advanced students and researchers. Noted vertebrate paleontologists Hans-Dieter Sues and Nicholas C. Fraser also review the biotic changes of this period and their possible causes.
Morson and Dawson's Gastrointestinal Pathology is one of the 'Gold Standards' of pathology textbooks. It has been completely revised to incorporate the latest advances in this rapidly evolving field including the developments in gastric cancer and Helicobacter pylori and the revised classification of other common gastrointestinal conditions. This new edition features a wealth of new material presented in full colour for the first time.
Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.
A sequel to Nicholas Orme's widely praised study, Medieval Children Children have gone to school in England since Roman times. By the end of the middle ages there were hundreds of schools, supporting a highly literate society. This book traces their history from the Romans to the Renaissance, showing how they developed, what they taught, how they were run, and who attended them. Every kind of school is covered, from reading schools in churches and town grammar schools to schools in monasteries and nunneries, business schools, and theological schools. The author also shows how they fitted into a constantly changing world, ending with the impacts of the Renaissance and the Reformation. Medieval schools anticipated nearly all the ideas, practices, and institutions of schooling today. Their remarkable successes in linguistic and literary work, organizational development, teaching large numbers of people shaped the societies that they served. Only by understanding what schools achieved can we fathom the nature of the middle ages.
The Triassic period is generally viewed as the beginning of the Age of Dinosaurs. For paleontologists, however, it also marks the rise of the world's first modern land ecosystems. Over the past three decades, extensive, worldwide fieldwork has led to the discovery of many new species of Triassic animals and plants, suggesting that faunal and floral changes already began in the Middle Triassic and were more protracted than previously thought. The Late Triassic is a pivotal time in the evolution of life on land, with many of the major groups of present-day vertebrates and insects first appearing in the fossil record. This book provides the first detailed overview of life on land during the Triassic period for advanced students and researchers. Noted vertebrate paleontologists Hans-Dieter Sues and Nicholas C. Fraser also review the biotic changes of this period and their possible causes.
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