Focused manuscript on the potential use/role of miRNAs in bioprocessing, specifically the production of complex proteins in mammalian cells. With that in mind I propose a draft list of topics/chapters along the following lines: Intro on CHO/bioprocessing/engineering challenges to set scene, Genomic organization, biogenesis and mode of action, Identifying miRNA targets: Computational prediction, transcriptomics, proteomices, UTR analysis, etc., miRNA expression in Chinese Hamster Ovary cells, miRNAs as engineering targets: pathway manipulation to impact bioprocess phenotypes, miRNAs as biomarkers, Detection methods: Northern, PCR, hybridization arrays, Next Gen Seq, Manipulation of expression in cultured cells: Transient/stable disregulation, Knockout.
This volume explains the genesis and development of the nexus between radical Basque nationalists and Irish republicans, how they have learnt from each other historically, and how they have utilised this relationship, at times, to their benefit. From medieval tales of shared origins to the violent conflicts largely wrought by ETA and the IRA, the Basque Country and Ireland have long been associated in popular imagination. Despite this, little is known of historical Basque-Irish relations and, in particular, the web of party-political, military and social movement connections between radical Basque nationalists and Irish republicans since the Irish Revolutionary Period (1916–23). Drawing on extensive archival research undertaken in Spain, Ireland and the UK, and more than 70 interviews conducted with politicians, former paramilitaries and grassroots activists, this is the first study to comprehensively document and analyse the emergence, evolution and implications of this mythified transnational relationship. Radical Basque Nationalist-Irish Republican Relations: A History will appeal to students and scholars of Irish republicanism, Basque nationalism, terrorism studies and social movements studies, as well as those interested in the contemporary history of Western Europe’s two most volatile regions.
NAMED A BEST BOOK OF THE YEAR BY THE WASHINGTON POST and REAL SIMPLE A profound and enchanting new novel from Booker Prize-longlisted author Niall Williams about the loves of our lives and the joys of reminiscing. You don't see rain stop, but you sense it. You sense something has changed in the frequency you've been living and you hear the quietness you thought was silence get quieter still, and you raise your head so your eyes can make sense of what your ears have already told you, which at first is only: something has changed. The rain is stopping. Nobody in the small, forgotten village of Faha remembers when it started; rain on the western seaboard was a condition of living. Now--just as Father Coffey proclaims the coming of electricity--it is stopping. Seventeen-year-old Noel Crowe is standing outside his grandparents' house shortly after the rain has stopped when he encounters Christy for the first time. Though he can't explain it, Noel knows right then: something has changed. This is the story of all that was to follow: Christy's long-lost love and why he had come to Faha, Noel's own experiences falling in and out of love, and the endlessly postponed arrival of electricity--a development that, once complete, would leave behind a world that had not changed for centuries. Niall Williams' latest novel is an intricately observed portrait of a community, its idiosyncrasies and its traditions, its paradoxes and its inanities, its failures and its triumphs. Luminous and otherworldly, and yet anchored with deep-running roots into the earthy and the everyday, This Is Happiness is about stories as the very stuff of life: the ways they make the texture and matter of our world, and the ways they write and rewrite us.
How ought a society to distribute its publicly funded healthcare resources? Few questions are in more urgent need of an answer. This multidisciplinary investigation brings together the insights of philosophy, clinical science, health economics, operational research and public policy analysis.
The instant New York Times bestseller. A brilliant recasting of the turning points in world history, including the one we're living through, as a collision between old power hierarchies and new social networks. “Captivating and compelling.” —The New York Times "Niall Ferguson has again written a brilliant book...In 400 pages you will have restocked your mind. Do it." —The Wall Street Journal “The Square and the Tower, in addition to being provocative history, may prove to be a bellwether work of the Internet Age.” —Christian Science Monitor Most history is hierarchical: it's about emperors, presidents, prime ministers and field marshals. It's about states, armies and corporations. It's about orders from on high. Even history "from below" is often about trade unions and workers' parties. But what if that's simply because hierarchical institutions create the archives that historians rely on? What if we are missing the informal, less well documented social networks that are the true sources of power and drivers of change? The 21st century has been hailed as the Age of Networks. However, in The Square and the Tower, Niall Ferguson argues that networks have always been with us, from the structure of the brain to the food chain, from the family tree to freemasonry. Throughout history, hierarchies housed in high towers have claimed to rule, but often real power has resided in the networks in the town square below. For it is networks that tend to innovate. And it is through networks that revolutionary ideas can contagiously spread. Just because conspiracy theorists like to fantasize about such networks doesn't mean they are not real. From the cults of ancient Rome to the dynasties of the Renaissance, from the founding fathers to Facebook, The Square and the Tower tells the story of the rise, fall and rise of networks, and shows how network theory--concepts such as clustering, degrees of separation, weak ties, contagions and phase transitions--can transform our understanding of both the past and the present. Just as The Ascent of Money put Wall Street into historical perspective, so The Square and the Tower does the same for Silicon Valley. And it offers a bold prediction about which hierarchies will withstand this latest wave of network disruption--and which will be toppled.
Spectator Politics is the first major study of metatheatre, or theatrically self-conscious performance, in Aristophanes. Using a reception-based performance criticism, Niall Slater elucidates the comic effectiveness of the earliest surviving comedies in the Western tradition. Slater demonstrates that Aristophanes employed metatheatre not simply to entertain but also to teach his audience how to read and interpret performance in other key public venues of the ancient democracy of Athens, such as performances in the political assembly and law courts. Aristophanes was, Slater contends, the first performance critic. Spectator Politics shows how Aristophanes' comedy served the Athenians by helping them to become active political participants, teaching them to see through deceptive performances, whether on stage or in the political sphere. His comedies use self-conscious performance to encourage the public to move out of the role of passive consumers of spectacle and to reengage the political process. Aristophanes' critique of performance prefigures much in the performance-dominated culture of the modern American political scene. Throughout, detailed readings of the original stagings illuminate the plays for today's audiences and performers, while Slater's cultural critique provides much for those interested in Athenian democracy and its lesson for the contemporary political scene. Spectator Politics offers a salutary demonstration of the power of art to expose and resist the performance powers of would-be demagogues.
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.