Microspheres and Regional Cancer Therapy takes an interdisciplinary approach to the subject of microspheres and regional cancer therapy. It synthesizes laboratory and clinical data to demonstrate the utility of microsphere-based strategies in the treatment of localized solid tumors (particularly in the liver) not amenable to surgery and as a component of strategies for treatment of disseminated disease. Using the same techniques that show the deficiencies of delivery strategies involving antibodies, liposomes, and synthetic polymers, clear evidence is presented describing how microspheres of appropriate size can be localized in solid tumor deposits in the liver with little exposure to other organs. To exploit this phenomenon, the extent and nature of the incorporation of active agents within microspheres is discussed in relation to release, pharmacokinetics, and tumor response achieved by intensification of therapy in the manner described. This book will benefit laboratory-based scientists and clinicians in pharmaceutics, pharmacology, physiology, surgical oncology, and nuclear medicine. In addition, cancer clinicians interested in the value of regional therapy will be able to evaluate the underlying theory and learn the necessary methodology.
This revised edition of Dr Neville A. Ritchie’s 1986 PhD dissertation explores the history and archaeology of the 19th century Chinese mining communities in the Clutha Valley, New Zealand. Lavishly illustrated with black-and-white line drawings of Chinese domestic and industrial sites, and of the artefacts excavated from them, this study offers unprecedented insight into the life and material culture of these male-only “sojourner” communities. Widely considered the most comprehensive archaeological study of overseas Chinese miners’ experience anywhere in the world, this volume contains the total summation and analysis of artefacts found in 23 Chinese sites excavated over nine years, which included two camps (with 40 individual huts and other features), a Chinese store and 20 rural sites, including miner’s huts and rock shelters. Considered by the Australian Society for Historical Archaeology to be a seminal work in the field of historical archaeology, this 2023 edition introduces Dr. Ritchie’s groundbreaking work to the next generation of archaeologists.
Addresses such issues as: climate change and resource depletion; community decay, data saturation, the future of universities, democratic devolution, leaders and led, and medical philosophy; and, biowarfare, the management of Near Space, international currency, and a planetary ethos.
With contributions by recognised experts in the field of education law, this book is a comparative study of the resolution of special education disputes, including via mediation. It analyses the varying approaches in England, Scotland, the US and the Netherlands and addresses major questions of dispute resolution, redress, judicial and non-judicial approaches and the protection of citizens' rights. The first review of mediation in citizen v. state disputes outside the context of the courts, this topical book also incorporates findings from a recent ESRC study into dispute resolution in special educational needs cases. It will not only be of interest to those concerned with education issues but also those interested in administrative justice, especially the role of mediation generally
Evidence-based, superbly illustrated, and easy to read, Berek & Hacker’s Gynecologic Oncology, Seventh Edition, remains your reference of choice for authoritative information on every aspect of gynecologic malignancies. Templated chapters provide quick access to guidance on everything from general principles through diagnosis and medical and surgical management. This fully revised edition offers the practical, state-of-the-art coverage you need when caring for women with preinvasive disease; ovarian, breast, uterine, cervical, vulvar, and vaginal cancers; and gestational trophoblastic disease.
A pioneering study of the neglected transnational activities and influences of two important, connected socialists, British-born Tom Mann (1856-1941) and Australian-born Robert Samuel ‘Bob’ Ross (1873-1931)
Originally published in 1972, this book is an analytical account of the socio-medical tribulations suffered by Glasgow’s east-end elderly leading to referral to geriatric wards. It examines why so many old people suffer from physical, mental and social deprivation in the final years of their lives. It shows by statistical studies and illustrative case histories that the basic cause is the survival into old age of people who are unfit to care for themselves, in such numbers that help from families, neighbours, the social services and the NHS is insufficient. From this study the expression the "geriatric giants" or the four I’s was coined: impairment of intellect (cerebral dysfunction), incontinence, immobility and instability (falls). The term ‘giant’ is seen to refer both to statistical frequency and to the huge personal burden of sufferers, escalating the need for socio-medical intervention. Prophetic in its predictions that the huge and complex social care problem would grow in the future much of this book remains relevant today.
In recent years historians and other social scientists have widely questioned the continued relevance of social class - as historical relationship, as sociological category, as philosophical concept, and in terms of its enduring political significance. The success of the British Conservative Party since 1979, combined with the weaknesses and failures of the Labour movement, have led historians and social scientists to reconsider the general nature of connections between the 'social' and the 'political' and the specific relations between the working class and socialist and Labour politics. This collection of essays is a multi-disciplinary critique of the new revisionism, which demonstrates the continued vitality and promise of non-reductionist and non-determinist modes of class analysis.
Berek and Hacker's Gynecologic Oncology is written for gynecologic oncologists and fellows, general gynecologists and medical and radiation oncologists and presents the general principles and medical and surgical treatment for the range of gyencologic cancers: cervical, breast, ovarian, vulvar and vaginal and uterine. Chapters are templated and evidence-based. The strength of this book is its ability to translate basic science to clinical practice. Gynecologic Oncology is one of the four gynecologic subspecialties (along with FPMRS, REI and MFM).
The type of local and school history before the reader may be unfamiliar. It is a definitive and scholarly history in the style of many grammar school histories in Queensland. Although it is not unknown for Australian public and private schooling, it is unique for Queensland state schools. By saying it is a ‘definitive and scholarly history’, what is meant is not that the history is complete; only that it reaches decisive conclusions in a substantive treatment. In this particular case, the historian is someone who has been trained at the level of a higher degree.
Microspheres and Regional Cancer Therapy takes an interdisciplinary approach to the subject of microspheres and regional cancer therapy. It synthesizes laboratory and clinical data to demonstrate the utility of microsphere-based strategies in the treatment of localized solid tumors (particularly in the liver) not amenable to surgery and as a component of strategies for treatment of disseminated disease. Using the same techniques that show the deficiencies of delivery strategies involving antibodies, liposomes, and synthetic polymers, clear evidence is presented describing how microspheres of appropriate size can be localized in solid tumor deposits in the liver with little exposure to other organs. To exploit this phenomenon, the extent and nature of the incorporation of active agents within microspheres is discussed in relation to release, pharmacokinetics, and tumor response achieved by intensification of therapy in the manner described. This book will benefit laboratory-based scientists and clinicians in pharmaceutics, pharmacology, physiology, surgical oncology, and nuclear medicine. In addition, cancer clinicians interested in the value of regional therapy will be able to evaluate the underlying theory and learn the necessary methodology.
Attemps to provide a comprehensive list of geological features in Queenslan which are deserving of protection. It also provides a preliminary blueprint for the protection of the most interesting examples of the geology of Queensland.
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