Lonely Planet: The world's number one travel guide publisher Lonely Planet's Ireland is your passport to the most relevant, up-to-date advice on what to see and skip, and what hidden discoveries await you. Sample Guinness in Dublin, wander wild Connemara and take in traditional music - all with your trusted travel companion. Get to the heart of Ireland and begin your journey now! Inside Lonely Planet's Ireland: NEW pull-out, passport-size 'Just Landed' card with wi-fi, ATM and transport info - all you need for a smooth journey from airport to hotel Improved planning tools for family travellers - where to go, how to save money, plus fun stuff just for kids What's New feature taps into cultural trends and helps you find fresh ideas and cool new areas our writers have uncovered NEW Accommodation feature gathers all the information you need to plan your accommodation NEW Where to Stay in Dublin map is your at-a-glance guide to accommodation options in each neighbourhood Colour maps and images throughout Highlights and itineraries help you tailor your trip to your personal needs and interests Insider tips to save time and money and get around like a local, avoiding crowds and trouble spots Cultural insights give you a richer, more rewarding travel experience - history, people, music, landscapes, wildlife, cuisine, politics Covers Dublin, Wicklow, Kildare, Wexford, Waterford, Carlow, Kilkenny, Cork, Kerry, Limerick, Tipperary, Clare, Galway, Mayo, Donegal, Belfast, Armagh, Londonderry, Antrim, Fermanagh, Tyrone, and more The Perfect Choice: Lonely Planet's Ireland is our most comprehensive guide to Ireland, and is perfect for discovering both popular and off-the-beaten-path experiences. About Lonely Planet: Lonely Planet is a leading travel media company and the world's number one travel guidebook brand, providing both inspiring and trustworthy information for every kind of traveller since 1973. 'Lonely Planet guides are, quite simply, like no other.' - New York Times 'Lonely Planet. It's on everyone's bookshelves, it's in every traveler's hands. It's on mobile phones. It's on the Internet. It's everywhere, and it's telling entire generations of people how to travel the world.' - Fairfax Media (Australia) eBook Features: (Best viewed on tablet devices and smartphones) Downloadable PDF and offline maps prevent roaming and data charges Effortlessly navigate and jump between maps and reviews Add notes to personalise your guidebook experience Seamlessly flip between pages Bookmarks and speedy search capabilities get you to key pages in a flash Embedded links to recommendations' websites Zoom-in maps and images Inbuilt dictionary for quick referencing Important Notice: The digital edition of this book may not contain all of the images found in the physical edition.
Treasure Neverland is about factual and fictional pirates. Swashbuckling eighteenth-century pirates were the ideal pirates of all time and tales of their exploits are still popular today. Most people have heard of Blackbeard and Captain Kidd even though they lived about three hundred years ago, but most have also heard of other pirates, such as Long John Silver and Captain Hook, even though these pirates never lived at all, except in literature. The differences between these two types of pirates - real and imaginary - are not quite as stark as we might think as the real, historical pirates are themselves somewhat legendary, somewhat fictional, belonging on the page and the stage rather than on the high seas. Based on extensive research of fascninating primary material, including testimonials, narratives, legal statements, colonial and mercantile records, Neil Rennie describes the ascertainable facts of real eighteenth-century pirate lives and then investigates how such facts were subsequently transformed artistically, by writers like Defoe and Stevenson, into realistic and fantastic fictions of various kinds: historical novels, popular melodramas, boyish adventures, Hollywood films. Rennie's aim is to watch, in other words, the long dissolve from Captain Kidd to Johnny Depp. There are surprisingly few scholarly studies of the factual pirates - properly analysing the basic manuscript sources and separating those documents from popular legends - and there are even fewer literary-historical studies of the whole crew of fictional pirates, although those imaginary pirates form a distinct and coherent literary tradition. Treasure Neverland is a study of this Scots-American literary tradition and also of the interrelations between the factual and fictional pirates - pirates who are intimately related, as the nineteenth-century writings about fictional pirates began with the eighteenth-century writings about supposedly real pirates. 'What I want is the best book about the Buccaneers', wrote Stevenson when he began Treasure Island in 1881. What he received, rightly, was indeed the best book: the sensational and unreliable History of the Pyrates (1724).
This compact and accessible reference work provides all the essential facts and figures about major aspects of modern Irish history from the passing of the Act of Union to the premiership of Bertie Ahern. Offering a full chronology , this book gives the reader a full insight on major aspects of modern Irish history. The book explores population, education, social structure and religion; economic statistics covering agriculture, trade, prices and wages, transport and unemployment and a further wealth of material on Irish women's history, treaties, elections, law, communications, a glossary and biographical information.
For Dummies Travel guides are the ultimate user-friendly trip planners, combining the broad appeal and time-tested features of the For Dummies series with up-to-the-minute advice and information from the experts at Frommer's. Small trim size for use on-the-go Focused coverage of only the best hotels and restaurants in all price ranges The fun and easy way to explore Europe From great museums and historic sights to fabulous food and trendsetting styles, Europe has it all. Get the lowdown on everything from passports to palaces, culture to nightlife, and cathedrals to cuisine. With mini-guides to fifteen of Europe's most popular cities and surrounding areas in eleven different countries, this book is your ticket to an exciting European adventure. Open the book and find: Down-to-earth trip-planning advice What you shouldn't miss -and what you can skip The best hotels and restaurants for every budget Lots of detailed maps
Irish political life has experienced great turmoil in recent years because of the scale and intricacy of political corruption being uncovered by parliamentary and quasi-judicial inquiries. There is genuine popular amazement and growing cynicism towards the seemingly never-ending wave of scandal and attendant tribunals. To understand political corruption in Ireland, this pamphlet examines the concept within a political-science analytical framework that allows both historical and international comparison. The book challenges the current explanations of political corruption, particularly those that stress a turning away from a political "golden age" in the 1960s "Understanding Political Corruption in Irish Politics" chronicles political scandals in the 1990s, looks at their causes and explains their consequences. It also suggests reform strategies that will reduce the incentives drawing politicians towards corruption and increase the likelihood and expense of being detected.
Ireland's love affair with Gaelic Games in general, and Gaelic football in particular, has never dimmed. Through the lean days of hunger and emigration, through the champagne-mojito-flavoured years of the Celtic Tiger and on after it slunk away with its tale between its legs, Ireland's love affair for 'our games' has endured.Fact-packed but light-hearted in style, this reliable reference book and a quirky guide reveals little-known facts and Gaelic football along with details of classic matches, statistical records, famous players, amusing anecdotes, and the general history of the game. This can be dipped into time and time again to reveal something new about this ancient game.
Lonely Planets Ireland is your passport to the most relevant, up-to-date advice on what to see and skip, and what hidden discoveries await you. Explore the Causeway Coast, have a pint in the pub, and drive the Ring of Kerry; all with your trusted travel companion. Get to the heart of Ireland and begin your journey now! Inside Lonely Planets Ireland Travel Guide: Up-to-date information - all businesses were rechecked before publication to ensure they are still open after 2020s COVID-19 outbreak NEW top experiences feature - a visually inspiring collection of Irelands best experiences and where to have them What's NEW feature taps into cultural trends and helps you find fresh ideas and cool new areas NEW pull-out, passport-size 'Just Landed' card with wi-fi, ATM and transport info - all you need for a smooth journey from airport to hotel NEW Accommodation feature gathers all the information you need to plan your accommodation NEW Where to Stay in Dublin map is your at-a-glance guide to accommodation options in each neighbourhood Improved planning tools for family travellers - where to go, how to save money, plus fun stuff just for kids Colour maps and images throughout Highlights and itineraries help you tailor your trip to your personal needs and interests Insider tips to save time and money and get around like a local, avoiding crowds and trouble spots Essential info at your fingertips - hours of operation, websites, transit tips, prices Honest reviews for all budgets - eating, sleeping, sightseeing, going out, shopping, hidden gems that most guidebooks miss Cultural insights give you a richer, more rewarding travel experience - history, people, music, landscapes, wildlife, cuisine, politics Over 90 maps Covers Dublin, Counties Wicklow & Kildare, Counties Wexford, Waterford, Carlow & Kilkenny, Cork, Kerry, Limerick & Tipperary, Clare, Galway, Mayo & Sligo, County Donegal, the Midlands, Belfast, Down & Armagh, Londonderry & Antrim, Fermanagh & Tyrone The Perfect Choice: Lonely Planets Ireland, our most comprehensive guide to Ireland, is perfect for both exploring top sights and taking roads less travelled. Looking for just the highlights? Check out Pocket Dublin, a handy-sized guide focused on the can't-miss sights for a quick trip. About Lonely Planet: Lonely Planet is a leading travel media company, providing both inspiring and trustworthy information for every kind of traveller since 1973. Over the past four decades, we've printed over 145 million guidebooks and phrasebooks for 120 languages, and grown a dedicated, passionate global community of travellers. You'll also find our content online, and in mobile apps, videos, 14 languages, armchair and lifestyle books, ebooks, and more, enabling you to explore every day. 'Lonely Planet guides are, quite simply, like no other.' New York Times 'Lonely Planet. It's on everyone's bookshelves; it's in every traveller's hands. It's on mobile phones. It's on the Internet. It's everywhere, and it's telling entire generations of people how to travel the world.' Fairfax Media (Australia)
Thermoplastic Aromatic Polymer Composites: A Study of the Structure, Processing and Properties of Carbon Fibre Reinforced Polyetheretherketone and Related Materials deals with the field of thermoplastic composite materials through a study of carbon fiber reinforced polyetheretherketone. The book is composed of twelve chapters. The first four chapters are an introduction and basic learning of thermoplastic composite materials. These chapters include discussions on the components of thermoplastics, product forms, and the microstructure of aromatic polymer composites. The processing and manufacturing technology, including the fundamental operations, control, and the wide implications of manufacturing the composite material, are analyzed. The service performance structure of three interactions, namely, material, design, and processing, are illustrated. The strength of thermoplastic composites is then considered through an analysis of both shear and extensions with elastic modulus, but in the case of material strength, the differences between tension and compression properties should be taken into account. The book also notes that the durability, temperature sensitivity, and environmental resistance should likewise be regarded for a structural composite to have practical value and satisfactory performance. Lastly, the text explains that the numerous applications of thermoplastic structural composites, such as in medicine, aviation, marine and space technology, automotive, and industrial machinery, are all important and a rigorous evaluation is therefore necessary. The book finally suggests that the research into the future developments in the thermoplastic structural composites and the trend toward new design strategies and processing technology are important in optimizing the composite's great potential. Industrial researchers in the field of chemistry and polymer composites, students, and academicians interested in the design and application of polymer composites will find this book relevant.
e eclectic scientist and inventor Prof. John Joly from Co. Offaly who, at fifty-eight, helped to defend Trinity College Dublin throughout the Rising. Many enlisted to fight for Irish Home Rule or Ulster Unionism, to find adventure or escape from poverty. None imagined they would find themselves on the streets of Dublin, killing – and being killed by – fellow Irishmen. Forty-one Irishmen in the British army died in action during the Rising, 106 were wounded. These men became a forgotten part of their country's history. • Also available: 'Blackpool to the Front: A Cork Suburb and Ireland's Great War 1914–1918' by Mark Cronin and 'When the Clock Struck in 1916: Close-Quarter Combat in the Easter Rising' by Derek Molyneux & Darren Kelly
This is the first historical monograph to demonstrate settler colonialism’s significance for Early America. Based on a nuanced reading of the archive and using a comparative approach, the book treats settler colonialism as a process rather than a coherent ideology. Spady shows that learning was a central site of colonial struggle in the South, in which Native Americans, Africans, and European settlers acquired and exploited each other’s knowledge and practices. Learned skills, attitudes, and ideas shaped the economy and culture of the region and produced challenges to colonial authority. Factions of enslaved people and of Native American communities devised new survival and resistance strategies. Their successful learning challenged settler projects and desires, and white settlers gradually responded. Three developments arose as a pattern of racialization: settlers tried to prohibit literacy for the enslaved, remove indigenous communities, and initiate some of North America's earliest schools for poorer whites. Fully instituted by the end of the 1820s, settler colonization’s racialization of learning in the South endured beyond the Civil War and Reconstruction.
Common-law judgments tend to be more than merely judgments, for judges often make pronouncements that they need not have made had they kept strictly to the task in hand. Why do they do this? The Intricacies of Dicta and Dissent examines two such types of pronouncement, obiter dicta and dissenting opinions, primarily as aspects of English case law. Neil Duxbury shows that both of these phenomena have complex histories, have been put to a variety of uses, and are not amenable to being straightforwardly categorized as secondary sources of law. This innovative and unusual study casts new light on – and will prompt lawyers to pose fresh questions about – the common law tradition and the nature of judicial decision-making.
In this groundbreaking history of Ireland, Neil Hegarty presents a fresh perspective on Ireland's past. Comprehensive and engaging, The Story of Ireland is an eye-opening account of a nation that has long been shaped by forces beyond its coasts. The Story of Ireland re-examines Irish history, challenging the accepted stories and long-held myths associated with Ireland. Transporting readers to the Ireland of the past, beginning with the first settlement in A.D. 433, this is a sweeping and compelling history of one of the world's most dynamic nations. Hegarty examines how world events, including Europe's 16th century religious wars, the French and American revolutions, and Ireland's policy of neutrality during World War II, have shaped the country over the course of its long and fascinating history. With an up-to-date afterword that details the present state of affairs in Ireland, this is an essential text for readers who are fascinated by current events, politics, and history. Spanning Irish history from its earliest inhabitants to the country's current financial crisis, The Story of Ireland is an epic and brilliant re-telling of Ireland's history from a new point of view.
Norwich in the Second World War is the story of the city and its people, both civilian and military, from the construction of the first air raid shelters in 1938 through to VE Day in 1945 and the return of Far Eastern prisoners of war in 1946. Featuring first-hand accounts of what happened when enemy bombers raided the city, notably during the notorious Baedeker Blitz of 1942, rare photographs and documents make this book a must for anyone who knows and loves the city of Norwich.
The deep and abiding sectarian divide splintering Northern Ireland has been the focus of considerable attention recently. In particular, the role parades and visual displays play in underscoring opposition has come into the spotlight with the emergence of heightened tensions, close on the heels of a tentative peace. Providing penetrating insights into the historical roots of Northern Ireland's ethnic hostilities, this timely book explores the role of images and material culture in shaping present attitudes. Ritual, identity, class and memory are shown to be potent forces informing trenchant animosities -- animosities which are visually reflected in banners and murals for unionists and nationalists alike. The pivotal role of the Twelfth of July parade in Belfast, when an estimated 100,000 either parade or watch the Orangemen, is highlighted. Anyone interested in the future of Northern Ireland and concerned about escalating conflict across the globe will warmly welcome this impressive study.
Lonely Planet: The world's number one travel guide publisher Whether exploring your own backyard or somewhere new, discover the freedom of the open road with Lonely Planet's Ireland's Best Trips. Featuring 34 amazing road trips, plus up-to-date advice on the destinations you'll visit along the way, you can explore Dublin's heritage, Connemara's scenery and Galway's pubs - all with your trusted travel companion. Jump in the car, turn up the tunes, and hit the road! Inside Lonely Planet's Ireland's Best Trips: Lavish colour and gorgeous photography throughout Itineraries and planning advice to pick the right tailored routes for your needs and interests Get around easily - easy-to-read, full-colour route maps and detailed directions Insider tips to get around like a local, avoid trouble spots and be safe on the road - local driving rules, parking, toll roads Essential info at your fingertips - hours of operation, phone numbers, websites, prices Honest reviews for all budgets - eating, sleeping, sight-seeing, hidden gems that most guidebooks miss Useful features - including Stretch Your Legs, Detours, Link Your Trip Covers Dublin, Ennis, Cork, Galway, Belfast, the Dingle Peninsula, Wexford, Waterford, Killarney, Limerick, Westport, Tralee, Kenmare, Ring of Kerry, Connemara, Glendalough, Doolin, Derry, Bangor, and more The Perfect Choice: Lonely Planet's Ireland's Best Trips is perfect for exploring Ireland by road and discovering sights that are more accessible by car. About Lonely Planet: Lonely Planet is a leading travel media company and the world's number one travel guidebook brand, providing both inspiring and trustworthy information for every kind of traveller since 1973. Over the past four decades, we've printed over 145 million guidebooks and grown a dedicated, passionate global community of travellers. You'll also find our content online, and in mobile apps, video, 14 languages, nine international magazines, armchair and lifestyle books, ebooks, and more. 'Lonely Planet guides are, quite simply, like no other.' - New York Times 'Lonely Planet. It's on everyone's bookshelves, it's in every traveler's hands. It's on mobile phones. It's on the Internet. It's everywhere, and it's telling entire generations of people how to travel the world.' - Fairfax Media (Australia) eBook Features: (Best viewed on tablet devices and smartphones) Downloadable PDF and offline maps prevent roaming and data charges Effortlessly navigate and jump between maps and reviews Add notes to personalise your guidebook experience Seamlessly flip between pages Bookmarks and speedy search capabilities get you to key pages in a flash Embedded links to recommendations' websites Zoom-in maps and images Inbuilt dictionary for quick referencing Important Notice: The digital edition of this book may not contain all of the images found in the physical edition.
Want to learn how to create great user experiences on today's Web? In this book, UI experts Bill Scott and Theresa Neil present more than 75 design patterns for building web interfaces that provide rich interaction. Distilled from the authors' years of experience at Sabre, Yahoo!, and Netflix, these best practices are grouped into six key principles to help you take advantage of the web technologies available today. With an entire section devoted to each design principle, Designing Web Interfaces helps you: Make It Direct-Edit content in context with design patterns for In Page Editing, Drag & Drop, and Direct Selection Keep It Lightweight-Reduce the effort required to interact with a site by using In Context Tools to leave a "light footprint" Stay on the Page-Keep visitors on a page with overlays, inlays, dynamic content, and in-page flow patterns Provide an Invitation-Help visitors discover site features with invitations that cue them to the next level of interaction Use Transitions-Learn when, why, and how to use animations, cinematic effects, and other transitions React Immediately-Provide a rich experience by using lively responses such as Live Search, Live Suggest, Live Previews, and more Designing Web Interfaces illustrates many patterns with examples from working websites. If you need to build or renovate a website to be truly interactive, this book gives you the principles for success.
A thorough updating of the best-selling, vital reference and textbook on melanocytic proliferations PRAISE FOR THE FIRST EDITION: “Well-written and entertaining” —Modern Pathology “An extremely helpful guide for the practicing dermatopathologist or general pathologist” —Archives of Pathology and Laboratory Medicine “An incredibly relevant clinical-histopathologic text” —Doody’s Melanocytic proliferations comprise a large number of pigmented lesions of the skin and muscosa. Of these, melanoma is of particular interest to clinicians and their patients. The rising number of incidences of melanoma has led to increased interest in the disease from diagnostic, management, and basic science perspectives. The Melanocytic Proliferations: A Comprehensive Textbook of Pigmented Lesions is the most complete single-source treatment of the subject available—thoroughly updated to reflect the very latest studies and clinical experience in diagnosing and treating melanocytic proliferation. This new edition of the bestseller presents an experience- and evidence-based review of pigmented lesions that encompasses the biology, diagnosis, and treatment of melanocytic proliferations and disorders, including melanoma. It comes with over 300 new color images—bringing the total to over 600—and contains two completely new chapters: Dermatoscopic Diagnosis of Melanoma; and Reflectance Confocal Microscopy. Chapter coverage includes: • An approach to the clinical diagnosis of melanoma, its precursors, and its clinical mimics • Freckles and lentigines • Benign acquired nevi • Dermal dendritic melanocytic proliferations/dermal melanocytoses • Spitz nevus • Combined nevus, deep penetrating nevus, plexiform spindle cell nevus, and borderline tumors of the deep penetrating nevus variant • Recurrent melanocytic nevus • Congenital nevi • Dysplastic melanocytic nevi, de novo intradermal epithelioid and lentiginous melanocytic dysplasias, and nevi at specific anatomic sites • Melanoma • Conjunctival melanocytic proliferations • Use of adjunctive immunoperoxidase, molecular, and ultrastructural studies in the diagnosis of melanocytic proliferations • Biology of melanoma • Borderline melanocytic proliferation • Dermatoscopic diagnosis of melanoma • Reflectance confocal microscopy • Therapy of melanoma The Melanocytic Proliferations: A Comprehensive Textbook of Pigmented Lesions is an incredibly important text for all clinical pathologists, dermatopathologists, surgical pathologists, dermatologists, cosmetic physicians, and surgeons.
Filled with practical learning activities to adopt within your classroom, The Learning and Teaching of Statistics and Probability places reasoning about quantities and quantification at the core of learning and teaching statistics. A companion website to this book is also available at https://neilhatfield.github.io/IMPACT_Statistics/, allowing readers to access a directory of resources – data collections and web-based applets – used in some of the instructional activities featured within this book. Through its presentation of conceptual analyses and resources for teaching with statistical data, the book’s five chapters establish key concepts and foundational ideas in statistics and probability, emphasizing the development of learner understanding and coherence, for example: Individual cases and their attributes Data collections, sub-collections, and relevant operations to quantify their attributes Samples, population, and quantifying variation Types of processes, meanings of randomness, and probability as a measure of stochastic tendency Sampling distributions and statistical inference. This highly informative yet practical book is an indispensable resource for teachers of secondary school mathematics, mathematics subject leads, and mathematics and statistics educators within the wider field of education.
The practice of capoeira, the Brazilian dance-fight-game, has grown rapidly in recent years. It has become a popular leisure activity in many cultures, as well as a career for Brazilians in countries across the world including the US, the UK, Canada and Australia. This original ethnographic study draws on the latest research conducted on capoeira in the UK to understand this global phenomenon. It not only presents an in-depth investigation of the martial art, but also provides a wealth of data on masculinities, performativity, embodiment, globalisation and rites of passage. Centred in cultural sociology, while drawing on anthropology and the sociology of sport and dance, the book explores the experiences of those learning and teaching capoeira at a variety of levels. From beginners’ first encounters with this martial art to the perspectives of more advanced students, it also sheds light on how teachers experience their own re-enculturation as they embody the exotic ‘other’. Embodying Brazil: An Ethnography of Diasporic Capoeira is fascinating reading for all capoeira enthusiasts, as well as for anyone interested in the sociology of sport, sport and social theory, sport, race and ethnicity, or Latin-American Studies.
Legal professionals are thought to have higher levels of mental health issues and lower levels of wellbeing than the general population. Drawing on qualitative data from new research with legal practitioners, this in-depth study of mental health and wellbeing in the UK and Republic of Ireland’s legal sector is a timely contribution to the urgent international debate on these issues. The authors present a comprehensive discussion of the cultural, structural and other causes of legal professionals’ compromised wellbeing. They explore the everyday demands and difficulties of the legal working environment and consider the impacts on individuals, the legal profession and wider society. Making comparisons with systems overseas, this is an invaluable resource that provides evidence-based suggestions for swift and effective organisational and policy-related interventions in the legal sector.
Historian Henry Steele Commager (1902-1998) was one of the leading American intellectuals of the mid-twentieth century. Author or editor of more than forty books, he taught for decades at New York University, Columbia University, and Amherst College and w
More than an introductory text, Respiratory Care: Principles and Practice, Fourth Edition by Dean Hess is a comprehensive resource will be referenced and utilized by students throughout their educational and professional careers.
The potentially long and arduous journey of writing a screenplay was just made easier to navigate with The Screenwriter's Roadmap. This book keeps you on track and helps you to write a finished, professional quality screenplay. Neil Landau provides you with 21 Guideposts that will help you nail down your screenplay's story structure, deepen its character arcs, bolster stakes, heighten suspense and diagnose and repair its potential weaknesses. The Guideposts are augmented by interactive exercises, end of chapter "homework" assignments, examples from the latest blockbusters and over 20 interviews with some of Hollywood's most successful screenwriters and directors.
This user-friendly resource offers complete and comprehensive coverage of the difficult challenges posed by drug-drug interactions. Over 170 case vignettes illustrate a variety of interactions (DDIs) to provide an unintimidating -- even entertaining -- approach to understanding these issues. Drug-Drug Interaction Primer builds on the author's earlier work, Drug Interactions Casebook: The Cytochrome P450 System and Beyond, and features updated references throughout and 29 new cases that provide such clinical examples as: a patient diagnosed with schizoaffective disorder transitions from haloperidol to aripiprazole with disastrous results; an AIDS patient's trimethoprim-sulfamethoxazole is replaced with warfarin following atrial fibrillation, resulting in ischemic stroke; and a delusional patient on risperidone is placed on phenytoin following seizures, and delusions return. Previous cases have been revised to enhance clarity. An introduction to core concepts, which includes brief reviews of each enzyme system, brings the reader up to speed on how to think about DDIs and begin to grapple with what might seem like an imposing subject. The vignettes that follow each include a case presentation and an explanation of the mechanism by which the interaction(s) occurred, and each derives from sound clinical evidence -- not merely extrapolations from drug characteristics -- to offer a more realistic understanding of DDIs. Most of the interactions described involve the cytochrome P450 enzyme system; others involve alterations in phase II metabolism and P-glycoprotein functioning, as well as plasma protein displacement effects. The appendices detail most drug-drug interactions between psychotropic agents and contain metabolic pathways and inhibitory and inductive profiles for antidepressants, antipsychotics, and mood stabilizing agents -- as well as tables that detail all known and clinically significant DDIs between pairings of any two agents from these drug classes. An extensive index allows quick reference. Among the book's other features: Reorganization by medical subspecialty -- psychiatry, internal medicine, neurology, surgery/anesthesia, and gynecology, oncology, and dermatology -- better facilitates clinical application. Comprehensive tables detail substrates, inhibitors, and inducers for P450, phase II, and P-glycoprotein. DDIs involving select nonpsychotropic agents such as tobacco, ethinylestradiol, and statins. Exploration of the paradigm of plasma protein binding mediated DDIs in detail, with cases conveniently indexed. These cases bring DDIs alive in a way that drier descriptions cannot, and this volume introduces more original material than will be found in other sources. Drug-Drug Interaction Primer is brimming with material that can be put to immediate use, offering insights that will improve any practitioner's skills.
Is Scottish politics mired in a constitutional dogfight with no end in sight? Why has Scottish Labour failed to develop a radical and credible alternative to independence? Is it possible for a campaigning politician to make a difference? Can people power lead to positive change? Over the last few years, political campaigner and former Labour msp Neil Findlay kept a log of his time in the Scottish Parliament, a time which he describes as one of perpetual crisis and scandal. This book is my account of being an elected politician. My comments convey my feelings and emotions as events unfolded. If they cause upset to some, then so be it. I can only report the truth. There is little doubt the tectonic plates of Scottish politics are shifting. Is this a time of hope or of despair? Time will tell. As a socialist, I am an optimist and live in hope and have a belief that tomorrow will always be better than today.
From medieval Carlingford in Louth to Blarney Castle in Cork, discover the top 100 places to visit in Ireland's Ancient East. Wander through time at sites such as Clonmacnoise, Newgrange and the Rock of Cashel, as well as at hidden gems like Athassel Priory in Tipperary, Loughcrew Passage Tombs in Meath and Heywood Gardens in Laois. From dolmens to round towers, Anglo-Norman castles to historic gardens, over 5,000 years of Ireland's history, heritage, archaeology and folklore are waiting to be discovered. Find out - which round towers can be climbed - where there is a 2,000-year-old trackway across a bog - which famous garden features a piece of the Berlin Wall - where St Nicholas is buried Included is practical information about each location and what to expect from the visitor experience. With easy-to-follow maps and specially commissioned photographs, this is the first guide to Ireland's Ancient East.
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