A Choice Outstanding Academic Title of the Year According to census projections, by 2050 nearly one in three U.S. residents will be Latino, and the overwhelming majority of these will be of Mexican descent. This dramatic demographic shift is reshaping politics, culture, and fundamental ideas about American identity. Neil Foley, a leading Mexican American historian, offers a sweeping view of the evolution of Mexican America, from a colonial outpost on Mexico’s northern frontier to a twenty-first-century people integral to the nation they have helped build. “Compelling...Readers of all political persuasions will find Foley’s intensively researched, well-documented scholarly work an instructive, thoroughly accessible guide to the ramifications of immigration policy.” —Publishers Weekly “For Americans long accustomed to understanding the country’s development as an east-to-west phenomenon, Foley’s singular service is to urge us to tilt the map south-to-north and to comprehend conditions as they have been for some time and will likely be for the foreseeable future...A timely look at and appreciation of a fast-growing demographic destined to play an increasingly important role in our history.” —Kirkus Reviews
Significant health-industry human resource needs increase the reliance on family and friends to support older adults hoping to age in place. This book explores how recent improvements in integrated home technologies have the potential to address those challenges. The book considers how embedded home sensors can be used to monitor the health and wellbeing of older adults and how that can be used to assist with supporting safety and well-being. The content is designed to help multiple stakeholders in the supportive smart home space to better understand the complexity of this field and the need for transdisciplinary collaboration. These stakeholders include the older adults who will benefit from supportive smart home technology; informal and formal caregiver and healthcare professionals concerned about the older adult’s well-being; researchers from multiple disciplines in the supportive smart home area and their funders; companies looking to develop solutions and services or expand their offerings; policy makers who want to ensure privacy and equity in access and a successful integration of these technologies into the evolving health and social services sectors; and students, the future leaders in AgeTech. Overall, the intent of the book is to inspire engineers, computer scientists, industrial designers, clinicians and healthcare providers, social scientists, students, policy makers, and older adults and their caregivers to collaborate in advancing the supportive smart home space to develop more options for aging in place.
Mickey G was my friend. This is a story about his father. Mickey grew up without his father, and he was in his late 50s before he learned what happened to his father and why his father never returned home. I feel very lucky that my life and Mickey’s crossed paths.
Prior to 1735, South America was terra incognita to many Europeans. But that year, the Paris Academy of Sciences sent a mission to the Spanish American province of Quito (in present-day Ecuador) to study the curvature of the earth at the Equator. Equipped with quadrants and telescopes, the mission’s participants referred to the transfer of scientific knowledge from Europe to the Andes as a “sacred fire” passing mysteriously through European astronomical instruments to observers in South America.By taking an innovative interdisciplinary look at the traces of this expedition, Measuring the New World examines the transatlantic flow of knowledge from West to East. Through ephemeral monuments and geographical maps, this book explores how the social and cultural worlds of South America contributed to the production of European scientific knowledge during the Enlightenment. Neil Safier uses the notebooks of traveling philosophers, as well as specimens from the expedition, to place this particular scientific endeavor in the larger context of early modern print culture and the emerging intellectual category of scientist as author.
This issue of Clinics in Chest Medicine focuses on Advances in Mechanical Ventilation. Articles include: Mechanical Ventilation Design Features; Assessing Respiratory System Mechanical Function; Ventilator Induced Lung Injury; Managing Acute Lung Injury; Patient-Ventilator Interactions; Extracorporeal Gas Exchange; Preventing Ventilator Associated Infections; Ventilator Discontinuation Process; Ventilator Management of the Non-injured Lung; Non-invasive Ventilation; and more!
Sample the untold history of Texas’s wine industry in this book filled with fascinating stories and photos. Spanish colonists may have come to Texas to spread Christianity, but under visionary Father Fray Garcia, they stayed and raised grapes. Later immigrants brought their own burgundy tastes of home, creating a unique wine country. When a North American pest threatened European vines, it was Texan scientist T. V. Munson who helped save the industry overseas. When Prohibition loomed stateside, Frank Qualia's Val Verde Winery in Del Rio survived by selling communion wine—and it’s now the longest-operating bonded winery in the state. Today, tourists flock to Texas vineyards, and the state sells more wine every year. Join local experts Kathy and Neil Crain and sample the untold story of Texas's wine industry, a 350-year story that is still reaching its savory peak.
This volume explores the development of literary culture in sixteenth-century England as a whole and seeks to explain the relationship between the Reformation and the literary renaissance of the Elizabethan period. Its central theme is the 'common' in its double sense of something shared and something base, and it argues that making common the work of God is at the heart of the English Reformation just as making common the literature of antiquity and of early modern Europe is at the heart of the English Renaissance. Its central question is 'why was the Renaissance in England so late?' That question is addressed in terms of the relationship between Humanism and Protestantism and the tensions between democracy and the imagination which persist throughout the century. Part One establishes a social dimension for literary culture in the period by exploring the associations of 'commonwealth' and related terms. It addresses the role of Greek in the period before and during the Reformation in disturbing the old binary of elite Latin and common English. It also argues that the Reformation principle of making common is coupled with a hostility towards fiction, which has the effect of closing down the humanist renaissance of the earlier decades. Part Two presents translation as the link between Reformation and Renaissance, and the final part discusses the Elizabethan literary renaissance and deals in turn with poetry, short prose fiction, and the drama written for the common stage.
A must for savvy travelers to the Longhorn State ? Delivers frank, up-to-date travel advice on Texas, a top destination state that had more than $100 million leisure travelers in 2001 who spent $40.4 billion ? Guides visitors to the best accommodations, dining, nightlife, and sights in Dallas-Fort Worth, Houston, San Antonio, Austin, Corpus Christi, El Paso, Amarillo, and more ? Highlights Texas's many family-friendly attractions (amusement parks, Big Bend and Guadalupe Mountains National Parks, and wonderful beaches), nature tourism options (such as the Great Texas Costal Birding Trail), and historic sites (such as the Alamo and the Caddoan Mounds) ? Provides the lowdown on Texan music and food and even offers tips on how to talk like a Texan
The real story of the Spanish Armada. In the winter of 1587 the Spanish Armada, the largest force of warships ever assembled, set sail to crush the English navy. This breathtaking overview of one of the most fascinating campaigns in European history begins with the execution of Mary Queen of Scots, the event that precipitated the launching of the Armada. From the first whispers of the threat against England and the English crown, to the return of the battered remnants of the fleet to Spain eighteen months later, it is a story rich in incident and intrigue. In this controversial study, Neil Hanson claims that Francis Drake’s intention was not to sink the Armada ships but to disable and plunder them. He further claims that Queen Elizabeth was a monarch who left many of the survivors of the battle to die of disease or starvation and whose parsimony, prevarication and cynicism left her unable to make crucial decisions. Drawing on previously undiscovered personal papers, Neil Hanson conveys in vivid detail how the highest and the lowest in the land fared in those turbulent months when the destiny of all Europe hung in the balance. From the Trade Paperback edition.
Book 9 of Silius Italicus' first-century Latin epic poem Punica begins the narrative of the Battle of Cannae (August 216 BC). This book is an integral part of the epic's three-book movement that narrates one of the largest battles in Roman history. It opens with the dispute between the consuls Paulus and Varro over giving battle, in the face of hostile omens and Hannibal's record of successful combat. On the eve of the battle, the Roman soldier Solymus accidentally kills his father Satricus, thereby presenting an omen of disaster for the Roman army. After Hannibal and Varro encourage their troops, the initial phase of the battle commences. The gods descend to the battlefield, and Mars and Minerva fight the sole full-scale theomachy in Latin epic. Aeolus summons the Vulturnus wind at Juno's request to devastate the Roman ranks. After the gods have departed, Hannibal's elephant troops advance and scatter the Roman forces. The book ends by recapitulating the opening episode: Varro admits his mistake in giving battle and flees the battlefield. This volume is the first full-scale commentary in English devoted exclusively to Punica 9. It features the Latin text with a critical apparatus and a parallel English translation. Detailed commentary notes provide information on literary style, use of language, poetic intertexts, and scholarly interpretation. The Introduction offers further context and background, including sections on Silius Italicus and his era, the historiographic and rhetorical traditions that he adopted, the inter- and intra-textuality of the Cannae episode, and the book's use of diction and metre.
The study of measurement and statistics can be less than inviting. However, in fields as varying as education, politics, and health care, assessment and the use of measurement and statistics have become integral parts of almost every activity undertaken. These activities require the organization of ideas, the generation of hypotheses, the collection of data, and the interpretation, illustration, and analysis of data. No matter where educated people look, this critical analysis is more important than ever in an age where information—and lots of it—is readily available. The ideas and tools contained in the Encyclopedia of Measurement and Statistics are approachable and can be invaluable for understanding a very technical world and the increasing flow of information. Although there are references that cover statistics and assessment in depth, none provides as comprehensive a resource in as focused and accessible a manner as the three volumes of this Encyclopedia. Through approximately 500 contributions, experts provide an overview and an explanation of the major topics in these two areas. Key Features Covers every major facet of these two different, but highly integrated disciplines—from mean, mode, and median to reliability, validity, significance, correlation, and much more—all without overwhelming the informed reader Offers cross-disciplinary coverage, with contributions from and applications to the fields of Psychology, Education, Sociology, Human Development, Political Science, Business and Management, Public Health, and others Provides cross-reference terms, further readings, and Web site URLs following most entries, as well as an extensive set of appendices and an annotated list of organizations relevant to measurement and statistics Appendices Features Appendix A is a guide to basic statistics for those readers who might like an instructional step-by-step presentation of basic concepts in statistics and measurement Appendix B is a table of critical values used in hypothesis testing and an important part of any reference in this area Appendix C represents a collection of some important and useful measurement and statistics Internet sites A primary goal of creating this set of volumes is to open up the broad discipline of measurement and statistics to a wider and more general audience than usual. Edited by bestselling author Neil J. Salkind, this Encyclopedia is specifically designed to appeal to beginning and intermediate-level students, practitioners, researchers, and consumers of information. It is a welcome addition to any academic library.
Late one hot summer night, a beautiful young actress named Eden Hale -- only hours removed from breast-augmentation surgery, and writhing in pain -- stumbles to the telephone and dials 911. Within minutes, an ambulance rushes her to San Francisco's Mercy Hospital. But by the time she arrives, she is dying, fast, of a mysterious, unrecognizable condition. Dr. Carroll Monks, the ER physician on duty, races to sort through her baffling symptoms in the few minutes he has left to save her. Monks has a sudden insight and, against the advice of his peers, risks a radical treatment, which will prove to be either a brilliant maneuver or a potentially deadly mistake. It fails. Eden Hale, vibrantly healthy and barely twenty-five years old, is dead. The fallout is immediate and intense. The plastic surgeon who operated on Eden -- Dr. D. Welles D'Anton, whose reputation as a surgical guarantor of perfection and agelessness has conferred on him a guru-like status -- blames Monks for her death. Criticism from Monks's hospital colleagues quickly follows and the threat of a lawsuit is not far behind. Monks's career is in jeopardy, but his own guilt and uncertainty are what haunt him worst of all. Convinced there's a hidden cause to Eden's death, Monks starts to delve into her past. Despite roadblocks that spring up in his path, he soon learns that the former prom queen was not the all-American girl she seemed to be: she was caught up in the world of pornography, and was even, possibly, having an illicit affair with D'Anton. Then Monks uncovers a secret that is far more frightening: other young women in D'Anton's care have wound up missing, dead, or horribly disfigured. In his search for the truth, Monks is drawn into a culture of unimaginable wealth and vanity -- only to discover that he is being used as a pawn in a decadent game of glamour and cruelty, one that places him in the crosshairs of a deadly psychopath. With To the Bone, Neil McMahon -- described by the Chicago Tribune as "a cross between Raymond Chandler and Thomas Harris" -- provides a heart-pounding journey into a world of murder and vanity gone wild that you won't soon forget, and demonstrates why he's been called "an author to remember" and "a writer you're going to be hearing a lot about.
When I was a kid in the late 1950s, while I was a student at Paoli Elementary School, I read the famous childrens book that talks about the Kid from Leftfield. Also around that time, I always said to myself, What is it going to be like in the year 2000? Ill be fifty years old! I couldnt comprehend being that old; the thought of it scared me, and Id probably be in a wheelchair or something worse. I bet a lot of people my age thought the same thing. This is the story of what that kid did when he reached the age of fifty.
This is the poignant and exciting story of a statistical anomaly, a B-24 bomber crew that completed 50 combat missions in World War II. This crew was part of the famous 450th Bomb Group, which was nicknamed the "Cottontails" because of their white rudders. As part of the 15th Army Air Force, they flew strategic bombing missions out of Manduria, Italy (in the heel of the boot) and struck strategic targets which were out of the reach of the 8th Army Air Force bases in England. The group lost 1,505 airmen in only a year and a half--the equivalent of losing their effective flying strength three times over. The book's title comes from the crew's bomber, Shadow, which in turn was named for the pilot's black cocker spaniel that flew with them on training missions. Based on interviews with the surviving crewmembers and their families as well as extant archival source material, the book details the childhood, training and post-war life of each of its 13 principal characters. Chapter One is a discussion of each man's boyhood years and Chapter Two provides details of the training that each received. In Chapter Three, the original crew of ten (Crew #4-N-33) was formed in Clovis, New Mexico. An assignment for training in Clovis and in B-24s meant that the crew had been designated for heavy bombardment. Chapter Four includes a description of the four main objectives for the crew, one of which was to participate in POINTBLANK, the Combined Bomber Offensive, which called for the destruction of German fighter aircraft plants, ball bearing plants, oil refineries, rubber plants, munitions factories, sub pens and bases. Details of the structural components of most missions are provided in Chapter Five. The crew completes its first missions in Chapter Six. In Chapter Seven, "Shadow" completes its last after taking enemy fire, and Chapter Eight introduces a new plane, Sleepy Time Gal. The book's Epilogue contains information about the post-war lives of the crew.
Art and architecture lovers, ecotourists, history buffs, gourmands, wine aficionados, culture scholars, outdoor sports fanatics—Spain truly has something for everyone. Its good weather and many varied attractions make it ideal for year-round vacationing. Spain is the home of diverse cultures and traditions. From the stoic independence of the Basques to the progressive architecture and design of the Catalans and the sultry rhythms and sun-drenched siestas of the Andalusians, you’ll discover an intriguing, welcoming country. This guide gets you going with info on: The three major areas: Northern Spain, including Barcelona, the Costa Brava, and the Basque Country; Central Spain, including Madrid and Castile, and Southern Spain, including Andalusia, Seville, Cordoba, and Granada How to get the best seats at a bullfight Strolling Barcelona’s La Rambia, a vibrant street parade, or tripping along on a tavern and tapas crawl Racing with beasts at the Running of the Bulls in Pamplona or leisurely strolling the crooked streets in a lively old district such as Cordoba’s Juderia, Salamanca’s old quarter, Barcelona’s Gothic Quarter, Granada’s Albaycin District, and more Exploring some of the finest art museums in Europe and seeing masterpieces by El Greco, Goya, Picasso, Miro, Dali, Chillida, Titian, Raphael, Botticelli, Rubens, and more Dining on Catalan haute cuisine in Barcelona, traditional Basque dishes in Bilbao, nueva cocina vasca in SanSebastian, truffles and foie gras in Madrid, regional and traditional French dishes in Cordoba, or tantalizing tapas anywhere Architecture dating back to the Romans and Moors, including Museo Guggenheim Bilbao, Segovia’s Roman Aqueduct, Avila’s city walls, and Granada’s Alhambra, a place of magic, mystery, and legend Staying in an opulent easly-20th-century palace, a 16th century convent, a farmhouse estate dating to the tenth century, an intimate inn, or roughing it and backpacking around Spain Meandering through Andalusia’s pueblos blancos amid the rolling hills and olive groves and near the famous sherry wineries and prancing horses in Jerez and the southern beaches of the Costa de la Lux and Costa del Sol Like every For Dummies travel guide, Spain For Dummies, 4th Edition includes: Down-to-earth trip-planning advice What you shouldn’t miss — and what you can skip The best hotels and restaurants for every budget Handy Post-it Flags to mark your favorite pages Whether you enjoy fiestas or siestas, vibrant cities or laid-back seacoasts, with this guide, you can plan a fantástico vacation.
This essential guide is a research-based practical handbook for assessing global developmental delay and other neurodevelopmental disorders in young children. It explains diagnostic, support, and treatment services available for children and their families, clarifying psychological and medical terminology, and global legislative and societal factors relating to assessment. Designed as a comprehensive compendium for student and practicing psychologists, it offers an introduction to historical perspectives around child development and developmental disorders, and how these have affected our understanding of neurodevelopmental disorders. It explains professional and ethical considerations surrounding the clinical practice of developmental assessments, and focuses on the crucial importance of understanding and supporting the parental experience of assessment and diagnosis. Key topics covered include: definitions and descriptions of genetic and chromosomal disorders and neurodevelopmental disorders; eligibility criteria for support and assistance; the Griffiths Scales, Bayley Scales, and other notable assessments for young children; autism spectrum disorder; the process of assessment and diagnosis, diagnostic tools, and report writing. Including a chapter of illustrative case studies of children with developmental disorders, this book will be essential reading for educational, clinical, and developmental psychologists working with children and their families, as well as post-graduate students training in the field.
The US-Soviet arms race, told through the story of a colorful and visionary American Air Force officer—melding biography, history, world affairs, and science to transport the reader back and forth from individual drama to world stage. "Compulsively readable and important.” —The New York Times Book Review In this never-before-told story, Neil Sheehan—winner of the Pulitzer Prize and the National Book Award -- details American Air Force officer Bernard Schriever’s quest to prevent the Soviet Union from acquiring nuclear superiority, and describes American efforts to develop the unstoppable nuclear-weapon delivery system, the intercontinental ballistic missile, the first weapons meant to deter an atomic holocaust rather than to be fired in anger. In a sweeping narrative, Sheehan brings to life a huge cast of some of the most intriguing characters of the cold war, including the brilliant physicist John Von Neumann, and the hawkish Air Force general, Curtis LeMay.
How are we to understand the nature and value of higher education's public purposes, mission, and work in a democratic society? How do-and how should-academic professionals contribute to and participate in civic life in their practices as scholars, scientists, and educators? Democracy and Higher Education addresses these questions by combining an examination of several normative traditions of civic engagement in American higher education with the presentation and interpretation of a dozen oral history profiles of contemporary practitioners. In his analysis of these profiles, Scott Peters reveals and interprets a democratic-minded civic professionalism that includes and interweaves expert, social critic, responsive service, and proactive leadership roles. Democracy and Higher Education contributes to a new line of research on the critically important task of strengthening and defending higher education's positive roles in and for a democratic society.
Examines the political, economic, and social transformation Mexico has undergone in recent decades, and argues that the United States' antagonistic policy toward the nation is doing more harm than good.
Based on extensive interviews with two Spaniard men who grew-up in peasant villages of Asturias during the 1930s. Their account provides a 'grassroots' insight into the poverty and social tensions of local life which eventually led to civil war.
Neil Cornwell's study, while endeavouring to present an historical survey of absurdist literature and its forbears, does not aspire to being an exhaustive history of absurdism. Rather, it pauses on certain historical moments, artistic movements, literary figures and selected works, before moving on to discuss four key writers: Daniil Kharms, Franz Kafka, Samuel Beckett and Flann O'Brien. The absurd in literature will be of compelling interest to a considerable range of students of comparative, European (including Russian and Central European) and English literatures (British Isles and American) – as well as those more concerned with theatre studies, the avant-garde and the history of ideas (including humour theory). It should also have a wide appeal to the enthusiastic general reader.
Explores how Bowen adapts Irish Protestant Gothic as a means of interpreting Irish experience during the Troubles of the 1920s and the Second World War, and also as a way of defining the defenselessness of those enduring the Blitz in wartime London. She employs versions of the Jamesian child as a way of offering a critique of the treatment of children in the European novel of adultery, and indeed, implicitly, of the Jamesian child itself. Corcoran relates the various kinds of return and reflex in her work - notably the presence of the supernatural, but also the sense of being haunted by reading - to both the Freudian concept of the 'return of the repressed' and T.S. Eliot's conception of the auditory imagination as a 'return to the origin'.
Here is an utterly new departure in biography of the Old West. Writing in the hangered, hard-boiled style made famous by Hemingway and O’Hara, James B. O’Neil has succeeded in transferring the color and idiom of the wild and roaring days of the West to the printed page. They Die But Once is authentic biography—the life story of Jeff Ake, last of the Western gunfighters and vaqueros—yet because of the facility with which the author has translated the spirit of the period into language attuned to the twentieth century, the story moves with all the breathtaking speed of a current gangster thriller. O’Neil discards all the saccharine sentimentality that has clouded the real West of the seventies and presents Jeff Ake’s story in the sharp, biting understatement of contemporary prose. With the reek of a Texan prison camp in his nostrils, Jeff Ake rode, rampant unreconstruction in his heart, away from the looted Federal Treasury in Austin, with three hundred of Price’s army, into Mexico, where he joined Porfirio Diaz’s bodyguard. Back he came, with horse-trappings of human Comanche-hide and six-guns blazing, to enter the bloody range wars. Hell-bent-for-leather, he rode up and down the range, while pistols barked their staccato tale of sudden death. In They Die But Once, you will find the reason why Pat Garrett died; the sad tale of the bullet of Billy the Kid; the true cause of John Wesley Hardin’s capture. Bill Longley, Jim Gillett, John Ringo, Kit Carson, Jesse and Frank James, General Custer, Gene Rhodes and Roy Bean (“The Law West of the Pecos”) live and fight and love and die in the thrill-studded pages of They Die But Once. You who have read and not quite believed Clarence Mulford and William Patterson White, hear and know: What they told is only what they dared tell, Jeff Ake tells even more—and can prove a lot of it!
In a book that fundamentally challenges our understanding of race in the United States, Neil Foley unravels the complex history of ethnicity in the cotton culture of central Texas. This engrossing narrative, spanning the period from the Civil War through the collapse of tenant farming in the early 1940s, bridges the intellectual chasm between African American and Southern history on one hand and Chicano and Southwestern history on the other. The White Scourge describes a unique borderlands region, where the cultures of the South, West, and Mexico overlap, to provide a deeper understanding of the process of identity formation and to challenge the binary opposition between "black" and "white" that often dominates discussions of American race relations. In Texas, which by 1890 had become the nation's leading cotton-producing state, the presence of Mexican sharecroppers and farm workers complicated the black-white dyad that shaped rural labor relations in the South. With the transformation of agrarian society into corporate agribusiness, white racial identity began to fracture along class lines, further complicating categories of identity. Foley explores the "fringe of whiteness," an ethno-racial borderlands comprising Mexicans, African Americans, and poor whites, to trace shifting ideologies and power relations. By showing how many different ethnic groups are defined in relation to "whiteness," Foley redefines white racial identity as not simply a pinnacle of status but the complex racial, social, and economic matrix in which power and privilege are shared. Foley skillfully weaves archival material with oral history interviews, providing a richly detailed view of everyday life in the Texas cotton culture. Addressing the ways in which historical categories affect the lives of ordinary people, The White Scourge tells the broader story of racial identity in America; at the same time it paints an evocative picture of a unique American region. This truly multiracial narrative touches on many issues central to our understanding of American history: labor and the role of unions, gender roles and their relation to ethnicity, the demise of agrarian whiteness, and the Mexican-American experience.
After James Cook's voyage in HMS Endeavour, Banks developed a network of scientists and explorers. Banks's correspondence is one of the great primary sources for studying the Pacific region during this important period of exploration and colonial expansion.
A failed marine, Judd can't believe his luck when Catriona falls for him. He lives in Minnesota; she's from Scotland. They work for the same company, they've messaged online for ages. But when they finally video chat, she turns out to be gorgeous. They may be thousands of miles apart, but they share a deep love of cycling and a passion for life. It's love at first sight. Judd throws his meager savings to the wind and flies across the Atlantic to meet Cat in person. Together, they plan a bike trip through the desolate Scottish Highlands. Perfect for cycling. Camping out. Being alone. But soon Judd discovers there's more to Cat than meets her alluring brown eyes. What Judd doesn't know is that someone is following them. Someone with sinister plans. Their lonely journey through the Highlands turns into a game of cat and mouse. Someone is making them ride for their lives. But who exactly is the hunter, and who is the hunted? About the author Anthony Neil Smith is a Professor and the Chair of English at Southwest Minnesota State University. He is the author of various novels. Originally from the Mississippi Gulf Coast, he now lives on the frozen prairie with his wife, two needy dogs, and two sneaky cats.
Sets forth the state of the science and technology in plasma protein production With contributions from an international team of eighty leading experts and pioneers in the field, Production of Plasma Proteins for Therapeutic Use presents a comprehensive overview of the current state of knowledge about the function, use, and production of blood plasma proteins. In addition to details of the operational requirements for the production of plasma derivatives, the book describes the biology, development, research, manufacture, and clinical indications of essentially all plasma proteins with established clinical use or therapeutic potential. Production of Plasma Proteins for Therapeutic Use covers the key aspects of the plasma fractionation industry in five sections: Section 1: Introduction to Plasma Fractionation initially describes the history of transfusion and then covers the emergence of plasma collection and fractionation from its earliest days to the present time, with the commercial and not-for-profit sectors developing into a multi-billion dollar industry. Section 2: Plasma Proteins for Therapeutic Use contains 24 chapters dedicated to specific plasma proteins, including coagulation factors, albumin, immunoglobulin, and a comprehensive range of other plasma-derived proteins with therapeutic indications. Each chapter discusses the physiology, biochemistry, mechanism of action, and manufacture of each plasma protein including viral safety issues and clinical uses. Section 3: Pathogen Safety of Plasma Products examines issues and procedures for enhancing viral safety and reducing the risk of transmissible spongiform encephalopathy transmission. Section 4: The Pharmaceutical Environment Applied to Plasma Fractionation details the requirements and activities associated with plasma collection, quality assurance, compliance with regulatory requirements, provision of medical affairs support, and the manufacture of plasma products. Section 5: The Market for Plasma Products and the Economics of Fractionation reviews the commercial environment and economics of the plasma fractionation industry including future trends, highlighting regions such as Asia, which have the potential to exert a major influence on the plasma fractionation industry in the twenty-first century.
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