Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights: . Reflects the current thinking in chemical process R&D for small molecules . Retains similar structure and orientation to the first edition. . Contains approx. 85% new material . Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up) . Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes) . Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes
This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. * Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" * Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more * Includes over 100 tips for rapid process development * Presents guidelines for implementing and troubleshooting processes
In The Physical Signature of Computation, Neal Anderson and Gualtiero Piccinini articulate and defend the robust mapping account--the most systematic, rigorous, and comprehensive account of computational implementation to date. Drawing in part from recent results in physical information theory, they argue that mapping accounts of implementation can be made adequate by incorporating appropriate physical constraints. According to the robust mapping account, the key constraint on mappings from physical to computational states--the key for establishing that a computation is physically implemented--is physical-computational equivalence: evolving physical states bear neither more nor less information about the evolving computation than do the computational states they map onto. When this highly nontrivial constraint is satisfied, among others that are spelled out as part of the account, a physical system can be said to implement a computation in a robust sense, which means that the system bears the physical signature of the computation. Anderson and Piccinini apply their robust mapping account to important questions in physical foundations of computation and cognitive science, including the alleged indeterminacy of computation, pancomputationalism, and the computational theory of mind. They show that physical computation is determinate, nontrivial versions of pancomputationalism fail, and cognition involves computation only insofar as neurocognitive systems bear the physical signature of specific computations. They also argue that both consciousness and physics outstrip computation.
In the eyes of the world, no European country appeared more vulnerable to its enemies or less likely to establish peace with them than inter-war Poland. This is the first full-length study of relations between Poland and the U.S. following World War I, as Poland turned to America to buttress its precarious position. Pease lucidly examines how Polish leaders of the 1920s, discerning America's essential aim of fostering stability in Europe, sought to enlist U.S. political and financial support on behalf of their beleaguered state. Drawing on exhaustive archival research, Pease unravels the fascinating ties between these unlikely diplomatic partners. He reveals how Poland not only had to fight an uphill battle against inter-war America's isolationism, but also had to counter America's reluctance to underwrite a nation surrounded by two strong and hostile neighbors, Germany and the Soviet Union. Poland's plea for political and financial backing was ultimately denied by both the White House and Wall Street with dire consequences for Poland's future and Europe's fragile peace. Authoritative and original, this book is valuable contribution to our understanding of America and Europe during the interwar years.
In The Physical Signature of Computation, Neal Anderson and Gualtiero Piccinini articulate and defend the robust mapping account--the most systematic, rigorous, and comprehensive account of computational implementation to date. Drawing in part from recent results in physical information theory, they argue that mapping accounts of implementation can be made adequate by incorporating appropriate physical constraints. According to the robust mapping account, the key constraint on mappings from physical to computational states--the key for establishing that a computation is physically implemented--is physical-computational equivalence: evolving physical states bear neither more nor less information about the evolving computation than do the computational states they map onto. When this highly nontrivial constraint is satisfied, among others that are spelled out as part of the account, a physical system can be said to implement a computation in a robust sense, which means that the system bears the physical signature of the computation. Anderson and Piccinini apply their robust mapping account to important questions in physical foundations of computation and cognitive science, including the alleged indeterminacy of computation, pancomputationalism, and the computational theory of mind. They show that physical computation is determinate, nontrivial versions of pancomputationalism fail, and cognition involves computation only insofar as neurocognitive systems bear the physical signature of specific computations. They also argue that both consciousness and physics outstrip computation.
Anderson and Piccinini offer the most systematic, rigorous, and comprehensive account of computational implementation to date. Their robust mapping account holds that the key for establishing that a computation is physically implemented is that the physical states bear neither more nor less information than the computational states they map onto.
Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights:• Reflects the current thinking in chemical process R&D for small molecules• Retains similar structure and orientation to the first edition. • Contains approx. 85% new material• Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up)• Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes)• Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes
The Johnson & Sims families were pioneer ranchers, settling in the same region--Lampasas & Burnet counties--in the dangerous years before the Civil War. After the War, Billy & Nannie Johnson & Dave & Laura Sims establish large ranches in adjoining counties in West Texas. At the turn of the century the two families united in a marriage of 14-year-old Gladys Johnson & 21-year-old Ed Sims. Several years later a nasty divorce ensued due in part to Gladys willfulness & Ed's drinking. More trouble followed over custody of their two children & Gladys took matters into her own hands.....
Research Ethics for Scientists A fully updated textbook helping advanced students and young scientists navigate the ethical challenges that are common to scientific researchers in academia As the number of scientific journals, government regulations, and institutional guidelines continue to grow, research scientists are increasingly facing ethical dilemmas. Even seasoned and honest scientists can unintentionally commit research misconduct or fail to detect and address intentional misbehavior. Research Ethics for Scientists is an authoritative “how-to” guide that clearly outlines best practices in scientific research. Critically examining the key problems that arise in research management and practice, this real-world handbook helps students and young scientists conduct scientific research that adheres to the highest ethical standards. Accessible chapters, logically organized into functional themes and units, cover all the major areas that are crucial for sustained success in science: ideas, people, data, publications, and funding. The second edition offers new and updated content throughout, including discussions of recent innovations to detect and adjudicate research misconduct, vulnerabilities in research practices that were exposed by the COVID-19 pandemic, and new methods people are using to cheat the system and skew the peer review process. Entirely new case studies focus on harassment and bullying in training and mentorship, anti-science and pseudoscience, equality and equity issues, the fabrication of data, and more. This edition integrates gender, race, student training, and other important social issues throughout. Presents up-to-date coverage of growing issues such as the ethics of rushing to publish Discusses the use of text-similarity detecting software to reveal plagiarism and image analysis techniques for detecting data and image manipulation Features new material on current trends such as universal open access (OA) publishing, increased research metrics, new models for peer review, working for multiple employers, and “shadow labs” for individual scientists Includes access to a companion website with PowerPoint slides of case studies and figures Written by an experienced researcher and PhD mentor, Research Ethics for Scientists: A Companion for Students, Second Edition is an indispensable resource for graduate students, postdoctoral researchers, early-career professors, and scientists involved in teaching scientists-in-training.
The standard-setting reference in medical toxicology—trusted as the leading evidencebased resource for poison emergencies A Doody's Core Title for 2017! For decades, one name has been synonymous with the most respected, rigorous perspectives on medical toxicology and the treatment of poisoned and overdosed patients: Goldfrank's Toxicologic Emergencies. Presented in full color, Goldfrank’s delivers essential, patientcenteredcoverage of every aspect of poison management. The editors and authors are recognized as preeminent scholars in their specialties and provide unmatched coverage of all aspects of toxicologic emergencies, from pharmacology and clinical presentation to cutting-edge treatment strategies. Goldfrank's Toxicologic Emergencies, Tenth Edition begins with an examination of medical toxicology principles and techniques. It then reviews the biochemical, molecular, and pathophysiologic basis of toxicology, followed by an intense focus on toxicologic principles related to special patient populations. Features Case studies enhance your understanding of the clinical application of the text material Practical focus on the pathophysiologic basis of medical toxicology The Antidotes in Depth sections delivers the expertise of toxicologists across the world as they present treatments for critically ill poisoned and overdosed patients and allow you to easily identify key issues relating to the use of complex and often unfamiliar therapies The principles of risk management, medicolegal decision making, patient safety, post mortem toxicology and the assessment of ethanol induced impairment described in chapters and Special Considerations emphasize the interface between medical toxicology, the law, and quality care
A unique guide to managing cranial neuropathy cost effectively—from diagnosis to treatment! Cranial neuropathy can be a symptom of a devastating, life-threatening condition or a benign disease with spontaneous full recovery in a majority of patients. While testing options are available, they can be costly and sometimes may be unnecessary. Cost-Effective Evaluation and Management of Cranial Neuropathy by Seilesh C. Babu, Neal M. Jackson, and an impressive team of multidisciplinary contributors reflect decades of experience. Combining evidence-based medicine from the literature with years of firsthand expertise, this reader-friendly book offers cost-effective methodology and in-depth insights for evaluating and managing cranial neuropathy. The textbook provides a clear-cut approach and practical algorithm for cranial nerve evaluation and management of neuropathy. Contributions from neurotologists, neurosurgeons, rhinologists, ophthalmologists, head and neck cancer surgeons, laryngologists, and speech language pathologists ensure a well-rounded and comprehensive approach. The text begins with an introduction to cost-effective management in medicine, laying a foundation for the book's primary focus. It concludes with cranial neuropathy radiology considerations and a helpful cost-effective summary with key points. Key Features: Unique algorithms provide clinicians with simple-to-follow, cost-effective methods for managing complex disorders that result in facial nerve weakness, hearing loss, and swallowing problems Pathology-specific chapters cover a wide range of conditions including olfactory disorders, vision disorders, audiovestibular disorders, facial and trigeminal nerve disorders, and spinal accessory nerve disorders Diagnosis and management of cranial nerve disorder symptoms such as vision loss, dysphagia, and dysphonia This excellent resource is a must have for all clinicians who potentially encounter patients with cranial nerve weakness, including primary care and emergency medicine physicians, otolaryngologists, neurologists, and neurosurgeons.
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