Natalia Komarova's Books

Computational Biology Of Cancer: Lecture Notes And Mathematical Modeling

By: Dominik Wodarz,Natalia Komarova

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Computational Biology Of Cancer: Lecture Notes And Mathematical Modeling

By: Dominik Wodarz,Natalia Komarova

The book shows how mathematical and computational models can be used to study cancer biology. It introduces the concept of mathematical modeling and then applies it to a variety of topics in cancer biology. These include aspects of cancer initiation and progression, such as the somatic evolution of cells, genetic instability, and angiogenesis. The book also discusses the use of mathematical models for the analysis of therapeutic approaches such as chemotherapy, immunotherapy, and the use of oncolytic viruses.

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Page Count

266

Publisher

World Scientific

Published Date

ISBN 10

9814481874

ISBN 13

9789814481878

Targeted Cancer Treatment in Silico

Small Molecule Inhibitors and Oncolytic Viruses

By: Natalia L. Komarova,Dominik Wodarz

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Targeted Cancer Treatment in Silico

Small Molecule Inhibitors and Oncolytic Viruses

By: Natalia L. Komarova,Dominik Wodarz

Countless medical researchers over the past century have been occupied by the search for a cure of cancer. So far, they have developed and implemented a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, small molecule inhibitors, and oncolytic viruses. However, patterns of these treatments' effectiveness remain largely unclear, and a better understanding of how cancer therapies work has become a key research goal. Cancer Treatment in Silico provides the first in-depth study of approaching this understanding by modeling cancer treatments, both mathematically and through computer simulations. The main goal of this book is to help expose students and researchers to in silico methods of studying cancer. It is intended for both the applied mathematics and experimental oncology communities, as mathematical models are playing an increasingly important role to supplement laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, the work will be a valuable resource for scientists and students alike.

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Page Count

235

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1461483018

ISBN 13

9781461483014

Dynamics Of Cancer: Mathematical Foundations Of Oncology

By: Dominik Wodarz,Natalia Komarova

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Dynamics Of Cancer: Mathematical Foundations Of Oncology

By: Dominik Wodarz,Natalia Komarova

The book aims to provide an introduction to mathematical models that describe the dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for advanced undergraduate or graduate courses, and also serves as a reference book for researchers. The book has a strong evolutionary component and reflects the viewpoint that cancer can be understood rationally through a combination of mathematical and biological tools. It can be used both by mathematicians and biologists. Mathematically, the book starts with relatively simple ordinary differential equation models, and subsequently explores more complex stochastic and spatial models. Biologically, the book starts with explorations of the basic dynamics of tumor growth, including competitive interactions among cells, and subsequently moves on to the evolutionary dynamics of cancer cells, including scenarios of cancer initiation, progression, and treatment. The book finishes with a discussion of advanced topics, which describe how some of the mathematical concepts can be used to gain insights into a variety of questions, such as epigenetics, telomeres, gene therapy, and social interactions of cancer cells.

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Page Count

533

Publisher

World Scientific

Published Date

ISBN 10

9814566381

ISBN 13

9789814566384

Healing Springs of Russia

By: Svetlana Malkhazova,Dmitry Orlov,Natalia Shartova,Sergey Starikov,Tatiana Puzanova

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Healing Springs of Russia

By: Svetlana Malkhazova,Dmitry Orlov,Natalia Shartova,Sergey Starikov,Tatiana Puzanova

This book provides the first diverse and multifaceted textual and cartographic overview of natural curative resources of mineral waters and peloids in Russia. In a readily understandable way the book informs about the genesis, history of exploration and geographical features of water springs, their properties and use as healing springs, as well as specifics and prospect of their contemporary use. The monograph features numerous color illustrations and photos and is oriented toward a general audience but also appeals to geographers, environmental and public health workers and other specialists interested in environmental and public health issues.

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Page Count

176

Publisher

Springer Nature

Published Date

ISBN 10

3030835340

ISBN 13

9783030835347

Cancer Immunotherapy

Chapter 15. Genetic Vaccines against Cancer: Design, Testing and Clinical Performance

By: Freda K. Stevenson,Gianfranco di Genova,Christian H. Ottensmeier,Natalia Savelyeva

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Cancer Immunotherapy

Chapter 15. Genetic Vaccines against Cancer: Design, Testing and Clinical Performance

By: Freda K. Stevenson,Gianfranco di Genova,Christian H. Ottensmeier,Natalia Savelyeva

The goal of mobilizing the immune response against cancer in patients is ambitious, and, to even approach success, all the tools of modern genetics have been required. Tools are needed for three tasks: to profile cancer cells, to understand how they survive and proliferate, and to activate immune pathways able to circumvent tumor protective mechanisms and mediate successful attack. Gene-based vaccines incorporate tumor antigen sequences together with genes encoding molecules identified as critical for inducing responses. The vaccine backbones activate innate immunity and, provided T-cell help is co-induced, DNA vaccines overcome regulation and lead to high levels of CD8+ T-cell attack on tumors. Delivery of DNA vaccines to large animals and patients has required new thinking and strategies such as electroporation are now in the clinic. Clinically meaningful immune responses are being induced and the community is developing new ways of evaluating immune responses in patients and connecting these to clinical outcome.

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128059117

ISBN 13

9780128059111

Computational Biology of Cancer

Lecture Notes and Mathematical Modeling

By: Dominik Wodarz,Natalia L. Komarova

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Computational Biology of Cancer

Lecture Notes and Mathematical Modeling

By: Dominik Wodarz,Natalia L. Komarova

- Provides an introduction to computational methods in cancer biology - Follows a multi-disciplinary approach

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Page Count

268

Publisher

World Scientific

Published Date

ISBN 10

9812560270

ISBN 13

9789812560278

Targeted Cancer Treatment in Silico

Small Molecule Inhibitors and Oncolytic Viruses

By: Natalia L. Komarova,Dominik Wodarz

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Targeted Cancer Treatment in Silico

Small Molecule Inhibitors and Oncolytic Viruses

By: Natalia L. Komarova,Dominik Wodarz

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Solve jigsaw puzzle

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Page Count

235

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1461483018

ISBN 13

9781461483014

Book's by Natalia Komarova

Computational Biology Of Cancer: Lecture Notes And Mathematical Modeling

Computational Biology Of Cancer: Lecture Notes And Mathematical Modeling

Targeted Cancer Treatment in Silico

Targeted Cancer Treatment in Silico

Dynamics Of Cancer: Mathematical Foundations Of Oncology

Dynamics Of Cancer: Mathematical Foundations Of Oncology

Healing Springs of Russia

Healing Springs of Russia

Cancer Immunotherapy

Cancer Immunotherapy

Computational Biology of Cancer

Computational Biology of Cancer

Targeted Cancer Treatment in Silico

Targeted Cancer Treatment in Silico

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