In March 2011 the Fukushima nuclear power plant (NPP) in Japan was hit by an earthquake and subsequent tsunami which resulted in the release of significant amounts of radioactive material. The incident led to the suspension of nuclear programmes by a number of countries. This book provides a definitive account of the accident. Outlines the main sequence of events of the 2011 Fukushima nuclear power plant accident, considers the responses of central and local government, and evaluates the response of the plant owner TEPCO Describes and assesses the effectiveness of the evacuation process and subsequent decontamination of the site and local area Offers recommendations for improving the safe design and operation of nuclear power plants and considers the future of the Fukushima plant and nuclear power generation in Japan
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by a slowly progressive motor dysfunction and loss of dopaminergic neurons located in the substantia nigra innervating the striatum, causing depletion of dopamine, which leads to a hyperactivation of the striatal medial spiny neurons. To understand the pathophysiological details of PD and for developing and screening the novel therapeutic and/or neuroprotective substances, animal models for PD induced by neurotoxins have been developed. Among them, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is the most commonly used since it causes a selective loss of dopaminergic neurons in the substantia nigra and induces typical PD-like symptoms both in human and in experimental animals with a relatively simple application. In this chapter, we first overview the characteristics of PD and animal models with neurotoxins to establish, then focus on, MPTP-treated mouse and common marmoset models for PD with their practical experimental protocols and applications.
In March 2011 the Fukushima nuclear power plant (NPP) in Japan was hit by an earthquake and subsequent tsunami which resulted in the release of significant amounts of radioactive material. The incident led to the suspension of nuclear programmes by a number of countries. This book provides a definitive account of the accident. Outlines the main sequence of events of the 2011 Fukushima nuclear power plant accident, considers the responses of central and local government, and evaluates the response of the plant owner TEPCO Describes and assesses the effectiveness of the evacuation process and subsequent decontamination of the site and local area Offers recommendations for improving the safe design and operation of nuclear power plants and considers the future of the Fukushima plant and nuclear power generation in Japan
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by a slowly progressive motor dysfunction and loss of dopaminergic neurons located in the substantia nigra innervating the striatum, causing depletion of dopamine, which leads to a hyperactivation of the striatal medial spiny neurons. To understand the pathophysiological details of PD and for developing and screening the novel therapeutic and/or neuroprotective substances, animal models for PD induced by neurotoxins have been developed. Among them, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is the most commonly used since it causes a selective loss of dopaminergic neurons in the substantia nigra and induces typical PD-like symptoms both in human and in experimental animals with a relatively simple application. In this chapter, we first overview the characteristics of PD and animal models with neurotoxins to establish, then focus on, MPTP-treated mouse and common marmoset models for PD with their practical experimental protocols and applications.
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.