3 cutting-edge books reveal the latest genetic breakthroughs – and their implications for you, your health, and your world These three cutting-edge books reveal how modern genetics has already transformed the world – and will transform it again and again in the coming years. Mobile DNA book thoroughly reviews our current scientific understanding of the significant role that mobile genetic elements play in the evolution and function of genomes and organisms–from plants and animals to humans. Renowned geneticist Haig Kazazian offers an accessible intellectual history of the field’s research strategies and concerns, explaining how advances have opened up new questions, and how new tools and capabilities have encouraged still more progress. He introduces today’s key strategies for advancing the field, and previews long-term research strategies that may lead to even deeper insights. Next, in Investigating the Human Genome, leading medical genetics scholar Moyra Smith reviews current and recent work in genetics and genomics to assess progress in understanding human variation and the pathogenesis of common and rare diseases linked to genetics. You’ll discover how these advances are shedding new light on issues ranging from human origins to psychiatric disease, Alzheimer’s to epigenetics. Finally, in Genes, Chromosomes, and Disease, Nicholas Wright Gillham offers an exceptionally readable overview of the rise and transformations of medical genetics – and of the eugenic impulses that it has inspired. From world-renowned leaders and experts, including Haig H. Kazazian, Moyra Smith, and Nicholas Wright Gillham
One of the most persistent themes in myth and legend from the world's many cultures is the story of the journey - the quest. In Mythical Journeys, Legendary Quests, Moyra Caldecott shows the connection between the sacred, mythic journeys as found in legend and story and the real journey of the individual soul towards enlightenment. This perennial quest for reassurance in the face of human mortality is spread as wide as our existence on the planet and throughout history. Indeed Carl Jung and Joseph Campbell have shown us that myth and legend are not just fantasy tales for children. They are powerful expressions, in code, of a deep yearning towards an understanding of human existence. Moyra Caldecott has selected material from many cultures to illustrate this: from ancient Egypt and Sumeria to aboriginal Australia, pre-Columbian America, Vietnam, India, Africa and Europe. For each legend she provides background on its origin and detailed analysis of its meaning and significance.
In more than thirty published books the novelist Moyra Caldecott has transported her readers through ancient history and into other worlds. Her writing is a manifestation of her lifelong quest for meaning and wisdom. Now, for the first time, she reveals the many levels of her own life as a writer and the extraordinary events and experiences that have inspired her life and her writing.
Ancient Egypt 3500 years ago - a land ruled by the all-powerful female king, Hatshepsut. Ambitious, ruthless and worldly: a woman who established Amun as the chief god of Egypt, bestowing his Priesthood with unprecedented riches and power. This is a story of vision and obsession, of mighty projects and heartbreaking failures - the story of a woman possessed by the desire for power and the need to love.
Moyra Caldecott has been writing poetry for many years, and has had many poems published in magazines and anthologies. She has frequently read her poems at venues in London and the West Country. She was a member of the Dulwich Group in the 1960s and 70s, and in 2005 she was made an honorary Bard of Bath. For the first time, a selection of her poems have been brought together in this book in celebration of her 80th birthday.
This essential guide defines literature of the eighteenth century as a literature written and received as public conversation. Moyra Haslett discusses and challenges conventional ways of reading the period, particularly in relation to notions of the public sphere. In her wide-ranging study, Haslett reads key texts - including The Dunciad, Gulliver's Travels and Pamela - in their literary and cultural contexts, and examines such genres as the periodical, the familiar letter, the verse epistle and the novel as textual equivalents of coterie culture.
Designed for AS and A2 students, Key Ideas in Politics focuses on both historical and contemporary political themes and ideas providing the reader with the background to analyse important political questions. It provides quick and easy-to-read summaries of key ideas and key thinkers enabling students to attain and assimilate knowledge quickly. Features track the history of each idea, the idea in action today, the debate that that surrounds it and its practical application.
Taking account of the British government's "End of Life Care Strategy", contributors set out the key issues affecting practice across a range of health and social care contexts. The book covers topics ranging from dying and death to symptom management and spiritual care, backed up with practical examples. Each entry comprises: a snapshot definition of the topic, key points, a discussion of the main debates, links to practice through thought-provoking case histories, and suggestions for further reading.
What happens when Muslim women gather together at the mosque to read the Qur'an, learn, and pray? How does family loyalty interact with mosque attendance for women? This book explores the growing Muslim women's piety movement through looking at one women's program in a Syrian suburban mosque. Community models shape individual behavior. The place and power of blessing help define the boundaries between orthodox and popular Islam. Modesty and shame, feasts and fasting, purity and prayer, interact to shape daily life possibilities for women involved in the mosque program. At the same time, the growing accessibility of religious teaching for women allows them to take up new places of authority in the Muslim ummah. Women read the Qur'an not just for blessing, but for what it has to say to issues of daily female and family life. And the words of communal dhikr devotion offer a window into the worshippers' consciousness of God and of Muhammad, Prophet of Islam. This detailed examination of a women's mosque program places it within the wider contemporary movement of piety and da'wa (mission) in Islam, offering an insight into the forces that are shaping communities and countries today.
An essential selection of Moyra Davey’s sly, surprising, and brilliant essays In these essays, the acclaimed artist, photographer, writer, and filmmaker Moyra Davey often begins with a daily encounter—with a photograph, a memory, or a passage from a book—and links that subject to others, drawing fascinating and unlikely connections, until you can almost feel the texture of her thinking. While thinking and writing, she weaves together disparate writers and artists—Mary Wollstonecraft, Jean Genet, Virginia Woolf, Janet Malcolm, Chantal Akerman, and Roland Barthes, among many others—in a way that is both elliptical and direct, clearheaded and personal, prismatic and self-examining, layering narratives to reveal the thorny but nourishing relationship between art and life.
Seeking Cures outlines the progress and implications of science's quest to identify therapeutic targets and initiate novel treatments at the gene, RNA, protein, and physiological levels. Also considered are aspects of treatment at the cellular level (e.g., those with hematopoietic stem cells or induced pluripotent stem cells).
Unlock your full potential with these revision guides which focus on the key content and skills you need to know. With My Revision Notes for Edexcel A2 Political Ideologies you can: Take control of your revision: plan and focus on the areas you need to revise, with content summaries and commentary from author Moyra Grant Improve your your ability to argue, explain and make important connections, which is essential for the synoptc questions Apply political terms accurately with the help of definitions and key words on all topics Perfect your essay-writing techniques to use logical argument backed up by relevant, up-to-date examples Get exam-ready with last-minute quick quizzes at http://www.hodderplus.co.uk/myrevisionnotes
After journeying to the Temple of the Sun to train for the priesthood under the Lord Guiron, Kyra rediscovers her love for Lord Khuren and uses her psychic powers against the corrupt magician Wardyke to save those she loves.
Genetic Disease Discovery and Therapeutics presents information on the methods used to determine how specific gene defects influence pathology and phenotype and to review novel therapeutic approaches designed for the treatment of specific genetic and genomic disorders.This book investigates methodologies applied to the characterization of downstream functional effects of specific gene mutations associated with altered phenotypes and clinical disease. It documents evidence of how specific mutations influence pathology and lead to disease manifestations. This book also reviews information on therapeutic approaches that could potentially be applied in diseases due to gene defects. Genetic Disease Discovery and Therapeutics is a valuable reference for scientists and graduate students involved in laboratory research related to genetics, physiology, pathology, and pharmacology as well as clinicians who encounter patients with genetic disorders. - Considers refined diagnostic techniques for genetic diseases - Documents evidence regarding mechanisms through which gene defects alter biochemical function and lead to pathology - Presents new techniques being applied to the treatment of gene and genome-based disorders - Aims to consider the goals of personalized precision medicine as defined by the NIH
In this new book, noted geneticist and veteran OUP author, Moyra Smith, present a comprehensive critical review of the translation of genetic and genomic research into health care. Dr. Smith's motivation for writing is driven by the gap that exists between the rather amazing discoveries in medical genetics and genomics at basic science levels and the translation to disease management in single gene disorders, specific genetic syndromes, and complex genetic diseases. She also examines information technology in genetic medicine, sociocultural factors that impact provision of medical care, and medical education issues with regard to translational genetics in order to help prepare a work force that is better able to utilize evidence-based medicine and to accomodate the rapid changes in genetic and genomic health care.
Etheldreda, Princess of East Anglia, Queen of Northumbria and Abbess of Ely, was a remarkable woman who lived in restless, violent times not unlike our own, when old beliefs were dying and new ones were struggling to emerge. Pagan clashed with Christian as the seven kingdoms of the Germanic tribes warred against each other and against the native Celts. Occasionally an uneasy peace was bought by the skilful use of the 'diplomatic marriage', and twice Etheldreda, though vowed to chastity, submitted to marriage for political reasons. When her second husband refused to accept the 'arrangement' between them, she fled south, her escape to the Island of Ely apparently aided by storms that intervened on her behalf. She lived only a few years as abbess of the religious community she founded at Ely before dying of plague. Ever since, pilgrims have turned to her for miracles of help and healing. But this is not just the story of a seventh-century Anglo-Saxon saint. It is about the general human struggle to comprehend the enigma of existence and to come to terms with Christ's God, faced as we are by a violent and cruel world. It is about the periods when we give up the struggle, reverting either to the darkest negativity or to superstition - and the rare but wonderful periods when we are lifted high by the inrush of spiritual certainty. This edition also contains several pages of chronology, genealogy, place names, notes and a map.
It is the 12th century AD. Neil lives with his parents on a farm on the remote island of Lewis in the Outer Hebrides. He is bored with his days and longs for excitement. He makes friends with Brother Durston, a Christian hermit living in a rocky cell nearby. The hermit speaks to the boy about the virtues of foregiveness and peaceful coexistence, and teaches the value of contemplation and prayer. But the visit of a Viking sea captain, Baldur, to the island makes the boy restless. He goes with Baldur to Iceland to deliver a walrus ivory chess set carved by Brother Durston to Baldur's father - the Wolfhound. But Baldur's father has died, and his grave has been robbed of the hero's famous weapons. Baldur's anger is intense, and he and Neil go on a dangerous and exciting journey across Iceland to recover the stolen weapons - the Weapons of the Wolfhound.
From beyond time and space they come to walk the earth once more - the Guardians of the Tall Stones, the Lords of the Sun... Deva is the beautiful and headstrong daughter of the High Priest of the greatest of the mighty stone circles. She seeks to master the arts of sorcery in order to reclaim her lover from a previous incarnation. Now, trapped by a desire she cannot control, she risks more than herself, and puts the whole community in danger... In a drama that takes place in Bronze Age Britain and 18th dynasty Egypt, ancient jealousies, hatreds and passions emerge to confront each other on the great journey to the higher realms. The Silver Vortex is the fourth book in the Guardians of the Tall Stones sequence, but can be read seperately.
The resurgence of Catholic tradition is rekindling devotion, zeal and, we pray, sanctity. But do some place traditionalism before Mother Church herself? This is the issue of our time, a unique time, 50 years after Vatican II when much (though not all) of the misapplication of the Council's teachings and liturgical aberrations have settled. In The Council in Question, journalist Moyra Doorly, an SSPX attendee, and Dominican Aidan Nichols vibrantly discuss the key issues of division between the Church and the Society. A must-read for a lover of Tradition!
Recent advances in neuroscience and genetics have greatly expanded our understanding of the brain and of the etiological factors involved in developmental delay and mental retardation. At the same time, the human genome project has yielded a wealth of information on DNA sequencing, regulation of gene expression, epigenetics, and functional aspects of the genome, which newly propels investigation into the pathogenesis of mental retardation. This book makes readily available current knowledge on the subject and applies it to clinical medicine, providing information essential to neurologists, geneticists, physicians and pediatricians as they search for the causes of mental handicap in their patients. Introductory chapters cover normal and abnormal brain structure, neurogenesis, neuronal proliferation, and signal transduction. Latter chapters delve into discussions of both the environmental factors that may lead to neurocognitive deficits and the cytogenetic, biochemical and molecular defects specifically associated with mental retardation. One chapter reviews gene involvement in non-syndromic mental retardation, autism, and language deficits, as well as multifactorial and genetically complex inheritance. The text concludes with a clinically practical discussion of carrier detection, presymptomatic diagnosis, and treatment of various genetic diseases through enzyme therapy, substrate deprivation, and the use of hemapoietic stem cells.
It is 72 AD, and most of Britain is under Roman domination. At Aquae Sulis, a place of pilgrimage and healing, hot waters gush ceaselessly from the earth. Since ancient times the waters have been associated with the supernatural, and are under the protection of the Celtic Goddess Sul. The Romans have renamed her Sulis Minerva, and have tamed the steaming waters to form a complex of public baths. A statue of the hated Emperor Claudius is being erected in the precincts of the Temple of Sulis Minerva. The centurion Decius Brutus, a Celt, is ordered to return to his home town to protect the statue and prevent trouble. But the local people, led by his proud father and his fiery daughter, Megan, are threatening rebellion... Meanwhile, Megan's twin sister Ethne is torn between her destiny as Oracle of Sul, and her love for Lucius, who is caught up in his own quest for spiritual enlightenment, with the help of the Orphic priest Demosthenes. Twenty miles away, on Glastonia Island, a small Christian community struggles to establish a new religion in a hostile land, away from Roman persecution. Cults from Rome, Greece, Egypt and Judaea vie with the native Celtic beliefs and form a rich backdrop to the human dramas that unfold. The Waters of Sul is set in a time of transition and adjustment, when beliefs are questioned and loyalties are tested. Love and hate, conflict and reconciliation, troubled romance and an uneasy traffic with the supernatural all feature in this brilliantly conceived novel from a masterful storyteller.
Who dares challenge the might of the Priests of Amun? A group of people are drawn inexorably together, and impelled by forces unknown to travel to Egypt to investigate what happened to the pharaoh Akhenaten who lived more than three thousand years before. Jack is fighting strange and powerful dreams. Finn is convinced he is a reincarnation of Akhenaten and has a personal interest in denying that the ghost exists. Emma believes she was Akhenaten's youngest daughter in a past life and longs to release her beloved father from the curse. Bernard, a medium, channels the voice of Akhenaten, pleading for help. Eliot won't have any of it and does everything in his power to cast doubt on their beliefs. Mary draws the threads together, describing her own compelling and mysterious encounters with Akhenaten. Their adventures are not what any of them expect, and have far-reaching consequences in their lives.
Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders connects neurodevelopment with genetics and behavior to better understand the underlying factors leading to cognitive neurodevelopmental disorders. This book focuses on mechanisms of disease and follows the development of specific brain regions, functions, and gene expression to causes and processes in autism, attention deficit disorder, and learning disabilities. Topics include brain mapping, brain plasticity, epigenetics, neuroimmunology, and many other factors that influence the development of these diseases. This book will promote understanding of recent investigations and developments related to brain development from fetal life onward with specific relevance to neurodevelopmental cognitive disorders and conditions. This is an essential reference for anyone who is looking to learn more about different aspects of neurodevelopment and emerging concepts in psychiatric disorders. - Discusses links between brain development, gene expression, and brain function - Covers neural stem cells, proliferation, migration, differentiation, and neurogenesis - Includes brain mapping, brain plasticity, epigenetics, neuroimmunology, and more - Provides insight into causation and brain function in autism, attention deficit disorder, and learning disabilities - Examines impact of society and environmental factors on mental health
In No Place for God, Doorly traces the principles of modern architecture to the ideas of space that spread rapidly during the twentieth century. She sees a parallel between the desacralization of the heavens, and consequently of our churches, and the mass inward search for a God of one's own. This double movement away from the transcendent God, who reveals himself to man through Scripture and tradition, and toward an inner truth relevant only to oneself has emptied our churches, and the worship that takes place within them, of the majesty and beauty that once inspired reverence in both believers and unbelievers alike.
To this day, throughout the ancient city of Bath, there exist statues and images of the man who was the legendary founder of the city, and the father of King Lear. A leper and a swineherd... a necromancer and a wise king... his memory lives on. Restless at the royal court, the young Prince Bladud sets off to consult an oracle in the west country - a wild wooded place near a mysterious hot spring that gushes from a cave. There the priestess tells him that he will be a great king, and that one day he will fly like an eagle. When he returns to his father's hill-fort at Trinovantum, ancient London, Bladud's head is full of magnificent dreams... until trickery entraps him in a loveless marriage. His unquenchable thirst for knowledge, sharpened by a mysterious experience at the burial mound of his forefathers, takes him away from his home and wife on a dangerous journey to faraway Greece. There he meets and falls in love with a woman who has appeared to him many times already in dreams and visions. On returning to his own country, he finds his father dying and his wife conspiring with his brother to disinherit him. Then, found to be suffering from a disease believed to be leprosy, he is driven from the court and shunned by his people. In this dark time he becomes a swineherd. One day, he notices his pigs are free of sores after wallowing in hot mud. He tries the healing waters of Sul himself, is cured, and returns to claim his throne... His was a golden age of wisdom and magic, where Otherworld beings mingle freely with the people of this world, and where swans and ravens and owls take on their own special mysterious significance. Full of brilliant imagination, this colourful fantasy draws its strength and inspiration from the strange and beautiful realms of Celtic and Greek myth and legend.
In ancient Egypt during the magnificent eighteenth dynasty the Pharaoh Akhenaten and his queen, the strong and beautiful Nefertiti, are engaged in a dramatic battle against the wealthy, corrupt and dangerously powerful priests of Amun. Haunting and full of surprises, Akhenaten: Son of the Sun gives a fascinating glimpse into an ancient civilisation. It is a story about hate and love, despair and hope, but more than that it is the story of extraordinary spiritual and psychic powers being tested to their limits. Akhenaten: Son of the Sun is part of Moyra Caldecott's magnificent Egyptian sequence. Don't miss Hatshepsut: Daughter of Amun, Tutankhamun and the Daughter of Ra and The Ghost of Akhenaten.
This is the first book in a European language to make a comprehensive study of the life and works of the astonishingly versatile and accomplished Meiji potter, Makuzu Kozan (1842 - 1916), who was acclaimed as one of the greatest ceramic artists of the Meiji period.The Meiji period, after the opening of Japan to the West in the mid-nineteenth century, was a time of momentous change for Japanese society and Kozan's Makuzu workshop makes an ideal case study to examine the effects of these changes on the Japanese ceramic industry. This book tells the story ofKozan's Makuzu wares from their origins in a traditional workshop in Kyoto to their maturity in a prolific factory in the newly-opened port of Yokohama, where Kozan's ability to cater to the demands of a new Western export market and to incorporate new Western glaze techniques led to enormoussuccess, both in Japan and abroad at the international exhibitions that flourished from the 1850s.Lavish illustrations highlight Kozan's remarkable and technical and artistic achievements, while ceramic marks and box inscriptions are analysed as a practical guide to dating Makuzu ware. Clare Pollard discusses the role of later generations of the Miyagawa family in the running of the workshop andrelates developments in Makuzu ware to the work of other major potters of the era, both in Japan and in Europe and America.Incorporating contemporary sources (including previously unstudied archival material from the Makuzu workshop itself), recent research and the study of a large corpus of Makuzu wares in museums and private collections all over the world, the book examines the artistic, political, and commercialfactors that influenced Kozan and his contemporaries as they strove to come to terms with shifting life-styles and changing attitudes to the arts, and moved towards the creation of a modern ceramic industry.
Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome's intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders. Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.