Advancing the science of medicine by targeting a disease more precisely with treatment specific to each patient relies on access to that patient's genomics information and the ability to process massive amounts of genomics data quickly. Although genomics data is becoming a critical source for precision medicine, it is expected to create an expanding data ecosystem. Therefore, hospitals, genome centers, medical research centers, and other clinical institutes need to explore new methods of storing, accessing, securing, managing, sharing, and analyzing significant amounts of data. Healthcare and life sciences organizations that are running data-intensive genomics workloads on an IT infrastructure that lacks scalability, flexibility, performance, management, and cognitive capabilities also need to modernize and transform their infrastructure to support current and future requirements. IBM® offers an integrated solution for genomics that is based on composable infrastructure. This solution enables administrators to build an IT environment in a way that disaggregates the underlying compute, storage, and network resources. Such a composable building block based solution for genomics addresses the most complex data management aspect and allows organizations to store, access, manage, and share huge volumes of genome sequencing data. IBM SpectrumTM Scale is software-defined storage that is used to manage storage and provide massive scale, a global namespace, and high-performance data access with many enterprise features. IBM Spectrum ScaleTM is used in clustered environments, provides unified access to data via file protocols (POSIX, NFS, and SMB) and object protocols (Swift and S3), and supports analytic workloads via HDFS connectors. Deploying IBM Spectrum Scale and IBM Elastic StorageTM Server (IBM ESS) as a composable storage building block in a Genomics Next Generation Sequencing deployment offers key benefits of performance, scalability, analytics, and collaboration via multiple protocols. This IBM RedpaperTM publication describes a composable solution with detailed architecture definitions for storage, compute, and networking services for genomics next generation sequencing that enable solution architects to benefit from tried-and-tested deployments, to quickly plan and design an end-to-end infrastructure deployment. The preferred practices and fully tested recommendations described in this paper are derived from running GATK Best Practices work flow from the Broad Institute. The scenarios provide all that is required, including ready-to-use configuration and tuning templates for the different building blocks (compute, network, and storage), that can enable simpler deployment and that can enlarge the level of assurance over the performance for genomics workloads. The solution is designed to be elastic in nature, and the disaggregation of the building blocks allows IT administrators to easily and optimally configure the solution with maximum flexibility. The intended audience for this paper is technical decision makers, IT architects, deployment engineers, and administrators who are working in the healthcare domain and who are working on genomics-based workloads.
In this collection of seven major essays (one of them published here for the first time), Monica Green argues that a history of women's healthcare in medieval western Europe has not yet been written because it cannot yet be written - the vast majority of texts relating to women's healthcare have never been edited or studied. Using the insights of women's history and gender studies, Green shows how historians need to peel off the layers of unfounded assumption and stereotype that have characterized the little work that has been done on medieval women's healthcare. Seen in their original contexts, medieval gynecological texts raise questions of women's activity as healthcare providers and recipients, as well as questions of how the sexual division of labor, literacy, and professionalization functioned in the production and use of medical knowledge on the female body. An appendix lists all known medieval gynecological texts in Latin and the western European vernacular languages.
This study is the first to examine the important political role played by astrology in Italian court culture. Reconstructing the powerful dynamics existing between astrologers and their prospective or existing patrons, The Duke and the Stars illustrates how the “predictive art” of astrology was a critical source of information for Italian Renaissance rulers, particularly in times of crisis. Astrological “intelligence” was often treated as sensitive, and astrologers and astrologer-physicians were often trusted with intimate secrets and delicate tasks that required profound knowledge not only of astrology but also of the political and personal situation of their clients. Two types of astrological predictions, medical and political, were taken into the most serious consideration. Focusing on Milan, Monica Azzolini describes the various ways in which the Sforza dukes (and Italian rulers more broadly) used astrology as a political and dynastic tool, guiding them as they contracted alliances, made political decisions, waged war, planned weddings, and navigated health crises. The Duke and the Stars explores science and medicine as studied and practiced in fifteenth-century Italy, including how astrology was taught in relation to astronomy.
Making Women's Medicine Masculine challenges the common belief that prior to the eighteenth century men were never involved in any aspect of women's healthcare in Europe. Using sources ranging from the writings of the famous twelfth-century female practitioner, Trota of Salerno, all the way to the great tomes of Renaissance male physicians, and covering both medicine and surgery, this study demonstrates that men slowly established more and more authority in diagnosing and prescribing treatments for women's gynaecological conditions (especially infertility) and even certain obstetrical conditions. Even if their 'hands-on' knowledge of women's bodies was limited by contemporary mores, men were able to establish their increasing authority in this and all branches of medicine due to their greater access to literacy and the knowledge contained in books, whether in Latin or the vernacular. As Monica Green shows, while works written in French, Dutch, English, and Italian were sometimes addressed to women, nevertheless even these were often re-appropriated by men, both by practitioners who treated women and by laymen interested to learn about the 'secrets' of generation. While early in the period women were considered to have authoritative knowledge on women's conditions (hence the widespread influence of the alleged authoress 'Trotula'), by the end of the period to be a woman was no longer an automatic qualification for either understanding or treating the conditions that most commonly afflicted the female sex - with implications of women's exclusion from production of knowledge on their own bodies extending to the present day.
It is a new beginning for Kratos. Living as a man, outside the shadow of the gods, he seeks solitude in the unfamiliar lands of Norse mythology. With new purpose and his son at his side, Kratos must fight for survival as powerful forces threaten to disrupt the new life he has created. The volume is an intimate chronicle of the years-long odyssey to bring Kratos and Atreus's beautiful and brutal world to life. Step into Midgard and explore beyond, as Dark Horse Books and Santa Monica Studio proudly present the quintessential companion to the enormously anticipated God of War. This is a document unlike any other that sets readers on an exhaustive behind-the-scenes journey to witness the creation of an epic of tremendous scale.
Completely revised and updated, and now in full color throughout, the Fourth Edition of this definitive reference is a must for all clinicians who treat breast diseases. Leading experts summarize the current knowledge of breast diseases, including their clinical features, management, underlying biologies, and epidemiologies. In addition to complete coverage of malignant breast diseases, benign diseases are discussed in relation to subsequent breast cancer development. The book reviews all major clinical trials and summarizes the information they provide on early detection and management of breast cancer. Close attention is also given to the increasing importance of molecular biology and genetics in this field. This edition features more than thirty new contributors, fourteen new or completely rewritten chapters, and more clinically oriented chapters. A companion Website will offer the fully searchable text and an image bank. Also included with this edition is the Anatomical Chart Company's Breast Anatomy and Disorders Pocket Guide. This durable, portable folding pocket guide provides a visual and textual overview of breast anatomy, disorders, and breast self-examination. With a write-on, wipe-off laminated surface, this guide is perfect for the on-the-go practitioner to show patients, caregivers, and families.
Wedded bliss or marriage misery? Forever simply doesn’t have the right ring to it for these ten couples … until love unexpectedly leads them strolling down the aisle. With tuxes and trains, turmoil and tenderness, this collection is just in time for readers ready to tie the knot. Holiday Wedding: Weddings are bad luck for Drew Cannon. After being dumped by his own fiancée a year ago, he ran off to tend to the family toy-making business in Tokyo. Now he’s returned home for the holidays and is forced to team up with his ex to plan last-minute nuptials for his twin brother. Will working together mend and reunite their broken hearts? The Confection Connection: Baker Carly Piper’s only way to save her bakery is to partner with her rival from a TV reality show to produce a wedding cake for a wealthy bride. Is this a half-baked proposal, or will love be the icing on the cake? Battling the Best Man: Dr. Kory Flemming can’t say no to returning home for her best friend’s wedding. Trouble is, Will Mitchell, her high school rival, is the best man, and he’s up to his usual flirtatious tricks. Can they set aside their rocky past to make a new future together? Bride by the Book: Small-town Arkansas attorney Garner Holt badly needs an assistant to sort out his cluttered office, but he didn’t expect a super-secretary like Miss Angelina Brownwood. She’s perfect until an online search reveals a flaw: Angelina isn’t a secretary. But does her secret mean he can’t make this unique woman his for life? An Inconvenient Love: To expand his real estate business, Luca Castellioni needs an English-speaking secretary and a wife, so he strikes a bargain with pretty stranger Sophia Stevens. Soon, he wants more marriage and not so much convenience in their agreement. Too bad his new wife has reconstructed her own life without him. Naked Truth: Special Agent Jack Boudreaux is a man who’s always looking for a good time—what better place for a pick up than a wedding? That’s fine with Kennedy St. George, whose ex-husband burned her emotionally and financially. But when Jack’s FBI assignment sends him undercover at a male strip club in her city, their one-night stand becomes a distracting and dangerous affair. The Bull Rider’s Manager: When rodeo rider manager Barb Carico indulges in a little Las Vegas R&R with sponsor Hunter Martin, things spin out of control and the duo winds up married. They plan to annul this marriage mistake ASAP, but an unexpected complication finds Hunter bargaining for more time with his new bride. Just for the Weekend: Multimillionaire Sam Mason is sick of gold diggers. When he meets role-playing kindergarten teacher Cleo James at a sci-fi convention in Vegas, she seems like the real thing. Then—surprise!—he wakes up married to this sexy stranger … only to find Cleo has vanished. Is he looking for a swindler or the love of his life? Hiding Places: Mona Smith is on the run to avoid getting mixed up in some dirty business with a drug kingpin. Linc Dray needs to produce a marriage certificate to secure the farm he inherited from his grandfather. It’s the perfect deal, but what are they going to do about the inconvenient emotions invading their marriage of convenience? The Bride’s Curse: Three brides return a gorgeous vintage wedding dress to Kelly Andrew’s Wedding Bliss store, claiming it’s cursed, which is definitely bad for business. Then Brett Atwell, the handsome nephew of the dress’s original owner, gets involved, and a mischievous spirit sends the two of them on a goose chase for a groom who went missing decades ago. Will love get its due at long last?
When Lily and Ida meet on a flight to America, they embark on a relationship that is to see them through two very different marriages. Lily wants passionately to help people, and to experience romance and adventure at the same time. Falling in love with a married man was not part of the plan. In order to escape her abusive father, Ida flees to America to marry Buddy, looking forward to a clean slate with her new husband. But is having a house and being Mrs. Someone enough for her? Married life will bring them comfort, distress, joy and tragedy in equal measure as the years unfold. Only their friendship can carry them through. First published in 1988, Dear Doctor Lily follows two women as they navigate the complexities of love, family, and friendship.
Grounded in public health practice, this text offers a comprehensive study of the health behavior theories that are the foundation of all health education and promotion programs. Your students will come away with a clear understanding of essential relationships between human behavior and health, as well as the practical application of theory and approaches to health promotion research and practice. Designed for graduates or upper level undergraduates, the book maintains a consistent, single voice and offers many examples throughout. Contents: Section I. Theory in Context: 1. Health Behavior in the Context of Public Health 2. A Social Ecological Perspective 3. Theories of Motivation and Behavior: A Brief History and Contemporary Perspectives Section II. Cognitive and Social Theories of Motivation and Behavior 4. Expectancy Value Models 5. Operant Conditioning, Self-Regulation, and Social Cognitive Theory 6. Social Influence Theory: The Effects of Social Factors on Health Behavior 7. Diffusion of Innovations Theory Section III. Behavior Change Theories 8. Learning, Teaching, and Counseling 9. Self-Determination Theory and Motivational Interviewing 10. Stage Models 11. Health Communication and Social Marketing 12. Communities and Health Promotion
Advancing the science of medicine by targeting a disease more precisely with treatment specific to each patient relies on access to that patient's genomics information and the ability to process massive amounts of genomics data quickly. Although genomics data is becoming a critical source for precision medicine, it is expected to create an expanding data ecosystem. Therefore, hospitals, genome centers, medical research centers, and other clinical institutes need to explore new methods of storing, accessing, securing, managing, sharing, and analyzing significant amounts of data. Healthcare and life sciences organizations that are running data-intensive genomics workloads on an IT infrastructure that lacks scalability, flexibility, performance, management, and cognitive capabilities also need to modernize and transform their infrastructure to support current and future requirements. IBM® offers an integrated solution for genomics that is based on composable infrastructure. This solution enables administrators to build an IT environment in a way that disaggregates the underlying compute, storage, and network resources. Such a composable building block based solution for genomics addresses the most complex data management aspect and allows organizations to store, access, manage, and share huge volumes of genome sequencing data. IBM SpectrumTM Scale is software-defined storage that is used to manage storage and provide massive scale, a global namespace, and high-performance data access with many enterprise features. IBM Spectrum ScaleTM is used in clustered environments, provides unified access to data via file protocols (POSIX, NFS, and SMB) and object protocols (Swift and S3), and supports analytic workloads via HDFS connectors. Deploying IBM Spectrum Scale and IBM Elastic StorageTM Server (IBM ESS) as a composable storage building block in a Genomics Next Generation Sequencing deployment offers key benefits of performance, scalability, analytics, and collaboration via multiple protocols. This IBM RedpaperTM publication describes a composable solution with detailed architecture definitions for storage, compute, and networking services for genomics next generation sequencing that enable solution architects to benefit from tried-and-tested deployments, to quickly plan and design an end-to-end infrastructure deployment. The preferred practices and fully tested recommendations described in this paper are derived from running GATK Best Practices work flow from the Broad Institute. The scenarios provide all that is required, including ready-to-use configuration and tuning templates for the different building blocks (compute, network, and storage), that can enable simpler deployment and that can enlarge the level of assurance over the performance for genomics workloads. The solution is designed to be elastic in nature, and the disaggregation of the building blocks allows IT administrators to easily and optimally configure the solution with maximum flexibility. The intended audience for this paper is technical decision makers, IT architects, deployment engineers, and administrators who are working in the healthcare domain and who are working on genomics-based workloads.
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