Research over the years has demonstrated that free radicals mediated oxidative stress lies at the helm of almost all patho-physiological phenomena. These findings emphasize on the need to understand the underlying molecular mechanism(s) and their critical role in the pathogenesis. This book aims to focus on these areas to provide readers a comprehensive outlook about the major redox sensitive pathways and networks involved in various disease conditions. In the first chapter of the book, basic information about the oxidative stress, its generation, its biomarkers and its role in body are discussed. In the next three chapters, the role of oxidative stress in various pathologies ranging from neurological disorders, to cardiovascular diseases, cancers, metabolic diseases and ageing have been described. Chapter 5 cumulatively describes the most important molecular signaling pathways that are affected by reactive oxygen species (ROS). These are the mechanisms which are common denominators in various pathological states. In the next part of the book, various antioxidant strategies to target and mitigate ROS have been discussed with details on the mechanisms. Selenium, being the research focus and interest of the authors for years, the role of selenium as an antioxidant as part of selenoproteins has been included in the book. Finally, the book culminates with authors’ perspective on the future of the redox biology field. Throughout the book, efforts have been made to use simplified language and suitable figures for ease to understand the contents. Although the authors have tried to touch on all the different aspects of oxidative stress in detail, the fact that it is a continuously growing field with updates coming every day, there might be some areas which might not be described in depth. This book is designed for students, young scientists to get acquainted with the redox biology. Overall, this book is a reference to understand the redox regulation of cellular signaling pathways involved in pathogenesis.
Fertilizer is a vital component of strategies for expanding foodproduction. The rapid growth in population and the widening food deficits inmany tropical countries ofAsia, Africa, and Latin America call attention to those aspects of fertilization that have been neglected but are expected to yield large economic payoffs in the future. Fertilizer sulfur falls into this category. In the past fertilizer sulfur received little attention from researchers and policymakers since sulfur deficiency was not considered a serious problem. It was not a problem because of low crop yields, extensive cropping, and the incidental supply of sulfur through rain, irrigation water, manures, and sulfurcontaining fertilizers. However, the situation has changed in the last three decades. Moder nagriculture based on high crop yields, intensive cropping, improved crop varieties, and greater use of sulfur-free fertilizers and environmental regula tions restricting sulfur emissions are creating large gaps between sulfur sup ply and sulfur requirements. Sulfur deficiencies are widespread and grow ing. Consequently, the full potential of a modern agricultural system in tropical countries is not being realized. This research effort results from the recognition of the seriousness of the sulfur problem and its adverse impact on food production as well as IFDC's dedication to the development and transfer of economically ef ficient fertilizer technology to tropical countries. This study represents a comprehensive analysis ofthe technical and economic linkages between fer tilizer sulfur and food production, and it provides guidelines for future directions in fertilizer sulfur research and public policy.
The Colon Classification, designed in 1924 by Padamshri S.R. Ranganthan (1892-1972), the National Research Professor in Library Science (1965-1972) is amongst a few living general bibliographic classification system. Colon classified created a new paradigm in library classifcation. By the midfifties it got international ecognition and acceptance. Ranganathan and his classification thoughts. It is the largest bibliography ever compiled on any singal classification systems. Each entry provides full bibliographic details. This endeavour has been to create a complete database on India's pride, the Colon classification as mark of humble homage to Dr.S.R. Ranganathan and his worldwide birth centenary celebrations.
Research over the years has demonstrated that free radicals mediated oxidative stress lies at the helm of almost all patho-physiological phenomena. These findings emphasize on the need to understand the underlying molecular mechanism(s) and their critical role in the pathogenesis. This book aims to focus on these areas to provide readers a comprehensive outlook about the major redox sensitive pathways and networks involved in various disease conditions. In the first chapter of the book, basic information about the oxidative stress, its generation, its biomarkers and its role in body are discussed. In the next three chapters, the role of oxidative stress in various pathologies ranging from neurological disorders, to cardiovascular diseases, cancers, metabolic diseases and ageing have been described. Chapter 5 cumulatively describes the most important molecular signaling pathways that are affected by reactive oxygen species (ROS). These are the mechanisms which are common denominators in various pathological states. In the next part of the book, various antioxidant strategies to target and mitigate ROS have been discussed with details on the mechanisms. Selenium, being the research focus and interest of the authors for years, the role of selenium as an antioxidant as part of selenoproteins has been included in the book. Finally, the book culminates with authors’ perspective on the future of the redox biology field. Throughout the book, efforts have been made to use simplified language and suitable figures for ease to understand the contents. Although the authors have tried to touch on all the different aspects of oxidative stress in detail, the fact that it is a continuously growing field with updates coming every day, there might be some areas which might not be described in depth. This book is designed for students, young scientists to get acquainted with the redox biology. Overall, this book is a reference to understand the redox regulation of cellular signaling pathways involved in pathogenesis.
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