1.1 Overview of Lab-on-Chip Laboratory-on-Chip (LoC) is a multidisciplinary approach used for the miniaturization, integration and automation of biological assays or procedures in analytical chemistry [1–3]. Biology and chemistry are experimental sciences that are continuing to evolve and develop new protocols. Each protocol offers step-by-step laboratory instructions, lists of the necessary equipments and required biological and/or chemical substances [4–7]. A biological or chemical laboratory contains various pieces of equipment used for performing such protocols and, as shown in Fig. 1.1, the engineering aspect of LoC design is aiming to embed all these components in a single chip for single-purpose applications. 1.1.1 Main Objectives of LoC Systems Several clear advantages of this technology over conventional approaches, including portability, full automation, ease of operation, low sample consumption and fast assays time, make LoC suitable for many applications including. 1.1.1.1 Highly Throughput Screening To conduct an experiment, a researcher fills a well with the required biological or chemical analytes and keeps the sample in an incubator for some time to allowing the sample to react properly. Afterwards, any changes can be observed using a microscope. In order to quickly conduct millions of biochemical or pharmacolo- cal tests, the researchers will require an automated highly throughput screening (HTS) [8], comprised of a large array of wells, liquid handling devices (e.g., mic- channel, micropump and microvalves [9–11]), a fully controllable incubator and an integrated sensor array, along with the appropriate readout system.
This book provides design-oriented models for the implementation of ultra-low-voltage energy harvesting converters, covering the modeling of building blocks such oscillators, rectifiers, charge pumps and inductor-based converters that can operate with very low supply voltages, typically under 100 mV. Analyses based on the diode and MOSFET models are included in the text to allow the operation of energy harvesters from voltages of the order of 100 mV or much less, with satisfactory power efficiency. The practical realization of different converters is also addressed, clarifying the design trade-offs of ultra-low voltage (ULV) circuits operating from few millivolts. Offers readers a state-of-the-art revision for ultra-low voltage (ULV) energy harvesting converters; Provides analog IC designers with proper models for the implementation of circuits and building blocks of energy harvesters, such as oscillators, rectifiers, and inductor-based converters, operating under ultra-low voltages; Addresses the design of energy harvesters operating from ultra-low voltages, enabling autonomous operation of connected devices driven by human energy; Demonstrates design and implementation of integrated ULV up-converters; Includes semiconductor modeling for ULV operation.
Ketum merupakan ubat herba tradisional yang telah lama digunakan di Malaysia dan negara jiran, Thailand untuk merawat pelbagai penyakit. Namun, penyalahgunaan ketum untuk tujuan rekreasi semakin berleluasa di Malaysia dan semakin serius. Memandangkan ketum juga berpotensi untuk dijadikan ubat bagi perubatan moden, maka manfaatnya perlu dipertimbangkan sewajarnya di sebalik kemudaratan yang dibawa. Sehingga kini, karya yang membincangkan isu ini masih kekurangan bukan sahaja di Malaysia, tetapi juga di seluruh dunia.
This book provides design-oriented models for the implementation of ultra-low-voltage energy harvesting converters, covering the modeling of building blocks such oscillators, rectifiers, charge pumps and inductor-based converters that can operate with very low supply voltages, typically under 100 mV. Analyses based on the diode and MOSFET models are included in the text to allow the operation of energy harvesters from voltages of the order of 100 mV or much less, with satisfactory power efficiency. The practical realization of different converters is also addressed, clarifying the design trade-offs of ultra-low voltage (ULV) circuits operating from few millivolts. Offers readers a state-of-the-art revision for ultra-low voltage (ULV) energy harvesting converters; Provides analog IC designers with proper models for the implementation of circuits and building blocks of energy harvesters, such as oscillators, rectifiers, and inductor-based converters, operating under ultra-low voltages; Addresses the design of energy harvesters operating from ultra-low voltages, enabling autonomous operation of connected devices driven by human energy; Demonstrates design and implementation of integrated ULV up-converters; Includes semiconductor modeling for ULV operation.
1.1 Overview of Lab-on-Chip Laboratory-on-Chip (LoC) is a multidisciplinary approach used for the miniaturization, integration and automation of biological assays or procedures in analytical chemistry [1–3]. Biology and chemistry are experimental sciences that are continuing to evolve and develop new protocols. Each protocol offers step-by-step laboratory instructions, lists of the necessary equipments and required biological and/or chemical substances [4–7]. A biological or chemical laboratory contains various pieces of equipment used for performing such protocols and, as shown in Fig. 1.1, the engineering aspect of LoC design is aiming to embed all these components in a single chip for single-purpose applications. 1.1.1 Main Objectives of LoC Systems Several clear advantages of this technology over conventional approaches, including portability, full automation, ease of operation, low sample consumption and fast assays time, make LoC suitable for many applications including. 1.1.1.1 Highly Throughput Screening To conduct an experiment, a researcher fills a well with the required biological or chemical analytes and keeps the sample in an incubator for some time to allowing the sample to react properly. Afterwards, any changes can be observed using a microscope. In order to quickly conduct millions of biochemical or pharmacolo- cal tests, the researchers will require an automated highly throughput screening (HTS) [8], comprised of a large array of wells, liquid handling devices (e.g., mic- channel, micropump and microvalves [9–11]), a fully controllable incubator and an integrated sensor array, along with the appropriate readout system.
Science and engineering disciplines are provoking fundamental and applied discoveries in numerous applications, such as to deeply understand brain functions, precisely diagnose diseases, and to then properly address these. The later advances call upon biomedical integrated circuits and systems (BioCAS) to provide needed research tools. In fact, with the increase of the personalized healthcare market and BioCAS featuring wearability, implantability and intelligence, it has become significantly more important to address these emerging trends. These circuits and systems deal with various signals and images such as electrophysiological, electrochemical, optical, and magnetic, which require various front-end circuits to acquire signals and usually cancel out the noise. With the booming artificial intelligence methods, these biosignals became mandatory for the monitoring, detection, diagnosis and even prediction of diseases for example.This monograph focusses on the current research activities and emerging trends that relate to the above-mentioned functionalities, and it should be of interest to students, researchers and engineers active in the fields related to Circuits and Systems for Biomedical Engineering.Section I is a summary of the main BioCAS research interests, and in Section II various biosignal acquisition circuits techniques are discussed. In Section III the authors cover circuits for biosignal processing, with emphasis on the newly emerging artificial intelligence. Sections IV and V contain a review of wireless power harvesting and communication circuits. Sections VI and VII represent circuits that help miniaturizing biomedical imaging systems, and other systems intended for the detection of chemical and molecular assays. Section VIII describes one of the main neural prostheses intended to address vision disorders, whilst the last section reviews electrode-tissue interfaces that essentially bridge the circuits and systems with the human body.
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