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Cortical Oscillations in Health and Disease

By: Roger Traub, MD,Miles Whittington, PhD

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Cortical Oscillations in Health and Disease

By: Roger Traub, MD,Miles Whittington, PhD

This book first reviews the case that brain oscillations not only are important for cognition, as long suspected, but also play a part in the expression of signs and symptoms of neuropsychiatric disorders. The cellular mechanisms of many of the clinically relevant oscillations have been studied by the authors and their colleagues, using in vitro slice methods as well as detailed computer simulations. A surprising insight is that gap junctions between principal neurons play an absolutely critical role in so many types of oscillation in neuronal populations; oscillations are not just the result of properties of individual neurons and their synaptic connections. Furthermore, the way in which gap junctions produce oscillations in the cortex is novel, involving as it does global properties of networks, rather than just the time constants of membrane currents. This insight has implications for therapeutics as well as for our understanding of normal brain functions.

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Oxford University Press

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ISBN 10

019971150X

ISBN 13

9780199711505

Cortical Oscillations in Health and Disease

By: Roger Traub, MD,Miles Whittington, PhD

Write a review Read reviews Take a Quiz Solve Book Puzzle

Cortical Oscillations in Health and Disease

By: Roger Traub, MD,Miles Whittington, PhD

This book first reviews the case that brain oscillations not only are important for cognition, as long suspected, but also play a part in the expression of signs and symptoms of neuropsychiatric disorders. The cellular mechanisms of many of the clinically relevant oscillations have been studied by the authors and their colleagues, using in vitro slice methods as well as detailed computer simulations. A surprising insight is that gap junctions between principal neurons play an absolutely critical role in so many types of oscillation in neuronal populations; oscillations are not just the result of properties of individual neurons and their synaptic connections. Furthermore, the way in which gap junctions produce oscillations in the cortex is novel, involving as it does global properties of networks, rather than just the time constants of membrane currents. This insight has implications for therapeutics as well as for our understanding of normal brain functions.

Average ratings

N/A

5

0%

4

0%

3

0%

2

0%

1

0%

Solve jigsaw puzzle

Age

Page Count

N/A

Publisher

Oxford University Press

Published Date

ISBN 10

019971150X

ISBN 13

9780199711505