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Animal Models for the Study of Human Disease

Chapter 9. Cardiovascular Models: Heart Secondarily Affected by Disease

By: Jitka Sviglerova,Jitka Kuncova,Milan Stengl

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Animal Models for the Study of Human Disease

Chapter 9. Cardiovascular Models: Heart Secondarily Affected by Disease

By: Jitka Sviglerova,Jitka Kuncova,Milan Stengl

Impairment, altered function or altered requirements of various organs lead to corresponding changes of cardiovascular system, especially its central organ, the heart. The heart adapts to the altered conditions and requirements by intensive remodeling. The remodeling is usually very complex, including both structural (e.g. hypertrophy, fibrosis) and functional (e.g. electrophysiological, contractile remodeling) changes. The remodeling is initially compensatory and beneficial optimizing the pumping function but gradually it may become detrimental (heart failure, life-threatening arrhythmias). In this chapter we have focused on three experimental models, in which the heart is not targeted primarily, however the primary disease eventually affects the cardiovascular system significantly: diabetes mellitus, renal failure, and dysfunctional autonomic innervation. Rat models of these three conditions are described in detail with special focus on methodological aspects and experimental results obtained in our laboratory.

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Page Count

62

Publisher

Elsevier Inc. Chapters

Published Date

ISBN 10

0128071990

ISBN 13

9780128071991

Chromatographic Analysis of Alkaloids

By: Milan Popl,Jan Fahnrich,Vlastimil Tatar

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Chromatographic Analysis of Alkaloids

By: Milan Popl,Jan Fahnrich,Vlastimil Tatar

Beginning with classification, nomenclature, and structures, this reference discussesphysicochemical properties of alkaloids relevant to the chromatographic process.Chromatographic Analysis of Alkaloids explores the main experimental factors affectingthe separation and detection of alkaloids in gas (GC), liquid (LC), and thinlayer(1LC) chromatography ... illustrates separation conditions described in recentliterature ... provides, for a given compound, the GC, LC, and 1LC techniquesavailable within the same paragraph ... surveys, in tabular form, the methods forsample preparation for chromatographic analysis ... contains over 1,200 up-to-datereferences covering the majority of papers on the chromatography of alkaloids... and more.Serving as a rich resource of practical information, Chromatographic Analysis ofAlkaloids is essential reading for analytical, organic, natural products, and forensicchemists and biochemists, pharmacologists, and graduate-level students in thesedisciplines.

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Page Count

684

Publisher

Routledge

Published Date

ISBN 10

1351460889

ISBN 13

9781351460880